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Acute Myeloid Leukemia with 11q23 Abnormalities

AML with 11q23 abnormalities


Presentation

  • We present here the outcome of 14 AML patients with 11q23 abnormalities transplanted beyond first complete remission (CR) or with primarily refractory disease. Eleven cases were de novo and three therapy-related AML.[ncbi.nlm.nih.gov]
  • Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.[books.google.com]
  • Prognosis Factors Favourble Unfavourable Morphology Auer rods Present Absent Eosinophils Present Absent Megaloblastic erythroid Absent Present Dysplastic Absent Present megakaryocytes FAB type M2,M3,M4 M0,M6,M7 87.[slideshare.net]
  • When present, the tumor frequently has a characteristic immunophenotype [CD 19 ( ), CD 10 (-), CD 34 ( /-), CD 15 ( ), and CD 24 (-)]. The t(v;11q23) is present in 5-6% of all AML cases.[propath.com]
  • Case Presentation A 52-years old lady, presented with fatigue and lower backache and being investigated for the same. Meanwhile MRI spine was done and it revealed wedge compression of D8 vertebra.[austinpublishinggroup.com]
Physician
  • The text continues its tradition of correlating basic science with the clinical practice of hematology and is organized to help physicians find clinical answers quickly and easily.[books.google.com]
  • *Medscape Business of Medicine Academy Survey, September 2015 Learn from Experienced Professionals Courses were developed especially for physicians by business health experts and experienced physicians.[medscape.com]
  • We thank the physicians and patients who participated in the sample collection for the Cancer and Leukemia Group B leukemia tissue bank.[pnas.org]
  • We thank the following centers and physicians for their participation in the CETLAM LMA-99 protocol: Institut Calalá d'Oncologia, Hospitalet (JJ Berlanga); Hospital de la Santa Creu i San Pau, Barcelona (L Muñoz, JF Nomdedéu, A Aventín, S Brunet, J Sierra[nature.com]
Excitement
  • This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer.[books.google.com]

Workup

  • Viral : Patients may require workup including imaging, serologies, and viral titers. Treatment includes anti-viral agents such as acyclovir. Fungal : Patients may require workup including imaging and fungal cultures.[wikidoc.org]

Treatment

  • Comprehensive and up-to-date, Treatment of Acute Leukemias: New Directions for Clinical Research offers oncologists practical guidelines for precise diagnosis and optimal treatment of childhood and adult acute leukemia, as well as insights into those[books.google.com]
  • It is important to identify those children who can be cured with standard treatments and those who should receive more individualized treatment.[queensmedical.com]
  • Several different treatments work on AML: Chemotherapy Stem cell transplant Radiation Targeted therapy Your treatment will have two phases: Phase 1: Remission induction therapy.[webmd.com]
  • Our world-renowned experts have contributed to World Health Organization diagnostic and treatment guidelines.[cancer.osu.edu]

Prognosis

  • AML is a deadly form of malignancy, the prognosis for which has not improved in the last two decades. More importantly, it is a malignancy that is seen in older adults, therefore the number of cases is likely to rise as the population ages.[books.google.com]
  • Clinical features Symptoms: DIC, extramedullary myeloid sarcoma and tissue infiltration (gingiva, skin) Translocations occur in AML (intermediate prognosis) and ALL (poor prognosis, Blood Cells Mol Dis 2008;40:192 ) Prognosis may be superior to other[pathologyoutlines.com]
  • Prognostic categories as determined by European LeukemiaNet 2017 classification include favorable prognosis, intermediate prognosis, and poor prognosis.[wikidoc.org]
  • Functional Categories and Prognosis We then identified the functional categories associated with poor prognosis and good prognosis.[journals.plos.org]
  • Some less frequent isolated cytogenetic abnormalities have been characterized for their impact on prognosis such as del(11q) (very good prognosis), isochromosome 17q or 19 (intermediate prognosis), or inv3/t(3q)/del(3q) (poor prognosis).[ 2 ] These results[mjhid.org]

Etiology

  • No direct evidence suggests a viral etiology. Certain syndromes with somatic cell chromosome aneuploidy, such as trisomy 21 noted in Down syndrome, are associated with an increased incidence of AML.[accessmedicine.mhmedical.com]
  • (The current diagnostic approach and classification scheme for AML) Ongoing controversies regarding etiology, diagnosis, treatment The most important controversy in childhood AML is the most appropriate use of allogeneic HSCT in first remission.[clinicaladvisor.com]
  • Etiology and pathogenesis of causative MLL gene abnormalities in AML The cause of 11q23/ MLL AML is unknown, but important factors include ionizing radiation (the highest incidence was observed five to seven years after radiation exposure), chemicals[intechopen.com]
  • As Virchow was uncertain of the etiology of the white blood cell excess, he used the purely descriptive term "leukemia" (Greek: "white blood") to refer to the condition. [98] Further advances in the understanding of acute myeloid leukemia occurred rapidly[en.wikipedia.org]

Epidemiology

  • Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.[books.google.com]
  • Epidemiology The incidence of acute leukemia is approximately 4 cases per 100,000 per year. 70% of these are AML. AML is generally seen in adults with a median age of 60 years. In this age group the incidence is 10 cases per 100,000.[wiki.clinicalflow.com]
  • "The leukemias: Epidemiologic aspects.". In Lilienfeld AM (ed.). Monographs in Epidemiology and Biostatistics. New York: Oxford University Press. p. I. ISBN 978-0-19-503448-6. Aoki K; Kurihars M; Hayakawa N (1992).[en.wikipedia.org]
  • Childhood acute leukemias are frequent in Mexico City: descriptive epidemiology. BMC Cancer. 2011;11:355, doi: [ Links ] 11. Rivera-Luna R, Cárdenas-Cardos R, Olaya-Vargas A, Shalkow-Klincovstein J, Pérez-García P, Pérez-González OA, et al.[scielo.org.mx]
  • Phenotype / cell stem origin AML: M5a in half cases, M4 (20%), M1 or M5b (10% each), M2 (5%); ALL: B-cell mostly, L1 or L2, CD19 in 60% of B-ALL cases, CD10 35%; T-ALL in rare cases ( Epidemiology 25% are infant ( See also 11q23 rearrangements in childhood[atlasgeneticsoncology.org]
Sex distribution
Age distribution

Pathophysiology

  • It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care.[books.google.com]
  • Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Acute myeloid leukemia (AML) is one of the most common adult leukemias, with almost 10,000 new cases diagnosed per year.[mayomedicallaboratories.com]
  • "Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation". Thromb J. 4 : 4. doi : 10.1186/1477-9560-4-4. PMC 1402263. PMID 16504043. 2.0 2.1 Chen C, Huang X, Wang K, Chen K, Gao D, Qian S (2018).[wikidoc.org]
  • In rare cases, people with AML can develop a chloroma, or solid tumor of leukemic cells outside the bone marrow, which can cause various symptoms depending on its location. [7] An important pathophysiological mechanism of leukemogenesis in AML is the[en.wikipedia.org]

Prevention

  • They eventually crowd out normal, healthy blood cells and prevent them from being produced. AML can accumulate in the blood stream and organs such as the lymph nodes, brain, liver, kidneys, ovaries, testicles, and skin.[seattlecca.org]
  • How can childhood AML be prevented? To date, there are no data to suggest that childhood AML is a preventable disease. What is the evidence? Creutzig, U, Zimmermann, M, Ritter, J.[clinicaladvisor.com]
  • .: Therapy related leukemias: susceptibility, prevention and treatment. Leuk Lymphoma 41 (3-4): 255-76, 2001.[cancer.gov]
  • If no further postremission or consolidation therapy is given, almost all people with AML will eventually relapse. [63] Therefore, more therapy is necessary to eliminate nondetectable disease and prevent relapse — that is, to achieve a cure.[en.wikipedia.org]
  • The differentiation block prevents the body from producing infection-fighting cells. Patients are at increased risk for the following types of infections: Bacterial : Patients may require workup including imaging and blood cultures.[wikidoc.org]

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