Presentation
A comprehensive textbook of adult emergency medicine for trainee doctors - covers all the problems likely to present to a trainee in the emergency department. [books.google.com]
The aim of the present study was to investigate the association of polymorphisms of IL1B-511C/T and +3953C/T, IL1RN intron 2, IL6-174G/C and TNF-308G/A genes with CINA. [ncbi.nlm.nih.gov]
The unique presentation in this patient presents an opportunity to study the pathological causation for neutropenia and, more specifically, isolated neutropenia. [cureus.com]
The first priority is to determine whether an infection is present. [merckmanuals.com]
Respiratoric
- Hemoptysis
Alveolar hemorrhage, manifesting as pulmonary infiltrates and hemoptysis requiring hospitalization, have been reported in NEUPOGEN ® -treated healthy donors undergoing peripheral blood progenitor cell (PBPC) collection mobilization Hemoptysis resolved [neupogenhcp.com]
Urogenital
- Hematuria
[…] sickle cell crises can occur in patients with sickle cell disorders receiving filgrastim products Discontinue NEUPOGEN ® if sickle cell crisis occurs Glomerulonephritis Has occurred in patients receiving NEUPOGEN ® Diagnoses were based on azotemia, hematuria [neupogenhcp.com]
[…] coronary angioplasty (1) Prostatectomy (1) Surgical complications (5) Surgical procedures, laparoscopic (1) Surgical wound infection (10) Transplantation (7) Transplantation of liver (1) ► Urologic care (6) Benign prostatic hypertrophy (1) Flank pain (1) Hematuria [innovations.ahrq.gov]
Formulary (50th Edition, September 2005) includes other side effects associated to the administration of recombinant human granulocyte colony stimulating factor; transient hypotension, epistaxis, urinary abnormalities (including dysuria, proteinuria and hematuria [pheniciagroup.com]
Workup
Obtaining a history of infections may aid in the current diagnostic workup. .. Obtaining a careful drug history may reveal the offending agent and spare the patient from an extensive diagnostic workup. .. [welchco.com]
In the vignettes described here, Patient 1 should be diagnosed with constitutional/ethnic neutropenia and not be subjected to further workup. [bloodjournal.org]
[…] future reference, as corticosteroids can change marrow morphology Biopsy is performed before splenectomy to evaluate for possible hypoplasia or fibrosis Unresponsiveness to standard treatment after 6 months is an indication for bone marrow aspiration See Workup [emedicine.medscape.com]
X-Ray
- Pulmonary Infiltrate
Evidence of reversal on cessation of treatment. 3 (or higher) Pneumonitis or pulmonary infiltrates Radiographic changes, respiratory function test abnormalities and requiring steroids or diuretics 2 (or higher) Pulmonary fibrosis Respiratory function [humanservices.gov.au]
[…] proteinuria, and renal biopsy Generally, events resolved after dose reduction or discontinuation of NEUPOGEN ® If causality is likely, consider dose-reduction or interruption of NEUPOGEN ® Alveolar Hemorrhage and Hemoptysis Alveolar hemorrhage, manifesting as pulmonary [neupogenhcp.com]
Adult respiratory distress syndrome (ARDS) : Adult respiratory distress syndrome has been reported in neutropenic patients with sepsis under filgrastim treatment who developed fever, pulmonary infiltration or respiratory distress. [pheniciagroup.com]
Microbiology
- Mycobacterium Avium Complex
avium complex infections (1) Mycoses (1) Norovirus gastroenteritis (1) Nosocomial infection (54) Occupational exposure (1) Otitis (1) Otitis media (1) Otitis media with effusion (1) Pertussis (3) Pneumococcal infections (1) Pneumonia (15) Pneumonia, [innovations.ahrq.gov]
Treatment
Treatment - Idiopathic adult neutropenia Treatments vary with the severity of neutropenia and the pattern of susceptibility to infection. [checkorphan.org]
The effect is usually sustained with persistent immunomodulating treatment, even if the cytokine treatment is discontinued ( 9 ). [tidsskriftet.no]
Ries CA (1976) Vincristine for treatment of refractory autoimmune thrombocytopenia. N Engl J Med 295: 1136 Google Scholar 12. Rosse WF (1983) Treatment of chronic immune thrombocytopenia. Clin Haematol 12: 267–284 Google Scholar 13. [link.springer.com]
Treatment should be discontinued if WBC counts exceed 100,000/mm3. [drugs.com]
Prognosis
Prognosis - Idiopathic adult neutropenia Not supplied. Treatment - Idiopathic adult neutropenia Treatments vary with the severity of neutropenia and the pattern of susceptibility to infection. [checkorphan.org]
Prognosis The prognosis for mild or chronic neutropenia is excellent. Recovery from acute neutropenia depends on the severity of the patient's infection and the promptness of treatment. Resources Books Linker, Charles A. "Blood." [medical-dictionary.thefreedictionary.com]
Prognosis [ edit ] This form usually lessens in severity within two years of diagnosis. [ citation needed ] The use of prophylactic antibiotics has been proposed. [2] See article at BioMed Central site: [1] [ verification needed ] References [ edit ] [en.wikipedia.org]
Prognosis Mortality from febrile neutropenia has reduced but remains significant. [patient.info]
Prognosis of Neutropenia How is Neutropenia Treated? Neutropenia References What is Neutropenia Neutropenia is a disorder of the blood, with low levels of a special type of cell called the neutrophil. [myvmc.com]
Etiology
Neutropenia can conceptually be viewed in 2 broad ways, by mechanism or etiologic category. Since the mechanisms for neutropenia are varied and not completely understood, the etiologic category is simplest to retain. [welchco.com]
If acute neutropenia is suspected to be drug- or toxin-induced, all potentially etiologic agents are stopped. [merckmanuals.com]
[…] generalized signs and symptoms such as fever, abdominal pain, malaise, back pain, and increased inflammatory markers (e.g., c-reactive protein and white blood cell count) Consider aortitis in patients who develop these signs and symptoms without known etiology [neupogenhcp.com]
Spontaneous resolution of neutropenia with complete remission is well documented in the literature and although a specific antibody has not been demonstrated in states of idiopathic neutropenia, this spontaneous resolution raised the possibility of an immune etiology [ichastaliklaridergisi.org]
Due to the patient's refusal to undergo a bone marrow biopsy, the underlying etiology of the neutropenia could not be established. Therefore, the patient was treated on an outpatient basis under the final diagnosis of chronic idiopathic neutropenia. [cureus.com]
Epidemiology
Toshiki Watanabe, Takuya Fukushima Springer, 27 abr. 2017 - 169 páginas This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia [books.google.es]
Epidemiology of incident immune thrombocytopenia: a nationwide population-based study in France. Blood. 2014 Nov 20. 124(22):3308-15. [Medline]. Danese MD, Lindquist K, Gleeson M, Deuson R, Mikhael J. [emedicine.medscape.com]
The epidemiology of benign leukopenia in Yemenite Jews. Isr J Med Sci 1993 29 297 9 ,,. Leukopenia in Negro workmen. Am J Med Sci 1941 201 407 12 ,,. Leukopenia in Negroes. N Engl J Med 1966 275 1410 3 ,,. Pseudo-neutropenia in American Negroes. [annals.org]
Weingarten MA, Pottick-Schwartz EA, Brauner A: The epidemiology of benign leukopenia in Yemenite Jews. Isr J Med Sci 29:297, 1993. 3. [medtextfree.wordpress.com]
Pathophysiology
With a strong focus on pathophysiology, this comprehensive new edition of Nursing the Acutely Ill Adult retains the case study approach that made the first edition so popular with students and educators alike. [books.google.es]
Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia. Expert Rev Hematol. 2008;1(II):217–29. PubMed CrossRef Google Scholar 8. Lima CS, Paula EV, Takahashi T, Saad ST, Lorand-Metze I, Costa FF, X. [link.springer.com]
Welte K, Dale DC: Pathophysiology and treatment of severe chronic neutropenia. Ann Hematol 72:158, 1996. 54. Fowler B: Genetic defects of folate and cobalamin metabolism. Eur J Pediatr 157:S60, 1998. 55. [medtextfree.wordpress.com]
Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management. Thromb Haemost. 2008 Jan. 99(1):4-13. [Medline]. [Full Text]. Audia S, Mahévas M, Samson M, Godeau B, Bonnotte B. Pathogenesis of immune thrombocytopenia. [emedicine.medscape.com]
Prevention
[…] care processes (977) Fall prevention (46) Immunizations (98) Prenatal care (68) Primary prevention (596) Secondary prevention (425) Tertiary prevention (10) ► Patient Population ► Age (662) Adolescent (13-18 years) (260) Adult (19-44 years) (77) Aged [innovations.ahrq.gov]
Isoniazid Ethotoin Valganciclovir Procainamide Caspofungin Clozapine Chediak-Higashi disease Mirtazapine Sulphonamides Barth syndrome Autoimmune lymphoproliferative syndrome type 1 Griscelli syndrome type 1 Bevacizumab Propionyl-CoA carboxylase deficiency Prevention [checkorphan.org]
Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease. [books.google.es]
Tea tree oil : Tea tree oil is purported to have antiseptic properties, and has been used traditionally to prevent and treat infections. [livingnaturally.com]
Management requires: annual bone marrow monitoring monthly CBC tests emotional support psychological therapy No specific prevention for neutropenia is known. [healthline.com]