Alcoholic hepatitis is a condition characterized by inflammation of the liver due to excessive alcohol consumption . Individuals who consume moderate to excess alcohol fall easy prey to this liver disease. It is necessary to avoid alcohol consumption once the disease has developed; failure to do so can cause serious life threatening complications. Malnutrition and malabsorption of nutrients contribute towards development of alcoholic hepatitis amongst the drinker’s population.
Excessive alcohol consumption causes alcoholic hepatitis. When the alcohol is broken down by the liver, it produces various toxic compounds that cause scarring of the liver tissues. This in turn causes the liver to swell giving rise to alcoholic hepatitis. In addition, other factors are also known to participate in causation of this liver disease. These include:
In the US, alcoholic hepatitis is known to affect about 2 million individuals. Women are more affected by this condition as compared to male, essentially because of the difference in the way body breaks down alcohol in both sexes. The incidence of alcoholic hepatitis strikes about 25 to 30% of the total population.
The exact physiology behind the association of alcohol and liver disease is not completely understood. With the little information that is available; it can be postulated that the byproduct of alcohol breakdown produces toxic compounds such as acetaldehyde that is injurious to the liver. The toxicogenic components cause irreversible scaring of the liver tissues leading to inflammation of the organ. This further leads to destruction of the liver cells and gradually the healthy cells of the liver are replaced by knots or web-like scars. This eventually causes loss of liver functioning paving way for development of liver cirrhosis.
The prognosis of the disease would depend on extent of damage to the liver and the severity of the symptoms. If the disease has been diagnosed in the initial stages and the individual stops intake of alcohol, then with proper treatment plan the result would certainly be favorable.
However, if individuals continue to abuse their body with alcohol intake then recovery process would slow down and individuals will gradually develop end stage liver disease. In such situations, the toxins would no longer be filtered from the body causing coma and finally leading to death. Severe alcoholic hepatitis carries a general mortality rate of up to 66% . The Glasgow Alcoholic Hepatitis Scoring (GAHS) is currently being used as a prognostic tool which deems to be up to 81% accurate in predicting a 28 day outcome .
Mild cases of alcoholic hepatitis usually are asymptomatic. As the disease progresses, the damage to the liver increases and the following signs and symptoms are evident:
Diagnosis of alcoholic hepatitis begins with a detailed history about alcohol consumption. This is one of the most important evidence suggesting the development of alcoholic liver disease. In addition, the following diagnostic procedures are employed for detecting liver damage:
When the above mentioned tests fail to draw out a confirmed diagnosis then liver biopsy may be done.
The following methods are carried out for treating alcoholic hepatitis:
Alcoholic hepatitis is a liver disease characterized by inflammation of the liver amongst the population who excessively drink alcohol, and have been doing so for several years. Once individuals develop this disease they are advised against alcohol consumption. Failure to adhere to this can cause liver cirrhosis, followed by coma and death.
Excessive alcohol consumption is the major factor contributing to alcoholic hepatitis. The breakdown of alcohol by the liver causes production of toxin compounds which are not eliminated from the body. Such series of events causes alcoholic hepatitis.
In mild cases of alcoholic hepatitis, the individuals usually experience no signs and symptoms. When the condition takes a severe turn, the symptoms include loss of appetite, undue fatigue, weight loss due to malnutrition, nausea accompanied by vomiting, fever, confusion, and jaundice, swelling in abdomen due to accumulation of fluid and abdominal pain.
Diagnosis of alcoholic hepatitis begins with a history of alcohol intake. An array of medical tests is ordered to diagnose the condition. These include blood tests to determine presence of anemia, liver function tests, CT scan and MRI of the liver and liver biopsy.
The individuals are advised against alcohol intake to arrest further liver damage. Medications are employed to reduce liver inflammation and correct malnutrition. In addition, nutrient rich food along with nutrimental supplements should be provided. Efforts should be channelized to avoid alcohol intake and individuals should be constantly monitored in this aspect.