Adenovirus infection encompasses an array of clinical syndromes that can be caused by adenoviruses, ranging from benign and self-limiting upper respiratory illness to life-threatening conjunctival infection in neonates, hemorrhagic cystitis and severe disseminated infection of various tissues. Microbiological testing is pivotal in order to make the diagnosis, primarily through methods that are able to detect viral deoxyribonucleic acid (DNA) in patient samples.
Adenoviruses, belonging to the group of double-stranded positive (+) sense DNA viruses, are a large group of pathogens responsible for numerous types of human disease  . They are divided into six subgroups (A, B, C, D, E, and F) and more than 60 different serotypes have been described in the literature   . Common modes of transmission include the fecal-oral, direct contact with infected secretions, and respiratory spread, suggesting that the virus is able to cause local outbreaks  . As the pediatric population is the age group where adenovirus infections are most prevalent, kindergartens, summer or college camps and schools are the main sites of outbreaks . In addition, hospital-based (nosocomial) and severe, sometimes even life-threatening outbreaks have known to occur . Adenovirus infection is seen across all ages and gender, although immunocompromised hosts seem to be at an increased risk compared to the immunocompetent . The clinical presentation of adenovirus infection depends on the organ or tissue affected. Keratoconjunctivitis ( the principal form of the disease that causes outbreaks) manifests with fever, vomiting, diarrhea, muscle pain and malaise, usually after an incubation period of 1-14 days, whereas rhinitis, fever, and cervical lymphadenopathy are typical for pharyngoconjunctival fever (PCF) . Other notable infections caused by adenovirus are those of the respiratory tract (both lower and upper), gastroenteritis, central nervous system infection (CNS), and hemorrhagic cystitis . Neonatal adenovirus infection, despite being rare, is a frequently fatal disease characterized by severe forms of conjunctivitis (as a result of viral transmission from the mother), cyanosis, respiratory failure, fever and a rash in neonates .
Entire Body System
The elder brother developed a high fever and was diagnosed with HAdV infection with an immunochromatographic kit for HAdV (IC-kit). He was transferred to our institute after persistent fever for 7 days. [ncbi.nlm.nih.gov]
Pharyngoconjunctival fever is a specific presentation of adenovirus infection, manifested as: high fever that lasts 4–5 days pharyngitis (sore throat) conjunctivitis (inflamed eyes, usually without pus formation like pink eye) enlargement of the lymph [en.wikipedia.org]
Bring down a fever. Ask your doctor if you can give your child acetaminophen ( Tylenol ) or ibuprofen ( Motrin ) to relieve aches and fever. [webmd.com]
HAdV infection also shows KD-like symptoms such as conjunctival injection, red cracked lips, and cervical lymphadenopathy. However, skin erythema and swollen red palms and soles followed by desquamation are distinctive features of KD. [ped-rheum.biomedcentral.com]
Figure 4: Lymphadenopathy. A large pre-auricular node can be palpated and visible on examination by studying the shadowing and elevation of the skin. [eyerounds.org]
Children may have fever and lymphadenopathy. Malaise and headache are reported. Inflammation may persist for weeks, and residual scarring and visual impairment may occur. [emedicine.medscape.com]
Respiratory symptoms may be accompanied by pharyngitis and lymphadenopathy. Although generally mild, outbreaks of pneumonia with high mortality in children have been reported. [infectiousdiseaseadvisor.com]
[…] a specific presentation of adenovirus infection, manifested as: high fever that lasts 4–5 days pharyngitis (sore throat) conjunctivitis (inflamed eyes, usually without pus formation like pink eye) enlargement of the lymph nodes of the neck headache, malaise [en.wikipedia.org]
[…] involvement) Physical Exam Fever Tonsillar erythema/exudate Cervical lymphadenopathy Otitis media Conjunctivitis Differential Diagnosis Characteristics of adenovirus infections: Acute respiratory illness Mostly in children Incubation period: 2 to 5 days Malaise [unboundmedicine.com]
Malaise and headache are reported. Inflammation may persist for weeks, and residual scarring and visual impairment may occur. [emedicine.medscape.com]
Keratoconjunctivitis ( the principal form of the disease that causes outbreaks) manifests with fever, vomiting, diarrhea, muscle pain and malaise, usually after an incubation period of 1-14 days, whereas rhinitis, fever, and cervical lymphadenopathy are [symptoma.com]
Symptoms Pneumonia- Fever with chills Dyspnea or short of breath Stabbing Chest Pain Sweating and Clammy Skin Loss of Appetite and Fatigue Confusion: Mostly observed after high fever Cough with Expectoration Hemoptysis: coughing drops of blood Chest Pain [epainassist.com]
See All 2 Answers 1 Answer A Among the many suspects of fatigue is the Epstein-Barr virus (EBV). EBV belongs to the family of herpes viruses including those that cause cold sores, genital herpes, chickenpox and shingles. [sharecare.com]
It occurs in an epidemic form among young recruits under conditions of fatigue and overcrowding Pneumonia: a complication of acute respiratory disease in both children and adults. Dr.T.V.Rao MD 18 19. [slideshare.net]
Further, the restriction of such epidemics to barrack-type conditions suggests that close contact and possibly stress and fatigue contribute to efficient transmission. [infectiousdiseaseadvisor.com]
- Streptococcal Pharyngitis
Pharyngeal HAdv infections are virtually indistinguishable from bacterial infections and often possess features commonly associated with streptococcal pharyngitis, such as fever, tonsillar exudates (in as many as 52% of children), and leukocytosis [25 [journals.plos.org]
Three children in Bangladesh who presented with diarrhoea, cough, dyspnoea, fever, and signs of malnutrition and died in the hospital were shown at post-mortem examination to have both adenovirus infection of the intestine (by immunofluorescence) and [ncbi.nlm.nih.gov]
Fever Dehydration Cough with expectoration. [epainassist.com]
Continued Symptoms Each type of adenovirus can affect you differently: Bronchitis : Cough, runny nose, fever, chills Colds and other respiratory infections : Stuffy and runny nose, cough, sore throat, and swollen glands Crou p: Barking cough, trouble [webmd.com]
Adenovirus can cause a cough that sounds like whooping cough (pertussis). Gastroenteritis is an infection of the stomach and intestines. Symptoms include diarrhea, vomiting, belly pain, and fever. [kidshealth.org]
- Throat Irritation
Adenovirus 14 infections usually begin with cold symptoms such as: a cough, runny nose, and mild fever and possibly throat irritation. [medicinenet.com]
- Dry Cough
cough Fever lasting 2 to 4 days Illness subsiding in 10 to 14 days DDx: rhinovirus, influenza, parainfluenza, RSV Viral pneumonia Sudden onset of high fever, rapid infection of upper and lower respiratory tracts, skin rash, diarrhea Mostly in children [unboundmedicine.com]
Enteric viral infectious should be considered in solid organ transplant recipients with chronic diarrhea. [ncbi.nlm.nih.gov]
You can buy medicines at the drugstore that can help stop or slow diarrhea. Do not use these medicines without talking to your provider if you have bloody diarrhea, a fever, or if the diarrhea is severe. Do not give these medicines to children. [mountsinai.org]
Jaw & Teeth
- Exudative Pharyngitis
Health Hazard: PATHOGENICITY: Varies in clinical manifestation and severity; symptoms include fever, rhinitis, pharyngitis, tonsillitis, cough and conjunctivitis; common cause of nonstreptococcal exudative pharyngitis among children under 3 years; more [viracore.ucsf.edu]
In some series of hospitalized children with documented adenoviral infection high fever, leukocytosis and exudative pharyngitis resembling bacterial infection has been observed. [infectiousdiseaseadvisor.com]
- Oral Ulcers
This was confirmed by isolation of an adenovirus type 2 with unusual laboratory features from liver, lung, colon contents, serum, esophageal swab, and oral ulcerations. [ncbi.nlm.nih.gov]
Conjunctival redness and edema Photophobia and blurry vision Swelling of eyelids Foreign body sensation within eye Symptoms of Meningitis and Encephalitis High Fever Stiff neck Headache Seizures Confusion and Sleepiness Nausea and Vomiting Skin Rash [epainassist.com]
fever, stomach cramps Swelling of the brain and spinal cord ( meningitis and encephalitis ): Headache, fever, stiff neck, nausea, and vomiting (this is rare) Urinary tract infections: Burning and pain while urinating, frequent need to go, blood in your [webmd.com]
Sudden onset of high fever, rapid infection of upper and lower respiratory tracts, skin rash, diarrhea Mostly in children from newborn to 3 years DDx: bacterial pneumonia, RSV, influenza, parainfluenza Acute pharyngoconjunctival fever Spiking fever, headache [unboundmedicine.com]
[…] throat pharyngitis runny nose rhonchi & rales nasal congestion swollen lymph nodes dry, harsh cough sounds like pertussis cough If adenovirus causes an infection in your gastrointestinal tract, then inflammation and symptoms might involve: fever vomiting headache [healthblurbs.com]
While each child may experience symptoms differently, the most common include: Respiratory infections runny nose sore throat fever severe cough swollen lymph nodes headache feeling of uneasiness non-productive "croupy" cough Intestinal tract infections [childrenshospital.org]
Despite the nonspecific signs and symptoms of an adenovirus infection, the physician must perform a thorough physical examination and obtain a detailed patient history. Patients (or parents of the infected children) should be asked about similar symptoms in people with whom they were in contact (schools, kindergartens, camps, other crowded areas), as it may provide valuable clues toward the diagnosis. To confirm adenovirus infection, a comprehensive microbiological investigation is necessary. It must be pointed out that detection of adenoviruses readily occurs in asymptomatic individuals, and thus the term adenovirus infection does not always imply to a disease state . In the presence of symptoms, however, the identification of this virus is highly suggestive that it is responsible for their onset. Direct methods in the form of isolation of virus in cultures or antigen/viral DNA detection from patient samples are recommended diagnostic tests, but since up to 3 weeks are necessary for viral cultures to yield conclusive results, the focus of diagnostics is turned to the latter method  . Polymerase chain reaction (PCR) is the gold standard for both screening and diagnostic purposes  . Based on the clinical and microbiological criteria, an adenovirus infection may be probable (absence of histologic criteria in the presence of typical symptoms) or proven (both microbiological and corresponding clinical confirmation), which can be further divided into local (when the virus is isolated from local specimens and not peripheral blood) or systemic (detection of virus in peripheral blood along with clinical manifestation) .
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