We have also reviewed the literature to present a discussion on presentation, diagnosis, and management of this rare tumor. [Indexed for MEDLINE] Free full text [ncbi.nlm.nih.gov]

We have also reviewed the literature to present a discussion on presentation, diagnosis, and management of this rare tumor. Keywords: Adult, neuroblstoma, adrenal gland How to cite this article: Gupta P, Maiti A, Aich RK, Deb AR. [cancerjournal.net]

Besides muscle weakness, our patient also presented with hyperaldosteronism which is quite rare and is considered an unexpected atypical presentation according to the medical literature [ 8 ]. [jmedicalcasereports.biomedcentral.com]

Presentation A 3 year old child presented with pain and a lump in the right side of the abdomen. An ultrasound was performed. [sonoworld.com]

In this index case, the patient was presented at 23 yrs of age which is rarely observed .Consequently clinical data regarding presentation, management, and outcome of adult patients with neuroblastoma are scarce and most patients appear to be treated [rroij.com]

• Subcutaneous Nodule

  nodules Paraneoplastic syndromes Chronic diarrhea → electrolyte imbalances Opsoclonus-myoclonus-ataxia : a paraneoplastic syndrome of unclear etiology involving rapid and multi-directional eye movements, rhythmic jerks of the limbs, and ataxia Hypertension [amboss.com]

  Non-tender, bluish, and mobile skin and subcutaneous nodules are because of metastasis to these sites. This is known as “blueberry muffin sign.” [intechopen.com]

In addition, little is known about the extent of the imaging approach and workup needed for the diagnosis of cystic congenital adrenal neuroblastoma. [ajronline.org]

The staging workup included a positron emission tomography (PET) scan, repeat computed tomography (CT) scan of the chest, abdomen, and pelvis, bone scan, and bilateral bone marrow aspirates and biopsies, all of which revealed no evidence of metastatic [theoncologist.onlinelibrary.wiley.com]

A laboratory workup disclosed decreased serum potassium level of 2.7 mEq/L and a normal serum sodium level of 135.9 mEq/L. Her kidney function was within normal limits with blood urea nitrogen (BUN) of 8.9 mg/dL and a creatinine level of 0.79 mg/dL. [jmedicalcasereports.biomedcentral.com]

This report describes the diagnosis, surgical treatment, and follow-up of a dog with an abdominal peripheral neuroblastoma. [figshare.com]

The risk of developing late effects depends on things like the specific treatments used and the child's age during treatment. [kidshealth.org]

A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. [vicc.org]

Our dedicated team of specialists evaluates your child in a single visit, and will create a customized treatment plan and begin your individualized treatment plan immediately. [mottchildren.org]

Your child’s specialist will be able to tell you much more about this treatment. At present, antibody treatment is given in combination with a medicine taken by mouh called retinoic acid. [macmillan.org.uk]

Incorrect: gender does not significantly affect prognosis in neuroblastoma. Comment Here Back to top [pathologyoutlines.com]

Besides, disease prognosis is not constant over time, and the conditional survival (CS) of patients with NB needs to be evaluated, especially for those who had survived over 14 years old. [auajournals.org]

Deletion of the short arm of chromosome 1 is the most common chromosomal abnormality present in neuroblastoma and confers a poor prognosis. [emedicine.medscape.com]

These generally present at an advanced stage, may have an aggressive course and worse prognosis; with ultimate survival being less than 5%. [cancerjournal.net]

Stage IV-S neuroblastoma involving the liver and ectopic liver report of an unusual case Yoshiaki Tsuchida, Kinji Yokomori, Sumio Saito, Hidefumi Kaku & Fumio Bessho Cancer (1984) Stage IV-S Neuroblastoma: Disseminated Malignancy With a Favourable Prognosis [nature.com]

Etiology Cause : unclear Genetic associations : chromosomal abnormalities, especially deletions (found in ∼ 50% of neuroblastomas) Deletions of the short arm of chromosome 1 (1p deletion) → amplification and overexpression of oncogene MYCN ( N-myc ) Risk [amboss.com]

Familial neuroblastoma: Case reports, literature review, and etiologic considerations. Cancer. 1986;57:1887-1893. Saks JB, Bryan PJ, Yulish BS, et al. Comparison of computed tomography and ultrasound in the evaluation of abdominal neuroblastoma. [appliedradiology.com]

etiology and causative factors of neuroblastoma are not well understood at this point. [eyewiki.aao.org]

[…] anywhere in distribution of sympathoadrenal neuroendocrine system Most in adrenal gland (~40%), followed by connective / subcutaneous / soft tissue (~20%), retroperitoneum (~15%), mediastinum (~10%) ( SEER Program: NIH Pub No 99-4649; Bethesda, MD, 1999 ) Etiology [pathologyoutlines.com]

Case reports, literature review, and etiologic considerations. Cancer 57(9): 1887–93 CrossRef CAS PubMed Google Scholar Shahar E, Shinawi M (2003) Neurocristopathies presenting with neurologic abnormalities associated with Hirschsprung’’s disease. [link.springer.com]

Epidemiological and Clinical Studies Niels LT Carlsen Acta Paediatrica (1994) Stage IV-S neuroblastoma involving the liver and ectopic liver report of an unusual case Yoshiaki Tsuchida, Kinji Yokomori, Sumio Saito, Hidefumi Kaku & Fumio Bessho Cancer [nature.com]

References: [2] [3] [4] [5] [6] Epidemiological data refers to the US, unless otherwise specified. [amboss.com]

"The epidemiology of neuroblastoma: a review". Paediatric and Perinatal Epidemiology. 23 (2): 125–43. doi : 10.1111/j.1365-3016.2008.00983.x. PMID 19159399. ^ Esthesioneuroblastoma at eMedicine ^ Cheung, Nai-Kong (2005). Neuroblastoma. [en.wikipedia.org]

Adrenal neuroblastoma occurs almost entirely in infants and in children; according to surveillance, epidemiology and end results. [rroij.com]

Epidemiology This set of tumors is considered almost exclusively a disease of pediatric population. Neuroblastoma is the most common solid extracranial tumor, accounting for third most common childhood cancer, after leukemia and brain tumors. [intechopen.com]

Pathophysiology Neuroblastoma is derived from precursor cells of the sympathetic nervous system, which require a cohort of transcription factors to properly differentiate into mature sympathetic neurons. [eyewiki.aao.org]

To prevent the problems this causes, stem cells (blood cells at their earliest stages of development) are collected from your child’s blood before the chemotherapy is given. These stem cells are then frozen and stored until required. [macmillan.org.uk]

Other postulated theories include toxic metabolites from cancer or from chemotherapy causing axoplasmic transport stasis. [23] Primary prevention As most of neuroblastoma is sporadic or genetic, there are no primary prevention measures. [eyewiki.aao.org]

Local control, metastatic control, and the prevention of relapse are the goal of treatment 7.1. [intechopen.com]

Retinoids are often used after other treatments to help prevent the cancer from growing back. Other treatment options include tumor vaccines and immunotherapy using monoclonal antibodies. [kidshealth.org]

Close attention is paid to these side effects and to antibiotics to prevent or treat infections. Other supportive care is also given. Also, new methods are continually being discovered to improve treatment approaches and to decrease side effects. [cincinnatichildrens.org]