Presentation
The course of AZOOR, its clinical presentations, hypothesis of etiology, differential diagnosis, workup, management, and prognosis are reviewed. [ncbi.nlm.nih.gov]
Eyes
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Retinal Pigmentation
Indocyanine green angiography showed atrophy of the choriocapillaris underlying areas of atrophy of the retinal pigment epithelium. [ncbi.nlm.nih.gov]
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Enlarged Blind Spot
At 1 year, the reduced full-field ERGs were almost normal size and the multifocal ERGs in the area corresponding to the enlarged blind spot were also improved. [dovepress.com]
Goldmann perimetry showed enlarged blind spots of Mariotte bilaterally in 2 patients and unilaterally in 3 patients. Another scotoma was seen in the nasal paracentral area, the inferior midperiphery, and centrally. [ncbi.nlm.nih.gov]
Psychiatrical
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Suggestibility
CONCLUSION: Evidence suggests that AZOOR is a unique form of autoimmune retinopathy and retinal manifestation suggests possible antiretinal antibody leakage from the disc margin with spread of immune products under the retina, resulting in large scotomata [ncbi.nlm.nih.gov]
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Loss of Initiative
In all patients vision loss was initially progressive, then stable. Symptoms were unilateral in 2 and bilateral but asymmetric in 2 patients. In each patient, loss of retinal function correlated with structural changes in the outer retina. [ncbi.nlm.nih.gov]
Workup
The course of AZOOR, its clinical presentations, hypothesis of etiology, differential diagnosis, workup, management, and prognosis are reviewed. [ncbi.nlm.nih.gov]
With further study, "we may be able to suggest specific systemic autoimmune workups in the future for these patients," they wrote. Dr. [medpagetoday.com]
Other Pathologies
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White Matter Lesions
While AZOOR previously has been linked to MS and demyelinating white matter lesions in the brain, our case seems unique due to concurrent development of AZOOR and retrobulbar optic neuritis as a CIS. [ncbi.nlm.nih.gov]
Treatment
Patients remained stable without treatment during a follow-up period ranging from 1 to 3 years. [ncbi.nlm.nih.gov]
Prognosis
The course of AZOOR, its clinical presentations, hypothesis of etiology, differential diagnosis, workup, management, and prognosis are reviewed. [ncbi.nlm.nih.gov]
Prognosis Due to the rarity and insufficient documented long term cases of AZOOR, it is difficult to characterize the progression and prognosis of this disease. [eyewiki.aao.org]
Etiology
Acute zonal occult outer retinopathy (AZOOR) is a disorder of unknown etiology with a predilection for young women. [ncbi.nlm.nih.gov]
Epidemiology
Diagnosis: Acute Zonal Occult Outer Retinopathy (AZOOR) and Acute Idiopathic Blind Spot Enlargement Syndrome (AIBSE) EPIDEMIOLOGY young women (30s) incidence unknown etiology: unknown SIGNS Normal Exam (33%) RPE changes (26%) Optic disc edema (20%) Grayish [webeye.ophth.uiowa.edu]
Epidemiology There has been a predominance of Caucasians, but the disease has been seen in all ethnic groups. The majority of patients are young females in their mid-thirties. [2] [4] [5]. Pathogenesis Mechanism is unknown. [eyewiki.aao.org]
Pathophysiology
PURPOSE: To elucidate the pathophysiology of the diseases recently grouped under the name of acute zonal occult outer retinopathy (AZOOR). [ncbi.nlm.nih.gov]
Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any [books.google.com]
Prevention
Washington Avenue, Room 508, New York, NY 10032; e-mail: [email protected] Supported in part by grants from the National Eye Institute/National Institutes of Health EY024091, EY021163, and EY09076; Foundation Fighting Blindness; and a grant from Research to Prevent [journals.lww.com]
Related Links: ConclusionsOur study provides new insight into underlying mechanisms of DM, and we suggest that we should pay more attention to these metabolic pathways in the prevention and treatment of DM. [medworm.com]
The study was supported in part by an unrestricted grant from Research to Prevent Blindness, by the Macula Foundation, by a grant from the Macula Society, and by the National Institute on Aging. The researchers reported no conflicts of interest. [medpagetoday.com]