Adams-Stokes syndrome is a disorder characterized by a sudden and transient loss of consciousness, due to an abrupt episode of change in heart rhythm. The patient may experience a sudden episode of bradycardia or absence of pulse and syncope that may be followed by epileptic seizures. Adams-Stokes syndrome may be caused by a variety of underlying cardiac pathologies and requires a comprehensive cardiovascular examination in order to be diagnosed with accuracy.
Presentation
An Adams-Stokes episode initially manifests with significant pallor, followed by impairment of consciousness that ranges from a fainting tendency to a complete loss of consciousness. The aforementioned episode is elicited by a sudden change in the heart rhythm, that may involve tachyarrhythmia or bradyarrhythmia.
Epileptic seizures without an aura may or may not accompany the Adams-Stokes related episode; their onset is usually acute and unexpected, as is their resolution. Patients tend to resume their prior activity without realizing that epileptic activity has taken place. After the individual has fully regained consciousness, flushing is observed, that can be attributed to reactive hyperemia. The episodes described above may develop regardless of the posture of the patient and may be experienced up to multiple times each day.
Approximately 10% to 20% of all Adams-Stokes syndrome episodes are induced by third-degree sinoatrial block paroxysms [1] [2]. A variety of supraventricular arrhythmias can also be held accountable for the syncopic events observed in Adams-Stokes syndrome and can even co-exist in the same patient [3] [4] [5]. The presence of a well-defined dysrhythmic condition leads to additional symptoms that can aid in the diagnosis of the underlying cause; symptoms most commonly associated with dysrhythmias that can lead to an Adams-Stokes episode include fatigue, palpitations, and discomfort.
Entire Body System
- Falling
[…] associated with atherosclerosis, diabetes, and long-lasting confinement to bed carotid sinus hypersensitivity (three types) 1) cardioinhibitory, resulting in symptomatic asystole of longer than 3 s. 2) vasodepressor, resulting in systolic blood pressure fall [gpnotebook.co.uk]
Upon falling in his bathroom, he had struck his [jamanetwork.com]
His W: Ein Fall von Adams-Stokes'scher Krankheit mit ungleichzeitigem Schlagen der Vorhöfe und Herzkammern (Herzblock), Deutsch. Arch. f. klin. Med. 64: 316, 1899. Google Scholar 8. [acpjournals.org]
They may also injure themselves from the fall itself. If you experience fainting spells, it is important that you get immediate medical care. Coronary heart disease is the number one cause of death in the United States, and it often goes undiagnosed. [simonsheart.org]
- Pallor
An Adams-Stokes episode initially manifests with significant pallor, followed by impairment of consciousness that ranges from a fainting tendency to a complete loss of consciousness. [symptoma.com]
Pallor, followed by flushing on recovery, can be reported. Some seizure-like activity sometimes occurs if the attack is prolonged. If anyone manages to check the pulse during an episode, it will be slow, usually less than 40 beats per minute. [cardiachealth.org]
Changes occurring with Stokes-Adams syndrome Stokes-Adams syndrome is characterized by the sudden loss of consciousness with convulsions, pallor followed by cyanosis and respiratory disorders. [bookinghealth.com]
Pallor, followed by flushing on recovery, can be reported. Some seizure-like activity sometimes occurs if the attack is prolonged[1]. If anyone manages to check the pulse during an episode, it will be slow, usually less than 40 beats per minute. [patient.info]
When faintness is related to primary cardiac pathology, there is usually a combination of dermal pallor and cyanosis. [ahcmedia.com]
- Congestive Heart Failure
Home / Analyst / Sindrome de stoke adams ppt background Dec 9, including Stokes-Adams syncope, congestive heart failure, or sudden death. In children .. Kearns-Sayre syndrome Clinical Presentation. [partetecar.tk]
If you have an irregular heartbeat (atrial fibrillation), disease of the heart valves, congestive heart failure or have had a recent heart attack, your physician may prescribe medications to thin your blood and/or reduce your cholesterol level. [cardiachealth.org]
Cardiovascular effects of isoproterenol in normal subjects with congestive heart failure. Am. Heart J. 1960; 60: 94 PubMed Abstract Full Text PDF Google Scholar Chandler D. Clapper M.I. [amjmed.com]
The general indications for pacemaker insertion include- Complete heart block associated with congestive heart failure Complete heart block with Stokes-Adams syncope Complete heart block following acute anterior or inferior wall myocardial infarction [homeopathyworldcommunity.ning.com]
- Amyloidosis
[…] artery disease Endocarditis and myocarditis Mitral/aortic valve disease History of previous AV nodal dysfunction/cardiac surgery Bundle-branch and/or fascicular block Acute myocardial infarction (MI) (especially acute right coronary artery occlusion) Amyloidosis [unboundmedicine.com]
Infiltrative processes including amyloidosis, sarcoidosis, cardiac tumours, Hodgkin's disease, multiple myeloma. Stokes-Adams attacks have been described as due to: Chronic or paroxysmal AV block. Sino-atrial (SA) block. [patient.info]
INFILTRATION: Sarcoidosis, Amyloidosis, Neoplasia DRUGS: Digioxin, Beta blockers, Amiodaron TRAUMA: Cardiac surgery. CONNECTIVE TISSUE DISEASE: SLE,RA 12. [slideshare.net]
(Psora/ Syphilis/ Sycosis) Infiltrative processes These include amyloidosis, sarcoidosis, tumors, Hodgkin's disease, multiple myeloma, Paget’s disease etc. [homeopathyworldcommunity.ning.com]
Pathology of the cardiac conduction system in amyloidosis. Ann. Int. Med. 1966; 65: 28 PubMed Crossref Google Scholar Harrison C.V. Lennox B. Heart block in osteitis deformans. Brit. [amjmed.com]
- Infectious Mononucleosis
[…] diseases: local infections like acute rheumatic fever, endocarditis, myocarditis, Lyme disease, and systemic infections like infectious mononucleosis Neuromuscular diseases (e.g., myotonic muscular dystrophy or Kearns-Sayre syndrome) Postoperative cardiac [unboundmedicine.com]
Cardiovascular
- Tachycardia
Oral medication was less apt to produce annoying tachycardia or angina in susceptible individuals than was sublingual isoproterenol. [jamanetwork.com]
tachycardia 上室頻拍 supraventricular tachycardia 洞結節リエントリー[性]頻拍 sinus nodal (node) reentrant (reentry) tachycardia 発作性上室頻拍 paroxysmal supraventricular tachycardia 異所性心房頻拍 ectopic atrial tachycardia 【同】心房頻拍 atrial tachycardia 【同】発作性心房頻拍 paroxysmal atrial [jams.med.or.jp]
Abstract Stokes-Adams attacks are related to paroxysmal or chronic atrioventricular (AV) block (50-60%), sinoatrial (SA) block (30-40%) or paroxysmal tachycardia or fibrillation (0-5%). [ncbi.nlm.nih.gov]
Paradoxically, in patients with SND, an episode of palpitation due to AF or sinus tachycardia precedes the episode of syncope. [drsvenkatesan.com]
- Heart Disease
Underlying heart disease should be managed appropriately. A cardiac pacemaker may be required[5]. [patient.info]
Underlying heart disease should be managed appropriately. A cardiac pacemaker may be required. [cardiachealth.org]
Coronary heart disease is the number one cause of death in the United States, and it often goes undiagnosed. [simonsheart.org]
disease - Hypertensive nephropathy - Secondary hypertension ( Renovascular hypertension ) Ischaemic heart disease Angina pectoris ( Prinzmetal's angina ) - Myocardial infarction (heart attack) - Dressler's syndrome Pulmonary circulation Pulmonary embolism [wikidoc.org]
- Slow Pulse
Observations of some cases of permanently slow pulse. Dublin Quarterly Journal of Medical Science. 1846;2(1):73–85. Harbison J, Newton JL, Seifer C, Kenny RA. Stokes Adams attacks and cardiovascular syncope. Lancet. 2002 Jan 12;359(9301):158-60. [litfl.com]
Deep and fast respiration changes to weak and slow pulse and respiration, convulsions and respiratory pauses that may last for 60 seconds. [whonamedit.com]
Adams and Stokes found their patients to have fatty degeneration of the cardiac muscle, and considered this to be the cause of the slow pulse and attacks of syncope. [annals.org]
- Hypotension
[…] resulting from sudden dilatation of venous capacitance vessels sometimes associated with vagally mediated bradycardia orthostatic hypotension sudden fall in blood pressure occurring on standing - can be secondary to hypovolaemia resulting from drugs, [gpnotebook.co.uk]
( Orthostatic hypotension ) - Rheumatic fever See also congenital ( Q20-Q28, 745-747 ) de:Adams-Stokes-Syndrom fi:Adams-Stokesin oireyhtymä Cardiology [wikidoc.org]
□ Other signs and symptoms include hypotension, heart rate ... [educalingo.com]
It may be entirely due to vascular component and hence it may simply represent hypotension without a true cardiac limb . [drsvenkatesan.com]
- Heart Failure
CHEST - HEART failure - accompanied by – faintness nux-m. CHEST - HEART failure - accompanied by – hypotension elat. CHEST - HEART failure - accompanied by - pulse; soft glon. [homeopathyworldcommunity.ning.com]
[…] disease; cardiac rhythm disturbances; heart failure and transplantation; disease of the thoracic aorta; tetralogy of Fallot; anesthesia; and postoperative care. [books.google.com]
failure There's more to see -- the rest of this entry is available only to subscribers. [unboundmedicine.com]
Home / Analyst / Sindrome de stoke adams ppt background Dec 9, including Stokes-Adams syncope, congestive heart failure, or sudden death. In children .. Kearns-Sayre syndrome Clinical Presentation. [partetecar.tk]
[…] conditions Heart failure - Cardiovascular disease - Cardiomegaly - Ventricular hypertrophy ( Left, Right ) Cerebrovascular diseases Stroke - Transient ischemic attack - Intracranial hemorrhage / cerebral hemorrhage : Extra-axial hemorrhage ( Epidural [wikidoc.org]
Neurologic
- Seizure
The aim of this paper is to review the Stokes-Adams attack and its similarity to epileptic seizure with a case report. [agris.fao.org]
Stokes at first suggested the name of "pseudo-apoplexy." for this disease and laid special stress on the syncopal character of the seizures and the absence of paralysis. [jamanetwork.com]
In most cases, seizures do not lead to delayed consequences. [bookinghealth.com]
Seizures may be provoked by acute conditions (e.g., stroke, traumatic brain injuryIndividuals who experience a single seizure do not necessarily have epilepsy. [partetecar.tk]
The patient may experience a sudden episode of bradycardia or absence of pulse and syncope that may be followed by epileptic seizures. [symptoma.com]
- Dizziness
An occasional temporary stoppage or extreme slowing of the pulse as a result of heart block, causing dizziness, fainting, and sometimes convulsions. [yourdictionary.com]
An occasional temporary stoppage or extreme slowing of the pulse as a result of heart block, causing dizziness, fainting, and sometimes convulsions. Also called Stokes-Adams syndrome. [medical-dictionary.thefreedictionary.com]
The attacks manifested themselves in sudden dizziness or fainting lasting a minute or two and were usually precipitated by swallowing [jamanetwork.com]
- Vertigo
Ad·ams-Stokes syn·drome ( a'dămz stōks ), a syndrome characterized by slow or absent pulse, vertigo, syncope, convulsions, and sometimes Cheyne-Stokes respiration; usually results from advanced AV block or sick sinus syndrome. [medical-dictionary.thefreedictionary.com]
Vertigo is generally also present. These prodromal symptoms may be manifest as much as several days before the attack itself appears. [jamanetwork.com]
Books relating to Adams-Stokes syndrome and brief extracts from same to provide context of its use in English literature. 1 Stedman's Medical Eponyms Adams-Stokes syndrome - characterized by slow or absent pulse, vertigo, syncope, convulsions, and sometimes [educalingo.com]
The feeling of impulsion is particularly characteristic of vertigo. All but the mildest forms of vertigo are accompanied by diaphoresis, pallor, nausea, and vomiting. [ahcmedia.com]
- Confusion
Symptoms: Symptoms include, Palpitations, dizziness, feeling confused, coldness, and sweating. [medigoo.com]
Recovery is fairly rapid, although the patient may be confused for a while afterwards. Typically, complete (third-degree) heart block is seen on the EKG during an attack. Attacks can happen a number of times in one day. [cardiachealth.org]
Recovery is fairly rapid, although the patient may be confused for a while afterwards. Typically, complete (third-degree) heart block is seen on the ECG during an attack but other ECG abnormalities such as tachy-brady syndrome have been reported[1]. [patient.info]
- Drop Attacks
System(s) affected: cardiovascular, nervous Synonym(s): drop attacks; Morgagni, Morgagni-Adams-Stokes; Spens syndrome Epidemiology Incidence Incidence rate of 5–10% for those age >70 years Prevalence Unknown (Overall prevalence of 3rd-degree atrioventricular [unboundmedicine.com]
Drop attacks. Transient ischemic attack (TIA or mini stroke). Syncope due to hypovolemia. Treatment Reversible causes such as drug toxicity should be addressed. Underlying heart disease should be managed appropriately. [cardiachealth.org]
A drop attack with third degree AV block is called a "Stokes Adams" attack, and is often associated with bizarre wide inverted T-waves. [hqmeded-ecg.blogspot.com]
Drop attacks. Transient ischaemic attack. Syncope due to hypoperfusion - eg, due to hypovolaemia. Stokes-Adams attack treatment Reversible causes such as drug toxicity should be addressed. Underlying heart disease should be managed appropriately. [patient.info]
(Psora/ Syphilis/ Sycosis) Differential diagnosis A fast tachyarrhythmia (may also reduce cardiac output but does not usually have the same brief but dramatic effect) Carotid sinus hypersensitivity Drop attacks Epilepsy (if convulsions occur) Orthostatic [homeopathyworldcommunity.ning.com]
Workup
Any patient presenting with a syncopic event is required to undergo multiple tests and examinations in order to detect the precise cause of the loss of consciousness. A fainting spell raises suspicion towards Adams-Stokes syndrome, when the patient reports a sudden-onset fainting tendency or loss of consciousness, following otherwise unexplained pallor. After the episode is resolved, the patient typically reports flushing.
For the physician to establish an accurate diagnosis of Adams-Stokes syndrome, many of the following tests should be carried out and evaluated:
- A comprehensive medical history, including underlying cardiovascular or other pathologies, prior similar episodes and their characteristics, as well as medication history. Digoxin is particularly known for its potential to lead to toxicity, a state which may further cause a third-degree atrioventricular block, amongst others, and an Adams-Stokes episode [6].
- Blood pressure and heart rate measurement.
- Electrocardiography (ECG): Although it may appear normal after the resolution of the episode, a 24-hour ECG monitoring will help to illustrate multiple types of dysrhythmia associated with the syndrome [7].
- Blood tests: Digoxin can be directly measured in the blood. Furthermore, blood tests can detect enzymes associated with myocardial infarction.
- Cardiac catheterization.
- Electrophysiologic studies.
A potential Adams-Stokes episode, complicated by convulsions should prompt neurological evaluation as well.
Rhythm
- Torsades De Pointes
The abrupt onset of complete heart block or cessation of tachyarrhythmia in patients with sick sinus syndrome lead to either prolonged asystole or torsade de pointes by prolonging the QT interval. [unboundmedicine.com]
Stokes-Adams attack is syncope (sometimes with seizure like activity) atrioventricular (AV) block, as well as ventricular (torsade de pointe) and. [partetecar.tk]
Typically, complete or third heart block is seen on the ECG during an attack but other ECG abnormalities such as tachy-brady syndrome have also been reported.[12] Torsades de pointes can also been seen.[8] Echocardiography or Ultrasound Echocardiography [wikidoc.org]
de pointes 心室細動 ventricular fibrillation ジギタリス不整脈 digitalis arrhythmia 心室不整脈 ventricular arrhythmia 心房不整脈 atrial arrhythmia QT延長症候群 long QT syndrome アンダースン症候群 Andersen's syndrome ジャーベル・ランゲ-ニールセン症候群 Jervell and Lange-Nielsen syndrome ロマノ・ワード症候群 Romano-Ward [jams.med.or.jp]
Blocks
- Right Bundle Branch Block
I45 Other conduction disorders I45.0 Right fascicular block I45.1 Other and unspecified right bundle-branch block I45.10 Unspecified right bundle-branch block Inclusion term(s): Right bundle-branch block NOS I45.19 Other right bundle-branch block I45.2 [icd10coded.com]
Prevention of cardiovascular disease through diet/exercise Commonly Associated Conditions Myocardial ischemia/acute MI High-degree AV conduction abnormality Atrial standstill Right bundle branch block (RBBB) CCAVB Systemic manifestations of connective [unboundmedicine.com]
block 完全左脚ブロック complete left bundle branch block 不完全左脚ブロック incomplete left bundle branch block 右脚ブロック right bundle branch block 完全右脚ブロック complete right bundle branch block 不完全右脚ブロック incomplete right bundle branch block ヘミ(片)ブロック hemiblock 【同】束枝ブロック fascicular [jams.med.or.jp]
block Right bundle branch block 16. [slideshare.net]
[…] or syndrome I45.9 Syndrome - see also Disease Adams-Stokes I45.9 (-Morgagni) Morgagni-Adams-Stokes I45.9 Spen's I45.9 Stokes I45.9 (-Adams) ICD-10-CM Codes Adjacent To I45.9 I45.10 Unspecified right bundle-branch block I45.19 Other right bundle-branch [icd10data.com]
- Third Degree Atrioventricular Block
Approximately 10% to 20% of all Adams-Stokes syndrome episodes are induced by third-degree sinoatrial block paroxysms. [symptoma.com]
block ウェンケバッハ型[第]2度房室ブロック Wenckebach second degree atrioventricular block モビッツII型[第]2度房室ブロック Mobitz type II second degree atrioventricular block [第]3度房室ブロック third degree atrioventricular block 心室内ブロック intraventricular block 脚ブロック bundle branch block [jams.med.or.jp]
Treatment
Types of Stokes-Adams syndrome Treatment tactics for Stokes-Adams syndrome Treatment of Stokes-Adams syndrome in Europe The cost of treatment in European hospitals Overview Stokes-Adams syndrome can be considered a complication of atrioventricular block [bookinghealth.com]
Treatment Initial treatment can be medical, involving the use of drugs like isoprenaline ( Isuprel ) and epinephrine (adrenaline). [ipfs.io]
Treatment [ edit ] Initial treatment can be medical, involving the use of drugs like isoprenaline ( Isuprel ) and epinephrine (adrenaline). [en.wikipedia.org]
Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. [drugs.com]
Interest in this problem is justified particularly since efforts toward prevention of attacks and rational treatment of Adams-Stokes seizures depend upon the identification of the basic underlying mechanism, namely, paroxysmal rapid heart action (including [jamanetwork.com]
Prognosis
The prognosis following treatment is very good.[10] However, if attacks occur after a myocardial infarction, the prognosis is bad.[10] Diagnosis History and Symptoms Stokes-Adams attacks may be diagnosed from the history, with paleness prior to the attack [wikidoc.org]
The prognosis following treatment is very good. References ↑ synd/1158 at Who Named It? ↑ R. Adams. Cases of Diseases of the Heart, Accompanied with Pathological Observations. Dublin Hospital Reports, 1827, 4: 353–453. ↑ W. Stokes. [ipfs.io]
The prognosis following treatment is very good. References [ edit ] ^ synd/1158 at Who Named It? ^ R. Adams. Cases of Diseases of the Heart, Accompanied with Pathological Observations. Dublin Hospital Reports, 1827, 4: 353–453. ^ W. Stokes. [en.wikipedia.org]
[…] paroxysmal ventricular fibrillation, as opposed to ventricular standstill, as the cause of Adams-Stokes seizures has encouraged us to report another case and to review the present concepts concerning various features of the condition, including etiology, prognosis [jamanetwork.com]
Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.com]
Etiology
Predominant sex: male = female Pediatric Considerations Rare during pregnancy Etiology and Pathophysiology Medications Digoxin (common) Calcium channel blockers β-Blockers (e.g., sotalol) Clonidine Propafenone (Rythmol), a class IC antiarrhythmic Isoproterenol [unboundmedicine.com]
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]
[…] importance of paroxysmal ventricular fibrillation, as opposed to ventricular standstill, as the cause of Adams-Stokes seizures has encouraged us to report another case and to review the present concepts concerning various features of the condition, including etiology [jamanetwork.com]
In addition, an expeditious approach for pinpointing the etiology of syncopal episodes is presented. [ahcmedia.com]
The clinical appearance is similar but also etiology entirely different, that caused by cardiac arrhythmia. Occasionally, patients who have syncopes can be treated with antiepileptic drugs. [egetipdergisi.com.tr]
Epidemiology
Epidemiology The condition is usually associated with coronary heart disease and so tends to occur in the elderly. Stokes-Adams attacks have been reported in much younger age groups, including those with congenital heart block[2, 3]. [patient.info]
System(s) affected: cardiovascular, nervous Synonym(s): drop attacks; Morgagni, Morgagni-Adams-Stokes; Spens syndrome Epidemiology Incidence Incidence rate of 5–10% for those age >70 years Prevalence Unknown (Overall prevalence of 3rd-degree atrioventricular [unboundmedicine.com]
Epidemiology and Demographics The syndrome was first described and published in 1717 by Marco Gerbec. There may be a associated family history with Adam-Stokes attacks. [wikidoc.org]
The Editor Epidemiology Syncope is a common presenting complaint among patients presenting to the ED and accounts for about 1-6% of all ED visits. 3,4 The Framingham study found a 3.3% incidence of syncope in a cohort of patients followed over a 26-year [ahcmedia.com]
Pathophysiology
This pacemaker is useful not only in the diagnosis of Adams-Stokes syndrome but also in pharmacological and pathophysiological studies and in determining when pacing should cease. [ncbi.nlm.nih.gov]
Predominant sex: male = female Pediatric Considerations Rare during pregnancy Etiology and Pathophysiology Medications Digoxin (common) Calcium channel blockers β-Blockers (e.g., sotalol) Clonidine Propafenone (Rythmol), a class IC antiarrhythmic Isoproterenol [unboundmedicine.com]
Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.com]
Pathophysiology The attacks are caused by loss of cardiac output due to cardiac asystole, heart block, or ventricular fibrillation.[4] The resulting lack of blood flow to the brain is responsible for the syncope. [wikidoc.org]
Prevention
We therefore developed a pacemaker for cardiac arrest monitoring and the prevention of Adams-Stokes syndrome and sudden cardiac death, which has the following functions: (1) the longest escape interval of the pacemaker not exceeding the value at which [ncbi.nlm.nih.gov]
Top « Medications Antiplatelets: Platelets are blood cells that help the blood to clot and prevent or stop bleeding in case of an injury. [cardiachealth.org]
[…] ventricular fibrillation, as opposed to ventricular standstill, as the cause of Adams-Stokes seizures has encouraged us to report another case and to review the present concepts concerning various features of the condition, including etiology, prognosis, prevention [jamanetwork.com]
Prevention of cardiovascular disease through diet/exercise Commonly Associated Conditions Myocardial ischemia/acute MI High-degree AV conduction abnormality Atrial standstill Right bundle branch block (RBBB) CCAVB Systemic manifestations of connective [unboundmedicine.com]
For Stokes-Adams seizure prevention, patients should have continuous electrocardiographic monitoring and active prophylactic treatment after an attack has subsided. [bookinghealth.com]
References
- Rasmussen K. Chronic sinoatrial heart block. American Heart journal. 1971; 81:38.
- Jensen G, Sigurd B, Meibom J, Sandoe E. Adams-Stokes syndrome caused by paroxysmal third-degree atrioventricular block. British Heart Journal, 1973;35: 5I6.
- Ferrer MI. The sick sinus syndrome in atrial disease. Journal of the American Medical Association, 1968; 206: 645-46.
- Slama R, Waynberger M, Motte G, Bouvrain Y. La maladie rhythmique auriculaire. Archives des Maladies du Coeur et des Vaisseaux, 1969; 62 (3): 297.
- Eraut D, Shaw DB. Sinus bradycardia. British Heart Journal, 1971; 33:742.
- Eichhorn EJ, Gheorghiade M. Digoxin. Prog cardiovasc dis. 2002; 44 (4): 251–66.
- Schlant RC, Adolph RJ, DiMarco JP, et al. Guidelines for electrocardiography. A report of the American College of Cardiology/American Heart Association Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (Committee on Electrocardiography). Circulation. 1992 Mar; 85(3):1221-8.