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Acute Lung Injury


Presentation

  • This presentation is not the classic description of TRALI. Our patient improved with supportive treatment and was successfully extubated on postoperative day 4.[ncbi.nlm.nih.gov]
Intravenous Administration
  • Intravenous administration of fluids, as well as vasopressors, are essential for blood pressure support. Use of diuretics, which are indicated in the management of transfusion associated circulatory overload (TACO), should be avoided in TRALI.[en.wikipedia.org]
Familial Adenomatous Polyposis
  • A 38-year-old woman who had familial adenomatous polyposis was admitted to the intensive care unit with an episode of severe sepsis 5 days after undergoing a pancreas-preserving duodenectomy.[ncbi.nlm.nih.gov]
Weight Loss
  • It was found that body weight loss, lung tissue microstructure lesions, transvascular leakage increase, malondialdehyde augmentation, and the reduction of superoxide dismutase and glutathione peroxidase levels caused by LPS challenge were all consistently[ncbi.nlm.nih.gov]
Camping
  • Additionally, activity of cAMP-related phosphodiesterase (PDE)4, but not PDE3 or PDE7, was significantly reduced by UFM24.[ncbi.nlm.nih.gov]
Abdominal Pain
  • A 39-year-old man with cholangiocarcinoma presented with fever and abdominal pain. He was hypotensive, jaundiced and had right upper quadrant tenderness.[ncbi.nlm.nih.gov]
Jaundice
  • He was hypotensive, jaundiced and had right upper quadrant tenderness. Laboratory testing showed a leucocytosis, elevated liver function tests, total bilirubin and International Normalised Ratio (INR).[ncbi.nlm.nih.gov]
Left Ventricular Dysfunction
  • The clinical presentation included pulmonary edema, severe postoperative lactic acidosis, left ventricular dysfunction, increased creatine phosphokinase, fatty infiltration of the liver, and hemodynamic instability requiring inotropic support.[ncbi.nlm.nih.gov]
Purpura
  • We report a thrombotic thrombocytopenic purpura (TTP) treatment-associated case of TRALI and review the history, pathogenesis, diagnosis and management of this syndrome. Current risk reduction strategies are also discussed.[ncbi.nlm.nih.gov]
  • Transfused plasma (from any component source) may also contain antibodies that cross-react with platelets in the recipient, producing usually mild forms of posttransfusion purpura or platelet aggregation after transfusion.Another nonspecific form of immunologic[en.wikipedia.org]
Cesarean Section
  • Congenital hypofibrinogenemia may be responsible for the development of subfascial hematoma, a complication of cesarean section, necessitating relaparotomy.[ncbi.nlm.nih.gov]

Workup

  • She was managed as TRALI after diagnostic workup and transported to the intensive care unit. In the following days her clinical status changed dramatically with complete recovery.[ncbi.nlm.nih.gov]

Treatment

Prognosis

  • Treatment and prognosis It tends to be self-limiting and treatment is supportive, with a prognosis substantially better than most causes of clinical acute lung injury. transfusion-associated circulatory overload (TACO) Promoted articles (advertising)[radiopaedia.org]
  • Since prognosis can be excellent, identification and emergent management is essential, particularly in patients with comorbid neurological disease.[ncbi.nlm.nih.gov]

Etiology

  • CONCLUSIONS: In the absence of any other known etiology, multiple defibrillation shocks may have played a role in the genesis of ALI in our patient, but this remains speculative.[ncbi.nlm.nih.gov]
  • Martínez-Salazar,Alberto Tobón-Castaño Infectio. 2014; 18(3): 120 4 Etiology and Outcomes of ARDS in a Rural-Urban Fringe Hospital of South India Tarun George,Stalin Viswanathan,Ali Hasan Faiz Karnam,Georgi Abraham Critical Care Research and Practice.[dx.doi.org]
  • The etiology of TRALI may be attributable to the presence of anti-HLA and/ or anti-granulocyte antibodies in the plasma of multiparous females or donors who have received previous transfusions.[fda.gov]

Epidemiology

  • Since reliable data on its epidemiology in Brazil are not available, the difficulty to diagnose, varied clinical presentation, and absence of specific laboratory data, case reports are important.[ncbi.nlm.nih.gov]
  • If there is no prognostic or epidemiological difference between ALI and ARDS patients, then the two categories should be combined.[thorax.bmj.com]
  • Additionally, most studies investigating the epidemiology of TRALI have focused on patients in the critical care setting.[anesthesiology.pubs.asahq.org]
  • However, these frequencies are higher than those found in national epidemiological studies conducted in the cities of Porto Alegre and São Paulo. (18-19) Comparison with other epidemiological studies is difficult due to methodological differences and,[scielo.br]
Sex distribution
Age distribution

Pathophysiology

  • The history, pathophysiology, and treatment of TRALI are discussed. Potential preventive measures are reviewed.[ncbi.nlm.nih.gov]

Prevention

  • Prevention of TRALI represents a complex challenge. There is no single intervention that will prevent every case of TRALI, but several interventions have been proposed to reduce the risk.[ncbi.nlm.nih.gov]

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