Presentation
The serology for EBV showed previous infection but anti-early antigen antibodies were present. No immunodeficiency was found. Neurological and GI recovery occurred after 6 months of parenteral nutrition and bethanechol. [ncbi.nlm.nih.gov]
In two instances, signs and symptoms of a small-fiber sensory neuropathy were present. [mayoclinic.pure.elsevier.com]
Entire Body System
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Galactorrhea
Case of acute polyradiculoneuropathy with various autonomic symptoms and amenorrhea-galactorrhea syndrome. Rinsho Shinkeigaku 1983;23: 526–530. pmid:6686094 View Article PubMed/NCBI Google Scholar 41. [journals.plos.org]
Respiratoric
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Paroxysmal Cough
Pain in the region of the parotid and submaxillary salivary glands, intermittent pain in the region of the vulva, and paroxysmal coughing are occasionally reported (Wagner 1957; Okada et al 1975; Okada et al 1988). [clinicalsciences.wordpress.com]
Gastrointestinal
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Food Poisoning
However since testing was performed about 3 weeks after the suspected food poison-ing, negative results were expected. [docslide.net]
However since testing was performed about 3 weeks after the suspected food poison- ing, negative results were expected. [researchgate.net]
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Absent Bowel Sounds
Dry and peeling skin, keratitis sicca, a distended abdomen, absent bowel sounds, a distended urinary bladder, diminished rectal tone, atonic dartos muscle, and absent bulbocavernous reflex may be observed. [clinicalsciences.wordpress.com]
Eyes
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Decreased Lacrimation
Key points • Acute pandysautonomia is an acquired disorder with widespread but variable sympathetic, parasympathetic, and enteric autonomic dysfunction, including orthostatic hypotension, anhidrosis, unreactive pupils, decreased lacrimation and salivation [medlink.com]
Skin
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Abnormal Sweating
A syndrome of idiopathic postural orthostatic tachycardia associated with symptoms of light-headedness, postprandial bloating, abnormal sweating, and gastrointestinal motility is considered to be a milder form of acute pandysautonomia (Schondorf and Low [clinicalsciences.wordpress.com]
Neurologic
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Paresthesia
Definition Guillain-Barre syndrome (GBS) is a type of acute inflammatory neuropathy. [1] [2] It is a clinically defined syndrome characterized by motor difficulty, absence of deep tendon reflexes, paresthesias without objective sensory loss, and increased [online.epocrates.com]
Loss of function “- symptoms” Disordered function “ symptoms” Sensory “Large Fiber” Vibration Proprioception Hyporeflexia Sensory ataxia Paresthesias Sensory “Small Fiber” Pain Temperature Dysesthesias Allodynia The clinical response to sensory nerve [slideshare.net]
Manual muscle test was intact, and showed no signs of hypesthesia or paresthesia in sensory nervous system. Deep tendon reflexes were decreased bilaterally at both lower extremities. There were no abnormalities in cerebellar function tests. [e-sciencecentral.org]
This is associated with distal paresthesias and loss of deep tendon reflexes. Progression is often maximal by the end of 4 weeks, then the condition usually plateaus before slowly improving. [emedicine.medscape.com]
He started to improve in his motor power within 3 weeks, but continued to have paresthesia for 6-8 months which partially responded to gabapentin. A year later he was neurologically asymptomatic. [ispub.com]
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Dysmetria
The initial and most severe symptom in all patients was ataxia of gait, followed by dysarthria and later by dysmetria of the limbs. Clinical examination did not reveal involvement of structures other than the cerebellum. Ocular motor ... [researchgate.net]
Urogenital
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Urinary Hesitancy
Nine months later the patient developed syncope on standing, abdominal distention, constipation, anhi-drosis, dryness of the mouth and eyes, urinary hesitancy, and cold intolerance over a three-week period. [dokumen.tips]
Workup
Additional workup included: the tumormarker Cyfra 211 and NSE were initially elevated, 2 month later nor-mal. [docslide.net]
Additional workup included: the tumormarker Cyfr a 21–1 and NSE were initially elevated, 2½ month later nor- mal. [researchgate.net]
Diagnostic workup The diagnosis is primarily based on recognizing the acute or subacute development of widespread autonomic dysfunction with preserved motor and sensory functions. [clinicalsciences.wordpress.com]
Lest you think I suddenly became really smart, I got this information from the following: Medscape: Autonomic Neuropathy Workup, Medical Paper You need to have a complete blood count, basic metabolic panel, liver function testing, and immunoelectrophoresis [ihpotblogspot.blogspot.com]
Polymyositis: Differential diagnoses & workup. Omaha, NE: eMedicine.com; updated November 6, 2009. Available at: . Accessed March 15, 2010. Kalluri M, Sahn SA, Oddis CV, et al. Clinical profile of anti-PL-12 autoantibody. [aetna.com]
Other Pathologies
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Gliosis
Abnormalities in the brain were confined to the brainstem and consisted of complete loss of neurons with severe fibrillary gliosis in the region of the Edinger-Westphal nuclei as well as loss of neurons with gliosis in the locus ceruleus and in the reticular [researchgate.net]
Treatment
Treatment of AAG is based on case reports. It is clear that AAG patients respond to immunomodulatory treatments but combination immunotherapy may be required to achieve a clinical response. [researchgate.net]
Symptomatic treatment is complex and is helpful in supporting function. If an autoimmune etiology is identified immunomodulatory treatments should be employed early in the course to avoid progressive disability. [medlink.com]
The findings are consistent with a dysimmune pathogenesis for this syndrome and suggest a possible treatment for future cases. [ncbi.nlm.nih.gov]
Short term high dose cortisone treatment is regularly employed in infectious diseases like optic neuritis [12]. Th is treatment of high dose corticosteroids is considerably safe [13] and therefore a therapeutic attempt seemed rea-sonable. [docslide.net]
Prognosis
The majority of cases have a poor prognosis with a chronic debilitating course. [ncbi.nlm.nih.gov]
Source MeSH Acute Disease Autonomic Nervous System Diseases Chronic Disease Humans Prognosis Pub Type(s) Journal Article Review Language eng PubMed ID 2486239 TY - JOUR T1 - Acute curable pandysautonomia and chronic progressive pandysautonomia. [unboundmedicine.com]
Th e majority of cases have a poor prognosis with a chronic de-bilitating course. [docslide.net]
Etiology
Further tests failed to find a cause of acute neuropathy especially where there was no evidence for paraneoplastic or infectious etiology. The patient was treated with high dose intravenous prednisolone and completely recovered. [ncbi.nlm.nih.gov]
Paraneoplastic disease was also found as a possible etiology in a few cases [6, 7]. [mafiadoc.com]
If an autoimmune etiology is identified immunomodulatory treatments should be employed early in the course to avoid progressive disability. [medlink.com]
Epidemiology
Epidemiology Acute pandysautonomia is a rare disorder affecting all ages (range 9 to 74 years) and both sexes. No specific information on epidemiology is available. Prevention No information was provided by the author. [clinicalsciences.wordpress.com]
All patients from a database including sera sent for routine antiganglioside-antibody testing and fulfilling ASAN criteria were collected and their epidemiological, clinical and electrophysiological features analyzed. [oatd.org]
The epidemiology of Guillain-Barré syndrome worldwide. A systematic literature review. Neuroepidemiology 2009; 32 (2) 150-163 5 Rocha MS, Brucki SM, Carvalho AA, Lima UW. Epidemiologic features of Guillain-Barré syndrome in São Paulo, Brazil. [thieme-connect.com]
There is a clear epidemiological relationship to antecedent infections, the best characterized of which is with campylobacter jejuni enteritis. [clinicaladvisor.com]
Epidemiology In general, these can occur in men and women at any age, but the epidemiology will depend on the particular cause. Some causes are very rare. [patient.info]
Pathophysiology
The purpose of this book is to present a focused approach to the pathophysiology, diagnosis, and management of the most common autonomic disorders that may present to the clinical neurologist. Autonomic Neurology is divided into 3 sections. [books.google.com]
In this article, the author discusses various clinical presentations with emphasis on early diagnosis, current pathophysiology, and treatment. [medlink.com]
Prevention
Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets [books.google.com]
Collaborative Meta-Analysis of Randomised Trials of Antiplatelet Therapy for Prevention of Death, Myocardial Infarction, and Stroke in High Risk Patients. [books.google.es]