Affected individuals present with irritable eyes and dryness of the mouth with variable expressivity. Mutations in FGF10 were recently described in ALSG and in lacrimo-auriculo-dento-digital (LADD) syndrome which are overlapping clinical entities. [ncbi.nlm.nih.gov]

The usual age of presentation is between birth and 20 years, with most cases diagnosed at age 2.5 years. [mitchmedical.us]

Sonis, DMD, DMSc Springer, ١٧‏/٠٩‏/٢٠١٥ - 408 من الصفحات The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge [books.google.com]

ConclusionWe present the entity of ALSG as an extremely rare, yetimportant, alternative diagnosis in cases suggestive of Sjogrenssyndrome. [docslide.com.br]

• Inflammation

  salivary fistulas or salivary gland tumours). back up Salivary gland inflammation (sialadenitis) The most frequent salivary gland disorders are acute bacterial and viral inflammations (sialadenitis, sialangitis). [med-college.de]

  Accessory parotid tissue Mid cheek mass Parotid gland aplasia Salivary gland inflammation Cite this Apa Standard Harvard Vancouver BIBTEX RIS Capaccio, P, Luca, N, Sigismund, PE & Pignataro, L 2012, ' Recurrent inflammation of accessory parotid tissue [moh-it.pure.elsevier.com]

  Clinical findings Recurrent ocular inflammation and infections; constant tearing and dryness of the mouth, increasing the risk of dental erosion, dental caries, periodontal disease and oral infections. [medical-dictionary.thefreedictionary.com]

  Symptoms associated with hypoplasia or aplasia of the major salivary glands include xerostomia, oral inflammation, dental caries and dental erosion. [ncbi.nlm.nih.gov]

  Mycotic Infections Actinomycosis Cause A.Israliae Types Primary ascending canalicular inflammation. Infection penetrates from mouth into gland and affects it entirely. [slideshare.net]

• Asymptomatic

  […] the oral cavity often related to other craniofacial abnormalities or alteration of structures deriving from the first or second archial branch, in particular the lacrimal glands; it can be total or partial and determine clinical states ranging from an asymptomatic [moh-it.pure.elsevier.com]

  D) Cyst Mucocele RanulaE) Asymptomatic enlargement Sialosis Allergic Associated with malnutrition and alcoholism 7. [slideshare.net]

  To our knowledge the reported cases of submandibular agenesis have been asymptomatic and associated with facial anomalies. [ejo.eg.net]

  (Figs. 47).Cervico facial MRI was performed on the parents of the patientto search for an asymptomatic disorder of the salivary glands, butthe imaging was normal in both cases.All these clinical and radiological findings, along with theabsence of major [documents.tips]

  Similar changes can usually also be found on the asymptomatic side. [egms.de]

• Recurrent Infection

  Twenty-year-old girl with recurrent localized infection of the parotid and a periparotid sinus. paper (Martinez et al. 2007). [mitchmedical.us]

  Traditional approach of treatment was followed by combined massage of the nasolacrimal sac and by prescribing antibiotic drops, three times daily to avoid recurrent infection, if any. In addition, probing under general anesthesia was planned. [saudijhealthsci.org]

  It is recommended for assessment of the effects of sialolithiasis, stenosis, and recurrent swelling, as well as recurrent infection. [47, 78, 79, 80] While generally considered safe, sialoendoscopy is not without risk. [emedicine.medscape.com]

  Tonsillectomy is also carried out as part of the procedure, in order to prevent stenosis and recurrent infection of the excretory ducts or salivary glands [238], [239]. [egms.de]

• Vomiting

  Necrotizing sialometaplasia in two patients with bulimia and chronic vomiting. Int J Oral Maxillofac Surg. 1998 Dec. 27(6):463-5. [Medline]. Lee DJ, Ahn HK, Koh ES, Rho YS, Chu HR. [emedicine.medscape.com]

• Hypertension

  However, long-term treatment has many side effects, including hypertension, weight gain, hyperglycemia, and osteoporosis. [pocketdentistry.com]

  Hypertension and glaucoma are relative contraindications [205]. An important recent addition is the use of botulinum toxin A to inhibit salivary gland secretion. [egms.de]

• Xerostomia

  […] other craniofacial abnormalities or alteration of structures deriving from the first or second archial branch, in particular the lacrimal glands; it can be total or partial and determine clinical states ranging from an asymptomatic condition to a severe xerostomia [moh-it.pure.elsevier.com]

  Causes severe xerostomia. 12. Diverticuli Small pouches or outpocketing of ductal system of one of the major salivary glands.Congenital fistula Sinus tract form either in crease behind the pinna or in front of tragus. [slideshare.net]

  Those patients suffer from epiphora, xerostomia and severe dental caries. This phenotype represents the autosomal-dominant aplasia of lacrimal and salivary glands syndrome (ALSG). [ncbi.nlm.nih.gov]

  Definition A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. [uniprot.org]

  Management of these cases is symptomatic and directed toward the xerostomia and other oral health care issues. [mitchmedical.us]

• Dental Caries

  Those patients suffer from epiphora, xerostomia and severe dental caries. This phenotype represents the autosomal-dominant aplasia of lacrimal and salivary glands syndrome (ALSG). [ncbi.nlm.nih.gov]

  Clinical findings Recurrent ocular inflammation and infections; constant tearing and dryness of the mouth, increasing the risk of dental erosion, dental caries, periodontal disease and oral infections. [medical-dictionary.thefreedictionary.com]

  Definition A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. [uniprot.org]

  The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections. [geniverse.concord.org]

• Irritability

  Affected individuals present with irritable eyes and dryness of the mouth with variable expressivity. Mutations in FGF10 were recently described in ALSG and in lacrimo-auriculo-dento-digital (LADD) syndrome which are overlapping clinical entities. [ncbi.nlm.nih.gov]

  Definition A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. [uniprot.org]

  The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections. [geniverse.concord.org]

• Hyperactivity

  Health sciences 2009) 3 22 45 60 Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. (PMID: 18081024) Laurin N … Barr CL (American journal of medical genetics. [genecards.org]

  Hidas et al. [6] studied salivary flow in children and adolescents with attention deficit hyperactivity disorder (ADHD). [egms.de]

• Tremor

  Adverse effects can include allergic reactions, confusion, irregular heartbeat, stomach upset/pain, sweating and facial erythema, tremor, elevations in blood pressure, fatigue, vomiting, vision changes, and headache. [86, 87] Nondrug therapies, including [emedicine.medscape.com]

In these cases, HIV testing should be added to the diagnostic tests and further cytological or histological workup considered [54]. [egms.de]

• Staphylococcus Aureus

  The organisms isolated were Staphylococcus aureus (in 61% of cases), with three patients (7%) having MRSA (methicillin resistant staphylococcus aureus) [62], other Gram-positive cocci (25%), Gram-negative rods (16%) and anaerobic bacteria (11%). [egms.de]

Treatment Medical treatment is indicated in some cases to try and control the growth of very large lesions. Corticosteroid treatment has been the mainstay of treatment for many years. [pocketdentistry.com]

There may be xerostomia, and swelling of the parotid and submandibular gland which increase for 12-24 hours then rapidly subside without treatment. [profmlotfy.com]

The next two sections contain chapters which describe the genomics of specific oral diseases and conditions, including the genetic basis for mechanism and risk of treatment toxicities associated with cancer therapy and bisphosphonates. [books.google.com]

Based on current experience and findings in the treatment of juvenile recurrent parotitis, we recommend the following treatment strategy [153] : 1. [egms.de]

[…] includes a brief description of each individual lesion or pathologic condition and the kind of pathologic process that it represents, followed by a discussion of its clinical and/or radiographic presentation, histopathologic features, and its treatment and prognosis [books.google.com]

PubMed CrossRef Google Scholar Bhayani MK, Yener M, El-Naggar A, Garden A, Hanna EY, Weber RS, Kupferman ME (2011) Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands. Cancer. Oct 21. [link.springer.com]

Most patients have an excellent prognosis with respect to morbidity and mortality; as a rule, it is very favourable. [egms.de]

Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands. Cancer. 2012 Jun 1. 118(11):2872-8. [Medline]. Sengul I, Sengul D. Pleomorphic adenoma of the lower lip: A review. [emedicine.medscape.com]

The purpose of this study was to identify genetic etiology of an ALSG family. We recruited a Turkish family with ALSG and performed a mutational analysis, based on the candidate gene approach, to clarify the molecular genetic etiology. [ncbi.nlm.nih.gov]

Etiology autosomal dominant aplasia of lacrimal and salivary glands (ALSG) is caused by mutation in the gene encoding fibroblast growth factor-10 (FGF10) (MIM.602115). [humpath.com]

Written by well-established clinicians, educators, and researchers in oral and maxillofacial surgery, this book brings together information on the etiology, diagnosis, and treatment of all types of salivary gland pathology. [books.google.com]

The exact etiology of lobular capillary hemangioma is still unknown. [ejo.eg.net]

(Fig 5) The most likely etiology of the disease is local ischemia of the minor salivary gland that result in squamous metaplasia of the ductal epithelium. The cause of this local ischemia is unknown. [profmlotfy.com]

Epidemiology True salivary gland aplasia is very rare and limited to a small number of case reports in the literature. 1 However, vascular anomalies affecting the salivary gland are relatively common. [pocketdentistry.com]

Epidemiology Subcommittee of the International Dry Eye WorkShop. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop. (2007). Ocul Surf. 2007;5:93–107. 47. Gipson IK. [tearfilm.org]

Relevant External Links for FGF10 Genetic Association Database (GAD) FGF10 Human Genome Epidemiology (HuGE) Navigator FGF10 Atlas of Genetics and Cytogenetics in Oncology and Haematology: FGF10 No data available for Genatlas for FGF10 Gene Structure and [genecards.org]

Scholar Li N, Xu L, Zhao H, El-Naggar AK, Sturgis EM (2011) A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology [link.springer.com]

The Surveillance, Epidemiology and End Results (SEER) database also records rhabdomyosarcomas of the salivary glands in 8% of 113 cases [179]. [egms.de]

Mechanistic studies performed to date in IgG4-RD promise to yield important insights about the pathophysiology of this disease and the pathways through which B cell depletion exerts its beneficial effects. [ivd.mbl.co.jp]

Alpha-adrenergic and muscarinic receptors in particular are involved in the pathophysiology of neuroleptic-induced salivation [208]. Idiopathic hypersalivation is another form of sialorrhoea of unknown origin. [egms.de]

A 7-year-old boy, reported to the department of Pedodontics and Preventive Dentistry with the chief complaint of persistent dryness of the mouth and eating difficulties. [jisppd.com]

1998 Reference: Veterinaria n.1/1998 Pages: 53 - 60 Download attachments: PDF (9742 Downloads) Read 5808 times 0 Shares Published in Veterinaria Anno 12, n. 1, 1998 Tagged under Dog Cat Endocrinology pancreas pancreatite Related items Leishmaniasis prevention [veterinaria.scivac.org]

Accordingly, treatment include symptomatic relief of pain and fever and prevention of dehydration. Persistent or recurrent cases are indicative for development of chronic bacterial sialoadenitis secondary to viral mumps. [profmlotfy.com]

[…] decay), infections of the mouth, [1] and upper respiratory tract infections (e.g., candidiasis, ascending sialadenitis, laryngitis and pharyngitis ). [2] Patients with salivary gland aplasia typically require regular application of topical fluoride to prevent [en.wikipedia.org]

Preventive regimen includes dietary counseling (sugar free), topical fluoride varnish application, sealants, and daily fluoride mouth rinses. [saudijhealthsci.org]