The lymphocyte subsets present in the infiltrate were characterized by immunohistochemical methods to establish the contribution of different elements of the cellular immune response. [ncbi.nlm.nih.gov]

• Cold Intolerance

  A 47-year-old woman complaining of cold intolerance, general weakness and amenorrhea of 10 months duration was diagnosed, by endocrine examinations, as having panhypopituitarism. [ncbi.nlm.nih.gov]

• Hemianopsia

  She had diabetes insipidus and bitemporal hemianopsia. Radiological evidence suggested a mass arising in the sella turcica with extension into the parasellar and suprasellar regions. [ncbi.nlm.nih.gov]

  Source MeSH Adult Antibodies, Antinuclear Female Hemianopsia Humans Hypopituitarism Inflammation Lymphocytes Pituitary Diseases Pituitary Function Tests Pituitary Gland, Anterior Pregnancy Pregnancy Complications Pub Type(s) Case Reports English Abstract [unboundmedicine.com]

  Compression of the pituitary gland itself may cause hypopituitarism, and compression of the optic chiasm results in bitemporal hemianopsia. Headache is also a common symptom of pituitary tumors. [emedicine.medscape.com]

  Bitemporal hemianopsia accounts for the majority of visual symptoms, with impaired acuity and diplopia being relatively uncommon. Endocrine dysfunction has been reported in up to 80% of cases. [surgicalneurologyint.com]

• Visual Impairment

  Repeated CT performed three months after delivery showed that the pituitary mass had undergone a spontaneous regression in size, and her visual impairment improved. [unboundmedicine.com]

  With mass effect and dural irritation, headache, and visual impairment have been reported in up to 50–70% of cases. Bitemporal hemianopsia accounts for the majority of visual symptoms, with impaired acuity and diplopia being relatively uncommon. [surgicalneurologyint.com]

• Nipple Discharge

  discharge * Amenorrhea * Left temporal mon- ocular anopsia PRL: 96 * suprasellar ext. 28 5 * Headache normal * 1.5x2.5cm contrast-enhancing lesion * suprasellar ext with chiasmatic compression TSH: Thyroid stimulating hormone FTI: Free Thyroid Index [medschool.lsuhsc.edu]

• Bitemporal Hemianopsia

  She had diabetes insipidus and bitemporal hemianopsia. Radiological evidence suggested a mass arising in the sella turcica with extension into the parasellar and suprasellar regions. [ncbi.nlm.nih.gov]

  Compression of the pituitary gland itself may cause hypopituitarism, and compression of the optic chiasm results in bitemporal hemianopsia. Headache is also a common symptom of pituitary tumors. [emedicine.medscape.com]

  Bitemporal hemianopsia accounts for the majority of visual symptoms, with impaired acuity and diplopia being relatively uncommon. Endocrine dysfunction has been reported in up to 80% of cases. [surgicalneurologyint.com]

• Oligomenorrhea

  Case 1 was a 35-year-old woman with remote history of pregnancy who presented with headache, oligomenorrhea and visual disturbances. The blood prolactin level was nearly undetectable, but no deficiency of other pituitary hormones was evident. [ncbi.nlm.nih.gov]

Autoimmune workup did not reveal any abnormality with CRP - 1.2 mg/l (normal < 7 mg/l); antinuclear antibodies (< 1:40), and antineutrophilic cytoplasmic antibodies (< 1:16), anti-TPO Ab - 4 IU/l (< 9), RA factor 4 IU/l (< 20), and anti-TTG Ab- 3.54 IU [ijem.in]

• Lymphocytic Infiltrate

  The removed tissue had histological features consistent with adenohypophysitis including a diffuse lymphocytic infiltrate. [ncbi.nlm.nih.gov]

Treatment with supraphysiologic doses of prednisone resulted in clinical and radiographic improvement. [ncbi.nlm.nih.gov]

To round out the clinician's understanding of the illness, a patient describes the experience of diagnosis, treatment, and follow-up. [books.google.com]

[…] of 12) in the non-treatment group. [e-enm.org]

(Gd) can variably enhance, usually homogeneously 7 dural enhancement may be present 8 infundibulum may be thickened 8 T2 hypointensity in parasellar region can be present and may be useful in differentiating from a pituitary adenoma 4 Treatment and prognosis [radiopaedia.org]

The histogenesis and prognosis of these tumours remain uncertain and need to be documented more thoroughly in the literature. [jmedicalcasereports.biomedcentral.com]

Until a specific pituitary antibody for this disease or a characteristic radiographic feature, as by MR spectroscopy, has been identified, the clinical diagnosis of this entity must rely on the histologic study of the pituitary Therapy and Prognosis The [pituitaryadenomas.com]

We report 2 further cases and review the etiology, immunology and pathology of the disease. [ncbi.nlm.nih.gov]

Abstract Autoimmune hypophysitis, often referred to as lymphocytic hypophysitis, is defined as an inflammatory condition of the pituitary gland of autoimmune etiology that leads to pituitary dysfunction. [scititles.com]

It was reasonably assumed, therefore, that this disease has an auto immune etiology. [pituitaryadenomas.com]

Lymphocytic hypophysitis is a primary inflammatory disorder that typically presents during or shortly after pregnancy. [30] Although of unknown etiology, lymphocytic hypophysitis is believed to be caused by an autoimmune process. [emedicine.medscape.com]

Perhaps this suggests an underlying and unifying autoimmune etiology for both GH and PCNSV with a common target found in both hypophyseal and vascular tissue. [surgicalneurologyint.com]

In this review, we provide an overview of the epidemiology, diagnosis, pathogenesis, treatment, and the role of organ-specific and antipituitary antibodies as potential markers of LYH. [clinsci.org]

National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) Program, via contract number N01-CN-67006, with Emory University, Atlanta SEER Cancer Registry, Atlanta, Georgia, U.S.A. [histology-world.com]

[…] throughout the day and in response to metabolic factors, making abnormal levels difficult to calibrate—further hampering diagnosis. [8] [9] [10] [11] [12] [13] Treatment [ edit ] Inflammation resolves usually after several months of glucocorticoid treatment Epidemiology [en.wikipedia.org]

The early observation suggested the possibility of a spectrum of progression starting with LYH and progressing to GH.[ 25 ] In contrast, other authors cited key epidemiological factors of LYH that were not found in GH including female bias, association [surgicalneurologyint.com]

Epidemiology The annual incidence of hypophysitis is estimated to be 1 in 7–9 million. [clindiabetesendo.biomedcentral.com]

Discrimination between these two conditions is of importance since, despite the similarity of their presentation, there are significant differences in pathophysiology. [ncbi.nlm.nih.gov]

[…] of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology [books.google.de]

Pathophysiology: The occurrence of pituitary inflammation associated with pregnancy is felt to be secondary to the involution of the pituitary gland that takes place during this time (4,7). [medschool.lsuhsc.edu]

The pathophysiologic process apparently begins as an acute inflammatory response with enlargement of the gland, as noted in 95% tissue-documented cases. [pituitaryadenomas.com]

Cortisol inhibits the release of CRH and ACTH from the hypothalamus and pituitary gland respectively, preventing further cortisol release. Cortisol is inactivated in the liver to inactive cortisone. [endocrinesurgeon.co.uk]

During an operation, neurosurgeons typically drain these cysts early, to prevent their potential rupture and consequent chemical meningitis. [neupsykey.com]

Miyai K (2007) Congenital thyrotropin deficiency—from discovery to molecular biology, postgenome and preventive medicine. Endocr J 54 : 191–203 47. [nature.com]

Yoon JW, Choi DS, Liang HC, Baek HS, Ko IY, et al. (1992) Induction of an organ-specific autoimmune disease, lymphocytic hypophysitis, in hamsters by recombinant rubella virus glycoprotein and prevention of disease by neonatal thymectomy. [omicsonline.org]