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Adult Idiopathic Neutropenia


Presentation

  • The aim of the present study was to investigate the association of polymorphisms of IL1B-511C/T and 3953C/T, IL1RN intron 2, IL6-174G/C and TNF-308G/A genes with CINA.[ncbi.nlm.nih.gov]
  • A comprehensive textbook of adult emergency medicine for trainee doctors - covers all the problems likely to present to a trainee in the emergency department.[books.google.com]
Inflammation
  • If this chronic inflammation is really the cause of the disorder or it simply represents the result of neutropenia remains to be elucidated. Copyright 2000 Wiley-Liss, Inc.[ncbi.nlm.nih.gov]
  • Schultz's (agranulocytosis) 288.09 Werner-Schultz (agranulocytosis) 288.09 Granulocytopenia, granulocytopenic (primary) 288.00 malignant 288.09 Lazy leukocyte syndrome 288.09 Leukopenia 288.50 malignant (see also Agranulocytosis) 288.09 Mucositis - see also Inflammation[icd9data.com]
Congestive Heart Failure
  • heart failure (34) Coronary arteriosclerosis (6) Coronary artery bypass surgery (3) Coronary heart disease (3) D-dimer test (1) Deep vein thrombosis (5) Door to balloon time (2) Dyslipidemia (3) Ejection fraction (1) Heart disease prevention (1) Heart[innovations.ahrq.gov]
Rhinitis
  • Neutropenic subjects had chronic (perennial) rhinitis 3.4 times more frequently than non-neutropenics.[ncbi.nlm.nih.gov]
  • 54) Occupational exposure (1) Otitis (1) Otitis media (1) Otitis media with effusion (1) Pertussis (3) Pneumococcal infections (1) Pneumonia (15) Pneumonia, pneumococcal (2) Pneumonia, pneumocystis carinii (2) Respiratory tract infections, upper (2) Rhinitis[innovations.ahrq.gov]
Constipation
  • Linzess Linaclotide For IBS With Constipation Or D, Khyber Teaching Hospital, Peshawar. Bone marrow granulocyte reserves and the bone marrow storage pool were evaluated in 10. A case of cyclic neutropenia in adults Muhammad.[friends-acronym.ga]
  • , oropharyngeal pain, and alopecia with AML are epistaxis, back pain, pain in extremity, erythema, ras h maculo-papular, diarrhea, constipation, and transfusion reaction with nonmyeloid malignancies undergoing myeloablative chemotherapy followed by BMT[neupogenhcp.com]
  • […] reported in patients treated with filgrastim/chemotherapy and placebo/chemotherapy was similar and included nausea and vomiting, alopecia, diarrhea, fatigue, anorexia, mucositis, headache, cough, skin rash, chest pain, generalized weakness, sore throat, constipation[pheniciagroup.com]
Heart Failure
  • […] for the Evaluation and Management of Heart Failure... ‏[books.google.com]
  • (36) Heart failure (27) Hypercholesterolemia (15) Hypercholesterolemia, familial (1) Hyperlipidemia (6) Hypertension (55) Hypertension screening (9) Hypertriglyceridemia (1) Ischemic stroke (3) Lipid disorders (1) Lipid-lowering therapy (4) Myocardial[innovations.ahrq.gov]
Osteopenia
  • […] inhibitors of hematopoiesis, including transforming growth factor-β 1 and tumor necrosis factor-α; (b) lymphopenia due to selective loss of primed/memory T-cells and NK cells; (c) increased splenic volume on ultrasonography in 48.1% of patients; (d) osteopenia[ingentaconnect.com]
  • Exercise (109) Fall (41) Fibromyalgia (1) Fracture (2) Hip fractures (1) Hip replacement (6) Injury of cervical spine (disorder) (1) Joint replacement surgery (4) Knee replacement (5) Musculoskeletal diseases (5) Osteoarthritis (4) Osteonecrosis (1) Osteopenia[innovations.ahrq.gov]
Hirsutism
  • […] measurement (4) Dehydration (2) Diabetes (158) Diabetes mellitus, insulin-dependent (7) Diabetes mellitus, non-insulin-dependent (28) Diabetic diet (6) Diabetic foot (5) Dyslipidemia (3) Gestational diabetes (1) Glycemic control (5) Hemochromatosis (3) Hirsutism[innovations.ahrq.gov]
Suggestibility
  • These findings are suggestive of a chronic inflammation in NI-CINA patients which provides the antigenic stimulus for ANA production, and they further support our previously reported suggestion for the possible involvement of such a low-grade chronic[ncbi.nlm.nih.gov]
  • All these findings are suggestive of the existence of an unrecognized low-grade chronic inflammatory process which may be involved in the pathogenesis of the disorder.[ingentaconnect.com]

Workup

  • Obtaining a history of infections may aid in the current diagnostic workup. .. Obtaining a careful drug history may reveal the offending agent and spare the patient from an extensive diagnostic workup. ..[welchco.com]
  • In the vignettes described here, Patient 1 should be diagnosed with constitutional/ethnic neutropenia and not be subjected to further workup.[bloodjournal.org]
  • […] future reference, as corticosteroids can change marrow morphology Biopsy is performed before splenectomy to evaluate for possible hypoplasia or fibrosis Unresponsiveness to standard treatment after 6 months is an indication for bone marrow aspiration See Workup[emedicine.medscape.com]
Cytopenia
  • During the follow-up, because of suspected progression/evolution, 14 patients were re-evaluated by bone marrow biopsy or peripheral immune-phenotyping: 4 cases were diagnosed with chronic NK expansion, 4 with HCL, and 2 with MDS, one refractory cytopenia[bloodjournal.org]
  • Cytopenias in adult patients without a clear cause, should raise suspicion of LGL-leukaemia ( 11 ).[tidsskriftet.no]
  • The following steps focus on screening for other cytopenias and megaloblastic anemia. The former is identified by obtaining a bone marrow biopsy/aspirate or flow cytometry. The latter is identified via serum vitamin B12 and folate levels.[cureus.com]
Lymphocytopenia
  • […] susceptibility to opportunistic infections Hyperimmunoglobulinemia D with periodic fever Hyperzincemia and hypercalprotectinemia Hypocomplementemic urticarial vasculitis Hypohidrotic ectodermal dysplasia with immunodeficiency ICF syndrome Idiopathic CD4 lymphocytopenia[se-atlas.de]
  • Neutropenia accompanied by monocytopenia, lymphocytopenia, or hypogammaglobulinemia is more serious than solitary neutropenia.[medtextfree.wordpress.com]
ST Elevation
  • ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction - executive summary. ‏ الصفحة 105 - Morrow DA, Antman EM, Charlesworth A, et al.[books.google.com]

Treatment

  • Treatment - Idiopathic adult neutropenia Treatments vary with the severity of neutropenia and the pattern of susceptibility to infection.[checkorphan.org]
  • Successful treatment of refractory idiopathic thrombocytopenic purpura and neutropenia with the monoclonal antibody, rituximab. Idiopathic neutropenia. Detailed Filgrastim dosage information for adults and children.[friends-acronym.ga]
  • Also has boxes featuring controversial areas of treatment. Practical and clinically orientated. Major changes to resuscitation guidelines. Complete rewriting of ENT section.[books.google.com]
  • The effect is usually sustained with persistent immunomodulating treatment, even if the cytokine treatment is discontinued ( 9 ).[tidsskriftet.no]

Prognosis

  • Prognosis - Idiopathic adult neutropenia Not supplied. Treatment - Idiopathic adult neutropenia Treatments vary with the severity of neutropenia and the pattern of susceptibility to infection.[checkorphan.org]
  • Prognosis The prognosis for mild or chronic neutropenia is excellent. Recovery from acute neutropenia depends on the severity of the patient's infection and the promptness of treatment. Resources Books Linker, Charles A. "Blood."[medical-dictionary.thefreedictionary.com]
  • Prognosis [ edit ] This form usually lessens in severity within two years of diagnosis. [ citation needed ] The use of prophylactic antibiotics has been proposed. [2] See article at BioMed Central site: [1] [ verification needed ] References [ edit ][en.wikipedia.org]
  • Prognosis Mortality from febrile neutropenia has reduced but remains significant.[patient.info]
  • Prognosis of Neutropenia How is Neutropenia Treated? Neutropenia References What is Neutropenia Neutropenia is a disorder of the blood, with low levels of a special type of cell called the neutrophil.[myvmc.com]

Etiology

  • Neutropenia can conceptually be viewed in 2 broad ways, by mechanism or etiologic category. Since the mechanisms for neutropenia are varied and not completely understood, the etiologic category is simplest to retain.[welchco.com]
  • If acute neutropenia is suspected to be drug- or toxin-induced, all potentially etiologic agents are stopped.[merckmanuals.com]
  • ., c-reactive protein and white blood cell count) Consider aortitis in patients who develop these signs and symptoms without known etiology. Discontinue NEUPOGEN if aortitis is suspected.[neupogenhcp.com]
  • Spontaneous resolution of neutropenia with complete remission is well documented in the literature and although a specific antibody has not been demonstrated in states of idiopathic neutropenia, this spontaneous resolution raised the possibility of an immune etiology[ichastaliklaridergisi.org]
  • Due to the patient's refusal to undergo a bone marrow biopsy, the underlying etiology of the neutropenia could not be established. Therefore, the patient was treated on an outpatient basis under the final diagnosis of chronic idiopathic neutropenia.[cureus.com]

Epidemiology

  • Toshiki Watanabe , Takuya Fukushima Springer , 27 abr. 2017 - 169 páginas This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia[books.google.es]
  • Epidemiology of incident immune thrombocytopenia: a nationwide population-based study in France. Blood. 2014 Nov 20. 124(22):3308-15. [Medline]. Danese MD, Lindquist K, Gleeson M, Deuson R, Mikhael J.[emedicine.medscape.com]
  • The epidemiology of benign leukopenia in Yemenite Jews. Isr J Med Sci 1993 29 297 9 ,,. Leukopenia in Negro workmen. Am J Med Sci 1941 201 407 12 ,,. Leukopenia in Negroes. N Engl J Med 1966 275 1410 3 ,,. Pseudo-neutropenia in American Negroes.[annals.org]
  • Weingarten MA, Pottick-Schwartz EA, Brauner A: The epidemiology of benign leukopenia in Yemenite Jews. Isr J Med Sci 29:297, 1993. 3.[medtextfree.wordpress.com]
Sex distribution
Age distribution

Pathophysiology

  • With a strong focus on pathophysiology, this comprehensive new edition of Nursing the Acutely Ill Adult retains the case study approach that made the first edition so popular with students and educators alike.[books.google.es]
  • Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia. Expert Rev Hematol. 2008;1(II):217–29. PubMed CrossRef Google Scholar 8. Lima CS, Paula EV, Takahashi T, Saad ST, Lorand-Metze I, Costa FF, X.[link.springer.com]
  • Welte K, Dale DC: Pathophysiology and treatment of severe chronic neutropenia. Ann Hematol 72:158, 1996. 54. Fowler B: Genetic defects of folate and cobalamin metabolism. Eur J Pediatr 157:S60, 1998. 55.[medtextfree.wordpress.com]
  • Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management. Thromb Haemost. 2008 Jan. 99(1):4-13. [Medline]. [Full Text]. Audia S, Mahévas M, Samson M, Godeau B, Bonnotte B. Pathogenesis of immune thrombocytopenia.[emedicine.medscape.com]

Prevention

  • Isoniazid Ethotoin Valganciclovir Procainamide Caspofungin Clozapine Chediak-Higashi disease Mirtazapine Sulphonamides Barth syndrome Autoimmune lymphoproliferative syndrome type 1 Griscelli syndrome type 1 Bevacizumab Propionyl-CoA carboxylase deficiency Prevention[checkorphan.org]
  • […] care processes (977) Fall prevention (46) Immunizations (98) Prenatal care (68) Primary prevention (596) Secondary prevention (425) Tertiary prevention (10) Patient Population Age (662) Adolescent (13-18 years) (260) Adult (19-44 years) (77) Aged adult[innovations.ahrq.gov]
  • Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease.[books.google.es]
  • Management requires: annual bone marrow monitoring monthly CBC tests emotional support psychological therapy No specific prevention for neutropenia is known.[healthline.com]
  • Tea tree oil : Tea tree oil is purported to have antiseptic properties, and has been used traditionally to prevent and treat infections.[livingnaturally.com]

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