Side effects of crizotinib mostly consist of grade 1-2 gastrointestinal events (nausea, vomiting, diarrhea and constipation), grade 1-2 edema and fatigue; grade 1 visual disorders, rare cases of elevated liver enzymes and pneumonitis. [ncbi.nlm.nih.gov]

Like many other types of cancer, lung cancer may also cause systemic symptoms, like loss of appetite or general fatigue. [cancercenter.com]

Some of the more common paraneoplastic syndromes that can be caused by non-small cell lung cancer include: High blood calcium levels (hypercalcemia), which can cause frequent urination, thirst, constipation, nausea, vomiting, belly pain, weakness, fatigue [cancer.org]

Some people with lung cancer have chest pain, frequent coughing, blood in the mucus, breathing problems, trouble swallowing or speaking, loss of appetite and weight loss, fatigue, or swelling in the face or neck. [ghr.nlm.nih.gov]

The signs and symptoms of elevated calcium in the blood include: thirst, fatigue, constipation, polyuria (increased urination), and nausea. [en.wikipedia.org]