We present a case of a 48-year-old man with histologically confirmed malignant transformation of a benign ameloblastic fibroma 10 years after initial presentation of a localized facial mass. [ncbi.nlm.nih.gov]

Her age at presentation was 22 years old, a little younger than the mean age of presentation, but still in the third decade of life, like most patients from previous reports. [hindawi.com]

• Accelerated Growth

  A 28-year-old asthmatic Nigerian female presented at the Oral Surgery Clinic of the University College Hospital with a 4-year history of a gradually enlarging right maxillary swelling which accelerated in growth following two pregnancies. [jomfp.in]

• Jaw Pain

  Unfortunately, in most cases, jaw pain is interpreted as of dental origin and the patient is treated accordingly. Dentists should be familiar with signs and symptoms of malignant tumors of the jaws, especially rare cases with unusual presentation. [ncbi.nlm.nih.gov]

• Dental Caries

  Salient Features Extensively revised and updated chapters Temporomandibular Joint Diseases section completely rewritten Physical and Chemical Injuries of the Oral Cavity chapter updated Extensive revision of Dental Caries and Forensic Odontology chapters [books.google.com]

• Ulcer

  Ameloblastic fibrosarcoma(AFS) is a rare malignant odontogenic tumor presented as painful swelling and intraosseous mass with occasional ulceration. The most frequent site is the mandible body. [kpubs.org]

  […] optimal treatment strategy Adjuvant chemotherapy and radiotherapy as needed; may reduce the recurrence rate and enhance the quality of life Clinical images Images hosted on other servers: Gross swelling Swelling, lower left mandible Swelling without ulceration [pathologyoutlines.com]

  Also, the extraction site of the second and third molar was filled with an irregular exophytic ulcerated mass which bled easily on palpation [ Figure 1 ]. [ncbi.nlm.nih.gov]

• Eye Pain

  pain, andproptosis for which he wore protective safety glasses. [dokument.tips]

• Suggestibility

  ConclusionThe results suggest that FASN and COX-2 overexpression may have a role in the pathogenesis of AM and AC¸ while in AFS, only FASN seems to be involved. [medworm.com]

  The lesion grew rapidly in the time from hospital admission until operation, suggesting progression from low to high malignancy. The correlation between the benign epithelial component and malignancy is discussed. [ncbi.nlm.nih.gov]

  Although most cases arise de novo, the documentation of a prior or pre-existing precursor lesion from ameloblastic fibroma suggests otherwise.1,2 A study by Kobayashi et al. suggested that up to one-third of AFS arise from AF while a review of literature [pjohns.pso-hns.org]

  They were found to be in mild-labeling indices suggesting of less aggressive tumor. Hence, we considered a conservative approach for the treatment. Treatment options for AF swings between conservative excision and aggressive resection. [njms.in]

• Facial Mass

  We present a case of a 48-year-old man with histologically confirmed malignant transformation of a benign ameloblastic fibroma 10 years after initial presentation of a localized facial mass. [ncbi.nlm.nih.gov]

  mass with accompanying paresthesia Diagnosis Diagnosis dependent on clinical, radiologic and pathologic correlation Radiology description Appears as an expansive, multilocular radiolucent lesion Often shows cortical perforation Radiology images Images [pathologyoutlines.com]

  The usual clinical presentation consists of a patient who complains of a painful but occasionally painless facial mass with accompanying paresthesia or dysesthesia. The duration of symptoms varies widely from a few weeks up to 2 years [7]. [hindawi.com]

• Dysesthesia

  The usual clinical presentation consists of a patient who complains of a painful but occasionally painless facial mass with accompanying paresthesia or dysesthesia. The duration of symptoms varies widely from a few weeks up to 2 years [7]. [hindawi.com]

  The usual clinical presentation consists of a patient who complains of a painful but occasionally painless facial mass with accompanying paresthesia or dysesthesia. The duration of symptoms varies widely from a few weeks up to 2 years [ 7 ]. [ncbi.nlm.nih.gov]

Surgical resection remains the standard treatment, as no clear or consistent pattern exists for the use of adjuvant therapy in the primary treatment of AFS. [ochsnerjournal.org]

This potential transformation alone does not justify radical treatment of all these benign lesions. [ncbi.nlm.nih.gov]

Other treatment modalities such as adjuvant chemotherapy and radiotherapy were found to be ineffective. [11] Our patient has remained tumor free till date after wide surgical excision which is the recommended treatment for AFS. [article.sapub.org]

The treatment is still controversial, without a definition regarding chemotherapy and radiotherapy as coadjutant treatment. Keywords: oral cancer; odontogenic tumor; maxillary neoplasms. [revestomatologia.sld.cu]

Its behaviour is relatively benign, with absence of metastatic disease, and the prognosis is reported to be good. It is a paradoxical neoplasm with "sarcomatous" morphological and immunohistochemical patterns but with a favourable clinical course. [ncbi.nlm.nih.gov]

[…] this highly lauded three-volume reference provides an interdisciplinary approach to the diagnosis, treatment, and management of head and neck diseases, including the incidence, etiology, clinical presentation, pathology, differential diagnosis, and prognosis [books.google.com]

Some authors have proposed that AFS should be considered as low grade fibrosarcoma [7] in view of its more favourable prognosis in comparison to fibrosarcomas of the orofacial region. [article.sapub.org]

Natural History, Complications, and Prognosis Prognosis Prognosis of fibrosarcoma depends on the tumor grade. [wikidoc.org]

Updated, reorganized, and revised throughout, this highly lauded three-volume reference provides an interdisciplinary approach to the diagnosis, treatment, and management of head and neck diseases, including the incidence, etiology, clinical presentation [books.google.com]

Suresh Vyloppilli: Malankara Orthodox Syrian Church Hospital and MedicalCollege Biomedical Journal of Scientific & Technical Research, 2017, vol. 1, issue 1, 222-223 Abstract: Ameloblastic Fibrosarcoma is an extremely rare odontogenic tumor with unclear etiology [econpapers.repec.org]

[…] malignant stroma Epidemiology Rare, < 100 case reports in English literature More common in males (1.5 - 1.6:1) Mean age: 3rd decade Sites More common in mandible (80%); favors posterior mandible Can have maxillary involvement; may extend into sinus Etiology [pathologyoutlines.com]

[…] counterpart to ameloblastic fibroma Terminology Ameloblastic fibrosarcoma Ameloblastic fibrodentinosarcoma: used when dentin is present within the malignant stroma Ameloblastic fibroodontosarcoma: used when enamel is present within the malignant stroma Epidemiology [pathologyoutlines.com]

Epidemiology and Demographics Fibrosarcoma accounts for about 5% of all primary bone sarcomas. Incidence Fibrosarcoma is a rare disease. Worldwide, the incidence of fibrosarcoma is 0.05 per 100,000 persons. [wikidoc.org]

452 Loya-Solis A, Gonzalez-Colunga KJ, Barboza- Quintana O (2015) Ameloblastic fibrosarcoma of the mandible a case report and brief review of the literature, Case Rep Pathol, Vol.2015 ; pp.245026 Fletcher CDM Fletcher CDM (2002) Soft tissue tumours Epidemiology [journal.kaomp.org]

It is a tumor of mesenchymal origin and the epidemiologic factors are still unknown, but many authors report radiation therapy history as a possible one (3). [scielo.isciii.es]

[…] of its compartment Stage II Stage IIA: High grade lesion that is confined to its anatomic compartment Stage IIB: High grade lesion that have extended outside of its compartment Stage III lesions are any grade or anatomic site that have metastasized Pathophysiology [wikidoc.org]

Pathophysiology Fibrosarcoma is a tumor of mesenchymal cell origin that is composed of malignant fibroblasts in a collagen background. There are two main types: primary and secondary. [emedicine.medscape.com]

Knowledge of the malignant potential in the mesenchymal spindle cells of ameloblastic fibroma will assist in determining the management of these benign tumours, and may prevent malignant transformation to ameloblastic fibrosarcoma. [ncbi.nlm.nih.gov]

Expanded section on bisphosphonate-related osteonecrosis of the jaws helps you effectively manage patients taking bisphosphonates to prevent bone loss, including information on oral complications, risk factors, and benefits. [books.google.com]

We hope this treatment will be sufficient to prevent recurrence and give our patient the best chance of long-term survival. [ochsnerjournal.org]

On the one hand, it would be good to take the measures recommended by the doctors to prevent further recurrences of the disease. [deti.zp.ua]

These factors are taken into account with careful evaluation (staging) of the tumor and determine the success of treatment in obtaining good local control and preventing subsequent disease spread. [emedicine.medscape.com]