Presentation
A 28-year-old male farmer presented to our emergency service with bilateral painful visual loss for the past 7 days that occurred suddenly after alcohol consumption. [ncbi.nlm.nih.gov]
Peak protection was present at 15.1-20.0 units/week (0.69, 0.53 to 0.89) and >4.5 units on the heaviest day (0.68, 0.57 to 0.82). [bmj.com]
Entire Body System
- Falling
Overall, men were more likely to fall in the moderate and high-risk behavioural profiles and show higher daily alcohol consumption patterns compared to women. [ncbi.nlm.nih.gov]
If you have diabetes, drinking alcohol may cause your blood sugar to either rise or fall. Plus, alcohol has a lot of calories. If you drink, do it occasionally and only when your diabetes and blood sugar level are well-controlled. [webmd.com]
To find out where you fall on the problem-drinking spectrum, read on for these surprising signs you may be drinking too much. John Lund/Getty Images You become a daredevil. [prevention.com]
It may also increase your risk of injury through road trauma, violence, falls and accidental death. What is a standard drink? A standard drink contains 10 grams of pure alcohol. [alcohol.gov.au]
And it's worrying, because older adults at are a high risk of death, injury or disease connected to alcohol use — from falls, for instance, or from adverse interactions between drugs and drinking. [npr.org]
- Disability
High-risk drinkers reported significantly lower pain severity/interference compared to the other groups; high-risk drinkers were also less likely to be on disability compared to other groups. [ncbi.nlm.nih.gov]
Alcohol also contributes to death and disability through accidents and injuries, assault, violence, homicide and suicide. This indicator is measured in litres per capita (people aged 15 years and older). [data.oecd.org]
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- Fatigue
Too much endorphin release can cause depression, lower sex drive, low testosterone, infertility, and extreme fatigue, among other complications. Liver My oh my, how the liver takes a hit when you get drunk. [quitalcohol.com]
For the first six months of 2018, I tried to stick to eating a ketogenic diet (this is a good guide to keto), which worked well to increase alertness and reduce fatigue throughout the day, but was hard to keep to. [businessinsider.de]
Fatigue but decreased ability to sleep. Decreased ability to concentrate. Mood changes (depression, anxiety, etc.) Sweating. Increased blood pressure. Rapid pulse. [drugabuse.com]
- Swelling
Of these, the urinary excretion of the osmolyte sorbitol proved to be novel, and suggests hepatocyte swelling due to ethanol influx following acute alcohol consumption. [ncbi.nlm.nih.gov]
"High risk" drinking has increased on pace with alcohol abuse, swelling from 9.7 percent of the population in 2002-2003 to 13.7 percent of the population in 2012-2013. [cnn.com]
Gastrointestinal
- Nausea
Alcohol can cause flushing, nausea, increased heart rate, and slurred speech. These may be confused with or mask the symptoms of low blood sugar. [webmd.com]
If you think you might be dependent on alcohol, or if you have physical withdrawal symptoms (e.g. shaking, sweating, nausea before you have your first drink of the day) then you should seek medical advice from your GP before you stop drinking. [drinkaware.co.uk]
Nausea. Vomiting. Dizziness/vertigo. Increased thirst. Redness of the eyes. Sensitivity to light and sound. Fatigue but decreased ability to sleep. Decreased ability to concentrate. Mood changes (depression, anxiety, etc.) Sweating. [drugabuse.com]
The sorts of withdrawal symptoms that suggest you may need medication include: anxiety after waking sweating and tremors nausea or retching in the morning vomiting hallucinations seizures or fits Staying healthy and in control Cutting down or stopping [nhs.uk]
Mixing alcohol with certain medications can cause nausea, headaches, drowsiness, fainting, a loss of coordination, internal bleeding, heart problems, and difficulties in breathing. Alcohol can also make a medication less effective. [rethinkingdrinking.niaaa.nih.gov]
- Vomiting
Depending on how much is taken and the physical condition of the individual, alcohol can cause: Slurred speech Drowsiness Vomiting Diarrhea Upset stomach Headaches Breathing difficulties Distorted vision and hearing Impaired judgment Decreased perception [drugfreeworld.org]
The person’s perception and judgement may be significantly impaired. 0.25 percent: This results in impairment of all mental, sensory, and physical capabilities so great that the person is at risk of choking on vomit, falling, or getting into a serious [americanaddictioncenters.org]
Ensure they lie on their side so they won't choke on their own vomit. Lastly, don't wait for all the symptoms of alcohol poisoning to manifest, and don't hesitate to call for emergency medical help immediately. [articles.mercola.com]
Aspiration pneumonia is a condition that occurs when people, sleeping off a very heavy night's drinking, suffocate when their own vomit is inhaled into their lungs. [medbroadcast.com]
Upon entering her bedroom, I saw that she was lying face down in vomit while breathing heavily. It was obvious that she needed hospitalization. [amsterdamnews.com]
- Abdominal Pain
A 43-year-old man presented with loose stools, abdominal pain and a weight loss of 15 kg. Investigations revealed a pancreatic insufficiency and an enteropathy with villous atrophy. Coeliaki was suspected. [ncbi.nlm.nih.gov]
Cardiovascular
- Palpitations
Symptoms of hypoglycemia are similar to intoxication, but unlike inebriation, it can cause heart palpitations. [livestrong.com]
Psychiatrical
- Suggestibility
We found main effects of both independent variables on judgments of victim responsibility, but no interaction, suggesting that the effects of alcohol and force are additive rather than interactive. [ncbi.nlm.nih.gov]
Experts said the findings, published in the journal Diabetologia, should not be seen as a green light to drink more than existing NHS guidelines suggest. [theguardian.com]
This relationship was strongest for beer, suggesting a possible influence for the type of alcohol ingested [ 31 ]. [doi.org]
"While this might suggest binge-drinking was harmful, the study did not find this, perhaps because the incidence of reported binge drinking was low." [independent.co.uk]
Neurologic
- Insomnia
Increased risk drinking is defined as 180-400 g/week for men and 120-280 g/week for women, with effects of less energy, depression/stress, insomnia, impotence, risk of injury, high blood pressure. [iard.org]
- Vertigo
Dizziness/vertigo. Increased thirst. Redness of the eyes. Sensitivity to light and sound. Fatigue but decreased ability to sleep. Decreased ability to concentrate. Mood changes (depression, anxiety, etc.) Sweating. Increased blood pressure. [drugabuse.com]
Workup
Reduction Aldehydes or ketones are reduced with sodium borohydride or lithium aluminium hydride (after an acidic workup). Another reduction by aluminiumisopropylates is the Meerwein-Ponndorf-Verley reduction. [en.wikipedia.org]
Treatment
The economic impact of alcohol reduction using nalmefene treatment was not evaluated. METHOD: The model simulates patient-level alcohol consumption over a 5-year time horizon across different treatment cohorts. [ncbi.nlm.nih.gov]
Center for Substance Abuse Treatment. Detoxification and Substance Abuse Treatment. Treatment Improvement Protocol (TIP) Series, No. 45. HHS Publication No. (SMA) 15-4131. Rockville, MD: Center for Substance Abuse Treatment, 2006. [drugabuse.com]
Prognosis
Conclusion: In total, 20% of people diagnosed with cancer were hazardous drinkers, despite the known relationship between alcohol use and a worse prognosis of the disease and an increased likelihood of recurrence. [ncbi.nlm.nih.gov]
Etiology
Males with AIP had lower total amount of spirits and lower proportion of binge drinking than those with AUD, suggesting the idiosyncratic etiology of AIP. [ncbi.nlm.nih.gov]
In recent years, increasing attention has been paid to the role of alcohol in the etiology of type 2 diabetes. A number of studies have investigated this issue, but with contradictory results. [care.diabetesjournals.org]
Second, as the etiology of AF remains incompletely understood in the majority of patients, identifying mechanisms of known risk factors might help to reveal new therapeutic targets. [jaha.ahajournals.org]
Epidemiology
KEYWORDS: DNA methylation; PACE consortium; alcohol; cord blood; epidemiology; epigenetics; meta-analysis; pregnancy [ncbi.nlm.nih.gov]
epidemiology 32, Marten H Hofker, professor of molecular genetics 76, S Goya Wannamethee, professor of epidemiology 77, Peter H Whincup, professor of cardiovascular epidemiology 78, Richard Morris, professor of medical statistics and epidemiology 77, [bmj.com]
Pathophysiology
Abstract Metabolomics studies of disease conditions related to chronic alcohol consumption provide compelling evidence of several perturbed metabolic pathways underlying the pathophysiology of alcoholism. [ncbi.nlm.nih.gov]
Our selection of biomarkers for study was guided by links to cardiovascular pathophysiology. [bmj.com]
Prevention
RESULTS: Approximately 14% of men and 12% of women reported alcohol consumption exceeding recommendations for cancer prevention. [ncbi.nlm.nih.gov]
American journal of preventive medicine / American College of Preventive Medicine ; Association of Teachers of Preventive Medicine New York, NY : Elsevier 1.1985 - Titel American journal of preventive medicine / American College of Preventive Medicine [zdb-katalog.de]