Twenty-five to 30% of congenital leukemia cases present with cutaneous leukemic infiltrates. Rarely, infants will have aleukemic leukemia cutis, presenting with leukemic skin lesions but without systemic symptoms or bone marrow involvement. [ncbi.nlm.nih.gov]

An unusual presentation of acute myelomonocytic leukemia. ( 2943614 ) De Coninck A....Roseeuw D.I. 1986 25 Aleukemic leukemia cutis. ( 3729513 ) Hansen R.M....Ash R. 1986 26 Aleukemic leukemia cutis: juvenile chronic granulocytic leukemia presenting with [malacards.org]

• Palpable Spleen

  On admission, clinical appearance was normal except for a palpable spleen. Abdominal ultrasound described an enlarged spleen of 172/60 mm with a 90 cm 2 surface. [dovepress.com]

• Malignant Pleural Effusion

  Indian Journal of Dermatology, Venereology and Leprology. 2010; 76(6): 710-712 [Pubmed] 6 Mediastinal mass and malignant pleural effusion in an aleukemic case with pre-B acute lymphoblastic leukemia Pei, S.-N., Kuo, C.-Y., Ma, M.-C., Wang, M.-C. [ijdvl.com]

• Testicular Pain

  Failure 466 Testicular Neoplasm 467 Testicular Pain 468 Tetanus 469 Thromboangiitis Obliterans 470 Thrombocytopenia Inherited Disorders 471 Thrombocytopenia in Pregnancy 472 Thrombophlebitis Superficial 473 Thyroid Nodule 474 TickRelated Infections 475 [books.google.de]

• Trichotillomania

  Disorders 471 Thrombocytopenia in Pregnancy 472 Thrombophlebitis Superficial 473 Thyroid Nodule 474 TickRelated Infections 475 Tinea Corporis 476 Tinea Versicolor Pityriasis Versicolor 477 Toxic Epidermal Necrolysis 478 Toxoplasmosis 479 Tracheitis 480 Trichotillomania [books.google.de]

Hence skin biopsy may be helpful in detecting the leukemia and facilitate further workup especially in cases of aleukemic leukemia, as was seen in our case. [bioline.org.br]

In 8 patients we established the diagnosis solely based on the peripheral smear, as after the year 2000, we subjected all children presenting with proptosis to a peripheral blood smear as part of the routine workup. [jhoonline.biomedcentral.com]

• Glycosuria

  Part II examines the leading signs habitus, hyperthermia, fever, infectious disease, respiratory, cardiovascular, digestive, hematopoietic, and uropoietic systems diseases, and glycosuria. [books.google.de]

• Philadelphia Chromosome Positive

  Imatinib in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia: current status and evolving concepts. Best Pract Res Clin Haematol. 2002;15:757–769.. [link.springer.com]

  chromosome-positive biphenotypic leukemia. ( 15540904 ) Onozawa M....Asaka M. 2004 16 Guess what. [malacards.org]

  Treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia The treatment of Philadelphia chromosome positive ALL depends on the patient’s age. [cancertherapyadvisor.com]

  Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia. Int J Hematol 2004;80:278-280 3. Taniguchi S, Hamada T, Kutsuna H, Ishii M. Lymphocytic aleukemic leukemia cutis. [koreascience.or.kr]

  The discovery of bcr-abl tyrosine kinase inhibitors such as imatinib (Gleevec) and dasatinib improved outcomes and should be prescribed in Philadelphia chromosome-positive patients. [lecturio.com]

This report describes a 6-month-old boy with aleukemic leukemia cutis, which regressed without any treatments within 6 months. [ncbi.nlm.nih.gov]

There are no curative therapeutic modalities, and it is fairly well accepted that the treatment of choice is immunosuppression. [dovepress.com]

Treatment Options Table I. Therapeutic Ladder for the Treatment of Leukemia Cutis Table 1. [dermatologyadvisor.com]

The timing of treatment and the prognosis in CLL depend on the stage of the disease. [medical-dictionary.thefreedictionary.com]

There is no clear evidence between the effects of skin infiltration on leukaemia prognosis. However ALC is usually associated with a very poor prognosis in leukaemic patients [ 3, 5 ]. [edoj.org.eg]

This condition is associated with a very poor prognosis and is often difficult to diagnose. We report a case of a 33 years old female with leukemia cutis preceding the onset of acute monocytic leukemia by four months. [ncbi.nlm.nih.gov]

Leukemia cutis probably is a dissemination of systemic leukemia to the skin, and the demonstration of leukemia in skin is associated with a very poor prognosis. [scienceopen.com]

Prognosis depends on various factors, including the following (see also table below): Age: Children have a better prognosis than adults. Gender: Boys usually have a poorer prognosis than girls. [lecturio.com]

Etiology Genetic and chromosomal aberrations, such as are found in other leukemias, are characteristic. [medical-dictionary.thefreedictionary.com]

Etiology of Acute Lymphoblastic Leukemia The Causes of Acute Lymphoblastic Leukemia In most cases, the etiology of ALL is idiopathic, although familial and hereditary linkages have not been ruled out, as a higher incidence is seen with some patients congenital [lecturio.com]

The etiology of the clinical condition with cardiorespiratory failure, pancytopenia, and disseminated intravascular coagulopathy together with skin hemorrhages and hepatosplenomegaly was at first elusive. [molcellped.springeropen.com]

[…] suggesting that chemotactic mechanisms may be involved. [12] Other factors associated with cutaneous involvement include aneuploidy of chromosome 8, acute myeloid leukemia with monocytic differentiation, and involvement of other extramedullary sites. [2] Etiology [emedicine.medscape.com]

CM Codes (U.S. only) C92.9 Myeloid leukemia, unspecified (effective October 01, 2015) C93.9 Monocytic leukemia, unspecified (effective October 01, 2015) C93.Z Other monocytic leukemia (effective October 01, 2015) Progression and Transformation None Epidemiology [seer.cancer.gov]

(This is an excellent recent review of the clinical manifestations, epidemiology, and histopathology. It discusses and compares the histopathology and immunophenotypes of several types of LC. There are several clinical and histologic photographs.) [dermatologyadvisor.com]

Epidemiology of Acute Lymphoblastic Leukemia ALL is the most common childhood cancer, accounting for 26 % of all cancers in children younger than 14 years. [lecturio.com]

6) Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225 Duesseldorf, Germany References Puumala SE, Ross JA, Aplenc R, Spector LG (2013) Epidemiology [molcellped.springeropen.com]

This edition is organized by symptoms and signs that may be individually different even in the same disease and must be analyzed and understood on a pathophysiological basis within the framework of the individual personality. [books.google.de]

Pathophysiology All types of leukemia result from the abnormal development of leukocytes in the bone marrow. [emedicine.medscape.com]

The pathophysiology of these diseases is undoubtedly reflected in the cytogenetic and molecular abnormalities that are present at diagnosis. [cancertherapyadvisor.com]

[…] initiation in most of the cases. 9 Immunosuppressive therapies are usually used in this context, including methotrexate, cyclophosphamide, and cyclosporine. 10 With the advent of potential new therapeutic options, a recent surge in the interest for the pathophysiology [dovepress.com]

Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets [books.google.de]

Prevention - Aleukemic leukemia cutis Not supplied. Diagnosis - Aleukemic leukemia cutis Not supplied. Prognosis - Aleukemic leukemia cutis Not supplied. Treatment - Aleukemic leukemia cutis Not supplied. Resources - Aleukemic leukemia cutis [checkorphan.org]

Related Journals of Aleukemic Leukemia Journal of Leukemia, Cancer Surgery, Advances in Cancer Prevention, Chemotherapy: Open Access, Blood & Lymph, Leukemia Research, Annals of Oncology, Cancer Letters, Critical Reviews in Oncology Hematology, Cancer [omicsonline.org]

In both childhood and adult ALL, allopurinol and hydration precede induction chemotherapy to prevent hyperuricemia caused by tumor lysis. [medical-dictionary.thefreedictionary.com]