Presentation
Thus, a patient with sarcoidosis may present with back pain or sacroiliac pain. [emedicine.medscape.com]
Peritoneal involvement is a rare presentation of sarcoidosis. Clinical presentation depends on the extent of organ involvement. In some cases,symptoms are no specific and uncommon findings have been reported so far. [ncbi.nlm.nih.gov]
+ ratio Pulmonary function tests Restrictive or obstructive pattern (see restrictive lung disease and obstructive lung disease) References:[12][7][13][1][9] Differential diagnoses Differential diagnosis of granulomatous disease Risk factors Clinical presentation [amboss.com]
Entire Body System
Musculoskeletal
- Arthralgia
Systemic symptoms include fatigue, night sweats, weight loss, fever, arthralgia and myalgia. [ncbi.nlm.nih.gov]
Acute sarcoidosis has an abrupt onset with constitutional symptoms (e.g., fever, malaise) as well as cough, dyspnea, anterior uveitis, erythema nodosum, and arthralgia, and it is self-limiting after a few years. [amboss.com]
- Sacroiliac Pain
Thus, a patient with sarcoidosis may present with back pain or sacroiliac pain. [emedicine.medscape.com]
Face, Head & Neck
- Facial Numbness
Neurologic manifestations include the following: Facial numbness and dysphagia Hoarseness Decreased gag reflex Headache Visual deficit Polydipsia Deafness Involvement of cranial nerves VII, VIII, IX, and X Basal granulomatous meningitis with involvement [emedicine.medscape.com]
Psychiatrical
- Visual Hallucination
Additional findings include abnormal eye movement, pupillary abnormalities, and visual hallucinations. [4] Musculoskeletal findings Musculoskeletal manifestations include myositis, bony lesions, and polyarthritis. [emedicine.medscape.com]
Treatment
Prednisone treatment is instituted, as discussed earlier. [emedicine.medscape.com]
Doctors will monitor your condition to check if it's getting any better or worse without treatment. This can be done with regular X-rays, breathing tests and blood tests. Medicines If treatment is recommended, steroid tablets are usually used. [nhs.uk]
Treatment Isolated pulmonary sarcoidosis: In most cases, no treatment is required. The disease is often asymptomatic, non‑progressive, and has a high rate of spontaneous remission. [amboss.com]
Prognosis
The long-term prognosis is generally good, but depends on the different organ manifestations and complications. Georg Thieme Verlag KG Stuttgart · New York. [ncbi.nlm.nih.gov]
Additional tests can help determine the severity of the disease, possible complications, and prognosis. [amboss.com]
Studies performed to correlate the presence of these markers with prognosis were not conclusive. [emedicine.medscape.com]
Etiology
Etiology The cause of sarcoidosis is still unknown;. Current hypotheses suggest that the etiology is multifactorial. [amboss.com]
Sarcoidosis is a chronic noncaseating granulomatous disease of unknown etiology that affects many organs and tissues, most commonly the lungs. [emedicine.medscape.com]
Epidemiology
Epidemiology Bimodal distribution: 25–35 years old with a second peak for females 45–65 years old Sex: ♀ > ♂ (2:1) Prevalence: 10 times higher among African Americans than whites in the US. [amboss.com]
Pathophysiology
References:[3] Pathophysiology Sarcoidosis is a systemic disorder characterized by widespread, immune-mediated formation of noncaseating granulomas. [amboss.com]
Prevention
This helps relieve symptoms and prevent damage to affected organs by reducing inflammation and preventing scarring. However, steroid tablets can cause unpleasant side effects such as weight gain and mood swings if taken in high doses. [nhs.uk]
The primary aims for treatment of ocular sarcoidosis are to restore vision and to prevent complications. The mainstay of treatment is topical, regional, and systemic corticosteroid therapy. [emedicine.medscape.com]