Presentation
Finally, our multiplex assay can detect all three tick-borne pathogens in a sensitive and specific manner irrespective of the level of each pathogen present in the sample. [ncbi.nlm.nih.gov]
Workup
Ultrasound
-
Enlargement of the Spleen
A. phagocytophilum lacking lpda1 revealed enlargement of the spleen, increased splenic extramedullary hematopoiesis, and altered clinicopathological abnormalities during mammalian colonization. [ncbi.nlm.nih.gov]
Serum
-
Cytopenia
[…] erythema migrans (EM) from this region, who have leukopenia and/or thrombocytopenia (typical findings in HGA and in the initial phase of TBE but not in patients with LB) are coinfected with Anaplasma phagocytophilum and/or with TBE virus, i.e. that cytopenia [ncbi.nlm.nih.gov]
Microbiology
-
Chlamydia Trachomatis
Shigella flexneri, Listeria monocytogenes, Chlamydia trachomatis, and Anaplasma phagocytophilum express effector proteins that modify host histones and chromatin structure. [ncbi.nlm.nih.gov]
Treatment
Treatment responses were reported for 14 cats, and the clinical abnormalities in these cats resolved when doxycycline was administered. [ncbi.nlm.nih.gov]
However, antibiotic treatment has to be taken as soon as possible when the disease-related symptoms are perceived. Pregnancy can also complicate the antibiotic treatment. [mechpath.com]
He completed 21 days of doxycyline treatment for HGE and was discharged after one month of hospitalisation. [jcp.bmj.com]
Etiology
Abstract The obligate intracellular bacteria Anaplasma phagocytophilum is the etiological agent of human granulocytic anaplasmosis (HGA), an acute febrile tick-borne disease. [ncbi.nlm.nih.gov]
Epidemiology
A. phagocytophilum epidemiological cycles are complex and involve different ecotypes, vectors, and mammalian host species. Moreover, the epidemiology of A. phagocytophilum infection differs greatly between Europe and the USA. [ncbi.nlm.nih.gov]
Pathophysiology
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Human granulocyte ehrlichiosis (HGE) is a zoonotic infection caused by a rickettsia-like agent. [mayomedicallaboratories.com]
Prevention
We report 2 additional cases of transfusion-transmitted A phagocytophilum in which leukocyte reduction of all transfused units failed to prevent microbial transmission. [ncbi.nlm.nih.gov]