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Acute Sarcoidosis

Löfgren syndrome


Presentation

  • The clinical presentation of sarcoidosis varies widely and depends on the manifestations in the individual organ. Systemic symptoms include fatigue, night sweats, weight loss, fever, arthralgia and myalgia.[ncbi.nlm.nih.gov]
Lymphadenopathy
  • Löfgren's syndrome, a specific phenotype of acute sarcoidosis, is characterised by bihilar lymphadenopathy, ankle arthritis and erythema nodosum. Chronic sarcoidosis can be asymptomatic, despite radiological changes, which may be extensive.[ncbi.nlm.nih.gov]
Fever
  • Systemic symptoms include fatigue, night sweats, weight loss, fever, arthralgia and myalgia.[ncbi.nlm.nih.gov]
Fatigue
  • Systemic symptoms include fatigue, night sweats, weight loss, fever, arthralgia and myalgia.[ncbi.nlm.nih.gov]
Cough
  • Organ-specific symptoms include cough and dyspnoea, with pulmonary involvement, headache and palsy in neurosarcoidosis, arrhythmias and heart failure in cardiac sarcoidosis, and manifold skin lesions with skin involvement.[ncbi.nlm.nih.gov]
Erythema
  • Löfgren's syndrome, a specific phenotype of acute sarcoidosis, is characterised by bihilar lymphadenopathy, ankle arthritis and erythema nodosum. Chronic sarcoidosis can be asymptomatic, despite radiological changes, which may be extensive.[ncbi.nlm.nih.gov]
Arthralgia
  • Systemic symptoms include fatigue, night sweats, weight loss, fever, arthralgia and myalgia.[ncbi.nlm.nih.gov]
Myalgia
  • Systemic symptoms include fatigue, night sweats, weight loss, fever, arthralgia and myalgia.[ncbi.nlm.nih.gov]
Arthritis
  • Löfgren's syndrome, a specific phenotype of acute sarcoidosis, is characterised by bihilar lymphadenopathy, ankle arthritis and erythema nodosum. Chronic sarcoidosis can be asymptomatic, despite radiological changes, which may be extensive.[ncbi.nlm.nih.gov]
Arthralgia
  • Systemic symptoms include fatigue, night sweats, weight loss, fever, arthralgia and myalgia.[ncbi.nlm.nih.gov]

Prognosis

  • The long-term prognosis is generally good, but depends on the different organ manifestations and complications. Georg Thieme Verlag KG Stuttgart · New York.[ncbi.nlm.nih.gov]

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