Presentation
Intravascular lymphoma (IVL) is a rare extra nodal subtype (usually of B-cell origin) presenting with infiltration of large neoplastic lymphocytes into lumina of blood vessels, leading to vascular occlusion. [ncbi.nlm.nih.gov]
Entire Body System
- Swelling
(swelling) Edema (swelling) leg Edema (swelling), arms and legs Edema of face Edema of foot Edema of lower extremity Edema, localized Edema, lower extremity Edema, peripheral Facial edema Leg edema Localized edema Pedal edema Pedal edema (foot swelling [icd9data.com]
Last Updated On December 19, 2017 By Anasarca is the medical term used for describing general swelling of body. It is the collection of fluid in the cellular spaces of the body leading to massive swelling. [diseasespictures.com]
The swelling is obvious, and the skin may look shiny and stretched. Sometimes, swelling is so extreme that a person has difficulty moving. Swelling can become so severe that fluid will leak out directly from the skin. This is known as weeping edema. [medicalnewstoday.com]
- Malnutrition
Severe malnutrition is another possible anasarca cause. Malnutrition of exacting vitamins, minerals, nutrients, and various necessary items can lead to diverse medical problems, based upon the type of deficiency. [pharmatutor.org]
Anasarca Picture 1: Anasarca (abdomen) Image Source: expression.psmalik.com Anasarca in Children The major cause of Anasarca in children is protein energy malnutrition – Kwashiorkor in which the protein deficiency is more severe than energy malnutrition [howshealth.com]
Anasarca is a severe and generalized form of edema with widespread subcutaneous tissue swelling. [1] It is usually caused by liver failure ( cirrhosis of the liver), renal failure, right-sided heart failure, as well as severe malnutrition/protein deficiency [en.wikipedia.org]
It's usually caused by liver failure or renal failure/disease and severe malnutrition/protein deficiency. [memidex.com]
- Congestive Heart Failure
End-stage congestive heart failure is a leading diagnosis among hospice patients without cancer. As in terminally ill cancer patients; the aim of the treatment was to focus on palliation and maximum symptom relief. [ncbi.nlm.nih.gov]
Heart transplant is also part of the treatment for patients with congestive heart failure. [symptomscausestreatment.com]
Anasarca often occurs in congestive heart failure, liver failure, or renal disease. See also edema. anasarcous, adj. anasarca Diffuse systemic oedema due to an accumulation of fluid in the interstitial space. [medical-dictionary.thefreedictionary.com]
- Inflammation
Juvenile dermatomyositis is a rare autoimmune disease characterized by inflammation of the muscle, skin, and other organs. Although localized edema is a common feature of juvenile dermatomyositis, generalized edema has been reported infrequently. [ncbi.nlm.nih.gov]
Inflammation of the hypodermis—the subcutaneous tissue that’s located beneath the surface of the skin and naturally contains fluids—is the most prominent sign and symptom of anasarca. [doctorshealthpress.com]
Those conditions typically isolate swelling/inflammation to a specific section of the body; however, the swelling/inflammation associated with Anasarca typically impacts the entire body. [thehealthyapron.com]
Elevated levels of serum C-reactive protein, ferritin and plasma D-dimer suggested that systemic inflammation caused anasarca by both decreased production of albumin and hyperpermeability associated with vascular endothelial damage similar to systemic [tandfonline.com]
- Fever
Synonyms: fever and ague; intermittent fever; periodic fever; malarial fever; marsh fever; paludal fever; miasmatic fever. [Gould1910]. Febris intermittans. A febrile condition in which there are alternating periods of chills, fever, and sweating. [antiquusmorbus.com]
pseudotumor cerebri, hyperhidrosis and hyperpigmentation of the skin, generalized lymphadenopathy, distal esophageal dysphagia, pleuritis, platelike pulmonary atelectasis, fluctuating renal insufficiency, hepatosplenomegaly, amenorrhea, and slight fever [ncbi.nlm.nih.gov]
[…] trouble) CONGESTION CONSTIPATION CONVULSIONS COUGH CYST CRAMPS DEBILITY DIABETES (Or diabetes mellitus) DIARRHEA DIPHTHERIA DIZZINESS (Vertigo) DROPSY (Generalized edema or anasarca) DYSENTERY (Summer complaint) DYSMENORRHEA DYSPEPSIA DYSPNEA FATIGUE FEVER [online.snh.cc]
Respiratoric
- Pleural Effusion
Although large pleural effusions are rare in amyloidosis, they are usually exudative and may be due to direct pleural infiltration or amyloid-induced heart, liver, renal or thyroid failure. [jhu.pure.elsevier.com]
Chest and abdomen CT showed massive bilateral pleural effusions, but no lung infiltrate, pericardial effusion or ascites or lymphadenopathy. [bloodjournal.org]
There were pleural thickening and encysted pleural effusion on the left, and atelectasis of adjacent lung portions. The right hemithorax showed small pleural effusion and thickening, in addition to a small nonspecific opacity in the right lung base. [scielo.br]
Patients present with weight loss, chest pain, pleural effusions, dyspnea, abdominal pain, upper and lower gastrointestinal bleeding, diarrhea, nausea, and vomiting. [shmabstracts.com]
Chest radiograph at that time revealed bilateral pleural effusions that were both reportedly milky in appearance when drained by thoracenteses. [ncbi.nlm.nih.gov]
Cardiovascular
- Heart Failure
Anasarca, a widespread swelling of the skin because of effusion of fluid into the extracellular space, is a common sign in end-stage heart failure causing much pain and discomfort. [ncbi.nlm.nih.gov]
[…] kidney disease (advanced stages with fluid retention) Constrictive pericarditis with associated heart failure Cor pulmonale resulting in right heart failure Diazoxide usually cause localized edma and not anasarca Corticosteriods Dilated cardiomyopathy [medicalopedia.org]
Heart transplant is also part of the treatment for patients with congestive heart failure. [symptomscausestreatment.com]
Skin
- Skin Rash
Abstract Dermatomyositis is an autoimmune disorder that causes proximal muscle weakness and skin changes which include generalized erythema, heliotrope rash and/or Gottron's papules. [ncbi.nlm.nih.gov]
He had no fever, skin rash, sicca syndrome or lichen planus. Chest and abdomen CT showed massive bilateral pleural effusions, but no lung infiltrate, pericardial effusion or ascites or lymphadenopathy. [bloodjournal.org]
Although presentations of JDM can be variable, symptoms typically include proximal muscle weakness and classic skin rashes such as Gottron’s papules and heliotrope rash. [ped-rheum.biomedcentral.com]
Common indications of allergy may include sneezing, itching, and skin rashes. [antiquusmorbus.com]
- Subcutaneous Nodule
CASE REPORT A 31 year old milk route salesman entered the Salt Lake Veterans Administration Hospital on June 6, 1955, because of subcutaneous nodules of three months' duration. He had been in good health until December, FULL TEXT [annals.org]
- Blister
Edema blisters (also known as "Edema bulla", "Hydrostatic bulla," and "Stasis blister") are a cutaneous condition that develop in patients with an acute exacerbation of chronic edema, particularly of the lower extremities, and in the setting of anasarca [diki.pl]
[…] angle-closure glaucoma 0/0 Acute appendicitis 0/0 Acute bacterial endocarditis 0/0 Acute bronchitis 0/0 Acute cervicitis 0/0 Acute chest syndrome 0/0 Acute compartment syndrome 0/0 Acute dacryoadenitis 0/0 Acute demyelinating encephalomyelitis 0/0 Acute edema blister [visualdx.com]
Differential Diagnosis Acute edema blister Acute kidney injury Acute myeloid leukemia Chronic kidney disease Congestive heart failure IgA nephropathy Liver cirrhosis Membranoproliferative glomerulonephritis Pericardial effusion Ventricular septum defect [ncbi.nlm.nih.gov]
- Eruptions
She also exhibited a bullous eruption localized to the right upper limb. Main Content Enter the password to open this PDF file: Preparing document for printing… 0% [escholarship.org]
She also exhibited a bullous eruption localized to the right upper limb. [ncbi.nlm.nih.gov]
[Hoblyn1855] A small pustule containing a straw colored fluid, and forming scaly eruptions about the head of young children; a species of scald-head. [antiquusmorbus.com]
Fetus
- Hydrops Fetalis
fetalis liver - see Cirrhosis, liver neonatorum - see Hydrops, fetalis newborn - see Hydrops, fetalis uremic - see Uremia Edema, edematous 782.3 cerebral - see Edema, brain cerebrospinal vessel - see Edema, brain connective tissue 782.3 due to epiglottis [icd9data.com]
fetalis not due to hemolytic disease 2016 2017 2018 2019 Billable/Specific Code Code on Newborn Record Applicable To Hydrops fetalis NOS nutritional E43 ICD-10-CM Diagnosis Code E43 Unspecified severe protein-calorie malnutrition 2016 2017 2018 2019 [icd10data.com]
2,6: nephrotic syndrome end-stage renal disease heart failure cirrhosis malnutrition hypothyroidism (myxedema) inferior or superior vena cava obstruction lymphedema due to lymphatic obstruction by tumor or filariasis sepsis with fluid resuscitation hydrops [radiopaedia.org]
Image Source: howshealth.com Picture 5: AP babygram detects fetal anasarca seen in hydrops fetalis. Image Source: Case courtesy of Dr. [healthfixit.com]
Face, Head & Neck
- Facial Edema
One week prior to renal biopsy, he had the sudden onset of facial edema and a urine protein/creatinine ratio of 7.8. Image 1. No change by light microscopy. Image 2. Diffuse and complete foot process effacement. [arkanalabs.com]
Periorbital and facial edema may also be associated. Although localized edema is a common feature of JDM, generalized edema has rarely been reported. Here, we report a 3.5-year-old boy with JDM presenting with generalized edema. [ncbi.nlm.nih.gov]
The stem definitely mentioned "facial edema making it difficult for the patient to open his eyes in the morning" and "generalized body edema" with trace proteins and >50 RBCs on a UA. [forums.studentdoctor.net]
She initially noticed bilateral lower extremity edema and right-sided facial swelling that subsequently progressed to include both sides of her face, her abdomen, pelvis, and labia. She also reports a 9-lb (3.54-kg) weight gain. [pedsinreview.aappublications.org]
Urogenital
- Kidney Failure
But most of all, anasarca is very common in patients with heart failure and kidney failure. [symptomscausestreatment.com]
Anasarca is very familiar in patients with heart failure and kidney failure. Cardiac problems and renal failure is one of the ordinary diseases that individuals experience globally. [pharmatutor.org]
Congestive Heart, Liver, or Kidney Failure In patients with congestive heart, liver, and kidney failure, various diuretics are necessary to help regulate sodium levels throughout the bloodstream. [doctorshealthpress.com]
It is common in patients who have kidney and heart failure. When there is a cardiac problem accompanied by renal failure, it can cause edema and anasarca. [healthylifemed.com]
Generalized edema or anasarca occurs kidney failure patients due to loss of protein in the urine. This results in malfunctioning of kidney and causes water and other toxins to be retained in the body. [healthncare.info]
- Oliguria
Common etiologies for secondary edema include: congestive heart failure (CHF), hepatic cirrhosis, acute or chronic renal failure (usually associated with significant oliguria or anuria), protein-losing glomerulopathies ( nephrotic syndrome ), pulmonary [thebigl.co]
There is increased permeability of capillaries to plasma proteins leading to fluid shift from the intravascular to the extravascular compartment, which clinically manifests as ascites, pleural effusion, oliguria, hemoconcentration and electrolyte imbalances [karger.com]
- Anuria
Common etiologies for secondary edema include: congestive heart failure (CHF), hepatic cirrhosis, acute or chronic renal failure (usually associated with significant oliguria or anuria), protein-losing glomerulopathies ( nephrotic syndrome ), pulmonary [thebigl.co]
Workup
A recent workup for cardiac, renal, and liver disease, including two-dimensional echocardiogram, liver and renal function tests, and abdominal ultrasound, was unremarkable. He reported a 15-pack year history of smoking and quit 3 years ago. [ncbi.nlm.nih.gov]
She was admitted for further workup and management. [ped-rheum.biomedcentral.com]
X-Ray
- Pericardial Effusion
[…] disorder and left Heart failure Chest X Ray · May show evidence of pulmonary edema (bat wing appearance of hilar region) · May show evidence of Pleural and Pericardial effusion (due to hypo-albuminemia) · May show cardiac hypertrophy in chronic heart [tirthankaronline.blogspot.com]
Lung congestion and pericardial and pleural effusions can cause attenuation in the ECG potentials; additionally, a similar change was recently observed in patients with AN. [ncbi.nlm.nih.gov]
Chest and abdomen CT showed massive bilateral pleural effusions, but no lung infiltrate, pericardial effusion or ascites or lymphadenopathy. [bloodjournal.org]
In the outside hospital ED, she had a Chest X-ray which showed bilateral pleural effusions and a pericardial effusion. [ped-rheum.biomedcentral.com]
Serum
- Hypoalbuminemia
The patient was known to suffer from clinically stable congestive heart failure and had not had previous hypoalbuminemia. [ncbi.nlm.nih.gov]
If the serum albumin level is less than 2.5 gm/dL, then hypoalbuminemia resulting in a decrease in intravascular oncotic pressure may be the cause of the edema, and a further investigation into the cause of the hypoalbuminemia is warranted. [thebigl.co]
Overall, 70% of patients with hypoalbuminemia had elevated fecal α1AT levels [ 6 ]. [academic.oup.com]
Pleura
- Pleural Effusion
Although large pleural effusions are rare in amyloidosis, they are usually exudative and may be due to direct pleural infiltration or amyloid-induced heart, liver, renal or thyroid failure. [jhu.pure.elsevier.com]
Chest and abdomen CT showed massive bilateral pleural effusions, but no lung infiltrate, pericardial effusion or ascites or lymphadenopathy. [bloodjournal.org]
There were pleural thickening and encysted pleural effusion on the left, and atelectasis of adjacent lung portions. The right hemithorax showed small pleural effusion and thickening, in addition to a small nonspecific opacity in the right lung base. [scielo.br]
Patients present with weight loss, chest pain, pleural effusions, dyspnea, abdominal pain, upper and lower gastrointestinal bleeding, diarrhea, nausea, and vomiting. [shmabstracts.com]
Chest radiograph at that time revealed bilateral pleural effusions that were both reportedly milky in appearance when drained by thoracenteses. [ncbi.nlm.nih.gov]
Treatment
Pre- and post-treatment data were analyzed using matched pairs. [ncbi.nlm.nih.gov]
[…] regimen that your doctor outlines for you • If your doctor prescribes any type of medication treatment, you should be certain to follow that treatment • Finally, you should review the treatment section of this guide and follow the steps outlined there [thehealthyapron.com]
Home treatments The following home-care tips may also speed the treatment of your anasarca: Keep moving: Exercise can help pump excess fluid back to your heart. [healthline.com]
Prognosis
Fetal hydrops is a known complication of sacrococcygeal teratoma (SCT) due to arteriovenous shunts within the tumor, which is clinically important and influence patients' prognosis. [ncbi.nlm.nih.gov]
Prognosis Multiple anecdotal remedies exist, yet none are proven or reported in scientific literature. Although survival rates are low, some water puppies do survive provided they receive immediate veterinary treatment. [embracepetinsurance.com]
Armitage JO, Longo DL: Clinical features, treatment, and prognosis of specific lymphoid malignancies; in Fauci A, Braunwald E, Kasper D, Hauser S, Longo D, Jameson J, Loscalzo J (eds): Harrison’s Principles of Internal Medicine, ed 15. [karger.com]
Etiology
Anasarca of an Unusual Etiology. Abstract published at Hospital Medicine 2011, May 10-13, Dallas, Texas. Abstract 292. Journal of Hospital Medicine. 2011; 6 (suppl 2). https://www.shmabstracts.com/abstract/anasarca-of-an-unusual-etiology/. [shmabstracts.com]
EDEMA/ ANASARCA/ ANGIOEDEMA Etiologies The accumulation of fluid in the intercellular space of subcutaneous tissue or in body cavities is referred to as edema. Anasarca refers to a diffuse generalized edema of multiple organ systems. [thebigl.co]
Abstract Congo-red-negative microfibrils have been described in various glomerular diseases, some of which have no known etiology. [ncbi.nlm.nih.gov]
Thus, large pleural effusions, especially chylous, without clear etiology should raise the suspicion for amyloidosis and lead to further investigations. [jhu.pure.elsevier.com]
Epidemiology
Epidemiology The epidemiology of anasarca is not studied yet, but it is one of the common complaints among the patients admitted to the hospital. [ncbi.nlm.nih.gov]
Epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. Clin Infect Dis 2008 ; 47 : 1209 – 15. 12. [academic.oup.com]
Pathophysiology
Her severe cerebral edema is of considerable pathophysiologic interest: 1) it developed in the setting of marked anasarca and persistent hypernatremia, and 2) although hepatic function was poor, it was not considered sufficiently deranged to induce cerebral [ncbi.nlm.nih.gov]
I'm thinking about the pathophysiology of the condition. The patient retains all this fluid because of underlying chemisty imbalances. Often low protein is at the heart of it. [allnurses.com]
Pathophysiology In the presence of hypoalbuminemia as seen in nephrotic syndrome or other disease entities, anasarca occurs as a result of low osmotic pressure in the capillaries. [healthfixit.com]
Prevention
The American Academy of Pediatrics recommendations for prevention of iron deficiency anemia are reviewed. [ncbi.nlm.nih.gov]
Listed below are the effective treatments/ remedies for the prevention of anasarca that may help to improve and to reduce swelling of the skin significantly. 1. Avoiding salt, water pills, etc. – It prevent skin breakdown 2. [healthosphere.com]