Presentation
[…] patients were symptomatic at presentation. [saudijgastro.com]
Clinical History 76 year old female presents with painful defecation, rectal bleeding and iron deficient anaemia. Lower GI endoscopy revealed a rectal mass. [eurorad.org]
The patient did not present important complications in the immediate postoperative period. [scielo.br]
Since smooth muscle is present throughout the body, leiomyosarcoma can occur anywhere in the body. [mdanderson.org]
Entire Body System
- Pain
Clinical History 76 year old female presents with painful defecation, rectal bleeding and iron deficient anaemia. Lower GI endoscopy revealed a rectal mass. [eurorad.org]
Case 2 An 88-year-old male presented to the emergency room with complaints of abdominal pain, fever, and chills. [hindawi.com]
In addition to low abdominal pain, the patient had experienced low back pain, urinary frequency, and tenesmus for approximately 1 year. She had undergone myomectomy 2 years previously in China. The patient’s menses had ceased at the age of 50. [ovarianresearch.biomedcentral.com]
The common symptoms of rectal leiomyosarcoma are changes in bowel habits, rectal and anal pain, a pressure sensation, and anal bleeding (6). In our case, the patient was admitted with complaints of anal bleeding and lower abdominal pain. [tcr.amegroups.com]
- Pathologist
The pathologic diagnosis can be difficult, and sometimes review of the biopsy by an expert pathologist is needed. A complete staging is needed before formulating a treatment plan. [mdanderson.org]
Microscopic diagnosis and differentiation of malignant from benign features require a pathologist with special interest and expertise with these lesions. [link.springer.com]
In our department, MDT meetings for colorectal malignant tumors have been established, and the committee includes surgical oncologists, medical oncologists, radiation oncologists, pathologists and radiologists. [tcr.amegroups.com]
- Surgical Procedure
Wide local excision was performed in 10 patients, whereas a more radical surgical procedure, including abdominoperineal resection (n=8), pelvic exenteration (n=2), and low anterior resection (n=1), were performed in 11 patients. [link.springer.com]
Five months after the surgical procedure, in a radiological follow-up, abdominal ultrasound and abdominal-pelvic CT without contrast, due to deterioration of the renal function, revealed pleural effusion, ascites, hepatomegaly as well as multiple well-defined [ncbi.nlm.nih.gov]
- Fever
Case 2 An 88-year-old male presented to the emergency room with complaints of abdominal pain, fever, and chills. [hindawi.com]
Case report A 61-year-old male patient, smoker, with a history of long-standing melena of several years, associated with fever, weight loss, and pelvic and lumbar pain of 3 months of evolution. [ncbi.nlm.nih.gov]
- Asymptomatic
Often these tumors are initially asymptomatic due to their submucosal origin. Clinical diagnosi depends on awareness of these lesions, digital rectal examination, endoscopic examination, and tissue biopsy. [link.springer.com]
The presenting symptoms are rectal pain, constipation, rectal fullness, and diarrhea, although some patients may be asymptomatic [3]. [ovarianresearch.biomedcentral.com]
Workup
The preoperative metastatic workup did not report abnormalities. Axial image of abdominal CT with contrast that shows a solid heterogeneous mass in the rectosigmoid junction (white arrow). [ncbi.nlm.nih.gov]
Treatment
Treatment by Cancer Type NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) are posted with the latest update date and version number. The NCCN Guidelines are copyrighted by the NCCN. All rights reserved. [nccn.org]
Due to its rarity, the standard treatment has not been defined. The purpose of this study was to present the follow-up of a patient with leiomyosarcoma of medium rectum submitted to exclusive operative treatment. [scielo.br]
What are the treatment options for leiomyosarcoma? Surgery is the mainstay of treatment for leiomyosarcoma, but radiation therapy and chemotherapy are often used in conjunction with surgery. [mdanderson.org]
Treatment The patient was offered surgical management via abdominoperineal resection, but he declined. [ncbi.nlm.nih.gov]
Surgery is the treatment of choice that offers the best oncologic results in these cases. [revistagastroenterologiamexico.org]
Prognosis
What is the prognosis for someone diagnosed with leiomyosarcoma? The prognosis for leiomyosarcoma varies greatly depending on the stage of disease. Size and metastatic spread are key factors in leiomyosarcoma. [mdanderson.org]
Conclusion In conclusion, leiomyosarcoma of the colon is a rare and aggressive neoplasm with poor prognosis. It can mimic other tumors and GI diseases but should be distinguished as a separate entity as the prognosis and treatment vary. [hindawi.com]
Leiomyosarcoma has a poor prognosis, with a 5-year survival rate of 30% in the minority of patients without associated risk factors. [scielo.org.co]
Prognosis is also poor; tumor size, histological grade, mitotic index, and local staging are the most known prognosis factors. [jmedicalcasereports.biomedcentral.com]
Using a histological grading system that included tumour differentiation, mitotic count and amount of necrosis, high grade sarcomas were associated with a worse prognosis. [pubmed.ncbi.nlm.nih.gov]
Etiology
[…] has currently been shown that the period can be shorter, with the appearance of radiation-induced tumors from 6 months to 20 years after treatment completion.3 It is known that the development of these tumors is the result of the interaction of many etiologic [revistagastroenterologiamexico.org]
Epidemiology
Definition / general Smooth muscle tumor with atypia plus either mitotic activity, tumor cell necrosis or size > 10 cm 10% of adult soft tissue sarcomas Variants are described separately above Epidemiology Skin / subcutis: see cutaneous variants above [pathologyoutlines.com]
A population- based epidemiologic and prognostic study of 48 patients, including cellular DNA content. [ncbi.nlm.nih.gov]
Prevention
Wide local resection was not superior to a more radical surgical approach in preventing tumor recurrence or improving survival. [link.springer.com]
The high risk of CRC is attributed to three main factors: the carcinogenic effect of chronic mucosal inflammation, genetic predisposition, and environmental factors. 1,2 To prevent morbidity and mortality associated with CRC in patients with IBD, endoscopic [scielo.org.co]