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Anaplastic Ganglioglioma


Presentation

  • The authors report the case of anaplastic ganglioglioma in an adult patient presenting as a CPA mass lesion. The presentation was bizarre, and the diagnosis was possible only after histopathologic examination of the resected mass.[ncbi.nlm.nih.gov]
Progressive Hearing Loss
  • A 32-year-old lady presented with complaints of gradually progressive hearing loss and tinnitus in her right ear along with headache and ataxia. Neurologic evaluation revealed right-sided sensorineural hearing loss and truncal ataxia.[ncbi.nlm.nih.gov]
Neck Mass
  • Lippincott Williams & WilkinsChapter 7: Intracranial, orbital, and neck masses of childhood [2] Wolf LüdemannEmail authorRouzbeh BananChristian HartmannHelmut BertalanffyConcezio Di Rocco (2017) Pediatric intracranial primary anaplastic ganglioglioma.[eurorad.org]
Cranial Neuropathy
  • Two of the three patients experienced symptomatic decline at recurrence, but experienced Karnofsky performance status (KPS) improvement after salvage therapy, including the reduction of cranial neuropathy and balance.[ncbi.nlm.nih.gov]
Truncal Ataxia
  • Neurologic evaluation revealed right-sided sensorineural hearing loss and truncal ataxia.[ncbi.nlm.nih.gov]

Workup

Atelectasis
  • .: Surface Properties in Relation to Atelectasis and Hyaline Membrane Disease. ‎ Página 485 - In: Scriver CR, Beaudet AL, Sly WS, et al., eds. The Metabolic Basis of Inherited Disease. 6th ed. New York: McGraw-Hill; 1989. ‎[books.google.es]

Treatment

  • The main treatment is removal of the entire tumor during surgery. If the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.[diseaseinfosearch.org]
  • The clinical course and optimal treatment of anaplastic gangliogliomas have not been well understood to date.[ncbi.nlm.nih.gov]
  • Articles will include: Posterior Fossa Tumors in Adult Patients; Lymphomas and Adult Brain Tumors; Pre-Treatment Evaluation of Gliomas; Post Treatment Evaluation of Gliomas; Metastasis in Adult Brain Tumors; Extraparenchymal Lesions in Adult Brain Tumors[books.google.de]

Prognosis

  • Gangliogliomas usually have a good prognosis. Histological features of anaplasia and a high MIB-1 labeling index may be predictive of a poor clinical outcome.[ncbi.nlm.nih.gov]
  • Although predicting the prognosis of anaplastic gangliogliomas is difficult, some authors stated that cell kinetic studies, such as MIB-1 staining, may be useful for predicting the prognosis ( 6 , 8 ).[jkms.org]
  • "Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database.". Neuro Oncol 19 (5): 678-688. doi : 10.1093/neuonc/now186. PMID 28453747.[librepathology.org]

Epidemiology

  • Using the Surveillance, Epidemiology, and End Results (SEER) cancer registry, we investigated potential clinicopathological factors that can affect outcome in patients with anaplastic ganglioglioma.[ncbi.nlm.nih.gov]
  • Definition / general Well differentiated neuroepithelial tumors composed of neoplastic ganglion cells (gangliocytoma) or combination of neoplastic ganglion cells and neoplastic glial component (ganglioglioma) Epidemiology 2% of all brain tumors Ages 2[pathologyoutlines.com]
  • Yu Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a surveillance, epidemiology, and end results analysis. Cancer 2012;118:4212-9. 10. CE Fuller, S Narendra, I. Tolocica Choroid plexus neoplasm.[pagepress.org]
  • Österreich und der Schweiz zusammengetragen wurden, haben wir sowohl klinisch-epidemiologische Eckdaten als auch histopathologische und immunhistochemische Merkmale von Gangliogliomen systematisch zusammengestellt. en In a series of 326 gangliogliomas , epidemiological[de.glosbe.com]
  • Outline maternal risk factors and epidemiology of FASD. This SAM is worth 1 CME credit.[neuropath.org]
Sex distribution
Age distribution

Pathophysiology

  • It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care.[books.google.de]
  • Molecular understanding of the ERK (extracellular regulated kinase) pathway and how it interacts with many pathophysiologic processes in cancer suggest that it may be a useful target for therapeutic intervention in glioblastoma.[neuropath.org]

Prevention

  • The outcome after surgery depends mainly on the possible amount of surgical resection, and oncological therapy is necessary to prevent recurrence of the disease.[ncbi.nlm.nih.gov]
  • Is chronic lung disease in low birth weight infants preventable? A survey of eight centers. ‎ Página 84 - Tanner JM, Whitehouse RH, Marubini E, Resele LF. The adolescent growth spurt of boys and girls of the Harpenden growth study. ‎[books.google.es]
  • Explaining Non-Compliance Dynamics in the EU - PDF Cézanne Site / Non-Site - PDF ANTIOXIDANTY A ICH ÚLOHA V PREVENCII NEKONTAGIÓZNYCH CHORÔB ANTIOXIDANTS AND THEIR IMPORTANCE FOR PREVENTION OF NON COMMUNICABLE DISEASES - PDF Vliesové fototapety Photo[alldocs.net]
  • Mutations in the CTNNB1 gene at various key phosphorylation sites have been identified in CRC and several other solid tumors and it seem to prevent destruction of β-catenin by the proteasome pathway, which then leads to constitutive activation of Wnt[intechopen.com]

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