We are going to present this case in the journal because of its rarity. [ncbi.nlm.nih.gov]

• Fatigue

  Side effects of crizotinib mostly consist of grade 1-2 gastrointestinal events (nausea, vomiting, diarrhea and constipation), grade 1-2 edema and fatigue; grade 1 visual disorders, rare cases of elevated liver enzymes and pneumonitis. [ncbi.nlm.nih.gov]

  Like many other types of cancer, lung cancer may also cause systemic symptoms, like loss of appetite or general fatigue. [cancercenter.com]

  Some of the more common paraneoplastic syndromes that can be caused by non-small cell lung cancer include: High blood calcium levels (hypercalcemia), which can cause frequent urination, thirst, constipation, nausea, vomiting, belly pain, weakness, fatigue [cancer.org]

  Some people with lung cancer have chest pain, frequent coughing, blood in the mucus, breathing problems, trouble swallowing or speaking, loss of appetite and weight loss, fatigue, or swelling in the face or neck. [ghr.nlm.nih.gov]

  The signs and symptoms of elevated calcium in the blood include: thirst, fatigue, constipation, polyuria (increased urination), and nausea. [en.wikipedia.org]

As pathologists manage these specimens, they need to minimise the amount of tissue used for diagnostic workup and preserve as much material for molecular testing as possible [ 1, 16, 22 ]. [doi.org]

Workup was also done for ruling out hypercoagulable state due to mutations and it was negative. CT scan of abdomen and pelvis showed a mass in the ascending colon (Figure 2) and CT head was negative. [oatext.com]

A detailed medical history should be obtained from each patient to determine the relevance of further diagnostic workup and management. Adenocarcinoma, like other forms of lung cancer, is usually advanced or metastatic at time of diagnosis. [en.wikipedia.org]

No further diagnostic workup was pursued until he was admitted with intractable pain. Eventual biopsy revealed adenocarcinoma, likely of pulmonary origin. [hindawi.com]

Trial Design and Treatment Figure 1. Figure 1. Trial Design. [doi.org]

Although treatment of penile metastasis is almost always palliative, early recognition may enhance survival for these patients. [ncbi.nlm.nih.gov]

By univariate analysis, HER-2/neu overexpression and poor cell differentiation are two important factors correlated with poor prognosis. [ncbi.nlm.nih.gov]

The exact mechanism of HPO is unknown but it thought to be hormonal or neurogenic in etiology. The triad of HPO includes distal clubbing, arthritis, and bilateral symmetrical periosteal formation. [en.wikipedia.org]

Oncology: Exceptions That Prove the Rule. 61 Casali M...Versari A 23533875 2013 5 Increased risk of histologically defined cancer subtypes in human immunodeficiency virus-infected individuals: clues for possible immunosuppression-related or infectious etiology [malacards.org]

The incidence of synchronous epithelial tumors with hematological malignancies is very uncommon, and its etiology and pathophysiology remains still unclear [3,4]. [omicsonline.org]

Table 1 Primary Cardiac Neoplasms With respect to indirect effects of neoplasms, the increased recognition of cardiac amyloidosis, a diagnosis that should prompt evaluation for an underlying neoplastic etiology, as well as the development of newer-generation [onlinejacc.org]

Comparison of aspects of smoking among the four histological types of lung cancer S A Kenfield 1, 2, E K Wei 2, M J Stampfer 1, 2, B A Rosner 2, 3, G A Colditz 4 1 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA [doi.org]

"Lung Cancer in Never Smokers: Clinical Epidemiology and Environmental Risk Factors". Clinical Cancer Research. 15 (18): 5626–5645. doi:10.1158/1078-0432.CCR-09-0376. PMC 3170525. PMID 19755391. [en.wikipedia.org]

Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives. J. Clin. Oncol. 31, 1997–2003 (2013) 96. Mazières, J. et al. [nature.com]

The pathophysiology of adenocarcinoma is complicated, but generally follows a histologic progression from cells found in healthy lungs to distinctly dysmorphic, or irregular, cells. [en.wikipedia.org]

The incidence of synchronous epithelial tumors with hematological malignancies is very uncommon, and its etiology and pathophysiology remains still unclear [3,4]. [omicsonline.org]

Natural history, pathophysiology, and diagnosis. Chest 122: 1440-1456. [Crossref] Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH (2007) Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy. [oatext.com]

Smoking prevention and cessation should continue to be the focus of public health efforts to reduce lung cancer incidence and mortality. [doi.org]

Lung Cancer Prevention For the majority of lung cancers, prevention is possible if a person never smokes and avoids second-hand smoke. [onhealth.com]

The peripheral location of adenocarcinoma in the lungs may be due to the use of filters in cigarettes which prevent the larger particles from entering the lung. [en.wikipedia.org]

Prevention There's no sure way to prevent lung cancer, but you can reduce your risk if you: Don't smoke. If you've never smoked, don't start. [mayoclinic.org]

Centers for Disease Control and Prevention. National Center for Health Statistics. CDC WONDER On-line Database, compiled from Compressed Mortality File 1999-2016 Series 20 No. 2V, 2017. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2016. [lung.org]