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Anaerobic Bacterial Infection

Infection Due to Anaerobic Bacteria


Presentation

  • Here we present a novel 3D skin ex vivo model to study anaerobic bacterial infections using ovine skin explants infected with D. nodosus.[orbit.dtu.dk]
  • The present proposal tests the hypothesis that the hypoxic environment of the CF airways promotes infection by obligate anaerobes as mixed infections that are pathogenic for the CF lung.[grantome.com]
  • Preauricular adenopathy may be present.[healio.com]
  • Exogenously acquired cases also sometimes occur via the gastrointestinal tract and may present as intoxication or as overt infection.[journals.lww.com]
Preauricular Adenopathy
Foul Smelling Discharge
  • Clinical symptoms suggestive of anaerobic infection include: • Foul-smelling discharge • Location of infection in proximity to a mucosal surface • Necrotic tissue, gangrene, pseudomembrane formation • Gas in tissues or discharges • Endocarditis with negative[labcorp.com]
  • Free gas in the tissues, abscess formation and foul-smelling discharge is commonly associated with the presence of anaerobic bacteria.[en.wikipedia.org]
  • Major Clues to Anaerobic Infection Foul-smelling discharge Infection in proximity to a mucosal surface Tissue necrosis, gangrene Gas in tissues or discharges Infection associated with malignancy Infections secondary to human or animal bite Infection related[antimicrobe.org]
Sulfur Granules
  • granules" Characteristics of Bacteroides MOST COMMON CAUSE OF SERIOUS ANAEROBIC INFECTIONS (B.[quizlet.com]
  • granules” in discharges (actinomycosis) • Classical clinical features of gas gangrene • Clinical setting suggestive for anaerobic infection (septic abortion, infection after gastrointestinal surgery, genitourinary surgery, etc) See table in Anaerobic[labcorp.com]
Epilepsy
  • List and discus the major conditions predisposing a patient to aspiration pneumonia and relate each to the host defenses that are defeated. alcohol, smoking, poor dentition, esophageal motility, stroke, Epilepsy, drug use, GERD, head and neck cancers,[brainscape.com]
Rhinitis
  • Acute dacryocystitis secondary to exudative rhinitis. Ophthalmic Plast Reconstr Surg 1993; 9: 51–52. Google Scholar 47. Wesley RE. Lacrimal disease. Curr Opin Ophthalmol 1994; 5: 78–83. Google Scholar 48. Bareja U, Ghose S.[link.springer.com]
  • Acute dacryocystitis secondary to exudative rhinitis. Ophthalmic Plast Reconstr Surg . 1993;9:51–52. doi:10.1097/00002341-199301001-00016 [CrossRef] : Faden HS. Dacryocystitis in children. Clin Pediatr (Phila) . 2006;45:567–569. : Bareja U, Ghose S.[healio.com]
Cyanosis
  • List the clinical signs of gas gangrene. crepitus, dishwater discharge, early onset of pain, rapid evolution of damage, cyanosis 1. Name the organism (genus and species) most commonly associated with antibiotic associated diarrhea. 2.[brainscape.com]
Lacrimation
  • Purulent material can be expressed from the lacrimal puncta.[healio.com]
  • Lacrimal disease. Curr Opin Ophthalmol 1994; 5: 78–83. Google Scholar 48. Bareja U, Ghose S. Clinicobacteriologic correlates of congenital dacryocystitis. Indian J Ophthalmol 1990; 28: 66–69. Google Scholar 49. Pollard ZF.[link.springer.com]
Photophobia
  • Diagnosis The patient presents with severe pain, reflex tearing, eye redness, decreased vision, and photophobia. Grayish corneal opacification is characteristic, the light reflex is dulled, and the cornea can be stained with fluorescein.[healio.com]
Agalactia
  • […] complication of a viral upper respiratory tract infection. 45 Microbial Etiology S. aureus , S. epidermidis , and, rarely, P. aeruginosa and Escherichia coli have been reported in older patients, 46 whereas S. pneumoniae , H. influenzae , Streptococcus agalactiae[healio.com]

Workup

Fusarium
  • Fungal causes are rare and include Aspergillus , Fusarium solani, and Candida albicans. A variety of aerobic and gram-positive and gram-negative bacteria can cause keratitis.[healio.com]

Treatment

  • Treatment of cytomegalovirus pneumonia with ganciclovir and intravenous cytomegalovirus immunoglobulin in patients with bone marrow transplants.[books.google.com]
  • Comparison of topical ciprofloxacin to conventional antibiotic therapy in the treatment of ulcerative keratitis. Am J Ophthalmol 1993; 115: 471–477. Google Scholar 40. Glasser DB, Gardner S, Ellis JG, Pettit T.[link.springer.com]
  • Stolberg L, Rolfe R, Gitlin N. et al .: D-lactic acidosis due to abnormal gut flora: Diagnosis and treatment of two cases. N Engl J Med 1982, 306: 1344–1348. 16.[journals.lww.com]
  • Treatment of anaerobic infection is complicated by the slow growth of these organisms, their polymicrobial nature, and the growing resistance of anaerobic bacteria to antimicrobials.[healio.com]
  • Discuss and evaluate the role of debridement in the treatment of gas gangrene. very important in removing devitalized tissue (anaerobic culture) and organism burden (decrease bug, decrease a toxin) 4.[brainscape.com]

Prognosis

  • Ilan Y, Oren R, Ben-Chetrit E: Acute pericarditis: Etiology, treatment and prognosis. Jpn Heart J 1991;32:315–321.[karger.com]
  • Prognosis Complete recovery should be achieved with the appropriate surgery and antibiotic treatment. Untreated or uncontrolled infections can cause severe tissue and bone destruction, which would require plastic surgery to repair.[encyclopedia.com]
  • […] patients described in these studies were either newborns or were over 6 weeks of age and suffered from chronic debilitating disorders such as malignant neoplasms, immunodeficiencies, chronic renal insufficiency, or decubitus ulcers and carried a poor prognosis[ccforum.biomedcentral.com]

Etiology

  • Delayed opening, inspissated secretion, or anatomical abnormality is a common etiology in infants.[healio.com]
  • Ilan Y, Oren R, Ben-Chetrit E: Acute pericarditis: Etiology, treatment and prognosis. Jpn Heart J 1991;32:315–321.[karger.com]
  • Culture of specimens from sites harboring endogenous anaerobic organisms or contaminated by endogenous organisms may be misleading with regard to etiology and selection of appropriate therapy.[labcorp.com]
  • Regardless of the etiology, anaerobes are predominant and the most frequent anaerobic isolates were anaerobic streptoccocci and Gram negative bacilli.[anaerobicinfections.blogspot.com]
  • The dynamic of sinusitis and other upper respiratory tract infections Changes in the microbial etiology of sinusitis over time Mechanism whereby viruses predispose to bacterial sinusitis • Disruption of the local immune defense, leading to bacterial attachment[sinusitisunderstood.blogspot.com]

Epidemiology

  • Epidemiologic, diagnostic, and clinical features. Ann Intern Med 1974; 80:83—93. ‏ الصفحة 183 - PS et aL Treatment of cytomegalovirus pneumonia with ganciclovir and intravenous cytomegalovirus immunoglobulin in patients with bone marrow transplants.[books.google.com]
  • Epidemiology Frequency United States The exact frequency of AGNB infection is difficult to calculate because of inappropriate methods of collection, transportation, and cultivation of specimens. AGNB are more commonly found in chronic infections.[emedicine.medscape.com]
  • Surgical site infections: epidemiology, microbiology and prevention. J Hospital Infect. 2008; 70 : 3-10 22. Aldridge KE, Ashcraft D, O'Brien M, Sanders CV.[jjmicrobiol.com]
  • Epidemiology of community-associated Clostridium difficile infection, 2009 through 2011 . JAMA Intern Med 173 : 1359 – 1367 . 8. Karkos PD ,, Asrani S ,, Karkos CD ,, Leong SC ,, Theochari EG ,, Alexopoulou TD ,, Assimakopoulos AD . 2009 .[asmscience.org]
  • However, because the origin of most anaerobes is endogenous, there are rarely epidemiological reasons to obtain their complete identification.[americorpshealth.biz]
Sex distribution
Age distribution

Pathophysiology

  • Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Anaerobic bacteria are the greatest component of the human body's normal bacterial flora colonizing the skin, oral cavity, and[mayomedicallaboratories.com]
  • Although there is compelling evidence that obligate anaerobic species are part of a complex microbial ecosystem in the CF lung, their role in the pathophysiology of CF lung disease remains unclear.[thorax.bmj.com]
  • Pathophysiology Although AGNB perform beneficial functions as part of the GI flora, they are also consummate opportunistic pathogens that can cause serious infections, typically in synergistic infections in combination with other anaerobic as well as[emedicine.medscape.com]
  • Pathophysiology The infection can occur as a result of tear stagnation in the lacrimal sac secondary to obstruction of the normal drainage of the tears through the nasolacrimal duct due to trauma, infection or inflammation, tumor infiltration, and after[healio.com]
  • The indigenous anaerobic microflora are, however, often profoundly affected by pathophysiological states and by exposure to antibiotics and other pharmacological compounds.[journals.lww.com]

Prevention

  • Early treatment with ganciclovir to prevent cytomegalovirus disease after allogeneic bone marrow transplantation. N EnglJMed ‏ الصفحة 143 - WIDMER AF, WENZEL RP, TRILLA A, BALE MJ, JONES RN, DOEBBELING BN.[books.google.com]
  • If diagnosed and treated early, the complications of PID can be prevented.[cdc.gov]
  • Explain why this organism is problematic as a hospital-acquired pathogen, how it is transmitted and what preventative strategies can be used to reduce rates. can be spread by very hardy spores (shed in feces) that are not killed by certain cleaning products[brainscape.com]
  • Getting treatment for minor infections can help prevent the spread of bacteria.[healthline.com]
  • Any such link could provide a potential mode of intervention in the prevention of colonic cancer.[anaerobicinfections.blogspot.com]

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