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Ameloblastic Carcinoma


Presentation

  • Here we elaborate the dilemmas in diagnosis and management of ameloblastic carcinoma through presentation of a representative case in a 56-year-old man presenting with a tumor in the mandible.[ncbi.nlm.nih.gov]
Anemia
  • As the patient of this case has hemolytic anemia, FNAB is well indicated because it causes minimal blood loss during the procedure.[scielo.br]
Hoarseness
  • Rare findings include the inability to open the mouth (trismus) or dysphonia, a voice disorder characterized by hoarseness, weakness, tingling or numbness (paresthesia), and, in rare cases, voice loss (my note: disruption of the voice because of laryngeal[rarediseases.org]
Nasal Discharge
  • Nasal discharge and blockage of the nasal passages may occur if the tumor involves the sinuses of the maxilla.[rarediseases.org]
Gingival Swelling
  • The patient was a 71-year-old man with gingival swelling and persistent bleeding.[ncbi.nlm.nih.gov]
  • The patient reported a 1-year history of a slow-growing gingival swelling ( Fig. 1 ) at the buccal aspect of his right mandibular premolars and canine teeth. The general dentist had been taking a watch-and-wait approach.[academic.oup.com]
Hyperpigmentation
  • Only very mild skin changes (hyperpigmentation CTC I and erythema CTC I, no desquamation) over the left cheek and mild mucous membrane reactions (mucositic CTC I-II) at the soft/hard left palate could be observed.[ro-journal.biomedcentral.com]
Neglect
  • The major prognostic factor is the clinical course of the disease which includes its aggressiveness, local destruction, and distant metastatic spread preferentially through hematologic route if neglected.[jdas.in]

Workup

  • To rule out metastasis, a complete metastatic workup was performed, to include head, neck, chest, and abdominal computed tomography with contrast. All laboratory values were normal.[academic.oup.com]
  • Staged workup including computed tomography of head and neck, chest radiograph, and abdominal ultrasonography needs to be done because even in the absence of local or regional recurrence, distant metastasis can occur. [15] PET scan is useful to monitor[njms.in]

Treatment

  • Diagnostic and treatment challenges are shown in this uncommon pediatric solid tumor of the jaw. Carboplatin and etoposide treatment showed some therapeutic effect upon the primary tumor, but lung infiltrations were not influenced.[ncbi.nlm.nih.gov]

Prognosis

  • Metastasis from an ameloblastic carcinoma is significantly correlated with poor prognosis. Therefore, diagnosis at an early stage and close periodic screening for metastasis are necessary to improve patient prognosis.[ncbi.nlm.nih.gov]

Etiology

  • However, without prior biopsy, the etiology and category of this ameloblastic carcinoma is speculative. Our case represents a histologically unequivocal case of ameloblastic carcinoma.[ncbi.nlm.nih.gov]
  • Retrieved articles were extensively reviewed for epidemiology, etiology, diagnosis, treatment options, and prognosis of ameloblastic carcinoma. [ FULL TEXT ] [ PDF ]* Article Access Statistics Viewed 1043 Printed 26 Emailed 0 PDF Downloaded 182 Comments[jdas.in]
  • […] an ameloblastoma with marked cytologic atypia Epidemiology Rare, 100 case reports in English literature Represent 1% of all odontogenic tumors Sites More common in mandible ( 80%), particularly posterior mandible Rare reports of maxillary involvement Etiology[pathologyoutlines.com]
  • However, without prior biopsy, the etiology and category of this ameloblastic carcinoma is speculative.[academic.oup.com]

Epidemiology

  • CONCLUSIONS: Our study has contributed to the improved characterization of the epidemiology, prognostic markers, treatment options and outcomes of AMECA.[ncbi.nlm.nih.gov]
  • Retrieved articles were extensively reviewed for epidemiology, etiology, diagnosis, treatment options, and prognosis of ameloblastic carcinoma. [ FULL TEXT ] [ PDF ]* Article Access Statistics Viewed 1043 Printed 26 Emailed 0 PDF Downloaded 182 Comments[jdas.in]
  • Definition / general Rare epithelial odontogenic tumor with histologic features of an ameloblastoma with marked cytologic atypia Epidemiology Rare, 100 case reports in English literature Represent 1% of all odontogenic tumors Sites More common in mandible[pathologyoutlines.com]
  • Each entity is extensively discussed with information on clinicopathological, epidemiological, immunophenotypic and genetic aspects of these diseases. This book is in the series commonly referred to as the "Blue Book" series. Contributors: :Dr.[books.google.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiological mechanism of its evolution is still poorly understood, and this has resulted in a lot of controversy about its biology [ 11, 19 ].[panafrican-med-journal.com]

Prevention

  • The presence of a firm preoperative diagnosis helps preventing suboptimal surgery, contributing to avoid recurrence of these tumors.[ncbi.nlm.nih.gov]
  • To prevent late recurrences, longtime follow up should be mandatory. » References 1. Barnes L, Eveson J, Reichart P, Sidransky D. Pathology and genetics of tumors of the head and neck.[indianjcancer.com]
  • Our findings suggest that the ring of desmoplastic connective tissue enclosing the intratumoral capillaries prevented the intravascular dissemination of malignant cells avoiding metastases.[gavinpublishers.com]
  • In cases of ameloblastic carcinoma, the treatment of choice is extended surgical resection with at least 2-3 cm of bone margins in order to prevent recurrence.[jiaomr.in]
  • In cases of maxillary ameloblastomas, a radical resection should be performed in order to prevent recurrence and development of malignancy.[headandneckoncology.biomedcentral.com]

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