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Alopecia Totalis


Presentation

  • The present case represents the youngest patient with myasthenia gravis associated with alopecia totalis.[ncbi.nlm.nih.gov]
Cushingoid
  • The body weight was maintained, the height continued to increase and there was no evidence of hirsutism, striae atrophicans, acne or cushingoid obesity.[ijdvl.com]
Small Hand
  • The next 48 hours seemed the longest in my life – every time I ran my hand through my hair I would pull out a small handful. Monday morning couldn’t come quickly enough.[cots-tri.co.uk]
Skin Discoloration
  • Other, less common side effects include vitiligo, which causes a rash and patchy skin discoloration. immunotherapy Potential Treatments for Alopecia Totalis and Alopecia Universalis Xeljanz / Tofacitinib Citrate Tofacitinib citrate , which also goes by[belgraviacentre.com]
  • Side-effects of steroid therapy After years of steroid therapy, patients reported having infections, allergic reactions, bleeding in their joints, rupture of their tendons and skin discoloration.[yeastinfection.org]
Premature Balding
Yellow Nails
  • nail syndrome L60.8 Other nail disorders L60.9 Nail disorder, unspecified L62 Nail disorders in diseases classified elsewhere L63 Alopecia areata L63.0 Alopecia (capitis) totalis L63.1 Alopecia universalis L63.8 Other alopecia areata L63.9 Alopecia areata[icd10data.com]
Negativism
  • Having published on the negativation of Type 1 associated autoantibodies with oral calcitriol (J Diabetes. 2013 PMID: 23302101) and recently on the cure of severe atopic dermatitis with calcitriol and it’s analog paricalcitol (Case Reports in Pediatrics[abstracts.eurospe.org]
Polyneuropathy
  • […] hydroxychloroquine: report of 2 cases. ( 23680203 ) Stephan F....Tomb R. 2013 16 Clinical characteristics and prognostic factors in early-onset alopecia totalis and alopecia universalis. ( 22787378 ) Cho H.H....Kwon O.S. 2012 17 Chronic inflammatory demyelinating polyneuropathy[malacards.org]

Workup

  • A detailed laboratory workup showed normal values for all measures of thyroid functioning and absence of antithyroid antibodies. A large screening for autoantibodies revealed only low-titer antinuclear antibodies (indirect immunofluorescence test).[nn.neurology.org]
  • Subjects with a positive or indeterminable PPD or QFT result must have a documented negative workup for tuberculosis and/or completed standard tuberculosis therapy. - Subjects must meet the following laboratory criteria: 1.[mountsinai.org]
  • Assessment All patients underwent a comprehensive workup at baseline, 1 st month and at the end of the 3 rd month which included weight and growth assessment, complete physical examination, and investigations such as complete hemogram, blood sugar levels[ijpd.in]

Treatment

  • Each patient received three treatments at 4-week intervals. A photograph of each patient was taken before and after the treatment.[ncbi.nlm.nih.gov]
  • Treatment [ edit ] Methotrexate and corticosteroids are proposed treatments. [1] Scalp cooling has specifically been used to prevent alopecia in docetaxel chemotherapy, [2] although it has been found prophylactic in other regimens as well. [3] [4] [5][en.wikipedia.org]

Prognosis

  • OBJECTIVE: We investigated the current long-term prognosis of individuals with AT/AU. METHODS: A retrospective chart review was performed in patients with AT/AU between 1994 and 2005.[ncbi.nlm.nih.gov]
  • Conclusion: Our results suggest that the long-term prognosis of AT/AU is more favorable than previously thought. However, the clinical burden of AT/AU is still substantial.[figshare.com]
  • This study showed a direct relationship between the severity of AA and long-term prognosis.[karger.com]
  • In view of the usually nearly hopeless prognosis for AT and AU and the results reported here, a trial course of topical, intralesional, and oral corticosteroid treatment would seem to be reasonable for highly motivated patients. ( Arch Dermatol 114:1486[jamanetwork.com]

Etiology

  • Abstract A psychological study on fifteen children with diverse etiologies of hair loss, viz., alopecia areata, alopecia totalis and trichotillomania was conducted in order to assess the degree of underlying psychodynamics in children with hair loss.[ncbi.nlm.nih.gov]
  • Asam U, Trager SE: Contribution to the etiology and pathogenesis of trichotillomania with special consideration of mother-child relations. Praxis der Kinderpsychol und Kinderpsychiatrie 22 :283–290, 1973. Google Scholar 5.[link.springer.com]

Epidemiology

  • OBJECTIVE: To describe the clinical and epidemiological features, therapeutic response and prognostic factors in a large series of patients diagnosed with AAT and AAU.[ncbi.nlm.nih.gov]
  • ObjectiveTo describe the clinical and epidemiological features, therapeutic response and prognostic factors in a large series of patients diagnosed with AAT and AAU.[gu.se]
  • Yet, epidemiological studies on AA are limited, and no clear conclusions can be drawn.[dovepress.com]
  • Epidemiology and natural disease course Estimated prevalence in the UK is 15 per 10,000 of the population. It can affect any age but onset is most common in childhood and adolescence.[patient.info]
  • A major goal of the Registry is to create a database where researchers can obtain epidemiologic data and blood samples from patients and families with alopecia areata.[nahrs.org]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiologic mechanism is unclear, but it is thought to be due to peribulbar T-cell inflammation, which results in premature induction of anagen follicles to catagen and telogen, without causing destruction of the hair follicle.¹ This mechanism[my.clevelandclinic.org]
  • Researchers interested in doing pathophysiology or treatment studies of this disease will also be able to contact patients having the appropriate form of the disease for the studies in question.[clinicaltrials.gov]
  • Despite the high incidence rate of spontaneous AA, a plethora of facts argue for a causal relationship between AA and alemtuzumab in this reported case: (1) the autoimmune pathophysiology of AA, (2) the untypical clinical presentation with onset of alopecia[frontiersin.org]
  • The exact role of possible factors needs to be clarified (see Pathophysiology). No known risk factors exist for alopecia areata, except a positive family history.[emedicine.medscape.com]

Prevention

  • "Short post-infusion scalp cooling time in the prevention of docetaxel-induced alopecia". Supportive Care in Cancer. 20 (12): 3255–3260. doi : 10.1007/s00520-012-1465-0. PMID 22539051. Lemieux, J. (2012).[en.wikipedia.org]
  • Ginger improves circulation, prevents nausea and is very useful for childhood diseases such as whooping cough and chicken pox. Licorice cleanses the blood, clears the lungs, prevents colds and increases energy.[myhealingpath.com]
  • Alopecia Totalis Prevention It is generally not possible to prevent AT as it is caused by certain genetic factors or unknown autoimmune responses.[primehealthchannel.com]
  • Having said that, taking appropriate precautions and ensuring the maintenance of healthy immune system can help prevent the condition.[advancedhair.uk]

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