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Adenovirus


Presentation

  • The patients presented with sudden onset respiratory distress that progressed rapidly to respiratory failure and death.[ncbi.nlm.nih.gov]
  • The present study aimed to detect and genotype HAdV and SaV in 172 fecal samples from children with AGE, collected during a surveillance study carried out in a low-income community in Belém, Pará, between 1990 and 1992.[ncbi.nlm.nih.gov]
  • Phylogenetic trees of the whole-genome, penton base, and fiber knob regions are presented in the top row with the hexon and its parts, “loop 1” and “conserved,” presented in the bottom row. All were generated after sequence alignments.[doi.org]
  • We present in vitro transduction profiles for HAdV-56 in direct comparison to the most commonly used HAdV-5-based vector. In vivo characterizations demonstrate that when it is delivered intravenously (i.v.)[ncbi.nlm.nih.gov]
  • Further analyses revealed that peptides present in fiber C-5, hexon C-5, penton base B-3 and C-5 proteins fulfilled the criteria of having surface accessibility, hydrophilicity, flexibility, antigenicity and beta turn.[ncbi.nlm.nih.gov]
Pathologist
  • Adenovirus hepatitis is a rare but important entity to be considered by the clinicians, radiologists, and pathologists.[ncbi.nlm.nih.gov]
  • Gross, histopathological, and ultrastructural analyses Gross and histopathological analyses of post-mortem tissues were performed by a board-certified veterinary pathologist specializing in nonhuman primate/laboratory animal medicine, a branch of Primate[doi.org]
Hypoxemia
  • Laboratory findings revealed that he had hypoxemia, thrombocytopenia and elevated transaminase. Chest imaging showed a consolidation with pleural effusion, which was rapidly progressed.[ncbi.nlm.nih.gov]
Kidney Failure
  • Furthermore, severe infections from human adenoviruses are more commonly associated with older age, immunosuppression, and chronic underlying conditions such as kidney failure [4], [41].[doi.org]
Neglect
  • LESSON: Although the most common cause that leads to HUS remains STEC, other etiologies like viral ones that may be responsible for severe enteric infection with progression into HUS should not be neglected.[ncbi.nlm.nih.gov]
Flaccid Paralysis
  • HAdV-C57 was isolated from the feces of a healthy child as part of an acute flaccid paralysis surveillance program (12 December 2001; Baku, Azerbaijan). It was serotyped by SN and provided an ambiguous typing result. Genome sequencing.[doi.org]

Workup

  • A routine microbiological workup for infectious causes of the outbreak, including bacterial, mycoplasma, and fungal cultures, was negative.[doi.org]
Hypertriglyceridemia
  • A 31-year-old female, with a history of treated mesencephalic astrocytoma, was hospitalized for fever, pancytopenia, elevated liver enzymes, hyperferritinemia and hypertriglyceridemia. Adenovirus viral load in blood was 7.3 10(9) copies/mL.[ncbi.nlm.nih.gov]
Neisseria Gonorrhoeae
  • The culturally grown Neisseria gonorrhoeae strain was resistant against penicillin, ciprofloxacin, and tetracycline. The patient was also found to have an eye infection with the unusual and likely recombinant adenovirus type 53.[ncbi.nlm.nih.gov]
Human Herpesvirus 6
  • Leveque N, Boulagnon C, Brasselet C, Lesaffre F, Boutolleau D, Metz D, Fornes P, Andreoletti L (2011) A fatal case of Human Herpesvirus 6 chronic myocarditis in an immunocompetent adult. J Clin Virol 52:142–145 CrossRef PubMed Google Scholar 7.[doi.org]

Treatment

  • This protocol facilitates rapid and cost-effective generation of virus-specific TCLs, which appear to provide an effective treatment option.[ncbi.nlm.nih.gov]
  • However, this treatment strategy has to be evaluated in vivo to develop a new treatment strategy for patients suffering with viral myocarditis.[ncbi.nlm.nih.gov]
  • Tumor growth in vivo was examined in a CRC mouse xenograft model following various treatments.[ncbi.nlm.nih.gov]
  • Other treatment, depending on the symptoms, may include intravenous fluids, oxygen, and breathing treatments. How Long Do Adenovirus Infections Last? Most adenovirus infections last from a few days to a week or two.[kidshealth.org]
  • Severe adenovirus pneumonia in immunocompetent hosts has rarely been reported and optimal treatment has not been established.[ncbi.nlm.nih.gov]

Prognosis

  • Timely diagnosis and appropriate management are essential to improve the prognosis of adenovirus hepatitis in immunocompromised patients.[ncbi.nlm.nih.gov]
  • BACKGROUND/AIM: Survivin expression has been shown to be associated with cancer progression, poor prognosis, and drug resistance.[ncbi.nlm.nih.gov]
  • The unfavorable prognosis factors being represented by the age of more than 5 years old, different etiologies from STEC, persistent oligoanuria, central nervous system and glomerular impairment, the association of fever with leukocytosis.[ncbi.nlm.nih.gov]
  • The prognosis declines as the severity of disease increases.[medicinenet.com]

Etiology

  • LESSON: Although the most common cause that leads to HUS remains STEC, other etiologies like viral ones that may be responsible for severe enteric infection with progression into HUS should not be neglected.[ncbi.nlm.nih.gov]
  • The HAdV was implicated in the etiology in 65.2% of cases. The sequencing of representative samples using hexon gene suggests the presence of serotype 8 and 4. The serotype eight sequences showed 99%-100% similarity with other Indian strains.[ncbi.nlm.nih.gov]
  • This study suggests that HAdV-52 may be one of many agents causing gastroenteritis of unknown etiology.[ncbi.nlm.nih.gov]
  • Attempts to isolate the virus from previous sea lion hepatitis cases were unsuccessful, but as the hepatitis had morphologic features resembling canine infectious hepatitis, and since the virus has a wide host range, it was thought that perhaps the etiologic[ncbi.nlm.nih.gov]
  • The difference in testing methods should be considered when designing surveillance studies “to estimate the burden of viral etiologies of respiratory diseases,” the researchers said.[healio.com]

Epidemiology

  • Child Child, Preschool China/epidemiology Conjunctivitis/epidemiology Conjunctivitis/etiology* Conjunctivitis/virology DNA, Viral/isolation & purification DNA, Viral/metabolism Female Genotype Humans Infant Infant, Newborn Logistic Models Male Middle[ncbi.nlm.nih.gov]
  • Other epidemiological feature was as follows: EAd were detected throughout the year. The predominant serotype was Ad40 during 1980-1985, while Ad41 were observed after 1986. EAd were detected most frequently from the children aged 0-3 years.[doi.org]
  • CONCLUSIONS: The present results reinforce the need for further studies to obtain epidemiological data about the circulation of these viruses in Brazil, especially in the Amazon Region, where data from the early 1990's are scarce.[ncbi.nlm.nih.gov]
  • Information on the genome type is important to the epidemiological study of HAdV-3.[ncbi.nlm.nih.gov]
  • Observations of these simultaneously reported emergent strains in China add to the understanding of the circulation, epidemiology, and evolution of these HAdV pathogens, as well as provide a foundation for developing effective vaccines and public health[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • We discuss the differential diagnosis and pathophysiology of allograft viral infections and concomitant rejection.[ncbi.nlm.nih.gov]
  • Many adenovirus infections are subclinical or asymptomatic. 15–70% of conjunctivitis worldwide Etiology and Pathophysiology DNA virus 60 to 90 nm in size, 6 species (A through F) with 50 known serotypes Adenovirus can remain dormant in lymphoreticular[unboundmedicine.com]
  • Pathophysiology Adenovirus is a double-stranded DNA virus that measures 70-90 nm and that has an icosahedral capsid.[emedicine.medscape.com]
  • There is little information about the epidemiology, pathophysiology and the usual route of infection of Ad-36. Human adenoviruses are associated with infection of the respiratory tract, gastrointestinal tract, and conjunctiva.[doi.org]

Prevention

  • Author information 1 Beijing Center for Disease Prevention and Control, No.16, Hepingli Middle Road, Beijing, 100013, People's Republic of China. 2 Research Centre for Preventive Medicine of Beijing, No.16, Hepingli Middle Road, Beijing, 100013, People's[ncbi.nlm.nih.gov]
  • We also observed that E1A stabilizes the FUBP1-p53 complex, preventing p53 promoter binding.[ncbi.nlm.nih.gov]
  • For guidance to prevent adenovirus infections in healthcare settings, see Prevention & Treatment for Health Care Professionals . Treatment There is no specific treatment for people with adenovirus infection.[cdc.gov]
  • Immune Engineering, Jiangsu Academy of Agricultural Sciences, Nanjing, China; National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Sciences, Nanjing, China; Jiangsu Co-innovation Center for Prevention[ncbi.nlm.nih.gov]

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