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Amphotericin B


Presentation

  • The present systematic review and meta-analysis showed that conventional amphotericin B presents the same efficacy profile as lipid-based formulations, although the latter were associated with a safer profile.[ncbi.nlm.nih.gov]
  • We present a successfully treated case with rhino-orbital mucormycosis caused by Rhizopus oryzae in a diabetic and dialysis patient.[ncbi.nlm.nih.gov]
  • Immunomodulatory drugs (IMiDs) present one example of immunomodulatory agents that improve cancer immunotherapy.[ncbi.nlm.nih.gov]
  • The goal of the present report was to show efficacious management including the association of topical treatment with amphotericin B complex lipid to standard therapy and the absence of side effects.[ncbi.nlm.nih.gov]
  • Ocular involvement is an unusual presentation of leishmaniasis, and the eyelid is not a common site of cutaneous lesions, likely due to the mobility of the lids.[ncbi.nlm.nih.gov]
Intravenous Administration
  • New medicines based on lipid-based systems have been commercialised in the last decade, these treatments are able to reduce the toxicity of the drug but intravenous administration is still required.[ncbi.nlm.nih.gov]
  • Toxicity studies demonstrated normal blood urea nitrogen (BUN) and plasma creatinine (PC) level and no sign of abnormal histopathology upon intravenous administration of micellar formulations.[ncbi.nlm.nih.gov]
  • It was selected over other amphotericins and nystatin as being less toxic for intravenous administration.[life-worldwide.org]
  • Intravenous administration of small doses of adrenal corticosteroids just prior to or during the amphotericin B infusion may help decrease febrile reactions.[rxlist.com]
Acrocyanosis
  • Amphotericin B liposome was discontinued, and anisodamine was used intravenously to treat acrocyanosis and pain induced by amphotericin B liposome for 9 days and patient was cured.[ncbi.nlm.nih.gov]
Subcutaneous Nodule
  • Herein, we report the case of a primary hemophagocytic syndrome patient who developed subcutaneous nodules in the 3(rd) month of bone marrow transplantation from which Aspergillus fumigatus was cultivated despite the fact that she was under antifungal[ncbi.nlm.nih.gov]
Ataxia
  • Two months after treatments, MRI was performed on the development of ataxia and a cerebellar abscess was detected. The abscess was surgically excised and local amphotericin B was applied.[ncbi.nlm.nih.gov]

Workup

Liver Biopsy
  • Liver biopsy showed images of nodular regenerative hyperplasia related to CGD as well as a histiocytic storage disease. We discuss the very prolonged use of L-AmB leading to the development of a lysosomal storage disease.[ncbi.nlm.nih.gov]

Treatment

  • In the overall treatment outcome analysis, initial cure (30 days after start of treatment) was observed in 128 (87.1 %), treatment failures in 10 (6.8 %), interruptions in 2(1.4 %) and deaths in 7 (4.8 %) patients.[ncbi.nlm.nih.gov]
  • Treatment response was assessed at each visit and the cases were followed up for 6 months. All the five patients responded well to the treatment and remained recurrence-free during follow-up.[ncbi.nlm.nih.gov]
  • Onychomycosis was clinically cured in all patients after a 12-month treatment. Mycological cure was obtained in all but 1 patient.[ncbi.nlm.nih.gov]
  • Surgical treatment with lung resection has traditionally been the treatment of choice for pulmonary cavities containing aspergillomas that cause hemoptysis.[ncbi.nlm.nih.gov]
  • Therefore, this technique could be an effective and safe method for the treatment of cryptococcal meningitis.[ncbi.nlm.nih.gov]

Prognosis

  • G. capitatum infection has been reported mainly in immunocompromised patients and the prognosis is poor with a mortality rate of approximately 50-75%.[ncbi.nlm.nih.gov]
  • This report suggests that a combination of liposomal amphotericin B and posaconazole can be a therapeutic option in patients with a poor prognosis.[ncbi.nlm.nih.gov]
  • View Article Google Scholar Parfrey NA: Improved diagnosis and prognosis of mucormycosis. Medicine. 1986, 65: 113-123.[bmcinfectdis.biomedcentral.com]

Etiology

  • To the best of our knowledge, this is the first proven report unequivocally proving the etiologic role of C. conglobata in bloodstream infection.[ncbi.nlm.nih.gov]
  • This case report describes infection by S. prolificans, which rarely becomes an etiologic agent in lung transplant patients, and shows that endobronchial topical amphotericin B instillation is a therapeutic option when systemic antifungal treatment is[ncbi.nlm.nih.gov]
  • ., site and severity of infection, etiologic agent, cardio-renal function, etc.). A single intravenous test dose (1 mg in 20 mL of 5% dextrose solution) administered over 20 to 30 minutes may be preferred.[globalrph.com]

Epidemiology

  • To characterize the clinical and epidemiological profiles of patients with visceral leishmaniasis (VL) treated with liposomal amphotericin B (LAmB) and to identify prognostic factors for death from VL in 2008-2012 in the state of Minas Gerais, Brazil.[ncbi.nlm.nih.gov]
  • Only one isolate (1/81) showed amphotericin B MIC above the epidemiologic cut-off value (ECV; 4 μg/mL). None of the isolates had a MIC of ECV for voriconazole, itraconazole and posaconazole.[ncbi.nlm.nih.gov]
  • (zygomycosis)" and "Treatment and prevention of invasive aspergillosis" and "Treatment and prevention of Fusarium infection" and "Cryptococcus neoformans: Treatment of meningoencephalitis and disseminated infection in HIV seronegative patients" and "Epidemiology[uptodate.com]
  • Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis . 2005;41:634-653. 27. Safdar A.[journals.lww.com]
  • Because of stark epidemiologic and clinical differences, results from trials in European settings should not be extrapolated to apply to low-income countries, and vice versa.[academic.oup.com]
Sex distribution
Age distribution

Prevention

  • This case highlights the importance of differentiating between pseudohyperphosphatemia and hyperphosphatemia to prevent complications.[ncbi.nlm.nih.gov]
  • The clinical manifestations and course can vary substantially, with appropriate management ranging from observation for self-healing lesions to urgent treatment to prevent damaging anatomical and cosmetic sequelae.[ncbi.nlm.nih.gov]
  • Secondary prophylaxis with LamB, applied during both consolidation therapy and myeloablative sibling allogeneic HSCT, was effective to prevent IFI recurrence despite the development of grade I acute graft-versus-host disease (GVHD) and limited chronic[ncbi.nlm.nih.gov]
  • (via antibiotic antifungal agent ) antiprotozoal drug Any antimicrobial drug which is used to treat or prevent protozoal infections. antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals.[ebi.ac.uk]
  • The treatment was given to prevent fungal infections. All studies were sponsored by the manufacturer of the study drug, voriconazole.[cochrane.org]

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