In the present chapter, we present a brief overview of these studies and discuss their contributions toward our understanding of the importance of miRNAs in normal and aged stem cell function in various model systems. [ncbi.nlm.nih.gov]

Comparative Biology of Aging presents trends found in comparative studies of aging. The Evolutionary Theory of Aging debates the models and hypotheses put forward to explain how aging evolved. [senescence.info]

• Falling

  BACKGROUND: Falls in older adults with cancer are common, yet factors associated with fall-risk are not well-defined and may differ from the general geriatric population. [ncbi.nlm.nih.gov]

  They are less able to protect themselves during falls. They are more likely to have side effects of drugs (such as drowsiness, loss of balance, and dizziness), which can make falls more likely. [merckmanuals.com]

• Pain

  […] in Australia: a prevalence study, Pain, 2001, vol. 89 (pg. 127 - 34 ) 20 Pain and pain-related interference with function in older Canadians: the Canadian study of health and aging, Disabil Rehabil, 2001, vol. 23 (pg. 654 - 64 ) 21 The health status [doi.org]

  How To Recognize And React To Heart Attacks Symptoms of Heart Attacks Chest pains, squeezing sensation – The pain can radiate into the arms and jaw. [laysamagazine.com]

• Weight Gain

  Calories: As people age, they tend to be less active and thus use less energy, making it easier to gain weight. If they try to consume fewer calories to avoid weight gain, they may not get all the nutrients needed—particularly vitamins and minerals. [merckmanuals.com]

  Professor Francesco Cappuccio says: “Short sleep has been shown to be a risk factor for weight gain, hypertension and Type 2 diabetes sometimes leading to mortality but in contrast to the short sleep-mortality association it appears that no potential [www2.warwick.ac.uk]

  Patients were classified as substantial weight losers (lost ≥5kg), weight gainers (gained ≥5kg), or weight stable (loss or gain Empirical models for exclusions To identify groups most susceptible to prior weight loss, we tested associations with 15 major [doi.org]

  gain in the first year of a baby's life. [aboutkidshealth.ca]

• Fatigue

  Sexual desire can be disturbed by fatigue, low testosterone or pain. Sexual excitement (erection) may be influenced by diabetes mellitus, arteriosclerosis, hypertension and side effects of antihypertensive and antiviral medication. [ncbi.nlm.nih.gov]

  Some candidate causes for this include depression, low socioeconomic status and cancer-related fatigue.” [www2.warwick.ac.uk]

  “You can’t think as clearly, you get fatigued more easily, you don’t tolerate heat as well. “People who complain of things like fatigue and mild headaches and constipation, most often they’re just dehydrated,” Foroutan says. Blueberries. [webmd.com]

  But beyond his credentials, Joon is a classic visionary who believes that the inexorable march towards old age, with all of its accompanying aches, pains and fatigue, is preventable. [paloaltopulse.net]

  Si Young Cho, Ji Hae Lee, Min Jeong Song, Pil Joon Park, Eui Seok Shin, Jong Hee Sohn, Dae-Bang Seo, Kyung Min Lim, Wan Gi Kim and Sang-Jun Lee, Effects of Chitooligosaccharide Lactate Salt on Sleep Deprivation-Induced Fatigue in Mice, Biological & Pharmaceutical [doi.org]

• Asymptomatic

  A patient, initially asymptomatic, who developed characteristic signs of the syndrome at the age of 6 months is reported. She was referred for evaluation only when she was two years and eleven months old. [ncbi.nlm.nih.gov]

  Leonsson M, Hulthe J, Oscarsson J et al. (2002) Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: relation to body mass index, gender, and other cardiovascular risk factors. [springerlink.com]

  Influence of cognitive reserve on neuropsychological functioning in asymptomatic human immunodeficiency virus-1 infection. Arch. Neurol. 53, 148–153 (1996). 52. Matura, S. et al. [doi.org]

  Therefore, osteoporosis is fundamentally an asymptomatic condition until the appearance of a bone fracture presenting itself as a complication with clinical visibility and often lifethreatening [ 32 ]. [immunityageing.com]

  Enrichment of prevention trials with asymptomatic people most at risk for AD is required to ensure that event rates are sufficiently high to evaluate the multitude of drug trials being considered for AD [ 20 ]. [genomebiology.com]

• Aspiration

  This conclusion banishes the ""fountain of youth" to the limbo of scientific impossibilities where other human aspirations, like the perpetual motion machine and Laplace's 'superman' have already been placed by other theoretical considerations. ‎ [books.google.de]

  These challenges can lead to substantial gaps in access to formal health and social services, with negative implications for older residents aging-in-place and the development aspirations of resource frontier communities. [ncbi.nlm.nih.gov]

  Oropharyngeal dysphagia clearly increases in the adult population and has been noted to occur in ∼50% of nursing home residents, resulting in a high frequency of aspiration pneumonia ( 5 ). [tools.wmflabs.org]

  Oropharyngeal dysphagia clearly increases in the adult population and has been noted to occur in ~50% of nursing home residents, resulting in a high frequency of aspiration pneumonia ( 5 ). [web.archive.org]

• Cough

  These can become quite large in some individuals and are capable of retaining food, causing patients to experience symptoms of cough, fullness, and gurgling in the neck region and the much more serious complication of pulmonary aspiration. [tools.wmflabs.org]

• Heart Disease

  […] with exertion, and heart attack can result from coronary artery disease. [medlineplus.gov]

  For example, we included 55, 35, and 43 cohort studies on diabetes, breast cancer, and ischemic heart disease, respectively, in our study compared with 16 studies on diabetes, 2 13 studies on breast cancer, 1 and nine studies on ischemic heart disease [doi.org]

  FOCUS ON AGING RESEARCH Understanding the underlying mechanism of aging is the most direct way of enabling researchers to tackle common diseases of old age, such as Alzheimer’s disease, heart disease and some forms of cancer. [afar.org]

  This controversy has significant public health implications because the two categories of aging theories suggest very different ways of approaching the treatment and prevention of age-related diseases such as cancer and heart disease that now cause about [programmed-aging.org]

• Heart Failure

  Having had a heart attack within 6 months of a surgical procedure greatly increases risk, as does poorly controlled heart failure. [merckmanuals.com]

• Hearing Impairment

  Introduction: The relationship between cognition and the ability to hear is well known. Due to changes in demographics, the number of people with sensorineural hearing loss and cognitive impairment is increasing. [ncbi.nlm.nih.gov]

• Dry Skin

  Wrinkles will appear sooner on dry skin than on oily skin. [vichyusa.com]

  Skin and hair Wrinkles More tears in the skin The fat layer under the skin, which acts as a cushion, thins. The body produces less collagen and elastin, which make the skin tough and elastic. Dry skin Glands in the skin produce less oil. [merckmanuals.com]

• Alopecia

  Venafra, Androgenetic alopecia: some thoughts and views about its topical treatment, Trends in Human Hair Growth and Alopecia Research, 10.1007/978-94-011-7873-0_22, (215-218), (1989). D. [doi.org]

• Acne Vulgaris

  People were split 50:50 over whether hypertension, acne vulgaris, or gall stones were diseases. The doctors were more likely to view the terms as referring to diseases. [bmj.com]

  REESE, Clinical, ultrasound and hormonal markers of androgenicity in acne vulgaris, British Journal of Dermatology, 133, 2, (249-253), (2006). [doi.org]

• Receding Hairline

  Reza Pashmineh Azar, Alexander Horst Thomas, Marcus Maurer and Gerd Lindner, Asymmetry of the Receding Hairline in Men With Early Androgenetic Alopecia, Journal of Cutaneous Medicine and Surgery, 20, 6, (546), (2016). [doi.org]

• Aggressive Behavior

  Moshkin MP, Potapov MA, Frolova OF, Evsikov VI: Changes in aggressive behavior, thermoregulation, and endocrine responses in BALB/cLac and C57Bl/6J mice under cold exposure. Physiol Behav 1993;53:535–538. [doi.org]

We also briefly reviewed available data on the treatment of arterial thrombosis in FVII deficiency. [ncbi.nlm.nih.gov]

Doctors Give Medicare’s Proposal To Pay For Telemedicine Poor Prognosis By Phil Galewitz October 10, 2018 Federal officials are proposing that Medicare pay doctors for a 10-minute “check-in” call with beneficiaries. [khn.org]

In the largest tumor group in our material, prostate cancer, the blood TL ≥9 years before diagnosis seemed to indicate a poor prognosis. [doi.org]

Aging individuals can develop generalized, exquisitely-pruritic, eczematous eruptions of uncertain etiology that can be therapeutically-refractory and life-altering. [ncbi.nlm.nih.gov]

Introduction Among those with depression, it is older adults who are most likely to attempt and complete suicide.[ 1 ] The role of concomitant physical disease, and the etiology of depression among seniors are poorly understood and confusing. [doi.org]

Reiter WJ, Schatzl G, Mark I et al. (2001) Dehydroepiandrosterone in the treatment of erectile dysfunction in patients with different organic etiologies. Urol Res 29: 278–281 PubMed CrossRef Google Scholar 46. [springerlink.com]

Author information 1 Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center, U1153 National Institute of Health and Medical Research (INSERM), U1125 National Institute for Agricultural Research (INRA), National Conservatory [ncbi.nlm.nih.gov]

Article Navigation 1 Division of Sleep Medicine 3 Departments of Epidemiology 5 Harvard Medical School, Boston, Mass * Address correspondence to: Sanjay R. [doi.org]

Tetraploidy, a condition in which a cell has four homologous sets of chromosomes, is often seen as a natural physiological condition but is also frequently seen in pathophysiological conditions such as cancer. [ncbi.nlm.nih.gov]

Even though new trials are ongoing, the recognition of this syndrome is essential to prevent cardiovascular and cerebrovascular complications. [ncbi.nlm.nih.gov]

These mechanisms therefore represent potential therapeutic targets in the prevention and treatment of such pathologies. Copyright © 2011 Cold Spring Harbor Laboratory Press; all rights reserved [doi.org]

Therefore, investigation on sequence specificity of DNA damage would provide clues on the biological significance of DNA damage which in turn may be beneficial for cancer prevention strategy. [ci.nii.ac.jp]