Edit concept Question Editor Create issue ticket

Aldehyde


Presentation

  • The clinical presentation of intraoral ACD reactions varies greatly, and as a result, clinicians often do not recognize the diagnosis.[ncbi.nlm.nih.gov]
  • Abstract Human salivary aldehyde dehydrogenase (hsALDH) is a very important anti-oxidant enzyme present in the saliva. It is involved in the detoxification of toxic aldehydes and maintenance of oral health.[ncbi.nlm.nih.gov]
  • When a group having priority for citation as a principal characteristic group is present, an aldehyde group is described by the prefix "formyl-".[acdlabs.com]
  • Abstract This commentary highlights the research presented by Zhu et al. [1].[ncbi.nlm.nih.gov]
  • In the present study, we found that the selective dopaminergic neuronal death in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse models was prevented by CA.[ncbi.nlm.nih.gov]
Pathologist
  • Staining evaluation was performed independently by two pathologists, and the expression level of ALDH1 was evaluated in terms of the percentage and intensity of positive cells.[ncbi.nlm.nih.gov]
Dyspnea
  • Concomitantly, behavioral and physiological symptoms of augmented acute acetaldehyde toxicity, such as staggering gaits, prone position, hypoactivity, abnormal deep breathing, and dyspnea, were observed in the ALDH2 knockout mice relative to wild-type[doi.org]
Rhinitis
  • Lip swelling developed following the use of a cinnamic aldehyde-containing mouthwash in a woman with allergic rhinitis and asthma.[ncbi.nlm.nih.gov]
Nausea
  • Acute exposure to acetaldehyde causes much of the unpleasant effects associated with ethanol intoxication, including nausea, palpitations, vomiting, dizziness, and headaches ( 24 ).[doi.org]
Lip Swelling
  • Lip swelling developed following the use of a cinnamic aldehyde-containing mouthwash in a woman with allergic rhinitis and asthma.[ncbi.nlm.nih.gov]
Ulcer
  • This finding is consistent with our results because in the erosive and ulcerative forms of oral lichen planus, which have an increased risk of transformation, salivary aldehyde dehydrogenase 1 was overexpressed.[ncbi.nlm.nih.gov]
  • This painful and debilitating side effect occurs in 95% of patients receiving radiation therapy for cancer, and ranges in severity from mild erythema to severe ulceration ( 274 ).[doi.org]
Hyperpigmentation
  • No changes in pigmentation occurred from a concomitant allergic patch test reaction to neomycin sulfate; only hyperpigmentation occurred at the site of an irritant patch test reaction to nonanoic acid.[ncbi.nlm.nih.gov]
Headache
  • […] even mild B1 deficiency in humans continued over a long period of time (the experiment ran six months) produces symptoms including apathy, confusion, emotional instability, irritability , depression, feelings of impending doom, fatigue, insomnia, and headaches[drlwilson.com]
  • Acute exposure to acetaldehyde causes much of the unpleasant effects associated with ethanol intoxication, including nausea, palpitations, vomiting, dizziness, and headaches ( 24 ).[doi.org]

Workup

  • Again, note that the acidic, aqueous workup required for LAH reductions is also that required to de-protect the acetal functionality. ADDITION OF OTHER CARBON NUCLEOPHILES TO CARBONYL COMPOUNDS I.[research.cm.utexas.edu]
Thrombocytosis
  • BACKGROUND: Thrombocytopenia during intoxication, rebound thrombocytosis during 1 to 3 weeks of abstinence, and subsequent normalization of the platelet count are common in alcoholics.[ncbi.nlm.nih.gov]

Treatment

  • TMZ treatment at high concentrations diminished ALDH1A3 protein and this downregulation made the tumor cells more sensitive to chemotherapy. ALDH1A3 was post-transcriptionally regulated since mRNA levels were not affected by TMZ treatment.[ncbi.nlm.nih.gov]
  • Using a murine xenotransplant model to emulate a clinical treatment strategy, established ALDH1A1 - leukemias were also sensitive to in vivo treatment with cyclophosphamide combined with arsenic trioxide.[ncbi.nlm.nih.gov]
  • RESULTS: We show that overall ROS production increases with cisplatin treatment in cells with ALDH2 mutation. The treatment of cisplatin in the wild type mice did not change the level of ROS compared to PBS treated controls.[ncbi.nlm.nih.gov]
  • Type 2 diabetes patients were re-classified as those with or without hypoglycemic treatment and those with or without glycemic control (according to glycated hemoglobin (HbA1c)).[ncbi.nlm.nih.gov]
  • BACKGROUND: Cisplatin is the standard first-line chemotherapeutic agent for the treatment of non-small cell lung cancer (NSCLC). However, resistance to chemotherapy has been a major obstacle in the management of NSCLC.[ncbi.nlm.nih.gov]

Prognosis

  • ALDH2 gene Glu504Lys was significantly associated with short-term prognosis. The genotype GA AA of ALDH2 gene Glu504Lys locus was an independent risk factor of poor 90-day prognosis.[ncbi.nlm.nih.gov]
  • Abstract Previously we showed that aldehyde dehydrogenase 1A1 (ALDH1A1) is a new mediator for resistance of DLBCL to CHOP and a facility predictor of clinical prognosis.[ncbi.nlm.nih.gov]
  • Abstract Potential biomarkers that can be used to determine prognosis and perform targeted therapies are urgently needed to treat patients with hepatocellular carcinoma (HCC).[ncbi.nlm.nih.gov]
  • It has been shown that ALDH1A3 is expressed in human glioblastomas and that its expression correlates with a worse prognosis.[ncbi.nlm.nih.gov]
  • Elevated ALDH1A3 expression in mesenchymal glioma stem cells highlights the potential of this isozyme as a prognosis marker and drug target.[ncbi.nlm.nih.gov]

Etiology

  • Accumulation of 4-HNE is also associated with the establishment of cardiomyopathies from different etiologies and with progression to heart failure ( 192, 218, 219 ). 4-HNE-modified proteins are significantly increased in myocardial biopsies from patients[doi.org]

Epidemiology

  • Furthermore, an ALDH2 inactivating mutation (termed ALDH2*2) is the most common single point mutation in humans, and epidemiological studies suggest a correlation between this inactivating mutation and increased propensity for common human pathologies[ncbi.nlm.nih.gov]
  • Interaction, Graduate School, Korea University, Seoul, Korea. mjshin@korea.ac.kr. 2 Department of Public Health Sciences, BK21PLUS Program in Embodiment: Health-Society Interaction, Graduate School, Korea University, Seoul, Korea. 3 MRC Integrative Epidemiology[ncbi.nlm.nih.gov]
  • Gov't MeSH terms AMP-Activated Protein Kinases/metabolism Aldehyde Dehydrogenase, Mitochondrial/metabolism* Animals Carcinoma, Hepatocellular/enzymology* Carcinoma, Hepatocellular/mortality Carcinoma, Hepatocellular/pathology Cell Line, Tumor China/epidemiology[ncbi.nlm.nih.gov]
  • Epidemiological studies show a correlation between Parkinson's disease with living in a rural area and/or exposure to agricultural pesticides ( 9, 62, 84, 308 ).[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • This study reviews the role of ALDH2 in modulating the pathways involved in the pathophysiology of IRI associated with oxidative stress, autophagy and apoptosis.[ncbi.nlm.nih.gov]
  • The ALDH2*2 allele has also been linked to chronic cardiovascular pathophysiologies.[doi.org]

Prevention

  • Activation of G i -receptors on MC and/or ischemic preconditioning (IPC) prevent renin release, thus providing anti-RAS cardioprotection.[ncbi.nlm.nih.gov]
  • Abstract The antioxidant system results essential to control and prevent lipid peroxidation due to stress damage in type 2 diabetes.[ncbi.nlm.nih.gov]
  • Special emphasis is placed on the role of ALDH2 in different organs, on therapeutic "preconditioning" strategies, and on the use of ALDH2 agonists such as Alda-1, which may become a useful therapeutic tool for preventing the deleterious effects of IRI[ncbi.nlm.nih.gov]
  • DHPG metabolism is inhibited by the monoamine oxidase inhibitor, pargyline which prevents the deamination of norepinephrine, and by the aldose reductase inhibitor AL 1576, which inhibits DHPG formation without affecting the deamination of norepinephrine[ncbi.nlm.nih.gov]
  • In the present study, we found that the selective dopaminergic neuronal death in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse models was prevented by CA.[ncbi.nlm.nih.gov]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!