Presentation
He was put on aspirin following surgery and took ibuprofen for fever for nearly a week prior to presentation. [ncbi.nlm.nih.gov]
Musculoskeletal
-
Morning Stiffness
He later developed a symmetric distal polyarthritis with morning stiffness mimicking RA. [ncbi.nlm.nih.gov]
Workup
All other workup was negative including urine eosinophils, urine casts, urine culture, urine drug screen, ANA, serum and urine electrophoresis, and renal ultrasound. [shmabstracts.com]
General Investigation The patient usually needs a complete workup. [myvmc.com]
Renal ultrasound may be ordered as part of the workup for acute renal failure, however, there are no pathognomonic signs for AIN on ultrasound. F. Over-utilized or “wasted” diagnostic tests associated with this diagnosis. [clinicaladvisor.com]
Treatment
Severe allergic reactions from bortezomib treatment including AIN have not been described in the literature. We report a 47-year-old white man who developed biopsy-proven allergic AIN after treatment with bortezomib for his C3 glomerulonephritis. [ncbi.nlm.nih.gov]
Prognosis
Prognosis of benign renal glycosuria is excellent and reversible. Acute interstitial nephritis (AIN) is one of the main causes of acute renal failure and may often result in tubular dysfunction. [ncbi.nlm.nih.gov]
Prognosis The overall prognosis for AIN is excellent. Most patients’ renal function recovers upon cessation of the offending agent. The improvement occurs within 6-8 weeks. [myvmc.com]
Features of interstitial fibrosis may be seen within 7-10 days and may be accompanied by tubular atrophy and portend a POOR prognosis with the development of variable degrees of CKD Immunofluorescence 1. Often negative 2. [renalandurologynews.com]
NSAIDs) P enicillins and cephalosporins P roton pump inhibitors rifam P in systemic infections mycoplasma autoimmune diseases systemic lupus erythematosus sarcoidosis Pathogenesis type IV hypersensitivity reaction T-cell-mediated attack on tubular cells Prognosis [medbullets.com]
Etiology
Many etiologies of AIN have been recognized--including allergic/drug-induced, infectious, autoimmune/systemic, and idiopathic forms of disease. The most common etiology of AIN is drug-induced disease, which is thought to underlie 60-70% of cases. [ncbi.nlm.nih.gov]
Epidemiology
Acute interstitial nephritis (AIN) is an important cause of acute kidney injury that has experienced significant epidemiological and clinical changes in the last years. [ncbi.nlm.nih.gov]
Epidemiology Relative Frequencies of Etiologies Drugs : account for 70-75% of acute interstitial nephritis cases Antibiotics : account for 30-49% of drug-associated acute interstitial nephritis cases Infections : account for 4-10% of acute interstitial [mdnxs.com]
Introduction Clinical definition acute interstitial nephritis (AIN), also known as tubulointerstitial nephritis, is an acute immune-mediated interstitial inflammation of the kidneys Epidemiology demographics male:female ratio is 3:1 in methicillin-induced [medbullets.com]
Epidemiology and clinical manifestations of adenovirus infection. Laatste update: 16 aug 2013. Chen EC, Yagi S, Kelly KR, Mendoza SP, Maninger N, Rosenthal A et al. [lci.rivm.nl]
Epidemiology[edit] Interstitial nephritis is uncommon ( 1% incidence) in patients without any symptoms but occurs in about 10-15% of hospitalized patients with acute kidney injury of unknown cause.[2] While it can occur in patients of all ages, it is [en.wikipedia.org]
Pathophysiology
The pathophysiologic causes, however, are varied. [ncbi.nlm.nih.gov]
DISCUSSION: The pathophysiology of TINU Syndrome remains poorly understood, probably involving both cellular and humoral immunity. [bjn.org.br]
Tubulointerstitial diseases of the kidney encompass diverse etiologies and pathophysiologic processes, and the patient can present with acute or chronic conditions. [emedicine.medscape.com]
Tubulointerstitial nephritis encompass diverse etiologies and pathophysiologic processes, and the patient can present with acute or chronic disease. [kidneypathology.com]
Prevention
A 68-year-old woman was scheduled to undergo percutaneous embolization of a pulmonary arteriovenous malformation (PAVM) to prevent a paradoxical embolic event. [ncbi.nlm.nih.gov]
can’t be prevented. [medanta.org]