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Amnionitis

Amnionitides


Presentation

  • A case of Haemophilus influenzae aminionitis in association with premature rupture of the membranes is presented.[ncbi.nlm.nih.gov]
Encephalopathy
  • Supportive measures include the use of acetaminophen (Tylenol), which is especially important during delivery to prevent neonatal encephalopathy (brain damage) (1).[abclawcenters.com]
  • Fever in labour and neonatal encephalopathy: a prospective cohort study. BJOG. 2001 Jun. 108(6):594-7. [Medline]. Andrews WW, Hauth JC, Cliver SP, Savage K, Goldenberg RL.[emedicine.medscape.com]
Regular Uterine Contractions
  • Indeed, this result is similar to the previous report that acute-histologic chorioamnionitis was significantly more common in women with regular uterine contractions with cervical dilatation 2cm than in those without regular uterine contraction [ 25 ][journals.plos.org]

Workup

  • […] diagnosis of acute chorioamnionitis Gross/microscopic examination of placenta, fetal membranes, umbilical cord [14] Complete blood cell (CBC) count and inflammatory biomarkers, blood culture, and chest x-ray Controversial: Lumbar puncture of neonates See Workup[emedicine.medscape.com]
Lymphocytic Infiltrate
  • infiltration of chorioamnion, associated with chronic villitis of unknown etilogy (71%), maternal hypertension (20%), preterm infants (40%) and intrauterine growth restriction (15%) ( Hum Pathol 1998;29:1457 ) Back to top[pathologyoutlines.com]

Treatment

  • Treatment for chorioamnionitis Treatment for a mother and baby with chorioamnionitis includes early delivery, supportive care, and antibiotic administration.[abclawcenters.com]
  • Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout.[books.google.com]
  • Treatment [ edit ] Antibiotic Treatment consists of: Standard: Ampicillin 2g IV every 6 hours Gentamicin 1.5 mg/kg every 8 hours Alternative: Ampicillin-Sulbactam 3g IV every 5 hours, Ticarcillin-Clavulanate 3.1g IV every 4 hours, Cefoxitine 2g IV every[en.wikipedia.org]
  • Establishing concern for IAI is key to initiating appropriate treatment and minimizing adverse outcomes.[exxcellence.org]
  • […] and Management The treatment depends on the severity of the condition, the patient’s medical history and the pregnancy trimester. [7] Antibiotic Treatment Antibiotic medications consisting of gentamicin, amoxicillin and metronidazole [3] may be prescribed[pregmed.org]

Prognosis

  • Risk factors premature rupture of membranes pre term premature rupture of membranes prolonged labor Treatment and prognosis Immediate initiation of intrapartum broad spectrum antibiotics greatly reduces adverse maternal and fetal outcomes from chorioamnionitis[radiopaedia.org]
  • Prognosis Medical assistance of newborn in delivery room Medical assistance of newborn in neo-natology department Neonatal ressuscitation 10 th Theme : Outlet Forceps.[umfcv.ro]
  • Prematurity and birth defects are confounding factors that must be considered when a prognosis is offered to parents or caregivers of an infected newborn.[emedicine.medscape.com]

Etiology

  • . * Infectious etiology. * Polymorphs in amnion /- chorion. * Rarely extends through fetal surface of amnion. * Umbilical cord may be involved. * Positive amniotic fluid culture. * Routes of infection: - hematogenous - transcervical - transfallopian -[fetalultrasound.com]
  • […] is associated with chronic lung disease (bronchopulmonary dysplasia, Wilson-Mikity syndrome, Hum Pathol 2002;33:183 ) Mixed cell infiltrate of mononuclear cells and neutrophils, primarily in the amnion and upper chorion Chronic chorioamnionitis Rare; etiology[pathologyoutlines.com]
  • Other etiologies for high maternal WBC counts include labor and recent administration of antenatal corticosteroids.[clinicaladvisor.com]
  • Premature rupture of membranes: definition, indications, technique. 6th Theme: Complications During the Third an Fourth Stage of Labor Postpartum hemorrhage; definition, etiologic diagnosis, treatment Uterine inversion: definition, diagnosis, treatment[umfcv.ro]

Epidemiology

  • Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005. JAMA. 2008 May 7. 299(17):2056-65. [Medline]. Huang J, Li S, Li L, Wang X, Yao Z, Ye X.[emedicine.medscape.com]
  • McElrath TF, Allred EN, Leviton A; Development Epidemiology Network Investigators.[journals.plos.org]
  • Coitus has been suggested in epidemiologic studies to be a risk factor for chorioamnionitis. 37 However, there is no direct evidence relating coitus with IAI, and a more recent study of 10,000 Israeli women found no increased risk of premature rupture[glowm.com]
Sex distribution
Age distribution

Pathophysiology

  • The expression of the inflammatory cytokines such as IL-1β, IL-6, IL-8 and TNF-α increase in case of infection.These cytokines may play an essential role in the pathophysiology of spontaneous pretem labor with intact membrane.An observational analytic[mji.ui.ac.id]
  • Pathophysiology The amniotic cavity is nearly always sterile prior to labor and rupture of membranes. Intact placental membranes and cervical mucus usually are effective in preventing entry of bacteria.[clinicaladvisor.com]
  • Pathophysiology of preterm birth: emerging concepts of maternal infection. Clin Perinatol. 2005 Sep. 32(3):561-9. [Medline]. Shennan A, Crawshaw S, Briley A.[emedicine.medscape.com]

Prevention

  • Centers for Disease Control and Prevention, Preventing early-onset Group B strep disease, May 2018. Cleveland Clinic, Chorioamnionitis, October 2012. UpToDate.com, Intra-amniotic infection (clinical chorioamnionitis or triple I), August 2018.[whattoexpect.com]
  • Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization[books.google.com]
  • Prevention of chorioamnionitis Preventing chorioamnionitis is critical.[abclawcenters.com]
  • News, August 15, 1997 Centers for disease control and prevention (2002) Prevention of perinatal group B Streptococcal disease: revised guidelines from CDC. MMWR 51:RR-11:1–28 External links [ edit ] Overview at Cleveland Clinic.[en.wikipedia.org]

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