A 15-year-previously-healthy male boy presented to the Hospital with a 6-day history of malaise, fever and cough. [ncbi.nlm.nih.gov]

We report a case of anti-synthetase syndrome presenting as acute interstitial pneumonia (AIP). CASE PRESENTATION We present the case of a 42-year-old school teacher of Malaysian origin. She was an ex-smoker. [academic.oup.com]

Fever is present in almost half of the patients on presentation and a history of viral-like symptomatology exists in most cases but extensive investigations for bacterial and viral agents are negative. [orpha.net]

Case Presentation A 51-year-old woman, nonsmoker, without underlying diseases, no suspicious case history was admitted to the hospital for further workup of symptoms of cough, expectoration, and progressive dyspnea. [hindawi.com]

Initial workup revealed ground-glass opacities on computed tomography (CT) scan of the chest. Cardiac workup was unrevealing with a normal myocardial perfusion stress test. [ncbi.nlm.nih.gov]

[…] can also be found in other diseases such as CTDs, which is another ILD classification, but is idiopathic when the cause is unknown despite a comprehensive workup. [consultant360.com]

[…] often needed to make a diagnosis, with pertinent information and expertise contributed by the pulmonologist, radiologist and pathologist. 4 High-resolution CT should be obtained in virtually all patients with a suspected ILD. 4 Additional diagnostic workup [appliedradiology.com]

BAL cell count and differential may be useful in the diagnostic workup of the hospitalized patient with ILD. [bmcmedicine.biomedcentral.com]

Acute interstitial pneumonia showing a marked reduction in lung capacity Treatment[edit] Treatment is primarily supportive. Management in an intensive care unit is required and the need for mechanical ventilation is common. [en.wikipedia.org]

This report describes a case of MDS in a patient who developed fatal acute interstitial pneumonitis (AIP) after the first seven-day course of intravenous azacitidine (75 mg/m(2)/day) treatment. [ncbi.nlm.nih.gov]

The lack of reports describing the use of CyA for the treatment of RA‐associated AIP warrants caution in its use; nevertheless, in our opinion, the poor prognosis of this complication of RA justifies treatment with this agent. Fig. 1. [academic.oup.com]

Management and treatment There is no proven treatment, however high-dose corticosteroids and cyclophosphamide are the drugs usually used. Prognosis The prognosis is severe and early mortality is high. [orpha.net]

Unfortunately, patients with polymyositis/dermatomyositis associated with pulmonary complications have a worse prognosis than patients with isolated forms. [ncbi.nlm.nih.gov]

It has a grave prognosis with 70% mortality in 3 months, despite mechanical ventilation. This review aims to clarify the relative clinical and pathological issues and terminology. [erj.ersjournals.com]

Prognosis The prognosis is severe and early mortality is high. The documents contained in this web site are presented for information purposes only. [orpha.net]

Prognosis depends on the histopathology findings and the specific form of interstitial lung disease and its response to therapy, which consists of high-dose steroids and immunomodulating agents. [rc.rcjournal.com]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

[…] specific etiologic agent or inciting event. [emedicine.medscape.com]

Katzenstein reserves the term AIP for those cases where there is no identifiable underlying etiology (such as sepsis). [histopathology-india.net]

Infectious etiology was excluded on the basis of microbiological investigations. [hindawi.com]

Epidemiology[edit] Acute interstitial pneumonitis occurs most frequently among people older than forty years old. It affects men and women equally. There are no known risk factors; in particular, smoking is not associated with increased risk. [en.wikipedia.org]

Summary Epidemiology Prevalence of Acute interstitial pneumonia (AIP) is estimated at 1 in 25,000. Clinical description AIP occurs over a wide age range, with a mean age of approximately 50 years. [orpha.net]

Many questions still linger regarding the epidemiology, pathogenesis, and outcome. [thieme-connect.com]

Extremely rare (no conclusive epidemiological data available) Mean age 50 years but can occur at any age (7 - 83 years) (Eur Respir J 2000;15:412) No sex predilection Sites Bilateral lung, usually in all five lobes of the lung Pathophysiology Both endothelial [pathologyoutlines.com]

We describe the case of a fulminant form of AIP and discuss the pathophysiological mechanisms of AIP with reference to the histological pattern. [ncbi.nlm.nih.gov]

[…] alveolar damage Epidemiology Extremely rare (no conclusive epidemiological data available) Mean age 50 years but can occur at any age (7 - 83 years) (Eur Respir J 2000;15:412) No sex predilection Sites Bilateral lung, usually in all five lobes of the lung Pathophysiology [pathologyoutlines.com]

Pathophysiology [ edit ] Macklin described the pathophysiology of Hamman's syndrome to be barotrauma, whereby rupture of alveolar membranes causes a positive pressure gradient of air from the lungs into the mediastinum (the Macklin effect). [3] Diagnosis [en.wikipedia.org]

In this report, we present a case of a mid-age female with AIPwho, though treated with intensive physical and pharmacologic care, still displayed a rapid progressive pathophysiologic process, and eventually died of respiratory failure. 2. [hindawi.com]

Eosinophilic pneumonia Eosinophilic pneumonia is similar to organizing pneumonia in pathophysiology, but is mediated instead by an inappropriate increase in the number of eosinophils and macrophages in alveoli. [appliedradiology.com]

Further study to identify causal factors is required in the hope of preventing morbidity and mortality related to this disease. [ncbi.nlm.nih.gov]

[…] of Medicine (JSV, KKB, RMC), National Jewish Medical and Research Center; Department of Pathology (CDC); Division of Pulmonary Sciences and Critical Care Medicine (MIS), University of Colorado Health Sciences Center, Denver, Colorado; Department of Preventive [journals.lww.com]

After a few days of adjuvant therapy with temozolomide and prophylaxis with trimetrophin-sulfamethoxazolo to prevent Pneumocystis Jiroveci, she had progressive and rapid worsening of symptoms with weakness, dyspnea and orthopnea. [currentdrugsafety.com]

To effectively follow up patients treated with gefitinib and to prevent deaths from gefitinib-induced lung injury, early recognition and intervention may prevent a fatal outcome, corticosteroids and non-invasive BIPAP-ventilation should be considered [jtd.amegroups.com]