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African Iron Overload

Neonatal Hemochromatosis


Presentation

  • The present study of 19 families with African iron overload failed to show evidence that the ferroportin (Q248H) mutation is responsible for the condition.[ncbi.nlm.nih.gov]
  • Conclusions: The present study of 19 families with African iron overload failed to show evidence that the ferroportin (Q248H) mutation is responsible for the condition.[doi.org]
  • Seite 272 - Salmon SE: A clinical staging system for multiple myeloma: Correlation of measured myeloma cell mass with presenting clinical features, response to treatment and survival. Cancer 36:842-854, 1975 6. ‎[books.google.de]
Vietnamese
  • Gerl, Michael Ventz, Marie-Luise Schneider, Carsten Büttner, Kamilla Wadowska, Wolfgang Kerner, Peter Schuff–Werner, Herbert Lochs and Hartmut Schmidt, A homozygous HFE gene splice site mutation (IVS5 1 G/A) in a hereditary hemochromatosis patient of Vietnamese[doi.org]
Liver Dysfunction
  • Transferrin saturation above normal range in male and female also need additional testing.Chemical evidence of tissue vitamin C deficiency and mild to moderate liver dysfunction are likely to be seen in individuals with African iron overload.[en.wikipedia.org]
Purpura
  • Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. ‎[books.google.de]
Withdrawn
  • Phlebotomy Iron overload disease can be simply and effectively treated using a procedure called phlebotomy, in which blood is regularly withdrawn from the arm veins to reduce excess iron stores in the body.[health24.com]

Treatment

  • Significant updates on bariatric surgery, Barrett's esophagus, endoscopic ultrasound, endosonography, treatment of liver disease, and much more keep you current on the latest advances.[books.google.de]
  • If you or a family member has been diagnosed with African iron overload, talk with your doctor or specialist about the most current treatment options.[diseaseinfosearch.org]
  • Treatment - Bantu siderosis The amount of hemoglobin is important when considering treatment options. If the patient has an ample blood supply, a physician can perform a phlebotomy (drawing blood).[checkorphan.org]
  • The authors review how the body absorbs, uses, and loses iron and explore both common and unusual causes of iron overload and treatment of the resulting disorders. Funding and Disclosures Dr. Ponka reports receiving consulting fees from F.[doi.org]

Prognosis

  • Prognosis - Bantu siderosis In Bantu siderosis, the resulting iron overload can eventually damage tissues and organs. Iron overload in the liver may lead to chronic liver disease (cirrhosis).[checkorphan.org]
  • When HHC is found early and properly managed, long-term prognosis, including life expectancy, should not differ from that of persons without the disorder.[diagnose-me.com]
  • Prognosis [ 3 ] C282Y homozygous patients with clinically ascertained HC have an increased risk of developing liver disease and hepatocellular carcinoma.[patient.info]
  • In one series of patients who presented with cardiomyopathy associated with hemochromatosis, therapeutic phlebotomy improved the prognosis in 70%; untreated patients had a worsening of their condition and mean survival of only one year.[library.med.utah.edu]
  • Feng‐Kai Sun, Shuai Gao, Yu‐Chen Fan, Chang‐He Shi, Zhao‐Hua Zhang, Li‐Yuan Wang, Feng Li, Xin‐You Li, Xiang‐Fen Ji, Jing Zhao and Kai Wang, High promoter methylation levels of glutathione‐S‐transferase M3 predict poor prognosis of acute‐on‐chronic hepatitis[doi.org]

Etiology

  • Wei‐Chen Lee and Miin‐Fu Chen, Epidemiology, Etiology, and Natural History of Hepatocellular Carcinoma, Malignant Liver Tumors, (52-55), (2009).[doi.org]
  • Abstract Although HLA-linked hemochromatosis greatly increases the risk for hepatocellular carcinoma in people of European ancestry, iron overload in Africa is not thought to be etiologically related to this malignancy.[ncbi.nlm.nih.gov]
  • Etiology Hereditary Hemochromatosis HFE-Related C282Y Homozygosity C282Y/H63D Compound Heterozygosity Other Mutations of HFE Non-HFE-Related Juvenile Hemochromatosis Autosomal Dominant Hemochromatosis (Solomon Islands) Secondary Iron Overload Iron-Loading[mdnxs.com]
  • Iron overload, irrespective of the underlying etiology, has varying manifestations, depending on the organs affected by the excessive iron deposit.[karger.com]

Epidemiology

  • Wei‐Chen Lee and Miin‐Fu Chen, Epidemiology, Etiology, and Natural History of Hepatocellular Carcinoma, Malignant Liver Tumors, (52-55), (2009).[doi.org]
  • Early diagnosis and treatment are therefore essential. [ 1 ] Aetiology and epidemiology [ 2 ] Defects of the HFE gene (located on the short arm of chromosome 6) cause the majority of cases of inherited haemochromatosis, which is therefore often referred[patient.info]
  • Epidemiology: The prevalance of HH, especially its classic form, is very high in white populations. The prevalance rate in Americans is roughly 1/200 for homozygosity, 1/50 for compound heterozygosity, and 1/10 for heterozygosity.[clinicaladvisor.com]
  • Introduction IRON overload in the absence of hyperplastic refractory anemia or blood transfusions is found in two epidemiologically important conditions: hereditary hemochromatosis and African dietary iron overload. 1 In hereditary hemochromatosis, an[nejm.org]
Sex distribution
Age distribution

Pathophysiology

  • Adewoye, Pathophysiology of iron overload-induced renal injury and dysfunction: Roles of renal oxidative stress and systemic inflammatory mediators, Pathophysiology, 10.1016/j.pathophys.2019.03.002, (2019). William C.[doi.org]
  • (See “Pathophysiology and diagnosis of iron overload syndromes”, section on ‘High levels of ferritin in the absence of iron overload’ and “Clinical features and diagnosis of hemophagocytic lymphohistiocytosis”, section on ‘Serum ferritin levels’.) — #[mdnxs.com]
  • Hemochromatosis: genetics, pathophysiology, diagnosis, and treatment. Cambridge: Cambridge University Press, 2000: 63–74. 37 Beutler E, Gelbart T. HLA-H mutations in the Askenazi Jewish population.[nature.com]

Prevention

  • Jian‐Gao Fan and Geoffrey C Farrell, Prevention of hepatocellular carcinoma in nonviral‐related liver diseases, Journal of Gastroenterology and Hepatology, 24, 5, (712-719), (2009).[doi.org]
  • Measures to prevent and treat this condition are needed.[ncbi.nlm.nih.gov]
  • Can iron overload disease be prevented? Iron overload disease is fully preventable when it is diagnosed and treated early enough.[health24.com]
  • A comparison of filtered leukocyte-reduced and cytomegalovirus (CMV) seronegative blood products for the prevention of transfusion-associated CMV infection after marrow transplant. Blood 1995; 86:3598-3603. ‎[books.google.de]
  • Prevention - Bantu siderosis Not supplied. Diagnosis - Bantu siderosis Diagnosis of Bantu siderosis involves a variety of blood tests to assess the total body iron.[checkorphan.org]

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