The structures described in the present paper and the inhibition studies provide an important opportunity for structure-based design of compounds to target aminoglycoside phosphotransferases for inhibition, potentially overcoming this form of antibiotic [biochemj.org]

In the present study, the authors attempted to determine the strong antibiotic activity of arbekacin against MRSA and particularly gentamicin-resistant MRSA. Arbekacin is not modified by the aminoglycoside-modifying enzyme, ANT (4')-1. [ncbi.nlm.nih.gov]

Mature non-coding RNAs and their precursors can present off-target sites, by forming secondary structures that resemble ribosomal RNA, thus providing an additional molecular basis for the toxicity of aminoglycosides. [biorxiv.org]

This is especially true of gentamicin which presently is widely used for treatment of infections due to gram-negative microorganisms. [google.com]

• Fatigue

  The significance of the Aminoglycosides Blood Test result is explained: A high Aminoglycosides Blood Test value may indicate aminoglycoside toxicity, which is marked by: Lower back pain Discolored urine Frequent urination Painful urination Fatigue Nausea [dovemed.com]

• Intravenous Administration

  "Intravenous Administration of Gentamicin Once Daily versus Thrice Daily in Adults." Eur. J. Clin. Microbiol. Infect. Dis. (1995) 88-91. 36. [antibiotikamonitor.at]

• Skin Rash

  Toxicity Dose-related (kidneys, vestibular, auditory and neuromuscular systems), minor skin rash, drug fever, decreased Mg2+, decreased Ca2+, decreased K+; it is common practice to monitor patients receiving AGs. aminoglycoside Therapeutics Any of a family [medical-dictionary.thefreedictionary.com]

• Tinnitus

  The aminoglycosides can cause deafness and TINNITUS if taken in excess or if not excreted normally because of kidney disease. [medical-dictionary.thefreedictionary.com]

  However, hearing loss and tinnitus have also been observed in some patients without mitochondrial diseases. [22] References [ edit ] ^ E.g., see www.merriam-webster.com/medical/aminoglycoside: "any of a group of antibiotics (as streptomycin and neomycin [en.wikipedia.org]

• Vertigo

  Vertigo-associated disorders. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/001432.htm. Accessed September 2012. Tan, K. et. al. (2003 March 15). [labtestsonline.it]

  Neomycin, kanamycin, and amikacin are the most likely to cause problems with hearing, and streptomycin and gentamicin carry the greatest risk of causing vertigo and loss of balance. [medical-dictionary.thefreedictionary.com]

  Adverse Effects All aminoglycosides cause Renal toxicity (often reversible) Vestibular and auditory toxicity (often irreversible) Prolongation of effects of neuromuscular blockers Symptoms and signs of vestibular damage are vertigo and ataxia. [merckmanuals.com]

• Dizziness

  If cells in the inner ear are damaged or destroyed, an individual may experience a loss of balance and feelings of dizziness. Damage to the middle ear may result in hearing loss or tinnitus. [medical-dictionary.thefreedictionary.com]

  Causes of Dizziness. Vestibular Disorders Association [On-line information]. Available online at http://vestibular.org/node/2. Accessed September 2012. (Reviewed 2010 May). Aminoglycoside Extended Interval Dosing and Monitoring in Adults. [labtestsonline.it]

• Tremor

  It is characterized by muscle tremor or palsy and rigid movements. Description Streptomycin, the first aminoglycoside, was isolated from Streptomyces griseus in the mid-1940s. This antibiotic was very effective against tuberculosis. [medical-dictionary.thefreedictionary.com]

The duration of treatment was 7-10 days in both groups. [ncbi.nlm.nih.gov]

Aminoglycosides are also used in combination therapy with penicillins for the treatment of enterococcal infections. Some compounds such as paromomycin have been employed in treatment of protozoal infections (46). [clicktocurecancer.info]

Interestingly, the introduction of a vaccine for Haemophilus influenzae B (Hib), a common cause of meningitis, has changed the epidemiology of this threatening infection and may result in the need for different antibiotic combinations as the infective [basicmedicalkey.com]

Results, Soundhar Ramasamy, Debojit Bose, Hemant Suryawanshi, Mukesh Lalwani, Sridhar Sivasubbu, View ORCID Profile Souvik Maiti doi: https://doi.org/10.1101/137935 ABSTRACT miRNAs are key non-protein coding regulators of gene expression in various pathophysiological [biorxiv.org]

Pathophysiologic Mechanisms of Selected Types of Nephrotoxicity. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1925868-overview. Accessed September 2012. [labtestsonline.it]

Towards the prevention of aminoglycoside antibiotic-related deafness From 2017-02-13 to 2020-02-12, Grant Agreement terminated Project details Total cost: EUR 251 857,80 EU contribution: EUR 251 857,80 Coordinated in: United Kingdom Funding scheme: MSCA-IF-GF [cordis.europa.eu]

This prevents the bacteria from growing, but does not necessarily kill them. [dovemed.com]

By blocking protein synthesis, aminoglycosides prevent the bacterium from reproducing and carrying out its basic functions. [evolution.berkeley.edu]

Certain drugs called neuromuscular blocking agents, often used to prevent patients from moving during surgery, enhance some of the side effects of aminoglycosides. [everydayhealth.com]

While deactivation of the foregoing antibiotics in order to prevent their interfering with the aminoglycoside antibiotic assay is theoretically possible, it is ordinarily difficult, especially since the testing laboratory may not have been told of the [google.com]