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Aggregatibacter Aphrophilus

Hemophilus Aphrophilus


Presentation

  • We present here what we believe to be the first case of Aggregatibacter aphrophilus pacemaker endocarditis.[ncbi.nlm.nih.gov]
  • A middle-aged gentleman with good past health presented with decreased vision (20/200) in his left eye. Other than fever, he was well on presentation, with no apparent focus of infection.[ncbi.nlm.nih.gov]
  • The authors present herein a rare case of posterior septic arthritis related to A aphrophilus involving lumbar spine with contiguous abscesses of psoas and paravertebral muscles. The infection likely originated from oral cavity.[ncbi.nlm.nih.gov]
  • We present a case of endocarditis with embolic stroke and digital infarction due to the recently renamed Aggregatibacter aphrophilus.[ncbi.nlm.nih.gov]
  • Here we present a case of Aggregatibacter aphrophilus pyogenic liver abscess in an immunocompetent young woman. She recovered uneventfully after repeated percutaneous abscess aspiration and antibiotic treatment for 5 weeks.[ncbi.nlm.nih.gov]
Weight Loss
Disability
  • The patient continued to experience high-grade fevers, disabling joint pain, and rising inflammatory markers, hence, empiric flucloxacillin was commenced at 2g q6hr.[journals.lww.com]
Decreased Breath Sounds
  • An examination of her respiratory system revealed decreased breath sounds and dullness to percussion in the base of her right lung. Examination of her cardiovascular system, abdomen and central nervous system were normal.[ncbi.nlm.nih.gov]
Regurgitation
  • His initial investigation was also suggestive of acute myocardial infarction but the transthoracic echocardiogram revealed massive aortic valve vegetation with perivalvular abscess leading to severe aortic regurgitation.[elsevier.es]
  • Intraoperative transesophageal echocardiography showed no mitral regurgitation after the repair.[ncbi.nlm.nih.gov]
Nausea
  • (a) Sagittal T1 with contrast; (b) Axial T1 with contrast; (c) Axial FLAIR showing surrounding edema; (d) Axial DWI; (e) Axial ADC Eight weeks later, he started to have worsening headache, nausea, and intermittent vomiting.[surgicalneurologyint.com]
Jugular Venous Distention
  • Physical exam in the office revealed a new systolic murmur consistent with tricuspid regurgitation (TR) and jugular venous distention (JVD). Blood cultures were drawn as an outpatient.[bmcresnotes.biomedcentral.com]
Leg Pain
  • Case Presentation A 45 year-old male with a past medical history of motor vehicle accident (MVA) a year ago presented to the Emergency Department (ED) with severe right hip and leg pain.[pubs.sciepub.com]
Night Sweats
  • A 62-year-old African American male with a medical history significant for dual-chamber pacemaker placement in 1996 for complete heart block with subsequent lead manipulation in 2007, presented to his primary care doctor with fever, chills, night sweats[ncbi.nlm.nih.gov]
  • He initially presented to his primary care physician with a four month history of subjective fevers, chills, night sweats, vomiting, fatigue, decreased energy, and a ten pound weight loss.[bmcresnotes.biomedcentral.com]
Dermatitis
  • Acute sacroiliac joint infection in a rugby player with atopic dermatitis. Clin J Sports Med. 2012;22:508–510. Keywords: Aggregatibacter aphrophilus; sacroiliitis ; gastroscopy ; aspirate ; sportsman Copyright 2017 Wolters Kluwer Health, Inc.[journals.lww.com]
Lacrimation
  • This first documented case of A. aphrophilus chronic lacrimal canaliculitis illustrates that optimal surgical management of chronic lacrimal canaliculitis allows for both accurate microbiological diagnosis and treatment.[ncbi.nlm.nih.gov]
  • Conclusion: This first documented case of A. aphrophilus chronic lacrimal canaliculitis illustrates that optimal surgical management of chronic lacrimal canaliculitis allows for both accurate microbiological diagnosis and treatment.[hal.archives-ouvertes.fr]
Hemianopsia
  • Presentamos el caso de una mujer de 68 años a quien se le detectó un absceso cerebral por Aggregatibacter aphrophilus tras presentar un cuadro caracterizado por vértigo, lateralización de la marcha y hemianopsia homónima derecha.[medigraphic.com]
Altered Mental Status
  • Factors predisposing to aspiration, such as altered mental status, alcoholism and periodontal disease have been linked to the development of empyema. However none of these were applicable to our patient.[ncbi.nlm.nih.gov]
Headache
  • A thirteen-year old boy was admitted to the Department of Neurosurgery after the onset of vomiting, headache and dizziness.[ncbi.nlm.nih.gov]
  • We report the case of a 57-year-old male who developed slowly progressive mental confusion with headaches, increased daytime sleepiness and mild gait disturbance within the last 3 weeks.[ncbi.nlm.nih.gov]
  • He presented initially with progressive intermittent headache for more than 6 months.[surgicalneurologyint.com]
Dizziness
  • A thirteen-year old boy was admitted to the Department of Neurosurgery after the onset of vomiting, headache and dizziness.[ncbi.nlm.nih.gov]
Communicating Hydrocephalus
  • The findings were consistent with communicating hydrocephalus secondary to ventriculitis and the left C1-C2 screw was found to be misplaced with perforation of the dura.[ncbi.nlm.nih.gov]

Workup

  • His other workup including blood cultures and transthoracic echocardiogram were negative for infectious etiologies.[surgicalneurologyint.com]
Toxoplasma Gondii
  • These risk factors include immunosuppression ( Toxoplasma gondii, Cryptoccus neoformans, Listeria monocytogenes, and Mycobacterium tuberculosis ), inoculation of brain parenchyma via trauma or surgery ( Staphylococcus aureus and Staphylococcus epidermidis[surgicalneurologyint.com]

Treatment

  • This case highlights the importance of identifying rare causes of endocarditis and recognizing that treatment may not differ from the standard treatment for typical presentations.[ncbi.nlm.nih.gov]
  • We report a case of unilateral chronic epiphora associated with chronic lacrimal canaliculitis resistant to prolonged topical antibiotic treatment in a 65-year-old woman without notable medical history.[ncbi.nlm.nih.gov]
  • The patient's general condition improved and the neurological deficit subsided as a result of the prompt recognition and treatment of this life threatening condition.[ncbi.nlm.nih.gov]
  • After appropriate treatment, his vision improved drastically from 20/200 to 20/30.[ncbi.nlm.nih.gov]
  • The patient was treated successfully with ampicillin-sulbactam after failing ceftriaxone treatment.[ncbi.nlm.nih.gov]

Prognosis

  • Our case demonstrates that with prompt diagnosis and appropriate treatment, visual prognosis of A. aphrophilus endophthalmitis can be promising.[ncbi.nlm.nih.gov]
  • Prognosis of children with IE due to HACEK group members varies, half of them suffering from complications and mortality rates of 10-12.5%.[ncbi.nlm.nih.gov]
  • Prognosis is determined by patient characteristics, the presence or absence of cardiac and non-cardiac complications, the infecting organism and the echocardiographic findings. 2 Clinical case We present the case of a 50-year-old homeless man, with unknown[elsevier.es]

Etiology

  • The etiology and pathophysiology of appendicitis have been well investigated. Aggregatibacter aphrophilus is a fastidious gram-negative coccobacilli.[ncbi.nlm.nih.gov]
  • It is an etiologic agent in infectious endocarditis caused by Gram-negative bacteria. Most often, it is found as a nonpathogenic, commensal resident of dental plaque and the oropharyngeal flora.[uniprot.org]
  • ; Pasteurellales; Pasteurellaceae; Aggregatibacter Data source GenBank (Assembly: GCA_000022985.1 ) BioProject: 36579 Keywords Human pathogen Disease H00334 Bacterial endocarditis H01068 Aggregatibacter aphrophilus infection Comment Well known as an etiologic[genome.jp]

Epidemiology

  • New in the second edition: · Five new chapters in Part I: Identification of Gram-Positive Bacteria, Identification of Gram-Negative Bacteria, Plaque Assays, Phage Display, and Epidemiological Methods · 15 new chapters in Part II, including Mycobacteria[books.google.com]
  • Survey of bacteriology, epidemiology, and treatment with antibiotics, 1963-1989. Dan Med Bull. 1991; 38 (5): 407-410. Yamashita J, Bone FJ, Hitchcock E. Brain abscess due to Haemophilus aphrophilus: case report.[medigraphic.com]
  • […] improvements both in diagnostic and therapeutic management. 2 Since cardiac valves can be destroyed leading to heart failure and vegetations can embolize, mainly to the brain but also to other organs, if left untreated IE can assume 100% mortality. 3 The epidemiology[elsevier.es]
Sex distribution
Age distribution

Pathophysiology

  • The etiology and pathophysiology of appendicitis have been well investigated. Aggregatibacter aphrophilus is a fastidious gram-negative coccobacilli.[ncbi.nlm.nih.gov]
  • They have been associated with local infection in the mouth and, collectively, cause 5-10% of cases of native valve endocarditis in persons who do not abuse illicit intravenous drugs. [1] Pathophysiology C hominis can be isolated from the nose or throat[emedicine.medscape.com]
  • Pharmacotherapy: A Pathophysiologic Approach. 7th ed. New York, NY: McGraw-Hill Medical; 2008:1832-1833. 3. Baddour LM, Wilson WR, Bayer AS, et al.[uspharmacist.com]

Prevention

  • Post cardiac surgery mediastinitis is the major infectious complication, despite the development of surgical techniques and the application of strict preventive measures. The Haemophilus influenzae mediastinitis is very rare.[ncbi.nlm.nih.gov]
  • Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection.[books.google.com]
  • The tenth issue in our growing online database, edited by James Newman, covers essential updates in the following topics: Long QT; Noninvasive ventilation; Fever of Unknown Origin; Post Bariatric Surgery; Hospital Fall Prevention; Mimics of Cellulitis[books.google.de]
  • Moreover, since A. aphrophilus is a member of the normal oral human flora, dental programs campaigns and health community surveillance are needed in order to prevent these kinds of infections.[elsevier.es]

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