Case presentation A 34-year-old man with no history of systemic disease presented with fever; he had lost 8 kg during the week before presentation. Physical examination revealed no significant findings. [ncbi.nlm.nih.gov]

Compared with the normal mammary tissue, EAN presents with benign hyperplasia of lactiferous ducts and the disorganized growth of two types of epithelial cells. [dovepress.com]

Pregnancy is not contraindicated, but if HCA larger than 5 cm are present, they should be resected before conception [1]. [karger.com]

Clinical presentation Adenomyomatosis per se is usually asymptomatic. It is, however, frequently associated with chronic biliary inflammation, most commonly gallstones (25-75%), but also seen in cholesterolosis (33%) and pancreatitis. [pacs.de]

• Asymptomatic

  In fact, adenomyomatosis is often asymptomatic and detected incidentally. [ncbi.nlm.nih.gov]

  She was asymptomatic and her physical examination, including blood pressure and temperature, was unremarkable. Her body mass index was 21.22. [karger.com]

  Clinical presentation Adenomyomatosis per se is usually asymptomatic. It is, however, frequently associated with chronic biliary inflammation, most commonly gallstones (25-75%), but also seen in cholesterolosis (33%) and pancreatitis. [pacs.de]

  Adenomyomatosis per se is usually asymptomatic. It is, however, frequently associated with chronic biliary inflammation, most commonly gallstones (25-75%), but also seen in cholesterolosis (33%) and pancreatitis 2. [radiopaedia.org]

• Pain

  Adenomyomatosis also can be associated with right upper quadrant pain. [ncbi.nlm.nih.gov]

  […] also been cases with increased uptake in areas of adenomyomatosis, leading to false positive results Treatment and prognosis Cholecystectomy may be performed as a result of one or more of the following: patient symptomatic with right upper quadrant pain [pacs.de]

  Because of the patient's acute pain, she was treated with supportive measures only. During a 3-day period, the patient's pain resolved, and she was dismissed. [mayoclinicproceedings.org]

  […] also been cases with increased uptake in areas of adenomyomatosis, leading to false positive results 7 Treatment and prognosis Cholecystectomy may be performed as a result of one or more of the following: patient symptomatic with right upper quadrant pain [radiopaedia.org]

• Inflammation

  Pathological tests revealed extensive inflammatory cell infiltration and caseous-like necrosis consisting of chronic granulomatous inflammation with acute necrotizing inflammation. [ncbi.nlm.nih.gov]

  The incidence increases with age, presumably the result of protracted inflammation (see below). There is a female predilection (M:F=1:3). It is most often an incidental finding and usually requires no treatment. [pacs.de]

  Sinclair et al. [10] described the case of a woman with important systemic inflammatory symptoms and biochemical signs of inflammation related to hepatic inflammatory adenomas which resolved after OCP cessation. [karger.com]

• Swelling

  […] women, typically in fourth and fifth decades of life, and extremely less in men and children.1,4 The tumor is usually unilateral and asymptomatic, and the common clinical symptoms are erosion, serous discharge (serous and/or sanguineous), nodularity, swelling [dovepress.com]

• Abdominal Pain

  Adenomyomatosis of the Gallbladder as a Cause of Recurrent Abdominal Pain. J. Pediatr. 2018 Nov; 202 :328-328.e1. [ PubMed : 29903530 ] 4. Pang L, Zhang Y, Wang Y, Kong J. [ncbi.nlm.nih.gov]

  Many patients are asymptomatic and the condition is discovered incidentally 4, but may present with abdominal pain from intraperitoneal hemorrhage. Gross pathology demonstrates multiple bulging nodules with prominent surface vascularity. [radiopaedia.org]

  CT (computed tomographic) Report Of Case A 41-year-old woman sought medical attention at her local hospital because of acute right upper abdominal pain. [mayoclinicproceedings.org]

• Nausea

  The common symptoms of pain in the right upper quadrant of the abdomen, dyspepsia, fatty food intolerance, nausea, and vomiting that have been reported in GAM cases did not appear in our patient, either. [ncbi.nlm.nih.gov]

Adenomyomatosis is often asymptomatic and incidentally detected, requiring no specific treatment. Adenomyomatosis also can be associated with right upper quadrant pain. [ncbi.nlm.nih.gov]

It is most often an incidental finding and usually requires no treatment. It may be found more often in chronically inflamed gallbladders (which are at higher risk for carcinoma), but it is not a premalignant lesion in itself. [pacs.de]

It is most often an incidental finding and usually requires no treatment. It may be found more often in chronically inflamed gallbladders (which are at higher risk for carcinoma), but it is not a premalignant lesion in itself 6. [radiopaedia.org]

Prognosis Apart from the right upper quadrant abdominal pain that some patients experience, this is a benign condition and carries a good prognosis. Not all patients are symptomatic. [ncbi.nlm.nih.gov]

Nuclear medicine PET/CT Metabolic characterization with FDG PET has been suggested as a useful adjunct in problematic cases, but there have also been cases with increased uptake in areas of adenomyomatosis, leading to false positive results Treatment and prognosis [pacs.de]

[…] medicine PET-CT Metabolic characterization with FDG PET has been suggested as a useful adjunct in problematic cases 4, but there have also been cases with increased uptake in areas of adenomyomatosis, leading to false positive results 7 Treatment and prognosis [radiopaedia.org]

The main treatment method is surgical resection, patients can obtain a good prognosis after a simple complete excision of the lesion. [dovepress.com]

The hypothesis of chronic inflammation as the etiology of adenomyomatosis is supported by the fact that patients are most frequently diagnosed in their 50s. [ncbi.nlm.nih.gov]

Epidemiology Adenomyomatosis is relatively common, found in ~9% of all cholecystectomy specimens. It is typically seen in patients in their 5 decade. The incidence increases with age, presumably the result of protracted inflammation (see below). [pacs.de]

Since patients are most frequently diagnosed in their 50s, the idea of chronic inflammation as the etiology seems plausible. [3] [4] Epidemiology Adenomyomatosis has been found in 1% to 8.7% of cholecystectomy specimens. [ncbi.nlm.nih.gov]

Pathophysiology [ edit ] Adenomyomatosis of the gallbladder as seen on ultrasound [2] Non-contrast abdominal ultrasound and contrast-enhanced ultrasound (CEUS) of adenomyomatosis of the gallbladder: [3] a The fundus of the gallbladder wall was thickened [en.wikipedia.org]

There is no known race predilection. [5] Pathophysiology Hyperplasia of the gallbladder wall is seen, with characteristic Rokitansky-Aschoff sinuses. Calculi and cholesterol crystals form within the sinuses. [ncbi.nlm.nih.gov]

Cryotherapy may be chosen to preserve as much intact nipple tissue as possible for women of childbearing age who need to breastfeed.13 And it is necessary for patients to have regular breast follow-up with annual breast physical examination and mammography to prevent [dovepress.com]

The prevention of its complications is extremely important and treatment, which has recently evolved through the development of molecular subtypes, should be adapted to each case. [karger.com]