She reported that two days previously she had developed fever and vomiting four hours after taking her first dose of fenofibrate (145 mg). [ncbi.nlm.nih.gov]

A 67-year-old woman with cellulitis of the left lower extremity was admitted with marked bilateral lymphedema of the lower extremities and diffuse erythema of the left lower extremity from foot to knee. She was given clindamycin and then vancomycin. [ncbi.nlm.nih.gov]

Sampson, Olga Klinkova, Julie Vitko and Beata Casanas, A Plethora of Pustules: Acute Generalized Exanthematous Pustulosis, The American Journal of Medicine, (2018). [doi.org]

The patient presented with an erythematous and pustular eruption after taking 1 tablet of paracetamol for a sore throat. [thedoctorsdoctor.com]

throat was treated with three doses of acetaminophen (10 mg/kg), and 12 hours later, she developed an erythematous rash over her gluteal region and legs. [fda.gov]

We describe a case of a woman with AGEP, who presented with generalized pustulosis lesions after the use of piroxicam for renal colic. [ncbi.nlm.nih.gov]

We assume that the administration of the 5 different antibiotics resulted in type IV allergy as well as secondary infection with Enterococcus faecium and Staphylococcus aureus, while the underlying periodontitis also contributed to the severity of this [ncbi.nlm.nih.gov]

We report a 50-year-old man who developed fever and a sudden eruption of widespread pustules 12 days after ingestion of celecoxib prescribed for a prolapsed intervertebral disc. [ncbi.nlm.nih.gov]

On day 5, her condition worsened, with erythema involving the entire back. Although treatment with clindamycin and vancomycin was discontinued, acute generalized exanthematous pustulosis developed. [ncbi.nlm.nih.gov]

(a) At first presentation, the patient showed suberythrodermic exanthema with typical non-follicular pustules. (b) Histology revealed slight acanthosis and subcorneal pustules filled with neutrophils. [medicaljournals.se]

[…] leg. with eosinophilia, psoriasis-like exanthema and AGEP [5]. [symbiosisonlinepublishing.com]

Drug-induced hypersensitivity syndrome (DIHS) and exanthema in drug reaction with eosinophilia and systemic symptoms (DRESS) each display a variety of histopathological findings, which may partly correlate with the clinical manifestations. [ncbi.nlm.nih.gov]

The disulfiram can induce multiple cutaneous reactions. [4], [5] The acneiform eruptions, dermatitis, exanthema, purpura, rashes, urticaria, and vasculitis are reported in literature. [6] Disulfiram induces eczema in patients sensitized to rubber. [ijdd.in]

Gonzalo-Garijo MA, Pérez-Calderón R, de ArgilaFernández-Durán D (2008) Severe generalized exanthema due to etanercept given for severe plaque psoriasis. Ann Allergy Asthma Immunol 100: 621-622. [omicsonline.org]

We report a case of severe AGEP with extensive blistering mimicking toxic epidermal necrolysis (TEN) in a 47-year-old woman. This was associated with a life-threatening primary mumps infection, complicated by perimyocarditis and encephalitis. [ncbi.nlm.nih.gov]

Stevens Johnson and TEN are characteristically different from AGEP by their slower onset (and longer duration) of 1-3 weeks, blisters instead of pustules, mucosal involvement, and lack of leukocytosis [4]. [oatext.com]

The signs and symptoms of Acute Generalized Exanthematous Pustulosis may include the following: Skin rashes on the face, armpits, and groin Small blisters with white/yellow fluid Fever and malaise (feeling of illness) Facial swelling The onset of the [dovemed.com]

Furthermore, the patient suffered from severe pruritus in the affected areas. [karger.com]

The patient complained of a burning sensation of the skin in addition to pruritus; and simultaneously had a fever of 38-39 C as the eruption expanded. Discussion: A spider bite may represent a possible causative factor of AGEP. [jstage.jst.go.jp]

Cutaneous adverse reactions (CAR) attributed to fenofibrate are rare and include acute hypersensitivity reactions such as severe skin rashes, urticaria, photosensitivity reactions, contact dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, pruritus [edoj.org.eg]

Off‐target ADRs may or may not be associated with immunological memory, although they can manifest with a variety of shared clinical features, including maculopapular exanthema, severe cutaneous adverse reactions (SCARs), angioedema, pruritus and bronchospasm [doi.org]

CASE REPORT A 69-year-old male was referred to our clinic because of generalized pruritus and erythema accompanied by high fever. He had a history of hypertension for 20 years and had been taking 16 mg candesartan cilexetil tablets. [kjim.org]

A 38-year-old primigravida whose labor had been induced developed erythema over her chest and abdomen. She was transferred to our department after a failed vacuum extraction, and delivered a mature infant by forceps. [ncbi.nlm.nih.gov]

The 2 groups were compared in terms of age, gender, systemic symptoms (such as fever, myalgias, or headaches), duration of disease, history of drug allergy, laboratory data, and pathologic findings. [doi.org]

The skin eruptions are often pruritic and accompanied by fever, headache, a high number of neutrophils and eosinophils in the blood, and elevated blood levels of markers for inflammation (i.e. erythrocyte sedimentation rate and C reactive protein). [en.wikipedia.org]

He gave history of taking a tablet of ASA for headache, few hours before development of the rash and fever. He had taken the same drug earlier innumerable times in last 15 years, without any side effects; however, it was a 325 mg tablet this time. [idoj.in]

After 24 hours, he was admitted with complaints of high fever (40 ), increased number of skin lesions, arthralgia, and headache. A dermatological examination revealed exanthema over 60% of the body accompanied by angioedema of the lips and eyelids. [kjim.org]

While many of the most severe cutaneous reactions are likely to present initially to the emergency department, it is important not to neglect the role of the ambulatory care provider in managing those cases which present to a clinic. [ijcasereportsandimages.com]

A 58-year-old woman with type 1 diabetes was hospitalized for treatment of an extensive blistering rash on the buttocks and trunk accompanied by fever, hypotension, tachycardia, neutrophilia, impaired renal function, and liver enzyme abnormalities. [ncbi.nlm.nih.gov]