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Anaplastic Oligodendroglioma

Glioblastoma


Presentation

  • The patient presented with left hip pain 3 years later. Radiography and computed tomography demonstrated osteosclerosis of the left proximal femur, and MRI revealed an intramedullary metastatic lesion.[ncbi.nlm.nih.gov]
Weakness
  • A 28-year-old man with history of anaplastic oligodendroglimoma in the left frontal lobe presented with worsening right leg weakness 2 months after surgical resection.[ncbi.nlm.nih.gov]
  • Cancers that are located in the frontal lobe may cause weakness on one side of the body, personality or behavior changes, and difficulty with short- term memory.[secure.ssa.gov]
  • If they are in the frontal lobe this may cause gradual changes in mood and personality, weakness or numbness in muscles of one side of the body.[thebraintumourcharity.org]
Nausea
  • The longitudinal analysis showed a significant increase in nausea/vomiting in the RT plus PCV chemotherapy arm during and shortly after chemotherapy.[ncbi.nlm.nih.gov]
  • Except for nausea etc while on chemo, you'd never know that anything had ever been wrong with him. His dr. was not optimistic. He basically gave us no hope. All he would say is that the median survival rate is 3 to 5 years.[csn.cancer.org]
  • (WHO grade III) Epidemiology of Oligodendroglioma peak age between 35 and 50 in childhood around 10 men are a little more often affected Symptoms of Oligodendroglioma mainly epileptic seizures as initial sign symptoms of cerebral pressure (headache, nausea[hirntumorhilfe.org]
Bone Pain
  • Four months before the demonstration of visceral metastases was obtained by bone marrow biopsy, the patient developed diffuse bone pain, pancytopenia, hypercalcemia, and panhypogammaglobulinemia.[ncbi.nlm.nih.gov]
Back Pain
  • If patients with these tumors have neck or back pain, spinal metastasis should be included in the differential diagnosis and further investigated.[ncbi.nlm.nih.gov]
Hip Pain
  • The patient presented with left hip pain 3 years later. Radiography and computed tomography demonstrated osteosclerosis of the left proximal femur, and MRI revealed an intramedullary metastatic lesion.[ncbi.nlm.nih.gov]
Leg Pain
  • We report a case of 67-year-old woman who after 1 month of severe low back and legs pain developed symptoms of raised intracranial pressure.[ncbi.nlm.nih.gov]
Dyslexia
  • Alterations Memory Loss Impaired Vision When it appears in the parietal lobe, it often causes: Disturbances in the sense of touch Problems with balance and coordination Inability to maintain concentration and perception of sensory and visual senses Dyslexia[cancerwall.com]
Pelvic Pain
  • In 2000 he developed hip and pelvic pain. A bone scan showed multiple skeletal lesions. Magnetic resonance imaging of the brain showed stability of intracranial disease.[ncbi.nlm.nih.gov]
Seizure
  • We describe a unique case, whereby a patient presenting with seizures and slight impairment of higher functions, underwent frontal lobectomy for a mass lesion.[ncbi.nlm.nih.gov]
Headache
  • A case of anaplastic oligodendroglioma with femoral metastasis is presented in a 37-year old male with a 2-year history of progressive headaches and dizziness associated with a 2-month history of epilepsy and right hemiparesis.[ncbi.nlm.nih.gov]
Personality Change
  • Symptoms may include seizures, headaches, and personality changes. Other symptoms may vary depending on the location and size of the tumors including short-term memory loss, visual loss, motor weakness, and language problems.[diseaseinfosearch.org]
  • The most common symptoms are seizures, headaches, and personality changes. Other symptoms vary by location and size of the tumor.[themiracleofasingleflower.wordpress.com]
  • Personality change. Diagnostic Evaluation A physical examination may show objective neurological findings or only minor cognitive changes.[cancer.gov]
Generalized Seizure
  • A 17-year-old woman presented with an anaplastic oligodendroglioma manifesting as generalized seizure. Neuroimaging studies revealed a right frontal tumor.[ncbi.nlm.nih.gov]
  • However, the patient didn’t perform any control and presented to our hospital in 2010, July, for a generalized seizure; MRI showed a considerable growth of the previously detected lesion, which presented hyperintense in T2 flair images with some nodular[jneuro.com]
Papilledema
  • The symptoms of increased intracranial pressure, such as headache, visual disturbances, and papilledema, are generally associated with intraventricular lesions.[dovepress.com]

Workup

  • Structural magnetic resonance imaging (MRI) and histopathologic tissue sampling are routinely performed as part of the diagnostic workup for patients with glioma.[ncbi.nlm.nih.gov]

Treatment

  • We hypothesized that chemotherapy would impair HRQOL during treatment but that there would be a similar HRQOL between treatment arms once off treatment.[ncbi.nlm.nih.gov]

Prognosis

  • The only clinical relevant meaning of this histologic diagnosis was the observation that the prognosis of OD was in general better than that of astrocytic tumors of similar grade.[ncbi.nlm.nih.gov]

Etiology

  • Epstein-Barr virus infection has been implicated in the etiology of primary CNS lymphoma.[cancer.gov]

Epidemiology

  • Author information 1 1] Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK [2] Inserm, U 1127, ICM, F-75013 Paris, France [3] CNRS, UMR 7225, ICM, F-75013 Paris, France [4] Institut du Cerveau et de la[ncbi.nlm.nih.gov]
  • Histology of Oligodendroglioma oligodendroglioma (WHO grade II) anaplastic oligodendroglioma (WHO grade III) Epidemiology of Oligodendroglioma peak age between 35 and 50 in childhood around 10 men are a little more often affected Symptoms of Oligodendroglioma[hirntumorhilfe.org]
  • Epidemiology [ 1, 2 ] The annual incidence of malignant glioma is 3-5/100,000. Exposure to ionising irradiation has been associated with increased risk of development of glioma.[patient.info]
  • Epidemiology Frequency United States The incidence of oligodendrogliomas ranges from 5-19% of all intracranial tumors. The newer studies showed incidence of oligodendrogliomas to be around 25% of all gliomas.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology of the seeding of intracranial tumours via the cerebrospinal fluid is reviewed.[ncbi.nlm.nih.gov]
  • Pathophysiology Oligodendrogliomas arise in the cerebral hemispheres and are distributed among the frontal, parietal, temporal, and occipital lobe, in approximately a 3:2:2:1 ratio.[emedicine.medscape.com]
  • All of these pathophysiological mechanisms, in addition to many other general factors, such as stasis, the presence of inflammation, dysproteinemia, infections, and entrapment, contribute to the hypercoagulable state.[dovepress.com]

Prevention

  • This case emphasizes the importance of considering this diagnosis to prevent unnecessary irradiation of such rumours.[ncbi.nlm.nih.gov]
  • Clinical trials look at new ways to prevent, find and treat cancer. Find out more about clinical trials .[cancer.ca]
  • Prevention Because the cause or causes of oligodenrogliomas are not known, there are no known preventions. Special concerns Repeat surgery may be necessary for oligodendrogliomas because these tumors sometimes redevelop.[encyclopedia.com]

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