We present 4 adolescents with an average age of 15 years who present with several month histories of significant weight loss and abdominal pain. All had an abdominal and pelvic computed tomography scan, which revealed an adenocarcinoma in the colon. [ncbi.nlm.nih.gov]

• Weight Loss

  On admission, symptoms were dominated by overall dysphagia, patient showing a weight loss of 10 kg for the last 30 days. Preoperative imaging tests did not revealed regional or distant metastatic disease. [ncbi.nlm.nih.gov]

  As the cancer grows, it may spread, producing systemic symptoms that affect your whole body, such as fatigue and weight loss. [cancercenter.com]

  February 2013 A 62-year old man presented to his primary care physician complaining of weight loss and bloody stool. [targetedonc.com]

  Unexplained weight loss. A weight loss of 10 pounds or more, when you haven't changed your diet and exercise habits, could be cancer, especially if you also have other colon cancer symptoms. [webmd.com]

• Anemia

  Laboratory results showed anemia and elevated CA 125 levels. A pelvic computed tomographic scan revealed a huge multicystic mass on the right ovary and a well-enhancing intraluminal mass located at the rectosigmoid junction. [ncbi.nlm.nih.gov]

  Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, colonic adenocarcinomas are divided into well, moderately, and poorly differentiated. [ebi.ac.uk]

  Anemia in females may arise from gynecologic causes, but it is a clinical maxim that iron deficiency anemia in an older man means gastrointestinal cancer until proved otherwise 15. [slideshare.net]

  In general: right sided tumors are larger and present with a mass, distant disease or iron deficiency anemia left sided tumors present earlier with altered bowel habit Colorectal cancers, 98% of which are adenocarcinomas, arise in the vast majority of [radiopaedia.org]

• Fatigue

  If the lungs are affected, symptoms may include shortness of breath, difficulty breathing, coughing, pain and/or fatigue. [cancercenter.com]

  […] microsatellite instability pathway (10% - 15%) Stage is most important prognostic factor Clinical features Increased carcinoma risk in patients with polyposis syndromes, Lynch syndrome and inflammatory bowel disease Right sided tumors cause anemia, weakness and fatigue [pathologyoutlines.com]

  Around 13 months after beginning therapy, the patient reported weight loss and fatigue. He underwent subsequent imaging, which found that he had progressive disease at that time. [targetedonc.com]

  Common side effects include: hair loss nausea fatigue vomiting Combination therapies often mix multiple types of chemotherapy or combine chemotherapy with other treatments. [medicalnewstoday.com]

  Fatigue and weakness. Feeling much more tired or weak than usual could be a sign that the tumor is bleeding and you've lost iron. Abdominal pain or bloating. Colon tumors can cause a blockage that makes it hard to fully empty your bowels. [webmd.com]

• Fever

  Our patient presented with 'B' symptoms (fever, drenching sweats, and more than 10% weight loss) and ascites. [jmedicalcasereports.biomedcentral.com]

  Appendicitis is inflammation of the appendix that can cause abdominal pain or swelling, loss of appetite, nausea, vomiting, constipation or diarrhea, inability to pass gas, or a low fever that begins after other symptoms. [cancer.net]

  If they do have symptoms, they may be vague and can include: Loss of appetite or feeling full early Fatigue Fever Itching Pain in the abdomen Swelling in the legs Weight loss Yellowing of the skin or whites of the eyes, called jaundice Lungs Because the [webmd.com]

  […] associated with potential causes: blood coating the stool suggests hemorrhoidal bleeding while blood mixed in the stool implies a more proximal source; bloody diarrhea and tenesmus is associated with inflammatory bowel disease while bloody diarrhea with fever [en.wikipedia.org]

  Lethargy or fever of unknown origin. These symptoms are due to a small occult, localised perforation or from tumour burden. Metastases tend to be more aggressive and grow more rapidly than the primary tumour. [surgwiki.com]

• Pleural Effusion

  If lung metastases are present there may be pleural effusions causing breathlessness. Effusions may require drainage. Colon Cancer (Adenocarcinoma of the Colon) References Braunwald E, Fauci AS, Kasper DL, et al. [healthengine.com.au]

• Abdominal Pain

  The patient was referred for an evaluation of lower abdominal pain and distension. Laboratory results showed anemia and elevated CA 125 levels. [ncbi.nlm.nih.gov]

• Diarrhea

  Improvement in the secretory diarrhea by the somatostatin analog Sandostatin suggested that the diarrhea was related to a functional neuroendocrine tumor within the colonic tumor, the first case to be reported in the literature. [ncbi.nlm.nih.gov]

  Common local symptoms include: Constipation Diarrhea Alternating diarrhea and constipation, or other changes in bowel habits Rectal bleeding or blood in the stool Abdominal bloating, cramps or discomfort A feeling that the bowel doesn't empty completely [cancercenter.com]

  […] important prognostic factor Clinical features Increased carcinoma risk in patients with polyposis syndromes, Lynch syndrome and inflammatory bowel disease Right sided tumors cause anemia, weakness and fatigue Left sided tumors cause change in bowel habits (diarrhea [pathologyoutlines.com]

  Complications from chemotherapy and biotherapy depend on the agents used, but may include nausea, vomiting, diarrhea, inability to fight infection and allergic reactions. [livestrong.com]

• Constipation

  We conclude that any child presenting with unexplained persistent constipation, abdominal distension or bleeding per rectum, colon cancer should be suspected and investigated with endoscopy or barium enema. [ncbi.nlm.nih.gov]

  Common local symptoms include: Constipation Diarrhea Alternating diarrhea and constipation, or other changes in bowel habits Rectal bleeding or blood in the stool Abdominal bloating, cramps or discomfort A feeling that the bowel doesn't empty completely [cancercenter.com]

  C., a thirty-three-year-old railroad brakeman, was admitted to the hospital on May 22, 1934, complaining of pain in the left half of the abdomen, distention, and constipation. [cancerres.aacrjournals.org]

  […] prognostic factor Clinical features Increased carcinoma risk in patients with polyposis syndromes, Lynch syndrome and inflammatory bowel disease Right sided tumors cause anemia, weakness and fatigue Left sided tumors cause change in bowel habits (diarrhea or constipation [pathologyoutlines.com]

  When the disease -- at any stage -- causes symptoms, they may include: Blood (usually dark red or black) in the stool Constipation and diarrhea. These can also be symptoms of other, less serious conditions. But if they persist, see your doctor. [webmd.com]

• Blood in Stool

  […] in stool Loss of appetite Change in bowel habits Location Rectum (15%), sigmoid (20%), descending colon (10%), transverse colon (12%), ascending colon (8%), cecum (8%) Location seems to be changing and moving back to cecum More common in right colon [learningradiology.com]

  There may be dark red or mahogany-colored blood mixed with the stool. [medical-dictionary.thefreedictionary.com]

  Some changes in bowels habits that may be considered colon cancer signs include: Change in frequency of bowel movements Constipation Change in consistency of stool (loose or watery stools) Blood in stools (either as bright red spots or dark tar-like stools [cancercenter.com]

  Blood in the stool, even blood that cannot be seen by the naked eye (occult blood—see Stool Occult Blood Tests ), can be a sign of cancer. Usually, the stool is tested every year. [msdmanuals.com]

  These symptoms can include: change in bowel habits blood in stool or rectal bleeding abdominal pain fatigue unexplained weight loss Doctors use a procedure called a colonoscopy to detect colon cancer. [healthline.com]

• Hematochezia

  Approximately six months after the initial surgery, he again presented complaining of hematochezia. A flexible sigmoidoscopy revealed a large fungating mass at 20 cm proximal to the anus (Figure 2). [omicsonline.org]

  Proximal tumors will cause occult fecal blood and anemia, whereas distal tumors will cause more changes in bowel habits and hematochezia. [med-ed.virginia.edu]

  This patient also reported mild intermittent hematochezia (about 10–12 episodes) for a month and gave a pertinent history of colon cancer in his mother at the age of 50. [karger.com]

  The presence of hematochezia is six-times greater in a LGIB than with a UGIB.[5] Occasionally, a person with a LGIB will not present with any signs of internal bleeding, especially if there is a chronic bleed with ongoing low levels of blood loss. [en.wikipedia.org]

  Other clinical findings that may provide clues to the diagnosis include a positive fecal occult (hidden) blood test (FOBT), bright red blood per rectum (hematochezia), or hematologic abnormalities, such as iron-deficiency anemia. [clinicaladvisor.com]

• Peripheral Neuropathy

  […] sensorial neuropathy (12.4% >grade 3). [cancer.gov]

The primary workup depends on the status of the patient. A CT scan or an ultrasound imaging of the abdomen is usually part of the initial workup on a patient presenting with abdominal pain to specifically exclude an acute abdomen [19]. [hindawi.com]

After a complete workup, the patient was diagnosed with stage IV poorly differentiated ASC of colon. He was started on palliative chemotherapy with fluorouracil and cisplatin. [karger.com]

Diagnostic workup is largely in line with the presenting features of the patients, and the diagnosis is usually made on the basis of colonoscopy and biopsy. However, when the presentation is unusual (as in our patient), diagnosis is difficult. [jmedicalcasereports.biomedcentral.com]

[…] was negative in all mucinous and nonmucinous types of bronchioloalveolar carcinomas, thereby proving that CDX2 is a useful immunohistochemical marker for the differential diagnosis of primary versus metastatic adenocarcinomas in the lung and in the workup [ijpmonline.org]

[…] structures (T4) N0 M0 Stage IIA T3 N0 M0 Stage IIB T4a N0 M0 Stage IIC T4b N0 M0 Stage IIIA T1-2 T1 N1/N1c N2a M0 Stage IIIB T3-4a T2-3 T1-2 N1/N1c N2a N2b M0 Stage IIIC T4a T3-4a T4b N2a N2b N1-2 M0 Stage IVA T1-4 N1-3 M1a Stage IVB T1-4 N1-3 M1b See Workup [emedicine.medscape.com]

• Microcytic Anemia

  anemia iron deficiency anemia in an elderly male is colon cancer until proven otherwise fecal occult blood test lacks sensitivity and specificity as it only tests for globin with a peroxidase false positive with high meat diet (myoglobin), radishes [medbullets.com]

• Pleural Effusion

  If lung metastases are present there may be pleural effusions causing breathlessness. Effusions may require drainage. Colon Cancer (Adenocarcinoma of the Colon) References Braunwald E, Fauci AS, Kasper DL, et al. [healthengine.com.au]

Treatment decisions are made based primarily on stage, and stage II patients are not routinely offered adjuvant therapy. Placing patients on a randomized clinical trial, until a standardized treatment is agreed upon, is one alternative. [ncbi.nlm.nih.gov]

[…] colon cancer clinical trials,lung cancer research,treatment for lung cancer,effects of lung cancer,cancer clinical trials,prostate cancer treatment,metastatic breast cancer,kidney cancer treatment,cancer center,breast cancer therapy,colon c,renal cancer [youtube.com]

High grade or abnormal cancer cells, or tumors that have caused a blockage or perforation of the colon may warrant further treatment. [coloncancercoalition.org]

They only give information about the cancer itself and the precise type of treatment you might need. Remember that not every patient with colon cancer even needs other types of treatment besides surgery. [cancer.org]

MSI is associated with a favorable prognosis, but poorly differentiated adenocarcinomas (PDAs) have a poor prognosis. In this study, we aimed to investigate this inconsistency by analyzing the heterogeneity of PDAs. [ncbi.nlm.nih.gov]

If you have colorectal cancer, you may have questions about your prognosis. A prognosis is the doctor’s best estimate of how cancer will affect someone and how it will respond to treatment. Prognosis and survival depend on many factors. [cancer.ca]

The syndrome may be associated with multiple etiologic agents or diseases. Malignancy, usually lymphoreticular, has been present in rare patients (less than 1%). [ncbi.nlm.nih.gov]

On the basis of these cases, a defect in the closure of the embryonic fissure is the most plausible etiology of the optic pit. [scielo.br]

Etiology • I. Genetic influences: – preexisting ulcerative colitis or polyposis syndrome – hereditary nonpolyposis colorectal cancer syndrome (HNPCC, Lynch syndrome) → germ-line mutations of DNA mismatch repair genes II. [slideshare.net]

Etiology According to the WHO Classification of Tumors of the Digestive System the following factors may play an etiological role in the development of CRC: - Diet (high caloric food, meat consumption) - Obesity - Sedentary lifestyle - Smoking - Alcohol [atlasgeneticsoncology.org]

Abstract Epidemiology and experimental studies provide an overwhelming support of the notion that diets high in red or processed meat accompany an elevated risk of developing pre-neoplastic colorectal adenoma and frank colorectal carcinoma (CRC). [ncbi.nlm.nih.gov]

J Natl Cancer Inst 100: 1184-7 31 Pera M, Manterola C, Vidal O, Grande L (2005) Epidemiology of esophageal adenocarcinoma. J Surg Oncol 92: 151-9. [codes.iarc.fr]

Cancer epidemiology 38, 448–454, 10.1016/j.canep.2014.04.004 (2014). 18. Mitry, E. et al. Epidemiology, management and prognosis of colorectal cancer with lung metastases: a 30-year population-based study. [nature.com]

Bermejo EMartínez-Frías ML Congenital eye malformations: clinical-epidemiological analysis of 1,124,654 consecutive births in Spain. Am J Med Genet 1998;75 (5) 497- 504PubMedGoogle Scholar 16. Blake KDDavenport SLHall BD et al. [jamanetwork.com]

Staging intramucosal colorectal adenocarcinoma invasive colorectal adenocarcinoma Epidemiology Colorectal cancer (CRC) is the second most common cause of cancer deaths in the United States. [humpath.com]

What is the best pathophysiology of colorectal cancer. The pathophysiology just has to be brief and concise. It also has to include nursing considerations for the patient. [medical-dictionary.thefreedictionary.com]

Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 126. National Cancer Institute website. [medlineplus.gov]

We conclude that although tissue CEA staining patterns appear useful in explaining pathophysiological features, they offer little additional information over plasma CEA toward the prognosis of patients with colorectal carcinoma operated with curative [scielo.br]

The pain of tendinopathy: physiological or pathophysiological? Sports Medicine. 2014; 44 (1):9–23. doi: 10.1007/s40279-013-0096-z. [ PubMed ] [ CrossRef ] [ Google Scholar ] 48. Sharma P., Maffulli N. [ncbi.nlm.nih.gov]

Pathophysiology Genetically, colorectal cancer represents a complex disease, and genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. [emedicine.medscape.com]

The mucin, in turn, creates a barrier that may, in fact, prevent chemotherapy medications from effectively penetrating cancer cells. In short, the chemo may not be able to get where it needs to be. [verywellhealth.com]

Colon cancer is preventable and curable. It is preventable by removing the precancerous colon polyps. It is curable if detected early when it can be surgically removed before it has spread to other parts of the body. [medicinenet.com]

The procedure takes 15 - 30 minutes during which time the patient is sedated to prevent discomfort. [coloncancerfoundation.org]

Lifestyle interventions in the prevention and treatment of cancer, American Journal of Lifestyle, septembre 2009, vol. 3, no 5, 337-48. [passeportsante.net]