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Aleukemic Leukemia

Aleukaemic Leukaemia


Presentation

  • Twenty-five to 30% of congenital leukemia cases present with cutaneous leukemic infiltrates. Rarely, infants will have aleukemic leukemia cutis, presenting with leukemic skin lesions but without systemic symptoms or bone marrow involvement.[ncbi.nlm.nih.gov]
  • We present 3 cases of ALC in pediatric patients.[ncbi.nlm.nih.gov]
  • A 20 year old man had presented with nodular swelling on the scalp of 6 months duration along with cervical lymphadenopathy. Biopsy and immunohistochemistry revealed myeloid sarcoma.[ncbi.nlm.nih.gov]
  • We present this case to illustrate how leukemia cutis can masquerade as a clinically benign-appearing cutaneous eruption without leukemic changes in blood or bone marrow.[ncbi.nlm.nih.gov]
  • We describe aleukemic leukemia cutis (ALC) in a 50-year-old woman who presented with numerous skin nodular lesions and lack of peripheral blood and bone marrow involvement until late in the evolution of her disease.[ncbi.nlm.nih.gov]
Palpable Spleen
  • On admission, clinical appearance was normal except for a palpable spleen. Abdominal ultrasound described an enlarged spleen of 172/60 mm with a 90 cm 2 surface.[dovepress.com]
Raynaud Phenomenon
  • Phenomenon 416 Rectal Pain 417 Red Hot Joint 418 Renal Cell Adenocarcinoma 419 Renal Failure Postrenal Causes 420 Renal Tubular Acidosis 421 Respiratory Failure Hypoventilatory 422 Reticulocytosis 423 Retinopathy Hypertensive 424 Rheumatic Fever 425[books.google.de]
Polyneuropathy
  • 394 Polyneuropathy Drug Induced 395 Polyneuropathy Symmetric 396 Popliteal Swelling 397 Postconcussive Syndrome 398 Posttraumatic Stress Disorder 399 Preeclampsia 400 Premenstrual Dysphoric Disorder 401 Pronator Syndrome 402 Proteinuria 403 Pruritus[books.google.de]
Trichotillomania
  • Disorders 471 Thrombocytopenia in Pregnancy 472 Thrombophlebitis Superficial 473 Thyroid Nodule 474 TickRelated Infections 475 Tinea Corporis 476 Tinea Versicolor Pityriasis Versicolor 477 Toxic Epidermal Necrolysis 478 Toxoplasmosis 479 Tracheitis 480 Trichotillomania[books.google.de]

Workup

  • Hence skin biopsy may be helpful in detecting the leukemia and facilitate further workup especially in cases of aleukemic leukemia, as was seen in our case.[bioline.org.br]
  • In 8 patients we established the diagnosis solely based on the peripheral smear, as after the year 2000, we subjected all children presenting with proptosis to a peripheral blood smear as part of the routine workup.[jhoonline.biomedcentral.com]
Glycosuria
  • Part II examines the leading signs habitus, hyperthermia, fever, infectious disease, respiratory, cardiovascular, digestive, hematopoietic, and uropoietic systems diseases, and glycosuria.[books.google.de]
Microcytosis
  • Macrothrombocytopenia Inherited 312 Malaria 313 MalloryWeiss Tear 314 Mastoiditis 315 Mediastinitis Acute 316 Melanocytic Nevi Moles 317 Melanonychia 318 Menieres Disease 319 Meningitis Chronic 320 Menopause 321 Metabolic Syndrome 322 Metatarsalgia 323 Microcytosis[books.google.de]

Treatment

  • This report describes a 6-month-old boy with aleukemic leukemia cutis, which regressed without any treatments within 6 months.[ncbi.nlm.nih.gov]
  • He was initially diagnosed with metabolic bone disease, and the hypercalcemia responded to treatment with intravenous hydration and bisphosphonates. However, the intact parathormone level was normal. He had no lymphadenopathy or organomegaly.[ncbi.nlm.nih.gov]
  • There are no curative therapeutic modalities, and it is fairly well accepted that the treatment of choice is immunosuppression.[dovepress.com]
  • Treatment Options Table I . Therapeutic Ladder for the Treatment of Leukemia Cutis Table 1.[dermatologyadvisor.com]

Prognosis

  • This condition is associated with a very poor prognosis and is often difficult to diagnose. We report a case of a 33 years old female with leukemia cutis preceding the onset of acute monocytic leukemia by four months.[ncbi.nlm.nih.gov]
  • Diagnostic difficulties, the importance of immunohistochemical markers, and the prognosis and therapy of aleukemic leukemia cutis are discussed.[ncbi.nlm.nih.gov]
  • There is no clear evidence between the effects of skin infiltration on leukaemia prognosis. However ALC is usually associated with a very poor prognosis in leukaemic patients [ 3 , 5 ].[edoj.org.eg]
  • Prognosis - Aleukemic leukemia cutis Not supplied. Treatment - Aleukemic leukemia cutis Not supplied. Resources - Aleukemic leukemia cutis[checkorphan.org]
  • ALC is often difficult to diagnose and is associated with a dismal prognosis. A 63-year-old male presented with nodular swellings on the face, a plaque extending over the right shoulder and multiple enlarged cervical lymph nodes.[ingentaconnect.com]

Etiology

  • Etiology Genetic and chromosomal aberrations, such as are found in other leukemias, are characteristic.[medical-dictionary.thefreedictionary.com]
  • (Of course, with the revival of the virus theory in the etiology of cancer, it may be both infectious and malignant in nature.) "Is the type cell of lymphoid or reticuloendothelial origin?" FULL TEXT[annals.org]
  • Etiology of Acute Lymphoblastic Leukemia The Causes of Acute Lymphoblastic Leukemia The etiology of ALL is idiopathic in most of the cases, but the familial and hereditary linkage cannot be ruled out, as higher incidence is seen with some congenital disorders[lecturio.com]
  • The etiology of the clinical condition with cardiorespiratory failure, pancytopenia, and disseminated intravascular coagulopathy together with skin hemorrhages and hepatosplenomegaly was at first elusive.[molcellped.springeropen.com]

Epidemiology

  • (This is an excellent recent review of the clinical manifestations, epidemiology, and histopathology. It discusses and compares the histopathology and immunophenotypes of several types of LC. There are several clinical and histologic photographs.)[dermatologyadvisor.com]
  • -CM Codes (U.S. only) C92.9 Myeloid leukemia, unspecified (effective October 01, 2015) C93.9 Monocytic leukemia, unspecified (effective October 01, 2015) C93.Z Other monocytic leukemia (effective October 01, 2015) Progression and Transformation None Epidemiology[seer.cancer.gov]
  • Epidemiology of Acute Lymphoblastic Leukemia Acute Lymphoblastic Leukemia as the Most Common Cancer in Children Acute lymphoblastic leukemia is the most common childhood cancer , accounting for 26 % of all cancers in children younger than 14 years.[lecturio.com]
  • 6) Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225 Duesseldorf, Germany References Puumala SE, Ross JA, Aplenc R, Spector LG (2013) Epidemiology[molcellped.springeropen.com]
Sex distribution
Age distribution

Pathophysiology

  • This edition is organized by symptoms and signs that may be individually different even in the same disease and must be analyzed and understood on a pathophysiological basis within the framework of the individual personality.[books.google.de]
  • […] initiation in most of the cases. 9 Immunosuppressive therapies are usually used in this context, including methotrexate, cyclophosphamide, and cyclosporine. 10 With the advent of potential new therapeutic options, a recent surge in the interest for the pathophysiology[dovepress.com]
  • The pathophysiology of these diseases is undoubtedly reflected in the cytogenetic and molecular abnormalities that are present at diagnosis.[cancertherapyadvisor.com]
  • Pathophysiology All types of leukemia result from the abnormal development of leukocytes in the bone marrow.[emedicine.medscape.com]

Prevention

  • Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets[books.google.de]
  • Prevention - Aleukemic leukemia cutis Not supplied. Diagnosis - Aleukemic leukemia cutis Not supplied. Prognosis - Aleukemic leukemia cutis Not supplied. Treatment - Aleukemic leukemia cutis Not supplied. Resources - Aleukemic leukemia cutis[checkorphan.org]
  • Related Journals of Aleukemic Leukemia Journal of Leukemia , Cancer Surgery, Advances in Cancer Prevention, Chemotherapy: Open Access, Blood & Lymph, Leukemia Research, Annals of Oncology, Cancer Letters, Critical Reviews in Oncology Hematology, Cancer[omicsonline.org]
  • In both childhood and adult ALL, allopurinol and hydration precede induction chemotherapy to prevent hyperuricemia caused by tumor lysis.[medical-dictionary.thefreedictionary.com]

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