Presentation
Ampullary adenomas may present with obstruction of the main gastrointestinal tract and/or biliary/pancreatic ducts. Common presentations include gastric outlet obstruction, gastrointestinal bleeding or acute pancreatitis. [karger.com]
An exquisite art program that focuses on clarity of presentation with an emphasis on anatomy, pathology, patient presentation, and clinical context. [books.google.com]
Ampullary neuroendocrine tumor presenting with biliary obstruction and gastric outlet obstruction. [jpalliativecare.com]
These tumors tend to present earlier than their pancreatic and distal bile duct brethren. [readbyqxmd.com]
Due to the early presentation of ampullary tumors and relative distance from the mesenteric vessels, vascular involvement is uncommon. [abdominalkey.com]
Entire Body System
- Localized Edema
Until recently the main response to this kind of lesion was duodenopancreatectomy, regardless of the cellular atypia and local edema. [jmedicalcasereports.biomedcentral.com]
Gastrointestinal
- Clay-Colored Stool
Ampullary cancer care at Mayo Clinic Symptoms Signs and symptoms of ampullary cancer may include: Yellowing of the skin and eyes (jaundice) Clay-colored stools Abdominal pain Fever Bleeding from the rectum Nausea Vomiting Weight loss When to see a doctor [mayoclinic.org]
POTENTIAL SIGNS AND SYMPTOMS The symptoms of biliary obstruction can depend on the cause of the obstruction, some are outlined below: Most common symptoms can include light or clay-colored stools, dark urine and Nausea and vomiting typically present in [aimisrobotics.com]
Liver, Gall & Pancreas
- Biliary Colic
These stones cause biliary colic, biliary obstruction, gallstone pancreatitis, or cholangitis (bile duct infection and inflammation). Cholangitis, in turn, can lead to strictures, stasis, and choledocholithiasis. [msdmanuals.com]
CHEMOTHERAPY Triclabendazole ◦ Single dose of 10 mg/kg ◦ Better absorption with fatty meal ◦ Adverse effect – biliary colic; antispasmodic to be administered concurrently ◦ Other drugs Bithionol dehydroemetine nitazoxanide 20. [slideshare.net]
They may cause severe pain (see biliary (colic) ) or they may pass into the common bile duct and cause obstructive jaundice or cholangitis. [encyclopedia.com]
Psychiatrical
- Loss of Initiative
She was treated with numerous antibiotics, whilst intermittent symptoms of recurrent vomiting and weight loss were initially attributed to her lung infections. [karger.com]
Workup
Diagnostic workup initially included abdominal computed tomography (CT) and magnetic resonance imaging (MRI) of the abdomen which demonstrated dilatation of the common bile duct. [hoajonline.com]
(ie, for staging purposes) Positron emission tomography (PET) or PET-CT scanning: PET or PET-CT scans can detect metastases that are too small to be reliably detected on a CT scan See Workup for more detail. [emedicine.medscape.com]
Abdominal radiology (New York). 2016 Feb [PubMed PMID: 26867916] [8] Blumer SL,Zucconi WB,Cohen HL,Scriven RJ,Lee TK, The vomiting neonate: a review of the ACR appropriateness criteria and ultrasound's role in the workup of such patients. [statpearls.com]
Choledocholithiasis Duodenal Ulcers Gallbladder Cancer Gallbladder Tumors Lymphoma, Non-Hodgkin Pancreatic Cancer Pancreatitis, Chronic Papillary Necrosis Papillary Tumors Other Problems to be Considered: Duodenal carcinoma Adenoma at the ampulla of Vater WORKUP [oncology-articles.blogspot.com]
X-Ray
- Cavitary Lesion
On CT, PADs appear as thin-walled cavitary lesions, originating from the medial aspect of the 2nd portion of the duodenum that typically contain gas. [eurorad.org]
On CT scan and MRCP, PAD may appear as thin-walled cavitary lesions on the wall of the second portion of the duodenum. Barium studies show PAD with contrast-filled out-pouchings that arise from the wall of the descending duodenum [1]. [academic.oup.com]
Treatment
Significant updates on bariatric surgery, Barrett's esophagus, endoscopic ultrasound, endosonography, treatment of liver disease, and much more keep you current on the latest advances. [books.google.de]
Surgery is the primary treatment for ampullary cancer. Advanced cases may be treated with stents and palliative treatment. Treatment of ampullary cancer is based on the size and stage of the tumor. [medindia.net]
The treatment we followed was transduodenal local excision of his ampulla of Vater. [jmedicalcasereports.biomedcentral.com]
Treatment When symptoms are severe, standard treatment is to perform an endoscopic procedure called ERCP (endoscopic retrograde cholangiopancreatography). ERCP is a procedure for the examination or treatment of the bile duct and pancreatic duct. [iffgd.org]
Prognosis
Primary surgical treatment with curative intent should be performed although this type of carcinoma associates with dismal prognosis. [pancreas.imedpub.com]
If left untreated, it is fatal Prognosis will depend on the presence of associated cardiac, tracheo-esophageal, anal, renal, or skeletal abnormalities (VATER) Double Bubble Sign. [learningradiology.com]
[…] with prognosis and survival. [emedicine.medscape.com]
Treatment and long-term prognosis are dependent upon the location of the mass. [gastrointestinalatlas.com]
Etiology
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]
The jejunal limb is subject to adhesion formation, internal herniation, volvulus, anastomotic obstruction, and other etiologies of ALS, as described above. Contraindications Surgical correction of ALS has no absolute contraindications. [laparoscopyhospital.com]
Biliary cysts: etiology, diagnosis and management. World J Gastroenterol 2012;18:4801–4810. 25. Lee HK, Park SJ, Yi BH, Lee AL, Moon JH, Chang YW. Imaging features of adult choledochal cysts: a pictorial review. Korean J Radiol 2009;10:71–80. 26. [kjronline.org]
We highlight the importance of high clinical suspicion and individualized treatment according to the patient's condition, severity, ALS etiology and locally available treatment possibilities. References 1. Cho YS, Lee TH, Hwang SO, et al. [scielo.isciii.es]
Definition / general By definition, centered in ampulla of Vater, arises from ampullary intestinal mucosa If advanced, cannot distinguish tumor origin between ampulla, distal common bile duct or pancreas Etiology May arise from villous adenoma or villoglandular [pathologyoutlines.com]
Epidemiology
Ampullary carcinoma: Epidemiology, clinical manifestations, diagnosis and staging. https://www.uptodate.com/contents/search. Accessed Sept. 8, 2019. [mayoclinic.org]
Between 1973 and 2005, 5,625 cases were recorded in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. [emedicine.medscape.com]
Methods Statistics Trigonometry Medical & Nursing Anatomy Anesthesiology Audiology Bacteriology Biochemistry Bioethics Biomedical Science Cardiology Cardiovascular Childbirth Chiropractic Dentistry Dermatology Diagnostic Imaging Drugs Endocrinology Epidemiology [brainscape.com]
FASCIOLIASIS Etiology: Zoonosis caused by trematode ◦ Fasciola hepatica ◦ Fasciola gigantica Epidemiology F. hepatica – temperate zones F. gigantica – tropical zones Now has become global in distribution 4. [slideshare.net]
One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35, 825 cases in the United States. J Clin Oncol 2008; 26:3063-72. [PMID: 18565894] [pancreas.imedpub.com]
Pathophysiology
This book in The Netter Collection of Medical Illustrations (the CIBA "Green Books") has been expanded and revised to capture current perspectives in hepatology, pancreatology, and gastroenterology - from normal anatomy and physiology through pathophysiology [books.google.com]
The pathophysiological features in intestinal obstruction are summarized in Figure 4. 6. [intechopen.com]
In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Saunders Elsevier; 2016. https://www.clinicalkey.com. Accessed June 13, 2019. Ryan DP, et al. [mayoclinic.org]
ERCP and endoscopic manometry seem to be useful in clarifying the pathophysiology of symptomatic choledochocele and ACPBD [ 20 - 23 ]. [omicsonline.org]
The pathophysiology and signs and symptoms associated with ALS result from partial or complete obstruction of the afferent loop. [laparoscopyhospital.com]
Prevention
Prevention Ampullary cancer is such a rare condition that experts aren’t sure what steps, if any, can be taken to prevent it. [hopkinsmedicine.org]
Because of its location, this cancer can cause obstruction of the common bile duct and prevent bile from flowing into the intestine and out of the body. [medicinenet.com]
[citation needed] The sphincter of Oddi controls the introduction of bile and pancreatic secretions into the duodenum, as well as preventing the entry of duodenal contents into the ampulla. [en.wikipedia.org]