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Alcoholic Cerebellar Degeneration


  • Presentation on theme: "Alcoholic Cerebellar Degeneration 907-1. Clinical Syndrome The clinical syndrome of alcoholic cerebellar degeneration is remarkably stereotyped. The usual.[slideplayer.com]
  • Occasionally patients will present with late-onset forms of this disease.[neuroweb.us]
  • Haemorrhage presents with occipital headache, vertigo, vomiting and altered consciousness.[patient.info]
  • Family history of similar complains was present. MRI sagittal T1 and T2w images show: Marked atrophy of the cerebellum.[neuroradiologycases.com]
  • The predominant motor feature can change with time and patients with cerebellar ataxia can develop increasingly severe parkinsonian features which dominate the clinical presentation.[orpha.net]
  • Since these patients are prone to falls, they frequently land up in the ERs with head injuries (intracerebral hematoma, epidural and subdural hematoma). See my post on neurotrauma ).[braindiseases.wordpress.com]
  • This means less brisk and slower in rise and fall. However, similar to reduced tone, this sign is very subjective and often reflexes appear to be normal in cerebellar disease.[geekymedics.com]
  • He is 53 and has to apply for disability due to mutiple falls and being a liability to his employer Hello Harry, you wrote: There are many different causes of ataxia with excessive alcohol use unfortunately being reasonably common. *******************[healthunlocked.com]
  • From a safety viewpoint, Fein said his team would like to study the elderly, who are at most risk for health consequences after a fall. Pass it on : Years after sobering up, heavy drinkers may still suffer balance problems.[livescience.com]
  • Clinical the child presents with hydrocephalus, cerebellar signs such as ataxia and nystagmus and falls. There may be spread to spinal cord.[medexam.net]
Difficulty Walking
  • The first indication generally is difficulty walking (gait ataxia). The condition typically progresses to the arms and trunk. Muscles weaken and waste away over time, causing deformities, particularly in your feet, lower legs and hands.[mayoclinic.org]
  • Symptoms may include: problems with learning and memory, including amnesia forgetfulness poor coordination difficulty walking Alcoholic neuropathy This condition occurs when the peripheral nerves are damaged by too much alcohol.[healthline.com]
  • There were no laboratory or physiological markers for ataxia, including hemoglobin A1a b, red blood cell transketolase, liver function enzymes, and measures of reaction time and hand-eye coordination.[ncbi.nlm.nih.gov]
  • Dysarthria and upper limb ataxia are rare. 4 Pathophysiology Ataxia may develop during periods of abstinence.[slideplayer.com]
  • Kymberly Gyure Differential diagnosis Age related cerebellar atrophy (generally milder) Other causes of cerebellar vermal atrophy: phenytoin use, heavy metal poisoning or a subset of the spinocerebellar ataxias Advertisement[pathologyoutlines.com]
  • Alcoholic cerebellar degeneration (ACD) is a disorder resulting from severe chronic alcoholism and malnutrition and is characterized by cognitive disturbances, ataxia of gait, and truncal instability, with generally preserved coordination of the upper[ncbi.nlm.nih.gov]
  • Cerebellar dysfunction evaluation used the Brief Ataxia Rating Scale (BARS). Association between alcohol intake and the BARS was assessed in generalized linear models adjusted for relevant confounders.[ncbi.nlm.nih.gov]
Cerebellar Ataxia
  • I have got Cerebellar Ataxia now diagnosed in 2008/9.[healthunlocked.com]
  • Cerebellar ataxia; Ataxia - acute cerebellar; Cerebellitis; Post-varicella acute cerebellar ataxia; PVACA Mink JW. Movement disorders. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed.[medlineplus.gov]
  • ataxia in diseases classified elsewhere Cerebellar ataxia associated with another disorder; Secondary cerebellar ataxia; underlying disease, such as:; celiac disease (with gluten ataxia) (K90.0); cerebellar ataxia (in) neoplastic disease (paraneoplastic[icd10data.com]
  • Cerebellar Ataxia Basics Cerebellar ataxia is a symptom, not a distinct disorder.[promises.com]
  • Identical cerebellar degeneration has been observed in non-alcoholic patients with severe malnutrition. 5 Eye Movements Square Wave Jerks Horizontal Saccadic Hypermetria Horizontal Gaze Evoked Nystagmus Saccadic Pursuit 6 Deficits Caused by Lesions of[slideplayer.com]
  • […] cerebellar vermis Pathophysiology Cerebellar changes may be related in part to thiamine deficiency Alterations in GABA receptor dependent neurotransmission have also been proposed as a pathogenic mechanism Clinical features Truncal ataxia Unsteady gait Nystagmus[pathologyoutlines.com]
  • Nystagmus (quick, small actions of the eyes.) Is there a known treatment for Alcoholic Cerebellar Degeneration? Typically, there is no recognized remedy for this condition.[hncmag.com]
  • However, it can be characterised further by noting the following: The direction of the nystagmus. Most nystagmus has a fast phase and a slow phase (termed “jerk” nystagmus).[geekymedics.com]
  • Clinical the child presents with hydrocephalus, cerebellar signs such as ataxia and nystagmus and falls. There may be spread to spinal cord.[medexam.net]
  • Thirty-two patients (49%) had clear clinical signs of the disease such as broad-based staggering gait, impaired heel-to-toe walking, terminal oscillations in heel-knee test and slow (3/s) leg tremor.[ncbi.nlm.nih.gov]
  • Tremor Cerebellar lesions can produce unilateral or bilateral intention tremor, or a truncal tremor. Nausea and vomiting Cerebellar lesions can produce nausea and/or vomiting.[patient.info]
  • Patients’ may have an intention tremor – a terminal tremor that occurs as the finger approaches the target. Be careful not to mistake an action tremor (which occurs throughout the movement) for an intention tremor.[geekymedics.com]
  • Rhythmic, alternating, oscillatory movement of a limb as it approaches a target (intention tremor) or of proximal musculature when fixed posture or weight bearing is attempted (postural tremor) Etiology Congenital malformations Such malformations are[merckmanuals.com]
  • Dysarthria and upper limb ataxia are rare. 4 Pathophysiology Ataxia may develop during periods of abstinence.[slideplayer.com]
  • Inherited periodic ataxia, dysarthria, nystagmus and vertigo.[patient.info]
  • In general, limb ataxia, dysarthria, and nystagmus were related to hemispheral but not to vermal atrophy. 1981 by the American Academy of Neurology AAN Members: Sign in with your AAN member credentials (e-mail or 6-digit Member ID number) Non-AAN Member[neurology.org]
  • In Friedreich ataxia, gait unsteadiness begins between ages 5 and 15; it is followed by upper-extremity ataxia, dysarthria, and paresis, particularly of the lower extremities. Mental function often declines. Tremor, if present, is slight.[merckmanuals.com]
  • Common symptoms of ataxia include: Clumsy speech pattern ( dysarthria ) Repetitive eye movements ( nystagmus ) Uncoordinated eye movements Walking problems (unsteady gait) The health care provider will ask if the person has recently been sick and will[medlineplus.gov]


  • Alcohol-induced ataxia can be diagnosed in patients with a history of heavy drinking if the workup does not reveal another possible cause for the gait disturbance.[mdedge.com]
  • […] include amyotrophic lateral sclerosis , beriberi , Charcot-Marie-Tooth disease , diabetic lumbosacral plexopathy , Guillain Barre Syndrome, diabetic neuropathy , mononeuritis multiplex and post-polio syndrome . [3] To clarify the diagnosis, medical workup[en.wikipedia.org]
MRI Shows Cerebellar Atrophy
  • MRI shows cerebellar atrophy. Lifespan is normal. The age of onset is in the 4 th to 5 th decade of life.[neuroweb.us]
Foam Cell
  • The diagnosis is made by elevated urinary sialyloligosaccharides, vacuolated white cells and foam cells with white cell a -N-neuraminidase deficiency. The mutated sialidase gene is located on chromosome 6p21.3.[neuroweb.us]


  • You will find more than 700,000 Americans every year going through treatment for alcoholic .[hncmag.com]
  • Treatment consists of improved nutrition, abstinence from alcohol, and physical therapy. See also alcoholism .[medical-dictionary.thefreedictionary.com]
  • Blueprints Neurology, Second Edition delivers everything you need for your neurology rotation in the classic, easy-to-follow Blueprints format, now including: Revised and updated diagnostic and treatment information throughout Updated and expanded sections[books.google.com]
  • Medina, seeks to underline the magnitude of neurologic diseases related to malnutrition and the importance of early detection and opportune treatment.[books.google.com]
  • Treatment is symtom specific and variable. ...Read more[healthtap.com]


  • Prognosis is poor with a median survival of 6-9 years. The documents contained in this web site are presented for information purposes only.[orpha.net]
  • […] naltrexone reduces cravings (opioid antagonist) gabapentin topiramate Psychotherapy Alcoholics Anonymous (AA) and other peer support groups - seem to be the most effective by some sources motivational interviewing to encourage entrance into AA rehabilitation Prognosis[medbullets.com]
  • Prognosis The prognosis depends on the motivation of the patient to stop drinking alcohol, and the extent of organ damage, which varies with each case.[encyclopedia.com]
  • These evaluations may demonstrate that the patient requires rehabilitation following discharge, and, depending upon the prognosis, even long-term placement in a skilled nursing facility. F. Prognosis and Patient Counseling.[clinicaladvisor.com]
  • Our experience suggests that patients with alcohol use disorder with cerebellar ataxia could have a good prognosis for ambulation.[mdedge.com]


  • In recognition of the multifactorial etiology of alcohol-related brain pathology, the influence and role of hepatic, endocrine, and nutritional factors are also examined. The second section addresses clinical syndromes and dis orders.[books.google.com]
  • Etiology Etiology of MSA is unknown but presence of cytoplasmic aggregates of α-synuclein, primarily in oligodendroglia, in combination with neurodegeneration in striatonigral and olivopontocerebellar structures are the pathological hallmark features.[orpha.net]
  • […] hesitate at the beginning of a word or syllable Tremor Rhythmic, alternating, oscillatory movement of a limb as it approaches a target (intention tremor) or of proximal musculature when fixed posture or weight bearing is attempted (postural tremor) Etiology[merckmanuals.com]
  • All possible etiologies should be considered when the clinical course is not firmly established.[practicalneurology.com]
  • Charcot arthropathy, also known as neuroarthropathy, is most commonly associated with diabetes mellitus, despite a variety of other etiologies. It has also been associated with chronic alcoholism in nondiabetic individuals.[emedicine.medscape.com]


  • Neurologic Consequences of Malnutrition begins with an overview of the epidemiology and incidence of malnutrition and neurologic disorders.[books.google.com]
  • […] features Characterized clinically by ataxia and gait disturbances in the setting of chronic alcoholism Pathologic features include cerebellar atrophy affecting the anterior / superior vermis with a loss of Purkinje cells and corresponding Bergmann gliosis Epidemiology[pathologyoutlines.com]
  • Summary Epidemiology Prevalence ranges from 1/50,000-1/20,000. MSA-parkinsonian type (MSA-p) predominates in the Western Hemisphere and MSA-cerebellar type (MSA-c) predominates in the Eastern Hemisphere. Genders are equally distributed.[orpha.net]
  • "Alcoholic Polyneuropathy: A Clinical and Epidemiological Study". Oxford Journals . 36 (5): 393–400. doi : 10.1093/alcalc/36.5.393 . a b c d Cornblath, David R.; Jerry R. Mendell; Kissel, John T. (2001).[en.wikipedia.org]
  • Epidemiological data are shown in Table 1 . The age of the alcoholics ranged from 26 to 64 years (mean 47 1 years). The mean reported a daily intake of ethanol was 177 8 g (range 100–310 g) over a period of 27 1 years (range 8–44).[academic.oup.com]
Sex distribution
Age distribution


  • Minagar has significant interest in pathophysiology and neuroimaging features of the inflammatory disease of human central nervous system, in general, and multiple sclerosis, in particular.[books.google.com]
  • Dysarthria and upper limb ataxia are rare. 4 Pathophysiology Ataxia may develop during periods of abstinence.[slideplayer.com]
  • […] features include cerebellar atrophy affecting the anterior / superior vermis with a loss of Purkinje cells and corresponding Bergmann gliosis Epidemiology Occurs in approximately 10% of alcoholic patients Sites Anterior / superior cerebellar vermis Pathophysiology[pathologyoutlines.com]
  • The pathophysiology of alcoholic polyneuropathy is an area of current research.[en.wikipedia.org]
  • The pathophysiology of cerebellar ataxias is as diverse as the various neurological and systemic diseases affecting the cerebellum.[practicalneurology.com]


  • This study confirmed the frequency of asymptomatic cerebellar degeneration in alcoholics, suggesting that early intervention in alcoholism in the subclinical phase is important to prevent the development of cerebellar symptoms.[ncbi.nlm.nih.gov]
  • […] laboratory abnormalities Radiology description Atrophy of the anterior / superior vermis Radiology images Images hosted on other servers: Marked diffuse cerebellar atrophy Prognostic factors Cerebellar damage remains even after abstinence from ethanol Prevention[pathologyoutlines.com]
  • , Complications Complications ED Management Inpatient Management Chronic Management Prevent further ethanol intake Prevent individual from harming self or others Sedate patient if agitated or aggressive Order urine toxicity screen Stabilize vitals if[medbullets.com]
  • Steps you can take for prevention include: educating yourself on how much alcohol is considered too much limiting your daily alcohol intake to one drink or less for women, and two drinks or less for men Ultimately, the best way to prevent alcohol-related[healthline.com]
  • The goal should be to maintain the highest possible level of autonomy, to cope with physical disability and to prevent secondary complications. With progression of the disease many patients will require walking aids and a wheelchair.[ataxia-study-group.net]

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