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Acute Pandysautonomia

Acute Panautonomic Neuropathy


Presentation

  • The serology for EBV showed previous infection but anti-early antigen antibodies were present. No immunodeficiency was found. Neurological and GI recovery occurred after 6 months of parenteral nutrition and bethanechol.[ncbi.nlm.nih.gov]
  • They originally presented as psychiatric disorders, such as hysterical neurosis, epilepsy, anorexia nervosa and hypochondriacal neurosis.[ncbi.nlm.nih.gov]
  • Vomiting and constipation were present in 4 patients, diarrhea and constipation were alternatively present in 1 patient, abdominal distention and abdominal pain were present in 2 patients. (4) Cardiovascular system manifestations included postural dizziness[ncbi.nlm.nih.gov]
  • In two instances, signs and symptoms of a small-fiber sensory neuropathy were present.[mayoclinic.pure.elsevier.com]
  • We present a previously healthy 24-year-old female patient, who developed a loss of accommodation, pupillotonia, lacrimation, swallowing disturbances, gastrointestinal symptoms and an atonic bladder with 750 ml residual volume.[ncbi.nlm.nih.gov]
Splenectomy
  • Treatment with 50 g of liothyronine sodium (Cytomel) daily and splenectomy did not relieve the patient's symptoms. By March 1970, 14 months after the onset of symptoms, the patient had lost 50 lbs despite adequate caloric intake.[dokumen.tips]
Hypoventilation
  • A 6-year-old girl had subacute onset of hypoventilation and apnea during sleep. Diffuse dysautonomic changes were identified, including dilated, nonreactive pupils, decreased tearing and sweating, and abnormal temperature and cardiovascular control.[researchgate.net]
Fecal Incontinence
  • Signs of dysautonomia include orthostatic hypotension, atony of the bladder, urinary and fecal incontinence, poor thermal homeostasis, abnormal bowel motility, and impotence.[dokumen.tips]
Dysmetria
  • The initial and most severe symptom in all patients was ataxia of gait, followed by dysarthria and later by dysmetria of the limbs. Clinical examination did not reveal involvement of structures other than the cerebellum. Ocular motor ...[researchgate.net]

Workup

  • Additional workup included: the tumormarker Cyfra 211 and NSE were initially elevated, 2 month later nor-mal.[docslide.net]

Treatment

  • The findings are consistent with a dysimmune pathogenesis for this syndrome and suggest a possible treatment for future cases.[ncbi.nlm.nih.gov]
  • Symptomatic treatment is complex and is helpful in supporting function. If an autoimmune etiology is identified immunomodulatory treatments should be employed early in the course to avoid progressive disability.[medlink.com]

Prognosis

  • The majority of cases have a poor prognosis with a chronic debilitating course.[ncbi.nlm.nih.gov]
  • Source MeSH Acute Disease Autonomic Nervous System Diseases Chronic Disease Humans Prognosis Pub Type(s) Journal Article Review Language eng PubMed ID 2486239 TY - JOUR T1 - Acute curable pandysautonomia and chronic progressive pandysautonomia.[unboundmedicine.com]
  • Th e majority of cases have a poor prognosis with a chronic de-bilitating course.[docslide.net]
  • In acute pandysautonomia patients, IVIG seemed to be effective and the prognosis was poor in severe cases.[ncbi.nlm.nih.gov]

Etiology

  • Further tests failed to find a cause of acute neuropathy especially where there was no evidence for paraneoplastic or infectious etiology. The patient was treated with high dose intravenous prednisolone and completely recovered.[ncbi.nlm.nih.gov]
  • If an autoimmune etiology is identified immunomodulatory treatments should be employed early in the course to avoid progressive disability.[medlink.com]
  • Acute Autonomic Neuropathy Generalized autonomic dysfunction of unknown etiology. Also known as acute pandysautonomia . May be subacute. Often preceded by acute illness of presumed viral origin as in Guillain-Barré syndrome.[neupsykey.com]

Epidemiology

  • All patients from a database including sera sent for routine antiganglioside-antibody testing and fulfilling ASAN criteria were collected and their epidemiological, clinical and electrophysiological features analyzed.[oatd.org]
  • The epidemiology of Guillain-Barré syndrome worldwide. A systematic literature review . Neuroepidemiology 2009; 32 (2) 150-163 5 Rocha MS, Brucki SM, Carvalho AA, Lima UW. Epidemiologic features of Guillain-Barré syndrome in São Paulo, Brazil .[thieme-connect.com]
  • There is a clear epidemiological relationship to antecedent infections, the best characterized of which is with campylobacter jejuni enteritis.[clinicaladvisor.com]
  • Epidemiology In general, these can occur in men and women at any age, but the epidemiology will depend on the particular cause. Some causes are very rare.[patient.info]
  • The Epidemiology of Guillain-Barré Syndrome Worldwide. A Systematic Literature Review. Neuroepidemiology . 2008 Dec 17. 32(2):150-163. [Medline] . McKhann GM, Cornblath DR, Griffin JW.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • The purpose of this book is to present a focused approach to the pathophysiology, diagnosis, and management of the most common autonomic disorders that may present to the clinical neurologist. Autonomic Neurology is divided into 3 sections.[books.google.com]
  • الصفحة 83 - Andreasen NC, Ehrhardt JC, Swayze VW, et al: Magnetic resonance imaging of the brain in schizophrenia: the pathophysiologic significance of structural abnormalities. ‏ الصفحة 83 - D. (1991).[books.google.com]
  • Butterworth-Heinemann, 2004 - 363 من الصفحات This unique resource discusses the pathophysiology, diagnosis, and management of clinical disorders manifested by the interaction of the brain with the gastrointestinal system.[books.google.com]
  • In this article, the author discusses various clinical presentations with emphasis on early diagnosis, current pathophysiology, and treatment.[medlink.com]

Prevention

  • Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets[books.google.com]
  • Collaborative Meta-Analysis of Randomised Trials of Antiplatelet Therapy for Prevention of Death, Myocardial Infarction, and Stroke in High Risk Patients. ‎[books.google.es]
  • Prevention - Acute cholinergic dysautonomia Not supplied. Diagnosis - Acute cholinergic dysautonomia Not supplied. Prognosis - Acute cholinergic dysautonomia Not supplied. Treatment - Acute cholinergic dysautonomia Not supplied.[checkorphan.org]
  • 498 412 PADELETTI P L 519 422 NONPHARMACOLOGICAL THERAPY 442 181 447 The Cleveland Clinic Experience 457 Intraoperative Radiomaze for Atrial Fibrillation Patients Undergoing 475 Is Overdrive Pacing Useful for the Prevention of Paroxysmal Atrial Fibrillation[books.google.it]

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