The present review focuses on the impact of cannabinoids on apoptosis and autophagy, the two main death pathways responsible for cancer cell death. [spandidos-publications.com]

• Plethora

  To maintain a normal size, each tissue must balance the plethora of opposite signals which arrive on its membrane surface and finely control each to prevent pathological conditions such as cancer. [spandidos-publications.com]

THC/temozolomide combined treatment enhances autophagy, whereas pharmacologic or genetic inhibition of this process prevents the effects of combined treatment, supporting that the activation of autophagy plays a crucial role in the mechanism of action [spandidos-publications.com]

View Article : Google Scholar : PubMed/NCBI 21 Eisenberg-Lerner A and Kimchi A: The paradox of autophagy and its implication in cancer etiology and therapy. Apoptosis. 14:376–391. 2009. [spandidos-publications.com]

View Article : Google Scholar : PubMed/NCBI 9 Green DR and Kroemer G: The pathophysiology of mitochondrial cell death. Science. 305:626–629. 2004. [spandidos-publications.com]

To maintain a normal size, each tissue must balance the plethora of opposite signals which arrive on its membrane surface and finely control each to prevent pathological conditions such as cancer. [spandidos-publications.com]