The lymphocyte subsets present in the infiltrate were characterized by immunohistochemical methods to establish the contribution of different elements of the cellular immune response. [ncbi.nlm.nih.gov]

Autoimmune workup did not reveal any abnormality with CRP - 1.2 mg/l (normal 7 mg/l); antinuclear antibodies ( 1:40), and antineutrophilic cytoplasmic antibodies ( 1:16), anti-TPO Ab - 4 IU/l ( 9), RA factor 4 IU/l ( 20), and anti-TTG Ab- 3.54 IU/ ml [ijem.in]

Treatment with supraphysiologic doses of prednisone resulted in clinical and radiographic improvement. [ncbi.nlm.nih.gov]

To round out the clinician's understanding of the illness, a patient describes the experience of diagnosis, treatment, and follow-up. [books.google.com]

(Gd) can variably enhance, usually homogeneously 7 dural enhancement may be present 8 infundibulum may be thickened 8 T2 hypointensity in parasellar region can be present and may be useful in differentiating from a pituitary adenoma 4 Treatment and prognosis [radiopaedia.org]

The histogenesis and prognosis of these tumours remain uncertain and need to be documented more thoroughly in the literature. [jmedicalcasereports.biomedcentral.com]

Until a specific pituitary antibody for this disease or a characteristic radiographic feature, as by MR spectroscopy, has been identified, the clinical diagnosis of this entity must rely on the histologic study of the pituitary Therapy and Prognosis The [pituitaryadenomas.com]

We report 2 further cases and review the etiology, immunology and pathology of the disease. [ncbi.nlm.nih.gov]

Abstract Autoimmune hypophysitis, often referred to as lymphocytic hypophysitis, is defined as an inflammatory condition of the pituitary gland of autoimmune etiology that leads to pituitary dysfunction. [scititles.com]

Conclusion: Infundibuloneurohypophysitis should be taken into account in the etiological diagnosis of hypopituitarism, particularly if it is associated with diabetes insipidus and in cases of growth hormone deficit, secondary hypogonadism, or multiple [karger.com]

It was reasonably assumed, therefore, that this disease has an auto immune etiology. [pituitaryadenomas.com]

Lymphocytic hypophysitis is a primary inflammatory disorder that typically presents during or shortly after pregnancy. [30] Although of unknown etiology, lymphocytic hypophysitis is believed to be caused by an autoimmune process. [emedicine.medscape.com]

[…] throughout the day and in response to metabolic factors, making abnormal levels difficult to calibrate—further hampering diagnosis. [8] [9] [10] [11] [12] [13] Treatment [ edit ] Inflammation resolves usually after several months of glucocorticoid treatment Epidemiology [en.wikipedia.org]

National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) Program, via contract number N01-CN-67006, with Emory University, Atlanta SEER Cancer Registry, Atlanta, Georgia, U.S.A. [histology-world.com]

In this review, we provide an overview of the epidemiology, diagnosis, pathogenesis, treatment, and the role of organ-specific and antipituitary antibodies as potential markers of LYH. [clinsci.org]

The early observation suggested the possibility of a spectrum of progression starting with LYH and progressing to GH.[ 25 ] In contrast, other authors cited key epidemiological factors of LYH that were not found in GH including female bias, association [surgicalneurologyint.com]

Epidemiology The annual incidence of hypophysitis is estimated to be 1 in 7–9 million. [clindiabetesendo.biomedcentral.com]

Discrimination between these two conditions is of importance since, despite the similarity of their presentation, there are significant differences in pathophysiology. [ncbi.nlm.nih.gov]

[…] of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology [books.google.de]

Pathophysiology: The occurrence of pituitary inflammation associated with pregnancy is felt to be secondary to the involution of the pituitary gland that takes place during this time (4,7). [medschool.lsuhsc.edu]

The pathophysiologic process apparently begins as an acute inflammatory response with enlargement of the gland, as noted in 95% tissue-documented cases. [pituitaryadenomas.com]

Cortisol inhibits the release of CRH and ACTH from the hypothalamus and pituitary gland respectively, preventing further cortisol release. Cortisol is inactivated in the liver to inactive cortisone. [endocrinesurgeon.co.uk]

During an operation, neurosurgeons typically drain these cysts early, to prevent their potential rupture and consequent chemical meningitis. [neupsykey.com]

Miyai K (2007) Congenital thyrotropin deficiency—from discovery to molecular biology, postgenome and preventive medicine. Endocr J 54 : 191–203 47. [nature.com]

Yoon JW, Choi DS, Liang HC, Baek HS, Ko IY, et al. (1992) Induction of an organ-specific autoimmune disease, lymphocytic hypophysitis, in hamsters by recombinant rubella virus glycoprotein and prevention of disease by neonatal thymectomy. [omicsonline.org]