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Aleukemic Leukemia

Aleukaemic Leukaemia


Presentation

  • Twenty-five to 30% of congenital leukemia cases present with cutaneous leukemic infiltrates. Rarely, infants will have aleukemic leukemia cutis, presenting with leukemic skin lesions but without systemic symptoms or bone marrow involvement.[ncbi.nlm.nih.gov]
  • We present 3 cases of ALC in pediatric patients.[ncbi.nlm.nih.gov]
  • A 20 year old man had presented with nodular swelling on the scalp of 6 months duration along with cervical lymphadenopathy. Biopsy and immunohistochemistry revealed myeloid sarcoma.[ncbi.nlm.nih.gov]
  • We present this case to illustrate how leukemia cutis can masquerade as a clinically benign-appearing cutaneous eruption without leukemic changes in blood or bone marrow.[ncbi.nlm.nih.gov]
  • We feel this unusual presentation of aleukemic leukemia cutis should be added to the evergrowing list of cutaneous manifestations of leukemia.[ncbi.nlm.nih.gov]
Myxedema
  • Regurgitation 326 Monoarthritis Acute 327 Mononucleosis 328 Mucormycosis 329 Mumps 330 Muscle Weakness 331 Muscular Dystrophy 332 Mycosis Fungoides 333 Myelodysplastic Syndrome 334 Myocarditis 335 Myoglobinuria 336 Myopathies Toxic 337 Myotonia 338 Myxedema[books.google.de]
Raynaud Phenomenon
  • Phenomenon 416 Rectal Pain 417 Red Hot Joint 418 Renal Cell Adenocarcinoma 419 Renal Failure Postrenal Causes 420 Renal Tubular Acidosis 421 Respiratory Failure Hypoventilatory 422 Reticulocytosis 423 Retinopathy Hypertensive 424 Rheumatic Fever 425[books.google.de]
Vertebral Fractures
  • A 16 year-old boy presented with severe hypercalcemia, diffuse osteolytic lesions and vertebral fractures.[ncbi.nlm.nih.gov]
Scrotal Pain
  • Pain 432 Seasonal Affective Disorder 433 Seizures Absence 434 Septicemia 435 Serotonin Syndrome 436 Sexually Transmitted Diseases Anorectal Region 437 Shoulder Pain 438 Sialadenitis 439 Silicosis 440 Small Bowel Obstruction 441 Smallpox 442 Sore Throat[books.google.de]
Papilledema
  • Orbital Lesions Cystic 359 Orofacial Pain 360 OsgoodSchlatter Disease 361 Osteoporosis 362 Otitis Externa 363 Ovarian Mass 364 Pagets Disease of Bone 365 Pain Midfoot 366 Pain Posterior Heel 367 Palpitations 368 Pancreatitis Acute 369 Panic Disorder 370 Papilledema[books.google.de]
Polyneuropathy
  • 394 Polyneuropathy Drug Induced 395 Polyneuropathy Symmetric 396 Popliteal Swelling 397 Postconcussive Syndrome 398 Posttraumatic Stress Disorder 399 Preeclampsia 400 Premenstrual Dysphoric Disorder 401 Pronator Syndrome 402 Proteinuria 403 Pruritus[books.google.de]
Trichotillomania
  • Disorders 471 Thrombocytopenia in Pregnancy 472 Thrombophlebitis Superficial 473 Thyroid Nodule 474 TickRelated Infections 475 Tinea Corporis 476 Tinea Versicolor Pityriasis Versicolor 477 Toxic Epidermal Necrolysis 478 Toxoplasmosis 479 Tracheitis 480 Trichotillomania[books.google.de]

Workup

  • Hence skin biopsy may be helpful in detecting the leukemia and facilitate further workup especially in cases of aleukemic leukemia, as was seen in our case.[bioline.org.br]
Glycosuria
  • Part II examines the leading signs habitus, hyperthermia, fever, infectious disease, respiratory, cardiovascular, digestive, hematopoietic, and uropoietic systems diseases, and glycosuria.[books.google.de]
Left Axis Deviation
  • Axis Deviation 298 Leg Length Discrepancies 299 Leg Ulcers 300 LeggCalvéPerthes Disease 301 Leptomeningeal Lesions 302 Leukoplakia Oral Hairy Oral Hairy Cell Leukoplakia 303 Lichen Simplex Chronicus 304 Listeriosis 305 Liver Lesions Benign Often Confused[books.google.de]

Treatment

  • This report describes a 6-month-old boy with aleukemic leukemia cutis, which regressed without any treatments within 6 months.[ncbi.nlm.nih.gov]
  • He was initially diagnosed with metabolic bone disease, and the hypercalcemia responded to treatment with intravenous hydration and bisphosphonates. However, the intact parathormone level was normal. He had no lymphadenopathy or organomegaly.[ncbi.nlm.nih.gov]
  • Treatment Options Table I . Therapeutic Ladder for the Treatment of Leukemia Cutis Table 1.[dermatologyadvisor.com]
  • The timing of treatment and the prognosis in CLL depend on the stage of the disease.[medical-dictionary.thefreedictionary.com]
  • Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color.[books.google.de]

Prognosis

  • This condition is associated with a very poor prognosis and is often difficult to diagnose. We report a case of a 33 years old female with leukemia cutis preceding the onset of acute monocytic leukemia by four months.[ncbi.nlm.nih.gov]
  • Diagnostic difficulties, the importance of immunohistochemical markers, and the prognosis and therapy of aleukemic leukemia cutis are discussed.[ncbi.nlm.nih.gov]
  • There is no clear evidence between the effects of skin infiltration on leukaemia prognosis. However ALC is usually associated with a very poor prognosis in leukaemic patients [ 3 , 5 ].[edoj.org.eg]
  • Prognosis - Aleukemic leukemia cutis Not supplied. Treatment - Aleukemic leukemia cutis Not supplied. Resources - Aleukemic leukemia cutis[checkorphan.org]
  • ALC is often difficult to diagnose and is associated with a dismal prognosis. A 63-year-old male presented with nodular swellings on the face, a plaque extending over the right shoulder and multiple enlarged cervical lymph nodes.[ingentaconnect.com]

Etiology

  • Etiology Genetic and chromosomal aberrations, such as are found in other leukemias, are characteristic.[medical-dictionary.thefreedictionary.com]
  • (Of course, with the revival of the virus theory in the etiology of cancer, it may be both infectious and malignant in nature.) "Is the type cell of lymphoid or reticuloendothelial origin?" FULL TEXT[annals.org]

Epidemiology

  • (This is an excellent recent review of the clinical manifestations, epidemiology, and histopathology. It discusses and compares the histopathology and immunophenotypes of several types of LC. There are several clinical and histologic photographs.)[dermatologyadvisor.com]
  • -CM Codes (U.S. only) C92.9 Myeloid leukemia, unspecified (effective October 01, 2015) C93.9 Monocytic leukemia, unspecified (effective October 01, 2015) C93.Z Other monocytic leukemia (effective October 01, 2015) Progression and Transformation None Epidemiology[seer.cancer.gov]
Sex distribution
Age distribution

Pathophysiology

  • This edition is organized by symptoms and signs that may be individually different even in the same disease and must be analyzed and understood on a pathophysiological basis within the framework of the individual personality.[books.google.de]
  • The pathophysiology of these diseases is undoubtedly reflected in the cytogenetic and molecular abnormalities that are present at diagnosis.[cancertherapyadvisor.com]

Prevention

  • Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets[books.google.de]
  • Prevention - Aleukemic leukemia cutis Not supplied. Diagnosis - Aleukemic leukemia cutis Not supplied. Prognosis - Aleukemic leukemia cutis Not supplied. Treatment - Aleukemic leukemia cutis Not supplied. Resources - Aleukemic leukemia cutis[checkorphan.org]
  • Related Journals of Aleukemic Leukemia Journal of Leukemia, Cancer Surgery, Advances in Cancer Prevention, Chemotherapy: Open Access, Blood & Lymph, Leukemia Research, Annals of Oncology, Cancer Letters, Critical Reviews in Oncology Hematology, Cancer[omicsonline.org]
  • In both childhood and adult ALL, allopurinol and hydration precede induction chemotherapy to prevent hyperuricemia caused by tumor lysis.[medical-dictionary.thefreedictionary.com]

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