Presentation
Here we elaborate the dilemmas in diagnosis and management of ameloblastic carcinoma through presentation of a representative case in a 56-year-old man presenting with a tumor in the mandible. [ncbi.nlm.nih.gov]
Entire Body System
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Anemia
As the patient of this case has hemolytic anemia, FNAB is well indicated because it causes minimal blood loss during the procedure. [scielo.br]
Jaw & Teeth
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Gingival Swelling
The patient was a 71-year-old man with gingival swelling and persistent bleeding. [ncbi.nlm.nih.gov]
The patient reported a 1-year history of a slow-growing gingival swelling (Fig. 1) at the buccal aspect of his right mandibular premolars and canine teeth. The general dentist had been taking a watch-and-wait approach. [academic.oup.com]
Skin
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Hyperpigmentation
Only very mild skin changes (hyperpigmentation CTC I and erythema CTC I, no desquamation) over the left cheek and mild mucous membrane reactions (mucositic CTC I-II) at the soft/hard left palate could be observed. [ro-journal.biomedcentral.com]
Workup
This patient’s diagnostic workup was complicated by her pregnancy and sarcoidosis. A CT scan was not performed until after biopsy results suggested carcinoma in order to prevent radiation exposure to the fetus. [cureus.com]
Avon et al.[4] reported the need for adjunctive diagnostic examination after the diagnosis of AC, which includes a workup consisting of CT, chest radiography, and neck evaluation to determine the presence of nodal metastasis. [jorr.org]
To rule out metastasis, a complete metastatic workup was performed, to include head, neck, chest, and abdominal computed tomography with contrast. All laboratory values were normal. [academic.oup.com]
Staged workup including computed tomography of head and neck, chest radiograph, and abdominal ultrasonography needs to be done because even in the absence of local or regional recurrence, distant metastasis can occur. [15] PET scan is useful to monitor [njms.in]
Treatment
Treatment outcome was favourable with a complete remission at 6 weeks post completion of radiotherapy while RT-treatment itself was tolerated well with only mild side effects. [ncbi.nlm.nih.gov]
Prognosis
Metastasis from an ameloblastic carcinoma is significantly correlated with poor prognosis. Therefore, diagnosis at an early stage and close periodic screening for metastasis are necessary to improve patient prognosis. [ncbi.nlm.nih.gov]
Etiology
However, without prior biopsy, the etiology and category of this ameloblastic carcinoma is speculative. Our case represents a histologically unequivocal case of ameloblastic carcinoma. [ncbi.nlm.nih.gov]
Retrieved articles were extensively reviewed for epidemiology, etiology, diagnosis, treatment options, and prognosis of ameloblastic carcinoma. [go.gale.com]
Retrieved articles were extensively reviewed for epidemiology, etiology, diagnosis, treatment options, and prognosis of ameloblastic carcinoma. [ FULL TEXT ] [ PDF ]* Article Access Statistics Viewed 1043 Printed 26 Emailed 0 PDF Downloaded 182 Comments [jdas.in]
[…] an ameloblastoma with marked cytologic atypia Epidemiology Rare, 100 case reports in English literature Represent 1% of all odontogenic tumors Sites More common in mandible ( 80%), particularly posterior mandible Rare reports of maxillary involvement Etiology [pathologyoutlines.com]
Epidemiology
Retrieved articles were extensively reviewed for epidemiology, etiology, diagnosis, treatment options, and prognosis of ameloblastic carcinoma. [go.gale.com]
CONCLUSIONS: Our study has contributed to the improved characterization of the epidemiology, prognostic markers, treatment options and outcomes of AMECA. [ncbi.nlm.nih.gov]
Retrieved articles were extensively reviewed for epidemiology, etiology, diagnosis, treatment options, and prognosis of ameloblastic carcinoma. [ FULL TEXT ] [ PDF ]* Article Access Statistics Viewed 1043 Printed 26 Emailed 0 PDF Downloaded 182 Comments [jdas.in]
Definition / general Rare epithelial odontogenic tumor with histologic features of an ameloblastoma with marked cytologic atypia Epidemiology Rare, 100 case reports in English literature Represent 1% of all odontogenic tumors Sites More common in mandible [pathologyoutlines.com]
Pathophysiology
The pathophysiological mechanism of its evolution is still poorly understood, and this has resulted in a lot of controversy about its biology [ 11, 19 ]. [panafrican-med-journal.com]
Prevention
The presence of a firm preoperative diagnosis helps preventing suboptimal surgery, contributing to avoid recurrence of these tumors. [ncbi.nlm.nih.gov]
To prevent late recurrences, longtime follow up should be mandatory. » References 1. Barnes L, Eveson J, Reichart P, Sidransky D. Pathology and genetics of tumors of the head and neck. [indianjcancer.com]
Our findings suggest that the ring of desmoplastic connective tissue enclosing the intratumoral capillaries prevented the intravascular dissemination of malignant cells avoiding metastases. [gavinpublishers.com]
In cases of ameloblastic carcinoma, the treatment of choice is extended surgical resection with at least 2-3 cm of bone margins in order to prevent recurrence. [jiaomr.in]
In cases of maxillary ameloblastomas, a radical resection should be performed in order to prevent recurrence and development of malignancy. [headandneckoncology.biomedcentral.com]