Blood 2017 129:3502; doi: https://doi.org/10.1182/blood-2017-03-773713 A 70-year-old man presented with abdominal swelling. He denied any constitutional symptoms, history of jaundice, infection, or foreign travel. [bloodjournal.org]

When symptoms are present it often has advanced locally and may have spread through the lining of the esophagus and involve lymph nodes or more distant sites. Etiology The exact etiology is unknown. [orpha.net]

Primary Seminal Vesicle Adenocarcinoma Presenting as Acute Urinary Retention and Hematuria: A Case Report Abstract Primary tumors of the seminal vesicle are extremely rare lesions, and adenocarcinoma is the most common histology found. [wjnu.org]

This study aimed to understand the impact of mutational status in advanced lung adenocarcinoma (ADC) presentation and prognosis. [erj.ersjournals.com]

The results for these second round predictions are presented in Fig. 1F and G. [clincancerres.aacrjournals.org]

• Pathologist

  It achieved a kappa score of 0.525 and an agreement of 66.6% with three pathologists for classifying the predominant patterns, slightly higher than the inter-pathologist kappa score of 0.485 and agreement of 62.7% on this test set. [arxiv.org]

  Of the three pathologists who initially viewed the H&E’s two favored the diagnosis of a poorly differentiated squamous carcinoma composed of small cells, and the other favored small cell carcinoma. [propath.com]

  When your colon was biopsied, the samples taken were studied under the microscope by a specialized doctor with many years of training called a pathologist. The pathologist sends your doctor a report that gives a diagnosis for each sample taken. [cancer.org]

  (‎World Health Organization, Regional Office for the Eastern Mediterranean, 2014-09-01)‎ In recent years, greater numbers of prostate biopsy cores are being submitted for histopathological assessment, with a concomitant increase in workload for the pathologist [apps.who.int]

  Moffitt’s multispecialty approach to treating adenocarcinoma lung cancer Patients at Moffitt benefit from the expertise of a multispecialty team that includes surgeons, radiation oncologists, medical oncologists, pathologists, cardiologists, pulmonologists [moffitt.org]

• Swelling

  […] men. (8) Common symptoms are: A persistent cough or coughing up blood Shortness of breath Wheezing Pain in the chest or shoulders when breathing Hoarseness Frequent respiratory tract infections Trouble swallowing Fatigue Weight loss Loss of appetite Swelling [everydayhealth.com]

  Blood 2017 129:3502; doi: https://doi.org/10.1182/blood-2017-03-773713 A 70-year-old man presented with abdominal swelling. He denied any constitutional symptoms, history of jaundice, infection, or foreign travel. [bloodjournal.org]

  Breast swelling. Red or flaky skin. Bloody fluid leaking from your nipple. Dimpled or uneven skin. Colorectal (colon) cancer. You may not notice any symptoms if the tumor hasn’t grown big enough. [my.clevelandclinic.org]

  […] metastases Two weeks following SRS A follow up MRI scan showed no evidence of new brain metastases CT scan showed: 4 smaller nodules in the left upper lobe The left lower lobe lung mass increased in size to 3.3 cm Ipsilateral mediastinal lymph node swelling [targetedonc.com]

  They may feel your organs to see if there is any swelling or a growth. They may also notice something's not right when you have regular screening tests like a colonoscopy, when a doctor puts a tube into your colon to check for polyps. [webmd.com]

• Fever

  Common symptoms include: Cough that doesn't go away Wet cough with blood or mucus Trouble breathing Pain in the chest Pain when swallowing Fever Those suffering from lung adenocarcinoma might also lose their appetites or lose weight without trying. [mercy.com]

  […] abdominal pain A persistent cough Shortness of breath Headache Memory problems Changes in vision or speech Weakness or fatigue Weight loss Difficulty urinating Loss of appetite Nausea or vomiting Jaundice (yellowing of the skin or whites of the eyes) Fever [everydayhealth.com]

  Others include: Breathing problems Chest pain Fever Trouble swallowing Poor appetite Weight loss If cancer spreads to other parts of the body, it can cause other symptoms, such as: Headaches and seizures, if cancer spreads to the brain Bone pain and fractures [docdoc.com.sg]

  Coughing (8-75%) Weight loss (0-68%) Shortness of breath (3-60%) Chest pain (20-49%): if the tumour involves the chest wall, pain may be localised to this area Haemoptysis (coughing up blood) : sputum may be streaked with blood Non-specific symptoms: fever [healthenginepb.wpengine.com]

  English Sepsis with neutropenic fever and consequent septic shock with fatal outcome has been observed in patients with metastatic pancreatic adenocarcinoma treated with ONIVYDE. [mymemory.translated.net]

• Falling

  Third, some tumors simply fail to stain with any marker: using the decision tree, such tumors fall into the “bin” at the bottom (breast or stomach or pancreas). [clincancerres.aacrjournals.org]

  It falls under the umbrella of non-small cell lung cancer (NSCLC) and has a strong association with previous smoking. While incidence and mortality have declined, it remains the leading cause of cancer death in the United States. [ncbi.nlm.nih.gov]

  The “other” insurance category includes forms of insurance reported by WCHS participants that did not fall into one of the four main categories above and included the following types of insurance coverage: school-provided, national government-provided [hindawi.com]

  It has been suggested that this increase is linked to falling rates of H pylori infection in Western society.60 The majority of data point to the idea that there is a true inverse relationship between infection with H pylori and risk of oesophageal adenocarcinoma [gut.bmj.com]

  […] on average 2.4% each year and death rates falling on average 2.2% each year over 2007-2016. [22] However, colorectal cancers remain the third most common cancer and third most common cause of cancer-related mortality in US men and women. [23] In addition [emedicine.medscape.com]

• Inflammation

  To evaluate the association of pre-diagnostic circulating inflammation markers with incident esophageal adenocarcinoma. 2. [whi.org]

  Higher amounts of PSA may be found in the blood of men who have prostate cancer, benign prostatic hyperplasia (BPH) or inflammation of the prostate. PSA can be used as a tumour marker. [cancer.ca]

  These include: Certain types of infections, including human papillomavirus (HPV), which has been observed in some patients with cervical and uterine cancers Chronic bowel inflammation Chronic inflammatory diseases that affect the female reproductive system [docdoc.com.sg]

  Lung adenocarcinoma usually occurs in the lung periphery, and in many cases, may be found in scars or areas of chronic inflammation.[1] Etiology By far, the main risk factor for any lung cancer, including adenocarcinoma, is smoking tobacco. [ncbi.nlm.nih.gov]

• Hoarseness

  It’s more likely to develop in women than in men. (8) Common symptoms are: A persistent cough or coughing up blood Shortness of breath Wheezing Pain in the chest or shoulders when breathing Hoarseness Frequent respiratory tract infections Trouble swallowing [everydayhealth.com]

  Hoarseness. Loss of appetite. Weight loss. Esophageal cancer. Difficulty swallowing. Pain, pressure or burning in your chest. Heartburn or indigestion. Coughing. Hoarseness. Stomach cancer. Stomach pain. [my.clevelandclinic.org]

  Additional symptoms of lung cancer include: chest pain difficulty breathing hoarseness loss of appetite and weight loss wheezing Pancreatic cancer Pancreas cancer is another cancer that usually has no symptoms until it’s very advanced. [healthline.com]

• Dyspnea

  After 5 cycles, he developed worsening dyspnea. A CT scan of his chest revealed a large pericardial effusion and decrease in size of right upper lobe lesion. [mdedge.com]

  […] unspecified bronchus or lung Diagrams / tables Images hosted on other servers: Histologic subtyping for surgeon Histologic pattern and prognosis Treatment Clinical features Cough, (productive if mucinous adenocarcinoma [Chest 2012;142:1338]), hemoptysis, dyspnea [pathologyoutlines.com]

  The female patient, who was not a smoker and had a history of hypertension in treatment, without any exposure, had chronic cough for more than a year, which had associated dyspnea at exertion and dyspnea in decubitus for the past 6 months. [medichub.ro]

  […] pneumonic form of BAC—characterized by extensive infiltration that appears remarkably similar to lobar pneumonia in 1 or more lung lobes—may benefit from palliative surgery. 15 Such patients may experience a severe productive cough with bronchorrhea and/or dyspnea [hematologyandoncology.net]

• Chest Wall Pain

  Symptoms of Lung Cancer (Adenocarcinoma of the Lung) Patients with adenocarcinoma of the lung may notice: Coughing (8-75%) Weight loss (0-68%) Shortness of breath (3-60%) Chest pain (20-49%): if the tumour involves the chest wall, pain may be localised [healthenginepb.wpengine.com]

• Nausea

  […] of metastatic breast adenocarcinoma can include: Bone, chest, joint, or abdominal pain A persistent cough Shortness of breath Headache Memory problems Changes in vision or speech Weakness or fatigue Weight loss Difficulty urinating Loss of appetite Nausea [everydayhealth.com]

  Nausea. Heartburn or indigestion. Can adenocarcinoma spread to other parts of my body? Yes. Adenocarcinoma can spread to other parts of your body. [my.clevelandclinic.org]

  Symptoms can include tummy pain, weight loss, and feeling and being sick (nausea and vomiting). Solid pseudopapillary neoplasm Solid pseudopapillary neoplasms grow mostly in the body and tail of the pancreas. They are more common in younger women. [pancreaticcancer.org.uk]

  They may prescribe drugs that fight nausea. Talk to your family and friends about how you're feeling, and don't hesitate to ask them for help while you're getting treatment. Also tell them about your worries and fears. [webmd.com]

  Other symptoms of pancreatic cancer include: appetite loss back pain feeling bloated heartburn nausea and vomiting signs of excess fat in the stool (stool smells bad and floats) Prostate cancer Often men have no symptoms of prostate cancer. [healthline.com]

• Vomiting

  […] than adenocarcinomas, and the outlook isn’t as good. (19) Symptoms of metastatic adenocarcinoma of the colon may include: Rectal bleeding or bloody stools Constipation, diarrhea, or other changes in bowel habits Abdominal pain or bloating Nausea or vomiting [everydayhealth.com]

  Nausea and vomiting. Feeling bloated. Loss of appetite. Back pain. Poop that floats. Lung cancer. The first symptom is usually a chronic cough. You may cough up saliva and mucous with small amounts of blood. [my.clevelandclinic.org]

  When this occurs, a patient may experience the following: Jaundice (yellowing of the skin and eyes) Dark or brown urine Light or gray, greasy stools Itchiness Abdominal or back pain Weight loss Loss of appetite Nausea Vomiting Enlarged liver or gallbladder [cancercenter.com]

  Symptoms can include tummy pain, weight loss, and feeling and being sick (nausea and vomiting). Solid pseudopapillary neoplasm Solid pseudopapillary neoplasms grow mostly in the body and tail of the pancreas. They are more common in younger women. [pancreaticcancer.org.uk]

  Other symptoms of pancreatic cancer include: appetite loss back pain feeling bloated heartburn nausea and vomiting signs of excess fat in the stool (stool smells bad and floats) Prostate cancer Often men have no symptoms of prostate cancer. [healthline.com]

• Dysphagia

  For palliative approaches, self-expanding metal stents (SEMS) can relieve dysphagia, and chemotherapy, radiation therapy and laser-based approaches are also considered. [orpha.net]

  We report a case of adenocarcinoma located on the dorsum of the posterior one third of the tongue adjacent to the circumvallate papillae in a woman presenting with globus sensation and mild dysphagia. [current-oncology.com]

  Some of the symptoms that people with adenocarcinoma of the lungs report include: Chest pain Cough Hemoptysis (coughing up blood) Difficulty breathing Wheezing Hoarseness Loss of appetite Dysphagia (difficulty swallowing) Unexplained weight loss As you [lunginjuries.org]

  Effect of stent size on complications and recurrent dysphagia in patients with esophageal or gastric cardia cancer. Gastrointestinal endoscopy. 2007 Apr 30;65(4):592-601. [medscape.com]

• Odynophagia

  CASE DESCRIPTION In December 2005, a 66-year-old woman presented to the otolaryngology clinic at our institution with mild dysphagia and a globus sensation, with no constitutional symptoms, odynophagia, or referred otalgia. [current-oncology.com]

• Confusion

  Socinski, MD: The case is of a 64-year-old gentleman who presents with a headache and some visual abnormalities—his left eye in some confusion. He eventually is evaluated by head of CT and is shown to have an occipital lesion on the right side. [targetedonc.com]

  Radiographs CT of abdomen can identify a primary site in 10% to 35% of patients Chest CT (rule out lung primary) Direct evaluation according to symptoms "Extensive radiologic evaluation of asymptomatic areas is rarely useful... expensive and often results in confusing [medicine.uiowa.edu]

  Constipation, diarrhea, or other changes in bowel habits Abdominal pain or bloating Nausea or vomiting Weakness or fatigue Jaundice (yellowing of the skin or whites of the eyes) Loss of appetite Weight loss Bone pain or fractures Difficulty breathing Confusion [everydayhealth.com]

  Changes are not characteristic, predisposing to diagnostic confusion(7). [medichub.ro]

  Focusing on invasion and using an illustrative case, we will explore the current recommendations that incorporate assessment of invasion to clarify the confusion caused by the different uses of the historical term ‘BAC’. [nature.com]

• Lethargy

  Weight loss (0-68%) Shortness of breath (3-60%) Chest pain (20-49%): if the tumour involves the chest wall, pain may be localised to this area Haemoptysis (coughing up blood) : sputum may be streaked with blood Non-specific symptoms: fever, weakness, lethargy [healthenginepb.wpengine.com]

  Weight loss (0-68%) Shortness of breath (3-60%) Chest pain (20-49%): if the tumour involves the chest wall, pain may be localised to this area Haemoptysis (coughing up blood): sputum may be streaked with blood Non-specific symptoms: fever, weakness, lethargy [healthengine.com.au]

[…] headache, impaired vision in left eye, and intermittent confusion that had begun a few weeks ago He is a current non-smoker with a 30-pack-year history Past medical history: hypertension diagnosed 3 years ago, well-controlled on losartan His cardiac workup [targetedonc.com]

Because histologically and immunohistochemically there is considerable overlap between colonic and vesical adenocarcinoma, extensive clinical and radiologic workup is required for diagnostic accuracy. [archivesofpathology.org]

Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities. World J Gastrointest Oncol. 2014 May 15. 6 (5):112-20. [Medline]. [Full Text]. Mao WM, Zheng WH, Ling ZQ. [medscape.com]

[…] the abdomen and liver Abdominal/pelvic MRI Positron emission tomography, including fusion PET-CT scan Other procedures that may be warranted include the following: Colonoscopy Sigmoidoscopy Biopsy of suspicious lesions Double-contrast barium enema See Workup [emedicine.medscape.com]

• Human Papillomavirus

  These include: Certain types of infections, including human papillomavirus (HPV), which has been observed in some patients with cervical and uterine cancers Chronic bowel inflammation Chronic inflammatory diseases that affect the female reproductive system [docdoc.com.sg]

  Human papillomavirus and survival in patients with base of tongue cancer. Int J Cancer 2011;128:2892–7. 13  Rischin D. Oropharyngeal cancer, human papilloma virus, and clinical trials. J Clin Oncol 2010;28:1–3. 14  Clark SK, Yarington CT Jr. [current-oncology.com]

  Other risk factors include: Diet high in processed meat Frequent drinking of extremely hot liquids Tobacco use (chewing tobacco, cigarettes and cigars) Alcohol use Obesity Family history History of lung, mouth or throat cancer Human papillomavirus (HPV [cancercenter.com]

  In addition, the prevalence of cancer-associated viral infections (e.g., human papillomavirus, human herpesvirus-8 (HHV8), human T-cell lymphotropic virus-1 (HTLV-1), hepatitis B virus (HBV)), may be higher among Caribbean populations compared to United [bmccancer.biomedcentral.com]

  InterSCOPE study: associations between esophageal squamous cell carcinoma and human papillomavirus serological markers. J Natl Cancer Inst. 2012 Jan 18. 104(2):147-58. [Medline]. [Full Text]. [medscape.com]

• Hepatocellular Carcinoma

  Squamous cell carcinoma and hepatocellular carcinoma (altogether 20 cases) were set as negative control. [unboundmedicine.com]

  Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [ NCIT:C2852 ] Synonyms: Carcinoma, Cribriform [ebi.ac.uk]

  /3) Hepatocellular carcinoma, NOS (M8200/3) Adenoid cystic carcinoma (M8312/3) Renal cell carcinoma (M8312/3) Grawitz tumor (8390-8420) Adnexal and Skin appendage Neoplasms (8430-8439) Mucoepidermoid Neoplasms (8440-8490) Cystic, Mucinous and Serous Neoplasms [en.wikipedia.org]

  Diagnosis is based on morphologic resemblance to hepatocellular carcinoma and positive immunostaining for α-fetoprotein. [archivesofpathology.org]

  Hepatocellular carcinomas expressed none of these markers: because the liver is commonly involved in metastatic spread, this facilitates the distinction between primary and secondary tumors. [clincancerres.aacrjournals.org]

Other adenocarcinoma treatments Other treatments for adenocarcinoma may include chemotherapy or radiation therapy. People who have radiosurgery or EEA surgery are able to continue other systemic treatments soon after their procedures. [upmc.com]

The following are treatment options for adenocarcinoma of unknown primary. Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. [cancer.ca]

[…] and better treatments. [verywellhealth.com]

[…] e20035 Background: The prognosis difference among lung adenocarcinoma patients with different pathological subtypes remains controversial. [ascopubs.org]

Furthermore, each of these elements impacts prognosis differently ( 4, 5 ). Using these microscopic parameters, the impact of morphology on prognosis in adenocarcinoma is currently under investigation ( 6 - 9 ). [ncbi.nlm.nih.gov]

The impact of the 2015 classification on prognosis was reviewed by a PubMed search for search terms “adenocarcinoma”, “lung pathology” and “prognosis” and relevant publications reviewed. [err.ersjournals.com]

The prognosis of AM was significantly worse than MAC but comparable with SRCC. [bmccancer.biomedcentral.com]

Prognosis for Adenocarcinoma The prognosis for lung cancers that are advanced at the time of diagnosis are generally poor. [lunginjuries.org]

Etiology The exact etiology is unknown. There is a strong association with GERD and obesity. There is no specific, known genetic link. [orpha.net]

Development of pericardial effusion with concurrent improvement or stability of malignant lesion, negative cytology and brisk response to corticosteroids indicates an immune etiology. [mdedge.com]

In addition, many of the known or suspected risk factors for esophageal adenocarcinoma, including smoking, alcohol and obesity, share a common suspected inflammatory etiology (Reid, 2010; Cook, 2013; Shaheen, 2013). [whi.org]

Genetic factors have been strongly implicated in the etiology of adenocarcinoma of the small intestine. [ncbi.nlm.nih.gov]

Etiology of Barrett’s esophagus and esophageal adenocarcinoma. Cancer Epidemiol Biomarks Prev1997;6:369–77. ↵ Chow WH, Finkle WD, McLaughlin JK, et al. [gut.bmj.com]

Epidemiological data], Ann Otolaryngol Chir Cervicofac 2002;119(5):271–280 Meccariello G1, Deganello A1, Choussy O2, Gallo O1, Vitali D1, De Raucourt D3, Georgalas C4. [med.stanford.edu]

Hence, the mysterious epidemiology of this cancer is not yet solved. [gut.bmj.com]

Caribbean Epidemiology Centre (CAREC). [bmccancer.biomedcentral.com]

Summary Epidemiology It has an estimated annual incidence of 1/35,000. Clinical description The age of onset is between 50-60 years and it is more frequently seen in males. [orpha.net]

Demographics, Epidemiology, and Inheritance of Pancreatic Ductal Adenocarcinoma. Semin Oncol 42(1):8-18, 2015. PMID: 2572604. [pancreapedia.org]

In the last 2 decades, adenocarcinoma has replaced squamous cell cancer of the lung as the most prevalent non-small cell cancer.[3] Pathophysiology Lung adenocarcinoma is classified into 4 types: adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma [ncbi.nlm.nih.gov]

Increasing evidence indicates that the interplay of autophagy and apoptosis is crucial in the pathophysiology of LUAD [17]. [hindawi.com]

Pathophysiology Genetically, colorectal cancer represents a complex disease, and genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. [emedicine.medscape.com]

[…] cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]

The CCO Chronic Disease Prevention Strategy provides a comprehensive plan for the way we will work with our partners to reduce new cases of major chronic diseases by decreasing the number of people with modifiable risk factors. [cancercareontario.ca]

Treatment includes surgical removal of the tumor to prevent its growth. After surgery, the patient may undergo chemotherapy and radiation to prevent the adenocarcinoma coming back. [news-medical.net]

These therapies can derail the cancer’s growth by preventing or changing chemical reactions linked to particular mutations. For example, some target therapies prevent cancer cells from receiving chemical “messages” telling them to grow. [drugs.com]

Prevention How can I reduce my risk for adenocarcinoma? Even though you can’t prevent cancer altogether, there are some things you can do to significantly lower your risk. [my.clevelandclinic.org]