In ticks, numerous ankA and msp4 variants were present. Copyright © 2014 Elsevier GmbH. All rights reserved. [ncbi.nlm.nih.gov]

• Fever

  The Biovar Phagocytophilum is the agent of a disease of the ruminants known to ovine races under the name of “tick-border fever” and, to the cattle, under the name of “pasture fever". [biomerieux-nordic.com]

  A·na·plas·ma pha·go·cy·to·phil·um ( an'ă-plaz'mă fā'gō-sī-tŏ-f'il-um ) A bacterial species that causes human granulocytic ehrlichiosis; also causes tick-borne fever in cattle; spread by ticks (Ixodes), it occurs in the United States in the Middle Atlantic [medical-dictionary.thefreedictionary.com]

  A 61-year-old woman presented with a 6-day history of fever, headache, and myalgia. Initial investigation showed neutropenia and thrombocytopenia. We diagnosed human granulocytic anaplasmosis by microscopic examination and serologic testing. [ncbi.nlm.nih.gov]

• Asymptomatic

  The donor remained asymptomatic and received no treatment. The cocomponent PLT unit was transfused to a 78-year-old male who died of causes unrelated to AP. This eighth case of probable TT-HGA indicates that leukoreduced PLTs may be infectious. [ncbi.nlm.nih.gov]

  What is unclear from these data is whether the discrepancy between the seroprevalence and symptomatic rate results from underdiagnosis of infection, asymptomatic serologic reactions, or even infections that produce cross-reactive serologic responses. [medscape.com]

  This suspicion is bolstered by the high rates of background seroprevalence (~12-15%) in endemic areas, a finding that also indicates that many infections are mild and self-limiting or asymptomatic. [columbia-lyme.org]

• Pain

  A 49-year-old woman was suffering from feverish symptoms, fatigue, arthralgia, general body pain, and anorexia for 2 weeks. Later, she visited the Bayannur Centers for Disease Control and Prevention Hospital in Inner Mongolia, China. [ncbi.nlm.nih.gov]

  Onset of anaplasmosis generally begins within a week of a tick bite, and often includes fever, severe headaches, malaise, muscle pains, and chills. Other symptoms may include confusion, hemorrhages, and renal failure. [aldf.com]

  Can cause lethargy, ataxia, inappetence, and weak or painful limbs. Bacterial mechanism Anaplasma phagocytophilum binds to fucosylated and sialylated scaffold proteins on neutrophil and granulocyte surfaces. [monsterologist.blogspot.com]

• Anorexia

  A 49-year-old woman was suffering from feverish symptoms, fatigue, arthralgia, general body pain, and anorexia for 2 weeks. Later, she visited the Bayannur Centers for Disease Control and Prevention Hospital in Inner Mongolia, China. [ncbi.nlm.nih.gov]

  The fever comes along with an anorexia, a loss of weight and a fall of the milk production which can be rough and massive. Other clinical signs consist of locomotive confusions, respiratory deficiencies, abortions. [biomerieux-nordic.com]

  Human Granulocytic Ehrlichiosis Causes fever, malaise, headaches, sweats, nausea, confusion, anorexia, vomiting, weakness, diarrhoea, pneumonia, vertigo, seizures, GI bleeding and a skin rash. [2] References ↑ Miert, A. S. J. P. A. Mvan., Duin, C. [en.wikivet.net]

• Anemia

  Frequent laboratory abnormalities identified in up to 329 patients include thrombocytopenia (71%), leukopenia (49%), anemia (37%), and elevated hepatic transaminase levels (71%). [medscape.com]

  General Laboratory Findings Typically observed during the first week of clinical disease: Mild anemia Thrombocytopenia Leukopenia (characterized by relative and absolute lymphopenia and a left shift) Mild to moderate elevations in hepatic transaminases [cdc.gov]

• Sputum

  Kits: EliGene® Anaplasma Phagocytophilum UNI Kit (ref: 90061-UNI) Package size: 50 reactions Analytical specificity: Anaplasma Phagocytophilum Specimens: urine, sputum, BAL, exudatesblood, urine, CSF, synovial fluid, tissue Compatible instruments: ABI [eligene.com]

• Loss of Appetite

  Early Illness Early signs and symptoms (days 1-5) are usually mild or moderate and may include: Fever, chills Severe headache Muscle aches Nausea, vomiting, diarrhea, loss of appetite Late Illness Rarely, if treatment is delayed or if there are other [cdc.gov]

• Skin Rash

  Human Granulocytic Ehrlichiosis Causes fever, malaise, headaches, sweats, nausea, confusion, anorexia, vomiting, weakness, diarrhoea, pneumonia, vertigo, seizures, GI bleeding and a skin rash. [2] References ↑ Miert, A. S. J. P. A. Mvan., Duin, C. [en.wikivet.net]

  Other symptoms include fever, headache, absence of skin rash, leucopenia, thrombocytopenia and mild injury to the liver. Clinical signs in animals The disease is multisystemic, but the most severe changes are anaemia and leukopenia. [monsterologist.blogspot.com]

  rash, leukopenia, thrombocytopenia, and mild injury to the liver. [medscape.com]

  Aside from the bacterial clusters, common features among these persons included fever, headache, myalgia, malaise, absence of skin rash, leukopenia, thrombocytopenia, and mild injury to the liver. Figure 2 Figure 2. [doi.org]

• Arthritis

  Inflammatory arthritis: a unique presentation of human anaplasmosis. Clin Rheumatol. 2019 Jan;38(1):257-259. - PubMed Uminski K, Kadkhoda K, Houston BL, Lopez A, MacKenzie LJ, Lindsay R, Walkty A, Embil J, Zarychanski R. [pubmed.ncbi.nlm.nih.gov]

• Headache

  A 61-year-old woman presented with a 6-day history of fever, headache, and myalgia. Initial investigation showed neutropenia and thrombocytopenia. We diagnosed human granulocytic anaplasmosis by microscopic examination and serologic testing. [ncbi.nlm.nih.gov]

  Human infection occurs when humans impinge on tick-small mammal habitats. [4,5,6,7] HGA is clinically variable, but most patients have a moderately severe febrile illness with headache, myalgia, and malaise. [medscape.com]

  Typical symptoms include fever, headache, chills, and muscle aches and they usually occur within 1-2 weeks of a tick bite. [eligene.com]

• Ataxia

  Other less common clinical findings included hepatosplenomegaly, ataxia, conjunctivitis and elevation of the nictitating membranes. [ncbi.nlm.nih.gov]

  Can cause lethargy, ataxia, inappetence, and weak or painful limbs. Bacterial mechanism Anaplasma phagocytophilum binds to fucosylated and sialylated scaffold proteins on neutrophil and granulocyte surfaces. [monsterologist.blogspot.com]

• Lethargy

  A phagocytophilum infection should be considered in cats evaluated for lethargy, anorexia and fever living in Ixodes species endemic areas. © ISFM and AAFP 2015. [ncbi.nlm.nih.gov]

  Can cause lethargy, ataxia, inappetence, and weak or painful limbs. Bacterial mechanism Anaplasma phagocytophilum binds to fucosylated and sialylated scaffold proteins on neutrophil and granulocyte surfaces. [monsterologist.blogspot.com]

• Borrelia Burgdorferi

  KEYWORDS: Anaplasma phagocytophilum; Babesia microti; Borrelia burgdorferi; Ixodes scapularis; Lyme disease [ncbi.nlm.nih.gov]

  ORIGINAL PAPER Monoinfections caused by Borrelia burgdorferi and Borrelia burgdorferi / Anaplasma phagocytophilum co-infections in forestry workers and farmers More details Hide details 1 Państwowa Szkoła Wyższa im. [medpr.imp.lodz.pl]

  Infestation of ticks with Borrelia burgdorferi and Francisella tularensis in Slovakia. Bratisl Lek Listy. 1990; 91: 251–256. 16. Kožuch O, Labuda M, Lysy J, Weismann P, Krippel E. [aaem.pl]

• Babesia Microti

  KEYWORDS: Anaplasma phagocytophilum; Babesia microti; Borrelia burgdorferi; Ixodes scapularis; Lyme disease [ncbi.nlm.nih.gov]

He completed 21 days of doxycyline treatment for HGE and was discharged after one month of hospitalisation. [jcp.bmj.com]

There was a lower baseline percentage of NK cells in patients not responding to antibiotic treatment. [ncbi.nlm.nih.gov]

However, antibiotic treatment has to be taken as soon as possible when the disease-related symptoms are perceived. Pregnancy can also complicate the antibiotic treatment. [mechpath.com]

Prompt treatment can reduce your risk of developing severe illness. [cdc.gov]

Abstract The obligate intracellular bacteria Anaplasma phagocytophilum is the etiological agent of human granulocytic anaplasmosis (HGA), an acute febrile tick-borne disease. [ncbi.nlm.nih.gov]

A. phagocytophilum epidemiological cycles are complex and involve different ecotypes, vectors, and mammalian host species. Moreover, the epidemiology of A. phagocytophilum infection differs greatly between Europe and the USA. [ncbi.nlm.nih.gov]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Human granulocyte ehrlichiosis (HGE) is a zoonotic infection caused by a rickettsia-like agent. [mayocliniclabs.com]

Sections Continuing Education Activity Introduction Etiology Epidemiology Pathophysiology Histopathology History and Physical Evaluation Treatment / Management Differential Diagnosis Complications Pearls and Other Issues Enhancing Healthcare Team Outcomes [pubmed.ncbi.nlm.nih.gov]

These studies should lead to a greater understanding of A. phagocytophilum pathogenesis and may suggest new ways to prevent infection. [grantome.com]

Young-Uk Cho 4, Yeong Seon Lee 1, Sung-Han Kim 2, Seon Do Hwang 1 View Affiliations Hide Affiliations Affiliations: 1 Division of Zoonoses, Center for Immunology and Pathology, Korea National Institute of Health, Korea Centers for Disease Control and Prevention [ajtmh.org]

Invasins of obligate intracellular pathogens are attractive targets for protecting against or curing infection because blocking the internalization step prevents survival of these organisms. [ncbi.nlm.nih.gov]