We present a fatal case of ischaemic colitis induced by amphetamine use in a 44-year-old woman who presented in extremis after a cardiac arrest en route to the emergency department. [ncbi.nlm.nih.gov]

• Nausea

  […] pounding, or racing heartbeat or pulse headache hives, itching, skin rash joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals mood swings muscle cramps, pain, stiffness, or spasms nausea [drugs.com]

  Side Effects Nausea, stomach upset, diarrhea, dry mouth, headache, nervousness, dizziness, trouble sleeping, loss of appetite, weight loss, irritability, or restlessness may occur. [webmd.com]

• Poor Oral Hygiene

  The causes include decreased salivation, corrosive substances in the smoke, and poor oral hygiene—called "meth mouth." When an amphetamine is suddenly stopped, symptoms vary. [merckmanuals.com]

• Dysgeusia

  Gastrointestinal: Diarrhea <1%, postmarketing, and/or case reports: Acute myocardial infarction, aggressive behavior, alopecia, anaphylaxis, angioedema, anorexia, blurred vision, bruxism, cardiomyopathy, change in libido, constipation, dermatillomania, dizziness, dysgeusia [drugs.com]

  Delayed / 0-6.0 fever / Early / 0-5.0 infection / Delayed / 0-5.0 dysmenorrhea / Delayed / 0-4.0 libido decrease / Delayed / 0-4.0 photosensitivity / Delayed / 0-4.0 hyperhidrosis / Delayed / 0-4.0 dental caries / Delayed / 0-4.0 dyspepsia / Early / 0-2.0 dysgeusia [pdr.net]

• Motor Restlessness

  It increases motor activity and mental alertness, and diminishes drowsiness and a sense of fatigue. In children with attention-deficit hyperactivity disorder, dexamphetamine decreases motor restlessness and enhances the ability to pay attention. [web.archive.org]

• Euphoria

  We conducted linear mixed effects models to examine relationships between sweet liking and drug-induced euphoria and stimulation. RESULTS: Sweet likers reported significantly greater amphetamine-induced euphoria than did sweet dislikers among women. [ncbi.nlm.nih.gov]

  Amphetamines increase alertness, enhance physical performance, and produce euphoria and a sense of well-being. Amphetamines suppress appetite and some people misuse amphetamines to lose weight. [merckmanuals.com]

  This leads to an increase in motor activity, causes euphoria, mental alertness and excitement and suppresses appetite. This drug causes dependence and may cause an increase in heart rate and blood pressure. [cancer.gov]

• Paranoid Ideation

  The results of an open study including eight amphetamine psychotic patients show that the symptoms of excitement and paranoid ideation are significantly decreased within 60 minutes of haloperidol intramuscular administration ( Angrist 1974 ). [doi.org]

• Delusion of Grandeur

  Long‐term users become irritable and garrulous and often suffer delusions of grandeur and exhibit behavior resembling paranoid schizophrenia. [nytimes.com]

• Painful Erection

  […] or frequent and painful erections Drug interaction overview Serotonin syndrome, a potentially life-threatening reaction, may occur when amphetamines are used in combination with other drugs that affect the serotonergic neurotransmitter systems such as [reference.medscape.com]

  weakness, signs of dehydration, or dark urine Prolonged or painful erection Changes of feeling or color in your fingers or toes Serious Side Effects Misuse of amphetamine medications may cause sudden death and serious cardiovascular adverse events. [nami.org]

• Hyperactivity

  Amphetamine-derived medications are being prescribed with increasing frequency to younger pediatric patients to treat attention deficit hyperactivity disorder. [ncbi.nlm.nih.gov]

  135.2062 Structure Simcomp Class Metabolizing enzyme substrate DG01644 CYP2D6 substrate Remark Same as: C07514 ATC code: N06BA01 Chemical structure group: DG00966 Product (DG00966): D07445 D02074 US > Efficacy Stimulant (central) Disease Attention deficit hyperactivity [kegg.jp]

  Amphetamines are used in the treatment of certain neurological conditions, such as attention deficit hyperactivity disorder and narcolepsy. The drugs are highly addictive and are sometimes abused. [yourdictionary.com]

• Headache

  A short history of headache, abdominal pain, vomiting and agitation preceded her admission. Imaging revealed changes consistent with ischaemic colitis. Emergency laparotomy revealed widespread colonic necrosis necessitating a subtotal colectomy. [ncbi.nlm.nih.gov]

  Side Effects Nausea, stomach upset, diarrhea, dry mouth, headache, nervousness, dizziness, trouble sleeping, loss of appetite, weight loss, irritability, or restlessness may occur. [webmd.com]

  When taken as prescribed, amphetamine-containing medication can cause the following side effects, which often improve as your body gets used to the drug: Loss of appetite Trouble sleeping Nausea Headaches Nervousness Dry mouth Moodiness and irritability [verywellmind.com]

• Insomnia

  The dose should be individualized based on patient response; reduce dose if bothersome adverse reactions (e.g., insomnia, anorexia) appear. Use: For the treatment of narcolepsy. [drugs.com]

  Contrary to the clinical observations described by Myles above, the symptom of insomnia was removed from the final version of the AWQ due to its low mean score (28 patients rated insomnia as 'not at all' present or rated it as causing 'very little' distress [www1.health.gov.au]

  He had also been using fenofibrate 267 mg/day for 3 years for hyperlipidemia and trazodone 100 mg/day for 5 months for insomnia. [ncbi.nlm.nih.gov]

  This effect may be clinically important if a patient is receiving an antihistamine agent for treatment of insomnia. [pdr.net]

• Akathisia

  […] system Headache Abnormal movements Respiratory Wheezing Dyspnea Shortness of breath Integumentary Excessive sweating Rash, pruritus Abscess, cellulitis Gastrointestinal Abdominal pain Nausea/vomiting Constipation/diarrhea Jaundice Rectal pain Psychiatric Akathisia [clinicaladvisor.com]

  Olanzapine showed minimal change in Barnes Akathisia Scale (BAS) global scores from baseline to endpoint (median=0.0, range=‐1.0‐0.0), whereas haloperidol showed a worsening effect by the increased change in BAS score (median=0.0, range=‐1.0‐3.0). [doi.org]

A component of the workup for new-onset hypertension in pregnancy often includes a urine drug screen. A labetalol metabolite is structurally similar to amphetamine and methamphetamine, thus causing potential cross-reactivity in drug immunoassays. [ncbi.nlm.nih.gov]

Basic information about the biosample assayed, internal standard, workup, GC or LC column and mobile phase, detection mode, and validation data for each procedure is summarized in two tables to facilitate the selection of a method suitable for a specific [doi.org]

• Fibrinoid Necrosis

  Surgery revealed fibrosis and fibrinoid necrosis around the aneurysm. The aneurysm was successfully embolized with Guglielmi detachable coil. A rapidly growing aneurysm in the major intracranial vessels resulting from amphetamine abuse is very rare. [ncbi.nlm.nih.gov]

• Gliosis

  Several forms of white matter abnormality are also common and may involve gliosis. Many of the limitations and inconsistencies in the literature relate to techniques and cross-sectional designs, which cannot infer causality. [ncbi.nlm.nih.gov]

treatment did not reduce amphetamine use. [ncbi.nlm.nih.gov]

For an overdose, treatment involves sedatives, blood pressure–lowering drugs and sometimes cooling treatments. [merckmanuals.com]

For the studies in which the treatment and/or controlled groups were divided into subgroups because of the differences of concurrent treatment, the continuous data of the subgroups receiving more rigorous treatment, e.g., higher doses of drug treatment [doi.org]

Multiple conditions are associated with DAH, of which Wegener's granulomatosis is the most frequent, and underlying disease determines the prognosis and treatment. [ncbi.nlm.nih.gov]

9.1.1 Ingestion 9.1.2 Inhalation 9.1.3 Skin exposure 9.1.4 Eye contact 9.1.5 Parenteral exposure 9.1.6 Other 9.2 Chronic poisoning 9.2.1 Ingestion 9.2.2 Inhalation 9.2.3 Skin exposure 9.2.4 Eye contact 9.2.5 Parenteral exposure 9.2.6 Other 9.3 Course, prognosis [inchem.org]

Since acute and chronic amphetamine psychoses may be different from each other in the respects of pathophysiology, clinical features, response to treatment, course of illness, and prognosis. [doi.org]

We report on two patients who severely and repeatedly mutilated their own genitalia while intoxicated on amphetamines and consider possible diagnostic etiologies. [ncbi.nlm.nih.gov]

Amphetamine is indicated for the treatment of attention-deficit/hyperactivity disorders (ADHD) as well as for the treatment of central nervous system disorders such as narcolepsy. 1 ADHD is a complex disorder associated with the substantial heterogeneity in etiology [drugbank.ca]

Epidemiology. Following its use in the Second World War, metamfetamine gained popularity as an illicit drug in Japan and later the United States. [doi.org]

Three researchers independently reviewed studies (Meta-analysis of Observational Studies in Epidemiology and Preferred Reporting Items for Systematic Reviews and Meta-analyses). Validity and bias were appraised. [ncbi.nlm.nih.gov]

In paticular, the epidemiologic topics of 3, 4-methylenedioxymethamphetamine (MDMA) called the rivival of LSD was described. [ci.nii.ac.jp]

BACKGROUND: Cocaine- and amphetamine-regulated transcript (CART) peptide is a candidate neuropeptide as a biomarker for major depressive disorder (MDD) because of its effects on emotion and distribution covering brain areas involved in the pathophysiology [ncbi.nlm.nih.gov]

It goes on to discuss briefly the significance of the receptor, agents acting upon it, its distribution, and currently hypothesized physiological and pathophysiological roles. [doi.org]

Description: Amphetamine is designed to prevent three things, (all are individually optional): Screen Saver Sleep Mode System Shutdown/Restart While there are apps out there that prevent the screen saver and sleep modes, when this app was originally written [foolishit.com]

Thereafter, we set to investigate if later potentiation of α5GABA A Rs in offspring's preadolescence (from postnatal day 22-28) could prevent the deficit in locomotor reactivity to amphetamine observed in adulthood, at postnatal day P60. [ncbi.nlm.nih.gov]

Resource Center, (1998). 22 Brands, B., (1998). 23 Goldstein, A., (2001). 24 Carson-DeWitt, R., (2001). 25 MEDLINEplus, (1998). 26 Carson-DeWitt, R., (2001). 27 Indiana Prevention Resource Center, (1998). 28 Indiana Prevention Resource Center, (1998) [cesar.umd.edu]

This lack of understanding presents obstacles to prevention, treatment and policy responses. [who.int]