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Adenocarcinoma
Malignant Adenoma

Presentation

Blood 2017 129:3502; doi: https://doi.org/10.1182/blood-2017-03-773713 A 70-year-old man presented with abdominal swelling. He denied any constitutional symptoms, history of jaundice, infection, or foreign travel. [bloodjournal.org]

When symptoms are present it often has advanced locally and may have spread through the lining of the esophagus and involve lymph nodes or more distant sites. Etiology The exact etiology is unknown. [orpha.net]

Primary Seminal Vesicle Adenocarcinoma Presenting as Acute Urinary Retention and Hematuria: A Case Report Abstract Primary tumors of the seminal vesicle are extremely rare lesions, and adenocarcinoma is the most common histology found. [wjnu.org]

This study aimed to understand the impact of mutational status in advanced lung adenocarcinoma (ADC) presentation and prognosis. [erj.ersjournals.com]

The results for these second round predictions are presented in Fig. 1F and G. [clincancerres.aacrjournals.org]

Workup

[…] headache, impaired vision in left eye, and intermittent confusion that had begun a few weeks ago He is a current non-smoker with a 30-pack-year history Past medical history: hypertension diagnosed 3 years ago, well-controlled on losartan His cardiac workup [targetedonc.com]

Because histologically and immunohistochemically there is considerable overlap between colonic and vesical adenocarcinoma, extensive clinical and radiologic workup is required for diagnostic accuracy. [archivesofpathology.org]

Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities. World J Gastrointest Oncol. 2014 May 15. 6 (5):112-20. [Medline]. [Full Text]. Mao WM, Zheng WH, Ling ZQ. [medscape.com]

[…] the abdomen and liver Abdominal/pelvic MRI Positron emission tomography, including fusion PET-CT scan Other procedures that may be warranted include the following: Colonoscopy Sigmoidoscopy Biopsy of suspicious lesions Double-contrast barium enema See Workup [emedicine.medscape.com]

Treatment

Other adenocarcinoma treatments Other treatments for adenocarcinoma may include chemotherapy or radiation therapy. People who have radiosurgery or EEA surgery are able to continue other systemic treatments soon after their procedures. [upmc.com]

The following are treatment options for adenocarcinoma of unknown primary. Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. [cancer.ca]

[…] and better treatments. [verywellhealth.com]

Prognosis

[…] e20035 Background: The prognosis difference among lung adenocarcinoma patients with different pathological subtypes remains controversial. [ascopubs.org]

Furthermore, each of these elements impacts prognosis differently ( 4, 5 ). Using these microscopic parameters, the impact of morphology on prognosis in adenocarcinoma is currently under investigation ( 6 - 9 ). [ncbi.nlm.nih.gov]

The impact of the 2015 classification on prognosis was reviewed by a PubMed search for search terms “adenocarcinoma”, “lung pathology” and “prognosis” and relevant publications reviewed. [err.ersjournals.com]

The prognosis of AM was significantly worse than MAC but comparable with SRCC. [bmccancer.biomedcentral.com]

Prognosis for Adenocarcinoma The prognosis for lung cancers that are advanced at the time of diagnosis are generally poor. [lunginjuries.org]

Etiology

Etiology The exact etiology is unknown. There is a strong association with GERD and obesity. There is no specific, known genetic link. [orpha.net]

Development of pericardial effusion with concurrent improvement or stability of malignant lesion, negative cytology and brisk response to corticosteroids indicates an immune etiology. [mdedge.com]

In addition, many of the known or suspected risk factors for esophageal adenocarcinoma, including smoking, alcohol and obesity, share a common suspected inflammatory etiology (Reid, 2010; Cook, 2013; Shaheen, 2013). [whi.org]

Genetic factors have been strongly implicated in the etiology of adenocarcinoma of the small intestine. [ncbi.nlm.nih.gov]

Etiology of Barrett’s esophagus and esophageal adenocarcinoma. Cancer Epidemiol Biomarks Prev1997;6:369–77. ↵ Chow WH, Finkle WD, McLaughlin JK, et al. [gut.bmj.com]

Epidemiology

Epidemiological data], Ann Otolaryngol Chir Cervicofac 2002;119(5):271–280 Meccariello G1, Deganello A1, Choussy O2, Gallo O1, Vitali D1, De Raucourt D3, Georgalas C4. [med.stanford.edu]

Hence, the mysterious epidemiology of this cancer is not yet solved. [gut.bmj.com]

Caribbean Epidemiology Centre (CAREC). [bmccancer.biomedcentral.com]

Summary Epidemiology It has an estimated annual incidence of 1/35,000. Clinical description The age of onset is between 50-60 years and it is more frequently seen in males. [orpha.net]

Demographics, Epidemiology, and Inheritance of Pancreatic Ductal Adenocarcinoma. Semin Oncol 42(1):8-18, 2015. PMID: 2572604. [pancreapedia.org]

Pathophysiology

In the last 2 decades, adenocarcinoma has replaced squamous cell cancer of the lung as the most prevalent non-small cell cancer.[3] Pathophysiology Lung adenocarcinoma is classified into 4 types: adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma [ncbi.nlm.nih.gov]

Increasing evidence indicates that the interplay of autophagy and apoptosis is crucial in the pathophysiology of LUAD [17]. [hindawi.com]

Pathophysiology Genetically, colorectal cancer represents a complex disease, and genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. [emedicine.medscape.com]

Prevention

[…] cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]

The CCO Chronic Disease Prevention Strategy provides a comprehensive plan for the way we will work with our partners to reduce new cases of major chronic diseases by decreasing the number of people with modifiable risk factors. [cancercareontario.ca]

Treatment includes surgical removal of the tumor to prevent its growth. After surgery, the patient may undergo chemotherapy and radiation to prevent the adenocarcinoma coming back. [news-medical.net]

These therapies can derail the cancer’s growth by preventing or changing chemical reactions linked to particular mutations. For example, some target therapies prevent cancer cells from receiving chemical “messages” telling them to grow. [drugs.com]

Prevention How can I reduce my risk for adenocarcinoma? Even though you can’t prevent cancer altogether, there are some things you can do to significantly lower your risk. [my.clevelandclinic.org]

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