When symptoms appear, they may include: Intermittent, unexplained fever Irritability or inconsolable crying Skin problems, including chilblains (rash, lesions, or swelling on fingers, toes and ears that get worse in cold weather) Weak or stiffened muscles [chop.edu]

[…] brain and skin.1 Patients typically exhibit either in utero manifestations resembling an acquired infection,2 or postnatal involvement in infancy, characterized by subacute encephalopathy and loss of acquired skills.3 Children with AGS commonly have fevers [onlinelibrary.wiley.com]

When symptoms appear, they may include: Intermittent, unexplained fever Irritability or inconsolable crying Skin problems, including chilblains (rash, lesions, or swelling on fingers, toes and ears that get worse in cold weather) Weak or stiffened muscles [chop.edu]

They develop encephalopathy with irritability, persistent crying, abnormal tone, posturing, and an exaggerated startle response. [onlinelibrary.wiley.com]

difficulties A decline in growth of the head Developmental delays Seizures In later-onset AGS, these symptoms may last for several months. [chop.edu]

When symptoms appear, they may include: Intermittent, unexplained fever Irritability or inconsolable crying Skin problems, including chilblains (rash, lesions, or swelling on fingers, toes and ears that get worse in cold weather) Weak or stiffened muscles [chop.edu]

They develop encephalopathy with irritability, persistent crying, abnormal tone, posturing, and an exaggerated startle response. [onlinelibrary.wiley.com]

Manifestations included spastic quadriplegia and anarthria but preserved intellect and increased iron signal in the basal ganglia. [onlinelibrary.wiley.com]

They develop encephalopathy with irritability, persistent crying, abnormal tone, posturing, and an exaggerated startle response. [onlinelibrary.wiley.com]

Over time, severe neurological dysfunction emerges as progressive microcephaly, spasticity, dystonia, and cognitive impairment. [onlinelibrary.wiley.com]