Presentation is often insidious, and a large proportion (50%) of patients may be asymptomatic at the time of detection 1. Alternatively, as these tumors can produce large quantities of mucus, patients may present with bronchorrhea. [radiopaedia.org]

[…] of AIS (39 years) and the average age of presentation of invasive adenocarcinoma (52 years) has been documented; this interval is shorter than the one seen in squamous cervical lesions (Gynecol Oncol 1999;75:55) Clinical features Typically asymptomatic [pathologyoutlines.com]

In the present study, multifocal lesions were present in 4 of 44 patients (9.1%), which falls between the previously reported rates of multifocal lesions. [bmccancer.biomedcentral.com]

• Asymptomatic

  Presentation is often insidious, and a large proportion (50%) of patients may be asymptomatic at the time of detection 1. Alternatively, as these tumors can produce large quantities of mucus, patients may present with bronchorrhea. [radiopaedia.org]

  A total of 17 patients (94.4%) were asymptomatic. In all cases AIS was confirmed following an abnormal cytological screening. Only a patient (5.6%) had clinical signs of AIS in the form of anomalous gynecological bleeding. [oatext.com]

  […] presentation of AIS (39 years) and the average age of presentation of invasive adenocarcinoma (52 years) has been documented; this interval is shorter than the one seen in squamous cervical lesions (Gynecol Oncol 1999;75:55) Clinical features Typically asymptomatic [pathologyoutlines.com]

  A few patients presented with certain symptoms, such as contact bleeding (2 cases) and vaginal discharge (1 case), but most were asymptomatic (41 cases, 93.2%). [bmccancer.biomedcentral.com]

• Pathologist

  The cone biopsy specimen must be thoroughly sectioned and examined by a gynecological pathologist, and the patient should remain under specialist supervision during the period of follow-up. [link.springer.com]

  Two independent pathologists with extensive experience specifically in gynecologic pathology reviewed all the cytological and histological slides for the purposes of this study. These reviewers were blinded to the patients’ outcomes. [bmccancer.biomedcentral.com]

  […] at the time of surgery for AIS is acceptable but not required and should be guided by the surgeon's risk assessment, which may include factors such as margin status of the preceding excisional specimen or postexcisional endocervical sampling results, pathologist [ncbi.nlm.nih.gov]

• Surgical Procedure

  Records were reviewed for epidemiological and clinical data, diagnostic methods, therapeutical surgical procedures, and follow-up outcomes. [oatext.com]

  Conclusions LEEP with negative SMs was a safe and feasible fertility-sparing surgical procedure for patients with AIS, and the obstetric outcome was satisfactory. However, long-term follow-up is mandatory. [bmccancer.biomedcentral.com]

• Inflammation

  […] nuclei without mitotic activity, GATA3 positive, p16 negative or focally positive Microglandular hyperplasia: Smaller and more uniform glands with frequent subnuclear and supranuclear vacuoles, bland nuclei, no mitotic activity, associated with acute inflammation [pathologyoutlines.com]

• Irritability

  […] cleaning and metalwork being over age 45 Colon AIS risk factors smoking heavy alcohol use eating a diet that is high in fat and low in fiber not getting enough physical exercise obesity history of chronic conditions of your intestines or colon, such as irritable [healthline.com]

  Eyes: If changes occur in the cornea, the person may have a feeling of irritation or burning that does not go away. Sometimes, a lump will appear, for example, in the breast. Not all lumps or tumors are cancerous. [medicalnewstoday.com]

Initial Workup of Patients Either glandular or squamous cytologic abnormalities can indicate presence of AIS. Cytologically, women with AGC require further evaluation for premalignant conditions of the cervix, uterus, and rarely, ovary. [link.springer.com]

• Human Papillomavirus

  Cervical adenocarcinoma in situ: human papillomavirus types and incidence trends in five states, 2008-2015. [pubmed.ncbi.nlm.nih.gov]

  Human papillomavirus (HPV) and cervical cancer. Available online at https://www.who.int/en/news-room/fact-sheets/detail/human-papillomavirus-(hpv)-and-cervical-cancer. Accessed March 3, 2019. (May 2018) U.S. [labtestsonline.it]

  Adenocarcinoma in situ and associated human papillomavirus type distribution observed in two clinical trials of a quadrivalent human papillomavirus vaccine. Int J Cancer. 2011;128:1344–53. [link.springer.com]

  Infection with high-risk human papillomavirus (HPV), commonly HPV-16 and HPV-18, is necessary for the development of abnormal cervical skin changes and nearly all types of cervical cancer. [parkview.com]

  HPV, human papillomavirus. Teoh. Adenocarcinoma-in-Situ Recommendations. Obstet Gynecol 2020. [ncbi.nlm.nih.gov]

Cervical AIS treatment Treatment for most types of AIS involves simply removing the AIS tumor, but treatment for cervical AIS is a little different. Your treatment for cervical AIS depends on a few different factors. [healthline.com]

The standard treatment for cervical AIS is hysterectomy, which is a more aggressive treatment than that used for squamous intraepithelial lesions. [bmccancer.biomedcentral.com]

One possible treatment is surgical removal of the cells with cryotherapy. What are the signs of eye cancer, and what is the treatment? Learn more here. [medicalnewstoday.com]

However, solid, invasive components are frequently present and despite radical treatment, recurrence rates are high. [radiopaedia.org]

Hysterectomy remains the standard treatment for AIS. Selected patients who wish to preserve fertility can be alternatively managed with conservative treatment (i.e., conization). [link.springer.com]

Mucinous subtypes have worse prognosis 4, probably due to aerogenous spread that forms infiltrating, multifocal, or satellite tumors 11. [radiopaedia.org]

[Crossref] Song T, Lee YY, Choi CH, Kim TJ, Lee JW, et al. (2015) The effect of coexisting squamous cell lesions on prognosis in patients with cervical adenocarcinoma in situ. Eur J Obstet Gynecol Repro Biol 190: 26-30. [oatext.com]

[…] features Typically asymptomatic Most commonly abnormal cervical cytology with atypical endocervical glandular cells (Aust N Z J Obstet Gynaecol 2004;44:436) Rarely vaginal bleeding Diagnosis Cytologic or histologic examination Prognostic factors Excellent prognosis [pathologyoutlines.com]

EGFR mutations increases from atypical adenomatous hyperplasia → adenocarcinoma in situ → minimally invasive carcinoma KRAS and BRAF mutations do not show same progression, suggesting other molecular alterations are also involved in tumor evolution Etiology [pathologyoutlines.com]

100,000 persons at the peak age of 30–39 years.6 The average interval between a diagnosis of clinically detectable AIS and early invasive cancer is at least 5 years.8 Additionally, approximately 55% of patients with AIS have a coexisting squamous lesion.7 Etiology [ncbi.nlm.nih.gov]

[…] invasion Size: ≤ 3 cm Diagnosed only after complete sampling of a resected lesion Terminology Bronchioloalveolar carcinoma (historical term, obsolete) ICD coding ICD-O: 8250/2 - adenocarcinoma in situ, nonmucinous 8253/2 - adenocarcinoma in situ, mucinous Epidemiology [pathologyoutlines.com]

Records were reviewed for epidemiological and clinical data, diagnostic methods, therapeutical surgical procedures, and follow-up outcomes. [oatext.com]

Centre, Nijmegen, The Netherlands H P van de Nieuwenhof, L F A G Massuger, J A de Hullu, M A P C van Ham & R L M Bekkers Netherlands Cancer Registry, Association of Comprehensive Cancer Centres, Utrecht, The Netherlands J A A M van Dijck Department of Epidemiology [nature.com]

[…] adenocarcinoma in situ, nonmucinous 8253/2 - adenocarcinoma in situ, mucinous Epidemiology ~5% of non small cell lung carcinomas (NSCLC) F = M (F slightly higher, in contrast to other NSCLC) References: J Clin Oncol 2005;23:8396, Lung Cancer 2004;45:137 Pathophysiology [pathologyoutlines.com]

Preventive Services Task Force. Screening for Cervical Cancer: U.S. Preventive Services Task Force Recommendation Statement. Annals of Internal Medicine, March 6, 2012, 156(5). [labtestsonline.it]

Preventive Services Task Force recommendation statement. Ann Intern Med 2012;156:880–91, W312. - PubMed Saslow D, Solomon D, Lawson HW, Killackey M, Kulasingam SL, Cain J, et al. [pubmed.ncbi.nlm.nih.gov]

Cervical adenocarcinoma: moving towards better prevention. Vaccine. 2011;29:9148–58. Article PubMed Google Scholar FUTURE II Study Group. Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions. [link.springer.com]

The finding that adenocarcinoma of the cervix is primarily related to HPV-16 and HPV-18 and that HPV vaccination has significantly prevented cervical adenocarcinoma in situ in clinical trials may indicate that vaccination is the most promising measure [parkview.com]

Often, doctors will also perform a hysterectomy to prevent cervical cancer from returning. However, if you wish to become pregnant in the future, you’ll need to go a different route. [healthline.com]