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Ampicillin-Sulbactam
Ampicillin / Sulbactam Injectable Solution [unasyn]

Presentation

A higher risk of treatment failure for antibiotic therapy was found for patients presenting to the ED with symptoms of cIAIs lasting >24 h. Alternative antimicrobial agents should be considered for treating these patients. [ncbi.nlm.nih.gov]

Entire Body System

  • Intravenous Administration

    Clinical and pharmacokinetic studies on intravenous administration of sulbactam/ampicillin in pediatrics. Jpn J Antibiot. 1989,42:623-638. 7. Nakao Y, Kimura H. Miura K. et al. [healio.com]

    ADMINISTRATION Injectable Administration Ampicillin; sulbactam is administered intravenously or intramuscularly. [pdr.net]

Urogenital

  • Uterine Tenderness

    Endometritis was defined as the presence of fever (38°C or higher) in association with one or more of the following: uterine tenderness, foul smelling lochia, and leucocytosis of >12.000 after exclusion other site of infection that developed within the [bmcinfectdis.biomedcentral.com]

Treatment

Randomized Intervention Model: Parallel Assignment Masking: Single (Participant) Primary Purpose: Treatment Official Title: A Comparative Study of Ampicillin/Sulbactam Versus Moxifloxacin in the Treatment of Complicated Intra-abdominal Infections Study [clinicaltrials.gov]

First-line treatment includes cefoxitin or cefotetan with doxycycline or clindamycin with gentamycin plus doxycycline. [ncbi.nlm.nih.gov]

Prognosis

Prognosis after community-acquired pneumonia in the elderly: a population-based 12-year follow-up study. Arch Intern Med. 1999;159:1550–5. PubMed CrossRef Google Scholar 6. Kaplan V, Clermont G, Griffin MF, et al. [link.springer.com]

Hedlund J, Hansson LO, Ortqvist A (1995) Short- and long-term prognosis for middle-aged and elderly patients hospitalized with community-acquired pneumonia: impact of nutritional and inflammatory factors. Scand J Infect Dis 27: 32-37. [omicsonline.org]

Etiology

A patient with multiple, pyogenic hepatic abscesses is described, and the pathophysiology, etiologies, clinical and laboratory manifestations, and management of the disease are reviewed. [ncbi.nlm.nih.gov]

Given the mixed bacterial etiology of such infections in both drug users and nonusers and given the need to initiate treatment before the results of antimicrobial susceptibility tests are known, empirical therapy with broad-spectrum antimicrobials may [academic.oup.com]

Epidemiology

STUDY OBJECTIVE: To evaluate epidemiology, resistance, and treatment outcomes of Acinetobacter baumannii bacteremia treated with imipenem-cilastatin or ampicillin-sulbactam for 72 hours or longer. DESIGN: Retrospective analysis. [ncbi.nlm.nih.gov]

In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. DOSAGE AND ADMINISTRATION Ampicillin and Sulbactam for Injection may be administered by either the IV or the IM routes. [druglib.com]

Pathophysiology

The patient remained under continuous observation and cardiac monitoring throughout her reaction, thus providing unique insight into the pathophysiology of myocardial injury caused by anaphylaxis. [ncbi.nlm.nih.gov]

Pharmacotherapy: A Pathophysiologic Approach. ISBN 978-1-260-11681-6. ^ a b c Clinical Pharmacology Web site. http://www.clinicalpharmacologyip.com/Forms/Monograph/monograph.aspx?cpnum=35&sec=moncontr&t=0[permanent dead link]. [en.wikipedia.org]

Prevention

Brief Summary: The efficacy and safety of a single dose of ampicillin/sulbactam compared to a single dose of cefuroxime at cord clamp for prevention of postcesarean infectious morbidity has not been assessed. [clinicaltrials.gov]

Conclusions Ampicillin/sulbactam was as safe and effective as cefuroxime when administered for the prevention of infections following cesarean delivery. [bmcinfectdis.biomedcentral.com]

BACKGROUND: The efficacy and safety of a single dose of ampicillin/sulbactam compared to a single dose of cefuroxime at cord clamp for prevention of post-cesarean infectious morbidity has not been assessed. [ncbi.nlm.nih.gov]

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