Clinically the patient presented with unilateral vitiligo on the left cheek, with partial loss of hearing and vision on the same side. ...read moreread less [typeset.io]

Description A 56-year-old diabetic and hypertensive lady presented to us with a history of exertional precordial pain. [casereports.bmj.com]

The initial presentation may be unilateral gradual loss of vision, followed by facial vitiligo and poliosis on the same side several years later. Ipsilateral reduced sensitivity to sound or hypoacusis may also develop. [dermnetnz.org]

Medicine Cutis 2016 The case of a 14-year-old adolescent girl with piebaldism is presented, along with a review of the pathogenesis, diagnosis, and management of this disease entity. Extra-Cutaneous Melanocytes T. AnbarR. HegazyS. [semanticscholar.org]

Treatment None Deaths Unknown Alezzandrini syndrome is a very rare syndrome characterized by a unilateral degenerative retinitis, followed after several months by ipsilateral vitiligo on the face and ipsilateral poliosis.[1]: 864 [2] Deafness may also be present [en.wikipedia.org]

• Epilepsy

  There was no history of any epilepsy or mental retardation. CT head was essentially normal. Funduscopy was suggestive of mild retinal pigmentary changes in the left eye and no evidence of diabetic retinopathy in the other eye. [casereports.bmj.com]

  Coauthor(s) Ewa Koziorynska, MD Assistant Professor of Neurology, Comprehensive Epilepsy Center, State University of New York Downstate Medical Center Ewa Koziorynska, MD is a member of the following medical societies: Sigma Xi, The Scientific Research [emedicine.medscape.com]

• Asymptomatic

  SUA is associated with severity of coronary atherosclerosis in patients with asymptomatic hyperuricemia. This inexpensive, readily measured biological parameter may be useful to monitor ACS patients. [pubmed.ncbi.nlm.nih.gov]

• Alopecia

  In order to best describe Alezzandrini syndrome, a discussion of Vogt-Koyanagi-Harada syndrome is necessary. [4, 5] In 1906, Vogt [6] reported a patient with nontraumatic uveitis, poliosis, and alopecia. [emedicine.medscape.com]

  […] tapetoretinal (retinal pigment epithelia) degeneration with the ipsilateral appearance of facial vitiligo and poliosis.6 A close differential is Vogt-Koyanagi-Harada syndrome characterised by bilateral decolouration of the skin, eyebrow, eyelashes, alopecia [casereports.bmj.com]

  Haque WM, Mir MR, Hsu S: Vogt-Koyanagi-Harada syndrome: association with alopecia areata. Dermatol Online J 2009;15:10. Gupta V, Gupta A, Bambery P, Radotra BD, Pandav SS: Vogt-Koyanagi-Harada syndrome following injury-induced progressive vitiligo. [karger.com]

  Skin and appendages involvement Cutaneous findings usually develop during the chronic or convalescent stage of the disease and include vitiligo, alopecia and poliosis of the lashes, eyebrows and scalp hair (Fig. 5). [ojrd.biomedcentral.com]

• Hearing Impairment

  Ocular findings may be accompanied by lymphocytic meningitis, hearing impairment and/or tinnitus in a variable proportion of patients. [ojrd.biomedcentral.com]

Low-dose intralesional lFN-a2 may be a safe alternative treatment of unresponsive localized DLE. [typeset.io]

There are two main types of clinical studies: Clinical trials determine if a new test or treatment for a disease is effective and safe by comparing groups receiving different tests/treatments. [rarediseases.info.nih.gov]

What is the treatment for Alezzandrini syndrome? There are no treatments for Alezzandrini syndrome. Topical steroids have limited benefit for vitiligo. Sun protection is important to prevent sunburn in skin affected by vitiligo. [dermnetnz.org]

Medical care includes eye exams, hearing tests and treatment for the vitiligo skin lesions.[11574] For more information, visit GARD. [rarediseases.org]

From Wikipedia, the free encyclopedia Alezzandrini syndrome Specialty Dermatology Symptoms Loss of Vision, Facial Vitiligo, Sound Sensitivity Causes Unknown Treatment None Deaths Unknown Alezzandrini syndrome is a very rare syndrome characterized by a [en.wikipedia.org]

Due to the small number of reported cases, the prognosis of patients with this syndrome remains unknown. Patients experience a gradual loss of vision and have an increased risk of retinal detachment. Progressive hearing loss has been reported. [dermnetnz.org]

Prognosis The prognosis for Alezzandrini syndrome currently is unclear because of the paucity of reports. Future clinical observations may help in elucidating this matter. [emedicine.medscape.com]

Some factors have been described as indicative of prognosis: I. Related to treatment: a.. [ojrd.biomedcentral.com]

No statistical relationships of QoL with disease duration, LIS type, or LIS etiology were found. [ojrd.biomedcentral.com]

Pathophysiology Although the etiology of Alezzandrini syndrome is unknown, several theories involving viral or autoimmune processes have been postulated. [emedicine.medscape.com]

Epidemiology of 2000 Chinese uveitis patients from Northeast China. Br J Ophthalmol. 2021 Mar. 105 (3):317-321. [QxMD MEDLINE Link]. Vogt A. Fruhzeities ergraven der zilien und bemerkungen uber den sogenannten plotzlichen einendieser veranderugn. [emedicine.medscape.com]

The current review discusses the general features of VKHD, including epidemiology, classification into categories, differential diagnosis and current therapeutic approaches. [ojrd.biomedcentral.com]

Pathophysiology Although the etiology of Alezzandrini syndrome is unknown, several theories involving viral or autoimmune processes have been postulated. [emedicine.medscape.com]

It may also contribute to the understanding of the pathophysiology of chorioretinal inflammatory disordes [99]. [ojrd.biomedcentral.com]

Sun protection is important to prevent sunburn in skin affected by vitiligo. Skin cancer risk should be assessed. High dose oral steroids should be prescribed if the patient has symptoms suggestive of acute uveitis. [dermnetnz.org]

Participating in research helps researchers ultimately uncover better ways to treat, prevent, diagnose, and understand human diseases. What Are Clinical Studies? Clinical studies are medical research involving people as participants. [rarediseases.info.nih.gov]

Advise patients to use sunscreens to prevent sunburn and subsequent skin cancer. Diagnostics No laboratory studies are required. Diagnosis is based on the clinical presentation. Also see Other Tests. Treatment See Medical Care. [emedicine.medscape.com]

Topical corticosteroids (e.g., dexamethasone 0.1 % or prednisolone acetate 1 % eyedrops) in combination with mydriatics/cycloplegics (e.g., tropicamide 1.0 % eyedrops) to reduce ciliary spasm and prevent posterior synechiae, are most frequently used [ [ojrd.biomedcentral.com]