Presentation
Retinal hemorrhages are present, the optic disc is swollen, and an exudative retinal detachment ( arrows ) is present inferiorly. Yellow Elschnig spots (asterisk) are present in the macula. B. Fluorescein angiogram corresponding to A. [entokey.com]
Hence 64% of the patients presented with cardiovascular involvement. [japi.org]
Bilateral, bullous, and serous detachments are usually present, and are frequently observed in the absence of significant retinal vascular abnormalities. [dovepress.com]
The vital signs upon presentation are summarized in Table 1. The patient’s physical exam showed bilateral costovertebral angle tenderness, and his laboratory tests are summarized in Table 2. [djo.harvard.edu]
Patients with acute or malignant hypertension can present with decreased vision and headaches, accompanied by significantly elevated blood pressure. However, they can also be asymptomatic. [morancore.utah.edu]
Entire Body System
- Pain
A 26-year-old Latino man with no past medical history of diabetes or hypertension presented to the emergency room complaining of nausea, back pain, fatigue, cough with yellowish sputum, and pleuritic chest pain. [djo.harvard.edu]
He has no complaint, and when asked he denies any chest pain or discomfort, difficulty breathing, dizziness, weakness, syncope, abdominal or back pain, nausea, vomiting or headache. He is alert and oriented to person, place, time and event. [emsworld.com]
Thirteen patients (26%) had complaints of headache, whereas 12 (24%) patients complained of chest pain on admission. Other symptoms included vomiting, giddiness, psychomotor agitation, and decreased urine output. [japi.org]
Dyspnoea Bibasal crepitations Raised jugular venous pressure (JVP) Hypertensive nephropathy Oliguria Intracerebral haemorrhage Drowsiness Coma Focal neurological signs Aortic dissection Tearing chest pain radiating to the back Differential in pulse and [oxfordmedicaleducation.com]
- Anemia
His anemia was though to be anemia of chronic disease secondary to renal failure and his dyslipidemia is consistent with nephrotic syndrome. [djo.harvard.edu]
These include diabetic retinopathy, retinopathy due to autoimmune disease, anemia, radiation retinopathy, and central retinal vein occlusion. [2] Keith Wagener Barker (KWB) Grades [ edit ] Grade 1 Vascular Attenuation Grade 2 As grade 1 + Irregularly [en.wikipedia.org]
Other conditions with diffuse retinal hemorrhage that can resemble hypertensive retinopathy include radiation retinopathy, anemia and other blood dyscrasias, ocular ischemic syndrome, and retinal vein occlusion. [eyewiki.aao.org]
Oliguria in MHTN occurs as a consequence of malignant nephrosclerosis, microangiopathic haemolytic anemia, polyarteritis nodosa, lupus, acute cortical necrosis and scleroderma. [academic.oup.com]
Miscellaneous: Migraine, Lyme disease, hypotension, acquired immunodeficiency syndrome (AIDS), interferon therapy, metastatic carcinoma, intravenous drug abuse (chronic), papilledema, acute pancreatitis, severe anemia, radiation retinopathy, leptospirosis [entokey.com]
- Weakness
Umapathi, Swee-Ling Wong First published August 21, 2006, DOI: https://doi.org/10.1212/01.wnl.0000218187.48702.3a A 42-year-old man, whose blood pressure averaged 230/130 mm Hg, presented with right brachiofacial weakness from acute left internal watershed [neurology.org]
Neurological examination did not show any motor or sensory weakness in the lower limbs. On ocular examination, she had vision of counting fingers in both eyes. [ijo.in]
He has no complaint, and when asked he denies any chest pain or discomfort, difficulty breathing, dizziness, weakness, syncope, abdominal or back pain, nausea, vomiting or headache. He is alert and oriented to person, place, time and event. [emsworld.com]
Table Legend: +++ = Strong association (relative risks/odds ratios >2.0), ++ = Moderate association (1.5 to 2.0), + = Weak association Classification and Epidemiology The traditional classification of hypertensive retinopathy 4 typically consists of four [reviewofophthalmology.com]
[…] associated with essential hypertension, coronary heart disease, and vasculogenesis. 5 Polymorphisms of apolipoprotein E and angiotensin-converting enzyme I/D genes, 51 chromosome 6p21.1, 52 novel chromosome 5, 53 and novel locus 12q24, 54 have shown weak [retinalphysician.com]
Cardiovascular
- Thrombosis
Lipid deposition in the intima often is associated with calcification and fibrosis, which can compromise the lumen and predispose the artery to thrombosis. [louisvillediabeticeyedoctor.com]
It has undergone spontaneous thrombosis. (Arrow showing round white lesion.) [nature.com]
Skin
- Flushing
Antihypertensives Choice includes (list not exhaustive): Sublingual / oral nifedipine : tabs - 0.5 - 1.0 mg/kg/dose (max. 40 mg) 12-hourly Side effects include tachycardia, flushing and fluid retention. [rch.org.au]
Eyes
- Retinal Hemorrhage
Key findings include the following: ● Retinal hemorrhages ● Retinal microaneurysms ● Retinal exudates ● Cotton wool spots ● Macular edema Complications of radiation retinopathy include retinal ischemia, retinal neovascularization, vitreous hemorrhage, [neuro-ophthalmology.stanford.edu]
and multiple superficial and deep retinal hemorrhages ( Figure 1 ). [dovepress.com]
[…] contrast, focal arteriolar narrowing, retinal hemorrhages, microaneurysms, and cotton wool spots reflect more transient changes of acute blood pressure elevation, and are linked only with concurrent blood pressure measured at the time of the retinal [reviewofophthalmology.com]
When associated with diabetes mellitus, systemic arterial hypertension, and retinal venous obstruction, they are generally seen concomitantly with retinal hemorrhages. [entokey.com]
Hypertensive retinopathy manifests with retinal arteriolar changes, cotton-wool spots, retinal hemorrhages, and retinal edema. Chronic hypertension results in arteriolosclerosis that in turn produces the so-called copper-wire arteries. [westcoastretina.com]
- Flame-Shaped Hemorrhage
Funduscopic examination shows arteriolar constriction, arteriovenous nicking, vascular wall changes, flame-shaped hemorrhages, cotton-wool spots, yellow hard exudates, and optic disk edema. [msdmanuals.com]
Chronic HTN : Arteriovenous crossing changes (“AV nicking”), retinal arteriolar sclerosis (“copper” or “silver” wiring), cotton-wool spots, flame-shaped hemorrhages, arterial macroaneurysms, central or branch occlusion of an artery or vein. [medium.com]
Pathophysiology Retinal hemorrhages (Figure 1-3) develop when necrotic vessels bleed into either the nerve fiber layer (flame shaped hemorrhage) or the inner retina (dot blot hemorrhage). [eyewiki.aao.org]
At presentation, optic discs welling, macular edema, and peripapillary flame-shaped hemorrhages and hard exudates were present in both eyes (a). [ojoonline.org]
Hypertensive retinopathy signs can be broadly classified into diffuse retinal signs, such as generalized arteriolar narrowing and arteriolar wall opacification, and localized signs, such as focal arteriolar narrowing, arteriovenous (AV) nicking, and blot and flame-shaped [reviewofophthalmology.com]
- Background Retinopathy
retinopathy and retinal vascular changes 2016 2017 2018 2019 Non-Billable/Non-Specific Code Code Also any associated hypertension ( I10.- ) Background retinopathy and retinal vascular changes Approximate Synonyms Bilateral hypertensive retinopathy Hypertensive [icd10data.com]
- Retinal Lesion
Areas of retinal pigment epithelium clump and atrophy (Elschnig spots), forming from the focal acute white retinal pigment epithelium lesions. [emedicine.medscape.com]
The lesions measure about one quarter of the disc area but are clinically larger, as they coalesce with adjacent lesions. [medtextfree.wordpress.com]
Neurologic
- Papilledema
Introduction Focal spasms followed by progressive sclerosis and narrowing of retinal vessels Results in flame hemorrhage from vessel rupture, formation of exudates, and papilledema Presentation Symptoms vision loss Physical exam tortuous retinal veins [medbullets.com]
In the presence of papilledema, the subsequent atrophy of the optic nerve can produce lasting and occasionally severe loss of visual acuity. [alpfmedical.info]
Hypertensive optic neuropathy can cause chronic papilledema, leading to optic nerve atrophy and severe loss of visual acuity [1]. [eyewiki.aao.org]
This manifests as hard exudates often in a “macular star” configuration, papilledema (leakage from arterioles supplying optic disk), cotton-wool spots (ischemia to nerve fibers), flame-shaped hemorrhages (necrosis, bleeding), optic nerve head edema. [medium.com]
[…] blood vessels): This usually occurs in a star configuration around the macula, which can indicate swelling of the macula and cause vision loss Retinal edema (swelling of the retina in other areas), which can lead to retinal detachment and vision loss Papilledema [dovemed.com]
Workup
Systemic workup: This is similar to that of acute central retinal artery obstruction. [entokey.com]
An extensive workup was carried out to define the etiology of the renal failure (Table 3). A kidney biopsy was not warranted given the ESRD and the potential complications associated with the procedure. [djo.harvard.edu]
The patient was transferred to the intensive care unit for therapeutic management of hypertension and systemic workup. [dovepress.com]
What is the proper workup of a patient with hypertension? Cleve Clin J Med 75: 663-72. ↑ 4.0 4.1 Garner, A. & Ashton, N. 1979. Pathogenesis of hypertensive retinopathy: a review. [eyewiki.aao.org]
Treatment
Make optimal use of the newest drug therapies, including Anti-VEGF treatment for wet ARMD and bevacizumab treatment for complications of diabetes. [books.google.com]
[…] in pregnancy Sodium nitroprusside is used only in hypertensive emergencies Reflex tachycardia Sodium and water retention Cyanide toxicity with long-term use of sodium nitroprusside Pharmacologic treatment in pregnancy First-line treatment: methyldopa [amboss.com]
Serial photographs of the retina demonstrated a progressive improvement in the hypertensive retinopathy (Panels B and C) after the successful treatment of the patient's elevated blood pressure. [nejm.org]
Treatment It does not exist a specific treatment for the retinopathy hipertensiva. The treatment consists in controlling adequately the arterial pressure. [oftalprat.com]
Prognosis
The condition is more common than usually perceived and would have a much worse prognosis than the usual forms of hypertension. [journals.lww.com]
What is the prognosis of the ocular ischemic syndrome? The prognosis of the ocular ischemic syndrome is poor. Laser panphotocoagulation of the ischemic retina may reduce neovascularization as with proliferative diabetic retinopathy. 17. [neuro-ophthalmology.stanford.edu]
Prognosis and Management The visual prognosis for central vision is good unless there are innumerable cotton-wool spots as with entities such as systemic lupus erythematosus, pancreatitis, Purtscher’s retinopathy, or intravenous drug abuse. [entokey.com]
In a classic study in 1939 Keith and colleagues [5] described the prognosis of people with differing severity of retinopathy. [en.wikipedia.org]
The prognosis has improved dramatically over the period of a few decades and with optimal treatment the five-year survival rate is >80%. [ 6 ] [patient.info]
Etiology
An extensive workup was carried out to define the etiology of the renal failure (Table 3). A kidney biopsy was not warranted given the ESRD and the potential complications associated with the procedure. [djo.harvard.edu]
[…] glomerulonephritis, polycystic kidney dz, chronic renal dz/failure -endo dz: cushing's, primary aldosteronism, pheochromocytoma, influence of exogenous hormones (glucocorticoids, estrogens) -vascular dz: renal a stenosis, polyarteritis nodosa, coarctation of aorta etiology [quizlet.com]
Epidemiology and Etiology The prevalence is uncertain. Cotton-wool spots are seen in over 40% of cases of diabetic retinopathy and also with acute systemic arterial hypertension. No hereditary pattern is known. [entokey.com]
Etiology Clinical features Hypertension is usually asymptomatic until complications of end-organ damage arise or an acute increase in blood pressure occurs (see hypertensive urgency below). [amboss.com]
Regardless of etiology, acutely or chronically elevated blood pressures can damage the eye, and in particular, the retina. Hypertensive retinopathy is the result of changes to the retinal vasculature in high blood pressure states. [morancore.utah.edu]
Epidemiology
The book is comprised of 56 chapters, beginning with detailed sections on epidemiology and pathophysiology of hypertension, followed by secondary hypertension. Further sections cover the examination, diagnosis, and management of hypertension. [books.google.com]
Epidemiology Hypertensive retinopathy can be divided into chronic and acute phases. The most commonly used classification is the Keith–Wagener–Barker classification. [entokey.com]
So far, only epidemiological studies uniformly found that qualitative retinal signs of hypertensive retinopathy are related with incidence of CV disease. [medium.com]
References: [4] [5] [1] [6] [7] [8] [9] [10] Epidemiological data refers to the US, unless otherwise specified. [amboss.com]
Epidemiology: Arterial hypertension in particular figures prominently in clinical settings. Vascular changes due to arterial hypertension are the most frequent cause of retinal vein occlusion. [alpfmedical.info]
Pathophysiology
The book is comprised of 56 chapters, beginning with detailed sections on epidemiology and pathophysiology of hypertension, followed by secondary hypertension. Further sections cover the examination, diagnosis, and management of hypertension. [books.google.com]
Hypertensive Retinopathy Prevalence Symptoms Diagnostic techniques and signs Pathophysiology Associated conditions Management 3. [slideshare.net]
Pathophysiology Embolic Hypertensive arteriolar necrosis Inflammatory See Diagnostic Evaluation below Clinical Signs Visual acuity: Central visual acuity is usually unaffected, although patients may note the sudden appearance of corresponding blind spots [entokey.com]
Pathophysiology Acute BP elevation typically causes reversible vasoconstriction in retinal blood vessels, and hypertensive crisis may cause optic disk edema. [msdmanuals.com]
Glomerulonephritis Chonic pyelonephritis Polycystic kidney disease Endocrine Cushing’s syndrome Conn’s syndrome Acromegaly Hyperthyroidism Phaeochromocytoma Arterial Coarctation of the aorta Drugs Alcohol Cocaine Amphetamines Pregnancy Pre-eclamplsia Pathophysiology [oxfordmedicaleducation.com]
Prevention
Prevention Well controlled blood pressure will prevent hypertensive retinopathy. Contact Us Please contact us at (239)390-3339 or click here to use our contact form [retinaandmacula.com]
Hypertensive Retinopathy can be prevented by undertaking routine visits to one’s primary care physician to control blood pressure. [dovemed.com]
or beta-blockers) If predialysis serum sodium level is < 140 mEq/L, dialysate sodium concentration may be decreased to minimize intradialytic sodium gain If patient develops edema, increase ultrafiltration rate to optimize fluid removal (optional) Prevention [clinicaladvisor.com]
[…] fashion to prevent end-organ damage. [medtextfree.wordpress.com]
Prevention The importance of having an examination of the fundus in hypertension patients, age and the presence of other cardiovascular risk factors makes it necessary to follow periodic monitoring from an ophthalmologist, for an examination of the fundus [barraquer.com]