We measured cartilage concentrations (normalized to dry weight) of racemized aspartate, GAG, COMP and deamidated COMP (D-COMP). Unpaired AKU, OA and non-OA samples were compared by non-parametric Mann-Whitney U test. [ncbi.nlm.nih.gov]

A 69-year-old man presented with shortness of breath and exertional chest pain. [ncbi.nlm.nih.gov]

A 69-year-old man presented with shortness of breath and exertional chest pain. [ncbi.nlm.nih.gov]

Male patient, 52 years old, sought medical help complaining about progressive appearance of hyperchromic papules on the lateral edge of the second finger of both hands for 02 years. He also complained about darkening of urine, sperm and underwear. [ncbi.nlm.nih.gov]

Dermatological examination revealed bilaterally symmetrical nontender, bluish papules with pitting, and crateriform plaques on palms [Figure 1]. Few hyperpigmented plaques were noted on the dorsum of hands and feet. [pigmentinternational.com]

Other systemic features include stones (renal, prostatic, salivary, gall bladder), renal damage/failure, osteopenia/fractures, ruptures of tendons/muscle/ligaments, respiratory compromise, hearing loss and aortic valve disease. [ncbi.nlm.nih.gov]

Other systemic features include: Stones ( renal, prostatic, salivary, gall bladder), osteopenia/ fractures, ruptures of tendons/ muscle/ ligaments, respiratory compromise and hearing loss. [pathopedia-india.com]

Neurogenic claudication resulting from focal hypertrophy of the ligamentum flavum in the lumbar spine due to ochronotic deposits has only been previously reported once in the literature. [ncbi.nlm.nih.gov]

Operative findings included ochronosis of a severely calcified aortic valve and the aortic intima, and bioprosthetic AVR and CABG were successfully performed. [ncbi.nlm.nih.gov]

High-dose vitamin C decreases urinary benzoquinone acetic acid, a derivative of HGA, but has no effect on HGA excretion [ Wolff et al 1989 ]. [ncbi.nlm.nih.gov]

High-dose vitamin C decreases urinary benzoquinone acetic acid but has no effect on HGA excretion, 8 and no credible studies have shown that treatment with vitamin C is clinically effective. 3 In our patients, neither vitamin C supplementation nor protein [content.nejm.org]

Serum tyrosine increased from normal adult reference interval to a mean   SD of 594   184 µmol /L at year-two monitoring with an increased urinary excretion from 103   81 µmol /24 h at baseline to 1071   726 µmol /24 h two years from therapy. [ncbi.nlm.nih.gov]