Edit concept Question Editor Create issue ticket

Alcoholic Cerebellar Degeneration


Presentation

  • Presentation on theme: "Alcoholic Cerebellar Degeneration 907-1. Clinical Syndrome The clinical syndrome of alcoholic cerebellar degeneration is remarkably stereotyped. The usual.[slideplayer.com]
  • It is our ambition to present a complete survey of all medical phenomena named for a person, with a biography of that person. Disclaimer: Whonamedit? does not give medical advice.[whonamedit.com]
  • Haemorrhage presents with occipital headache, vertigo, vomiting and altered consciousness.[patient.info]
  • Family history of similar complains was present. MRI sagittal T1 and T2w images show: Marked atrophy of the cerebellum.[neuroradiologycases.com]
  • The predominant motor feature can change with time and patients with cerebellar ataxia can develop increasingly severe parkinsonian features which dominate the clinical presentation.[orpha.net]
Falling
  • Since these patients are prone to falls, they frequently land up in the ERs with head injuries (intracerebral hematoma, epidural and subdural hematoma). See my post on neurotrauma ).[braindiseases.wordpress.com]
  • This means less brisk and slower in rise and fall. However, similar to reduced tone, this sign is very subjective and often reflexes appear to be normal in cerebellar disease.[geekymedics.com]
  • He is 53 and has to apply for disability due to mutiple falls and being a liability to his employer Hello Harry, you wrote: There are many different causes of ataxia with excessive alcohol use unfortunately being reasonably common. *******************[healthunlocked.com]
  • From a safety viewpoint, Fein said his team would like to study the elderly, who are at most risk for health consequences after a fall. Pass it on : Years after sobering up, heavy drinkers may still suffer balance problems.[livescience.com]
  • Clinical the child presents with hydrocephalus, cerebellar signs such as ataxia and nystagmus and falls. There may be spread to spinal cord.[medexam.net]
Asymptomatic
  • The distribution of severely affected regions was more restricted in the asymptomatic cases than in the symptomatic cases.[ncbi.nlm.nih.gov]
  • Symptomatic cases (cases 1-3) showed more severe and widespread change than asymptomatic cases (cases 4-6).[ncbi.nlm.nih.gov]
  • Pathophysiology Cerebellar changes may be related in part to thiamine deficiency Alterations in GABA receptor dependent neurotransmission have also been proposed as a pathogenic mechanism Clinical features Truncal ataxia Unsteady gait Nystagmus May be clinically asymptomatic[pathologyoutlines.com]
  • Some cases are seemingly asymptomatic and may only be recognized on careful examination.[en.wikipedia.org]
Difficulty Walking
  • Symptoms may include: problems with learning and memory, including amnesia forgetfulness poor coordination difficulty walking Alcoholic neuropathy This condition occurs when the peripheral nerves are damaged by too much alcohol.[healthline.com]
Suggestibility
  • The finding that ataxic alcoholics do not have higher alcohol consumption than nonataxic alcoholics suggests that alcoholic cerebellar degeneration is not a dose-dependent phenomenon, and that alcoholics with cerebellar degeneration may have an idiosyncratic[ncbi.nlm.nih.gov]
  • CONCLUSIONS: The findings suggest that these 2 groups have similar cognitive deficits but that upper extremity motor functions are more significantly impaired in the ACD group and that quantitative tasks of motor function reveal these impairments.[ncbi.nlm.nih.gov]
  • This study confirmed the frequency of asymptomatic cerebellar degeneration in alcoholics, suggesting that early intervention in alcoholism in the subclinical phase is important to prevent the development of cerebellar symptoms.[ncbi.nlm.nih.gov]
  • It will be noted that evidence accrued from recent research suggests that neurologic disturbances may actually antedate the onset of drinking in some alcoholics.[books.google.com]
  • These findings suggest that in ACD, severe lesions successively develop: (i) in the anterior superior vermis; (ii) anterior superior hemisphere; (iii) anterior inferior hemisphere; and (iv) anterior inferior vermis.[ncbi.nlm.nih.gov]
Ataxia
  • There were no laboratory or physiological markers for ataxia, including hemoglobin A1a b, red blood cell transketolase, liver function enzymes, and measures of reaction time and hand-eye coordination.[ncbi.nlm.nih.gov]
  • Dysarthria and upper limb ataxia are rare. 4 Pathophysiology Ataxia may develop during periods of abstinence.[slideplayer.com]
  • Cerebellar dysfunction evaluation used the Brief Ataxia Rating Scale (BARS). Association between alcohol intake and the BARS was assessed in generalized linear models adjusted for relevant confounders.[ncbi.nlm.nih.gov]
  • BACKGROUND: Alcoholic cerebellar degeneration (ACD) is a disorder resulting from severe chronic alcoholism and malnutrition and is characterized by cognitive disturbances, ataxia of gait, and truncal instability, with generally preserved coordination[ncbi.nlm.nih.gov]
  • Kymberly Gyure Differential diagnosis Age related cerebellar atrophy (generally milder) Other causes of cerebellar vermal atrophy: phenytoin use, heavy metal poisoning or a subset of the spinocerebellar ataxias Advertisement[pathologyoutlines.com]
Cerebellar Ataxia
  • A form of hereditary cerebellar ataxia. American Journal of Human Genetics, Chicagio, 1950, 2: 1-29. What is an eponym? An eponym is a word derived from the name of a person, whether real or fictional.[whonamedit.com]
  • I have got Cerebellar Ataxia now diagnosed in 2008/9.[healthunlocked.com]
  • Cerebellar ataxia; Ataxia - acute cerebellar; Cerebellitis; Post-varicella acute cerebellar ataxia; PVACA Mink JW. Movement disorders. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed.[medlineplus.gov]
  • ataxia in diseases classified elsewhere Cerebellar ataxia associated with another disorder; Secondary cerebellar ataxia; underlying disease, such as:; celiac disease (with gluten ataxia) (K90.0); cerebellar ataxia (in) neoplastic disease (paraneoplastic[icd10data.com]
Tremor
  • Tremor Cerebellar lesions can produce unilateral or bilateral intention tremor, or a truncal tremor. Nausea and vomiting Cerebellar lesions can produce nausea and/or vomiting.[patient.info]
  • Classic pill-rolling rest tremor is uncommon. MSA-c is a form of MSA with predominant cerebellar features such as gait and limb ataxia, oculomotor dysfunction and dysarthria.[orpha.net]
  • Patients’ may have an intention tremor – a terminal tremor that occurs as the finger approaches the target. Be careful not to mistake an action tremor (which occurs throughout the movement) for an intention tremor.[geekymedics.com]
  • Rhythmic, alternating, oscillatory movement of a limb as it approaches a target (intention tremor) or of proximal musculature when fixed posture or weight bearing is attempted (postural tremor) Such malformations are almost always sporadic, often occurring[merckmanuals.com]
Nystagmus
  • Identical cerebellar degeneration has been observed in non-alcoholic patients with severe malnutrition. 5 Eye Movements Square Wave Jerks Horizontal Saccadic Hypermetria Horizontal Gaze Evoked Nystagmus Saccadic Pursuit 6 Deficits Caused by Lesions of[slideplayer.com]
  • […] cerebellar vermis Pathophysiology Cerebellar changes may be related in part to thiamine deficiency Alterations in GABA receptor dependent neurotransmission have also been proposed as a pathogenic mechanism Clinical features Truncal ataxia Unsteady gait Nystagmus[pathologyoutlines.com]
  • Nystagmus (quick, small actions of the eyes.) Is there a known treatment for Alcoholic Cerebellar Degeneration? Typically, there is no recognized remedy for this condition.[hncmag.com]
  • However, it can be characterised further by noting the following: The direction of the nystagmus. Most nystagmus has a fast phase and a slow phase (termed “jerk” nystagmus).[geekymedics.com]
  • Inherited periodic ataxia, dysarthria, nystagmus and vertigo.[patient.info]
Dysarthria
  • Dysarthria and upper limb ataxia are rare. 4 Pathophysiology Ataxia may develop during periods of abstinence.[slideplayer.com]
  • Inherited periodic ataxia, dysarthria, nystagmus and vertigo.[patient.info]
  • In general, limb ataxia, dysarthria, and nystagmus were related to hemispheral but not to vermal atrophy. 1981 by the American Academy of Neurology AAN Members: Sign in with your AAN member credentials (e-mail or 6-digit Member ID number) Non-AAN Member[neurology.org]
  • In Friedreich ataxia, gait unsteadiness begins between ages 5 and 15; it is followed by upper-extremity ataxia, dysarthria, and paresis, particularly of the lower extremities. Mental function often declines. Tremor, if present, is slight.[merckmanuals.com]
  • Common symptoms of ataxia include: Clumsy speech pattern ( dysarthria ) Repetitive eye movements ( nystagmus ) Uncoordinated eye movements Walking problems (unsteady gait) The health care provider will ask if the person has recently been sick and will[medlineplus.gov]

Workup

  • Alcohol-induced ataxia can be diagnosed in patients with a history of heavy drinking if the workup does not reveal another possible cause for the gait disturbance.[mdedge.com]
  • […] polyneuropathy include amyotrophic lateral sclerosis, beriberi, Charcot-Marie-Tooth disease, diabetic lumbosacral plexopathy, Guillain Barre Syndrome, diabetic neuropathy, mononeuritis multiplex and post-polio syndrome. [3] To clarify the diagnosis, medical workup[en.wikipedia.org]
Gliosis
  • Kymberly Gyure Microscopic (histologic) description Loss of cerebellar Purkinje cells with corresponding Bergmann gliosis Narrowing of the molecular layer and a reduced number of granular cells may also be seen Microscopic (histologic) images Images hosted[pathologyoutlines.com]

Treatment

  • You will find more than 700,000 Americans every year going through treatment for alcoholic.[hncmag.com]
  • Medina, seeks to underline the magnitude of neurologic diseases related to malnutrition and the importance of early detection and opportune treatment.[books.google.com]
  • Treatment is symtom specific and variable. ...Read more[healthtap.com]
  • […] description Atrophy of the anterior / superior vermis Radiology images Images hosted on other servers: Marked diffuse cerebellar atrophy Prognostic factors Cerebellar damage remains even after abstinence from ethanol Prevention of cerebellar damage by treatment[pathologyoutlines.com]
  • Alcohol and other drug (AOD) treatments may need to be modified for a person with an ARBI.[betterhealth.vic.gov.au]

Prognosis

  • Prognosis is poor with a median survival of 6-9 years. The documents contained in this web site are presented for information purposes only.[orpha.net]
  • […] naltrexone reduces cravings (opioid antagonist) gabapentin topiramate Psychotherapy Alcoholics Anonymous (AA) and other peer support groups - seem to be the most effective by some sources motivational interviewing to encourage entrance into AA rehabilitation Prognosis[medbullets.com]
  • Prognosis The prognosis depends on the motivation of the patient to stop drinking alcohol, and the extent of organ damage, which varies with each case.[encyclopedia.com]
  • These evaluations may demonstrate that the patient requires rehabilitation following discharge, and, depending upon the prognosis, even long-term placement in a skilled nursing facility. F. Prognosis and Patient Counseling.[clinicaladvisor.com]
  • Our experience suggests that patients with alcohol use disorder with cerebellar ataxia could have a good prognosis for ambulation.[mdedge.com]

Etiology

  • In recognition of the multifactorial etiology of alcohol-related brain pathology, the influence and role of hepatic, endocrine, and nutritional factors are also examined. The second section addresses clinical syndromes and dis orders.[books.google.com]
  • Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10coded.com]
  • Etiology Etiology of MSA is unknown but presence of cytoplasmic aggregates of α-synuclein, primarily in oligodendroglia, in combination with neurodegeneration in striatonigral and olivopontocerebellar structures are the pathological hallmark features.[orpha.net]
  • Charcot arthropathy, also known as neuroarthropathy, is most commonly associated with diabetes mellitus, despite a variety of other etiologies. It has also been associated with chronic alcoholism in nondiabetic individuals.[emedicine.medscape.com]
  • Imaging is not necessary to confirm the diagnosis but can help confirm cerebellar atrophy and rule out other etiologies of cerebellar disease.[clinicaladvisor.com]

Epidemiology

  • Neurologic Consequences of Malnutrition begins with an overview of the epidemiology and incidence of malnutrition and neurologic disorders.[books.google.com]
  • […] features Characterized clinically by ataxia and gait disturbances in the setting of chronic alcoholism Pathologic features include cerebellar atrophy affecting the anterior / superior vermis with a loss of Purkinje cells and corresponding Bergmann gliosis Epidemiology[pathologyoutlines.com]
  • Summary Epidemiology Prevalence ranges from 1/50,000-1/20,000. MSA-parkinsonian type (MSA-p) predominates in the Western Hemisphere and MSA-cerebellar type (MSA-c) predominates in the Eastern Hemisphere. Genders are equally distributed.[orpha.net]
  • Effects of the disease range from mild discomfort to severe disability. [5] Epidemiology [ edit ] Total recorded alcohol consumption per capita of individuals 15 years or older, in liters of pure alcohol.[en.wikipedia.org]
  • Gluten ataxia in perspective: epidemiology, genetic susceptibility and clinical characteristics. Brain . 2003;126:685-91. Hou J-G, Jankovic J. Movement disorders in Friedreich's ataxia. J Neurol Sci. 2003;206:59-64. Jankovic J, Tolosa E, eds.[bcm.edu]
Sex distribution
Age distribution

Pathophysiology

  • Dysarthria and upper limb ataxia are rare. 4 Pathophysiology Ataxia may develop during periods of abstinence.[slideplayer.com]
  • […] features include cerebellar atrophy affecting the anterior / superior vermis with a loss of Purkinje cells and corresponding Bergmann gliosis Epidemiology Occurs in approximately 10% of alcoholic patients Sites Anterior / superior cerebellar vermis Pathophysiology[pathologyoutlines.com]
  • The pathophysiology of alcoholic polyneuropathy is an area of current research.[en.wikipedia.org]

Prevention

  • This study confirmed the frequency of asymptomatic cerebellar degeneration in alcoholics, suggesting that early intervention in alcoholism in the subclinical phase is important to prevent the development of cerebellar symptoms.[ncbi.nlm.nih.gov]
  • […] laboratory abnormalities Radiology description Atrophy of the anterior / superior vermis Radiology images Images hosted on other servers: Marked diffuse cerebellar atrophy Prognostic factors Cerebellar damage remains even after abstinence from ethanol Prevention[pathologyoutlines.com]
  • , Complications Complications ED Management Inpatient Management Chronic Management Prevent further ethanol intake Prevent individual from harming self or others Sedate patient if agitated or aggressive Order urine toxicity screen Stabilize vitals if[medbullets.com]
  • Steps you can take for prevention include: educating yourself on how much alcohol is considered too much limiting your daily alcohol intake to one drink or less for women, and two drinks or less for men Ultimately, the best way to prevent alcohol-related[healthline.com]
  • The goal should be to maintain the highest possible level of autonomy, to cope with physical disability and to prevent secondary complications. With progression of the disease many patients will require walking aids and a wheelchair.[ataxia-study-group.net]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!