Abstract We present the case of a woman with Gaucher disease who was being given alglucerase as enzyme replacement therapy. She was found to be pregnant: the treatment was continued. [ncbi.nlm.nih.gov]

[…] replacement therapy used safely and effectively throughout the whole pregnancy of a Gaucher disease patient R Aporta Rodriguez, JL Escobar Vedia, AM Navarro Castro, G Aguilar Garcia, A Cabrera Torres Haematologica January 1998 83: 852-853; doi: Abstract We present [haematologica.org]

Presented at the 13 th Annual WORLDSymposium; February 13-17, 2017; San Diego, CA. [raredr.com]

Designed specifically with physicians, pharmacologists, and other members of the health care delivery team in mind, the CRC Desk Reference of Clinical Pharmacology features more than 2,000 entries appearing in three formats: Short reviews: these present [books.google.de]

• Virilization

  Approximately 25% of patients with detectable IgG antibodies experience hypersensitivity Derived from pooled human placental tissue that may contain viral agents; manufacturing steps are designed to reduce viral transmission risk Monitor for signs of early virilization [reference.medscape.com]

  As hCG has been detected in Ceredase ®, physicians should be alert for signs of early virilization in males under the age of ten. [drugs.com]

  As hCG has been detected in Ceredase® (alglucerase injection), physicians should be alert for signs of early virilization in males under the age of ten. [rxlist.com]

• Precocious Puberty

  One case of precocious puberty has been reported to date, however due to the recent introduction of manufacturing steps designed to reduce the level of hCG in Ceredase ®, the likelihood of this occurrence is reduced. [drugs.com]

  One case of precocious puberty has been reported to date, however due to the recent introduction of manufacturing steps designed to reduce the level of hCG in Ceredase (alglucerase injection) ®, the likelihood of this occurrence is reduced. [rxlist.com]

• Intravenous Administration

  Nonetheless, after intravenous administration of alglucerase, improvements are evident within 6 months of therapy. Patients have increased haemoglobin levels and platelet counts, and decreased incidences of epistaxis and bruising. [ncbi.nlm.nih.gov]

• Oral Ulcers

  Additional adverse symptoms which have been reported include: fatigue, vasomotor irritability or hot flash, weakness, headache, light headedness, dysosmia, oral ulcerations, backache and transient peripheral edema, and diarrhea. [drugs.com]

• Palpitations

  After 3 months of treatment, immediately after starting an infusion, he experienced flushing, cough, tachycardia, palpitation, chest pain and excessive sweating, which reoccurred on a consecutive administration. [ncbi.nlm.nih.gov]

• Osteopenia

  Skeletal complications, including osteonecrosis and osteopenia with secondary pathological fractures, are a common feature of Gaucher disease. [drugs.com]

• Erythrocytosis

  Patient 13 had impaired pulmonary function due to his Gaucher's disease and was undergoing frequent therapeutic phlebotomies to control his erythrocytosis. [nejm.org]

Alglucerase has provided a breakthrough in treatment for patients with this relatively rare disease. [ncbi.nlm.nih.gov]

Study design: A retrospective analysis of growth in 99 children and adolescents with type 1 Gaucher disease before treatment, and in 54 of those subjects during treatment, was done. [scholars.northwestern.edu]

Results The results of treatment are presented in Table 1. All the patients had a decrease in the size of the liver and spleen (if one was present) except Patient 14, who had no hepatomegaly at the start of treatment. [nejm.org]

Another form of pulmonary involvement in GD is pulmonary hypertension (PHT): a severe complication associated with poor prognosis. [kundoc.com]

As an alternative, analyses of observational data from a large international disease registry using standard epidemiologic matching and modeling methods may offer a feasible and methodologically sound approach. [nature.com]

Four possible pathophysiological mechanisms might account for the development of PTH in the individual with GD: 1. perivascular infiltration by Gaucher cells with vascular obliteration; 2. plugging of the capillaries with Gaucher cells; 3. occlusion of [kundoc.com]

Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Alendronate is used to treat or prevent postmenopausal osteoporosis and steroid-induced osteoporosis. [emedicinehealth.com]

Uptake by both of these types of cell is prevented by mannan. The results suggest that the cellular mechanisms responsible for improvement of Gaucher patients receiving alglucerase treatment is probably more complicated than previously recognized. [ncbi.nlm.nih.gov]

[…] alimentary tract and metabolism products 1.1 A16AA Amino acids and derivatives 1.2 A16AB Enzymes 1.3 A16AX Various alimentary tract and metabolism products 2 QA16Q Other alimentary tract and metabolism products for veterinary use 2.1 QA16QA Drugs for prevention [en.wikipedia.org]

Tea tree oil : Tea tree oil is purported to have antiseptic properties, and has been used traditionally to prevent and treat infections. [healthinhandorganics.com]