Splenomegaly was also observed. A bone marrow biopsy revealed normal trabecular bone, 65% of total marrow cellularity in separate marrow spaces, myeloid hyperplasia and severe eosinophilia. [ncbi.nlm.nih.gov]

Physical examination and imaging studies show massive splenomegaly with no lymphadenopathy. There was no hypercalcemia or increased in serum LDH. [pathologyoutlines.com]

The acute type shows a rapidly progressive clinical course and most of the characteristic features of ATL: leukemic manifestation, generalized lymphadenopathy, hepatomegaly, splenomegaly, skin involvement, hypercalcemia, and the infiltration of other [clinicalgate.com]

The patient was a 74-year-old Japanese woman with rheumatoid arthritis (RA) who developed generalized lymphadenopathy with elevated levels of lactase dehydrogenase (LD), and soluble IL-2 receptor (sIL-2R). [ncbi.nlm.nih.gov]

Hypercalcemia from increased osteoclast bone resorption • 4 clinical subtypes of ATLL Acute subtype – Most common subtype, 60%, often in children – Severe peripheral blood lymphocytosis, WBC, lactate dehydrogenase (LDH), skin lesions, lymphadenopathy [basicmedicalkey.com]

In acute ATLL, symptoms develop rapidly and include fatigue, skin rash and enlarged lymph nodes in the neck, armpit and groin. [leukaemia.org.au]

[…] person-years. 1 This virus causes adult T-cell leukemia–lymphoma. 2 We report a case of adult T-cell leukemia–lymphoma during pregnancy.A 23-year-old woman was admitted to a hospital in South Carolina because of a 7-day history of sore throat, fever, and fatigue [nejm.org]

Epidemiology endemic regions Japan Caribbean sub-Saharan Africa Middle East Central and South America Characteristic finding is “flower” cell on peripheral blood smear Presentation Symptoms hypercalcemia constipation altered mental status kidney stone weakness fatigue [medbullets.com]

Other symptoms can include night sweats, fatigue, fever, and a condition called pruritis (a feeling of the persistent need to scratch). [knowcancer.com]

It is most commonly used in combination with chemotherapy The radiation may be administered by a machine placed outside the body, or by placing a radioactive material inside the body The side effects of radiation therapy include nausea, vomiting, fatigue [dovemed.com]

We suggest that sputum evaluation in patients with ATLL risk factors can be diagnostic. [ncbi.nlm.nih.gov]

The symptoms and signs include abdominal pain, diarrhea, ascites, jaundice, pleural effusion, cough, sputum, fever, and unconsciousness because of organ involvement, hypercalcemia, and/or opportunistic infections. 2. [clinicalgate.com]

The patient herein reported presented diffuse abdominal pain with duration of eight months in addition to ascites. The diagnosis of the acute leukemia type of ATL was done with base on clinical, laboratory and imaging findings. [ncbi.nlm.nih.gov]

Itching involving the skin (ATLL, Sezary syndrome) Feeling full quickly when eating or abdominal pain or fullness (T-PLL) If you are concerned about any changes you experience, please talk with your doctor. [cancer.net]

In March 1987, the patient returned to the hospital because of abdominal pain, nausea, vomiting, and somnolence. Laboratory studies revealed a leukocytosis with abnormal lymphocytes, a calcium level of 20.5 mg/dL, and an amylase level of 1,209 IU/L. [cdc.gov]

[…] rashes, abdominal pain, and a general feeling of illness If the brain is involved, then neurological symptoms such as the following may be observed: Confusion Tinnitus (ringing in the ears) Hearing and visual impairment If the gastrointestinal (GI) tract [dovemed.com]

The symptoms and signs include abdominal pain, diarrhea, ascites, jaundice, pleural effusion, cough, sputum, fever, and unconsciousness because of organ involvement, hypercalcemia, and/or opportunistic infections. 2. [clinicalgate.com]

Phototherapy was also initiated, but had to be discontinued due to the development of photosensitivity. Treatment with the combination of mogamulizumab and etoposide (25 mg/day for 21 days) was started in May 2014. [ncbi.nlm.nih.gov]

[…] presented with a rare case of adult T-cell leukemia/lymphoma (ATL) occurring as only intracerebral mass lesion manifesting as progressively worsening headaches, transient mild weakness of the left lower extremity, bilateral papilledema, and left homonymous hemianopsia [ncbi.nlm.nih.gov]

A 69-year-old Japanese male presented with a 3-month history of bilateral ptosis with lacrimal gland bulge. He came from western Japan, an area endemic for human T-lymphotropic virus Type 1 infection. [ncbi.nlm.nih.gov]

A 69-year-old Japanese male presented with a 3-month history of bilateral ptosis with lacrimal gland bulge. He came from western Japan, an area endemic for human T-lymphotropic virus Type 1 infection. [ncbi.nlm.nih.gov]

mental status kidney stone weakness fatigue anorexia Physical exam hepatoseplenomegaly in 50% lymphadenopathy in almost all skin lesions variable morphology plaque, papule, nodulotumoral, erythroderma, and purpuric Evaluation Complete blood count 5% [medbullets.com]

A 48-year-old female presented with a rare case of adult T-cell leukemia/lymphoma (ATL) occurring as only intracerebral mass lesion manifesting as progressively worsening headaches, transient mild weakness of the left lower extremity, bilateral papilledema [ncbi.nlm.nih.gov]

Although ATL cells were not detected in the autopsied lungs and a variety of other tissues, cytoplasmic inclusion bodies, which are commonly observed in RNA viral infection, were abundantly observed in the autopsied lung tissue. [ncbi.nlm.nih.gov]